Deng, Chu-Xia

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

Bunting, S. F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. (2010) · Cell

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 1,671

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

Ahn, B.-H., Kim, H.-S., Song, S., Lee, I. H., Liu, J., Vassilopoulos, A., Deng, C.-X., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences

Sirtuins and Resveratrol in MedicineMitochondrial Function and Pathology

Cited by 1,291

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

Kim, H.-S., Patel, K., Muldoon-Jacobs, K., Bisht, K. S., Aykin-Burns, N., Pennington, J. D., van der Meer, R., Nguyen, P., Savage, J., Owens, K. M., et al. (2010) · Cancer Cell

Sirtuins and Resveratrol in MedicineMitochondrial Function and Pathology

Cited by 785

The role of TGF-β/SMAD4 signaling in cancer

Zhao, M., Mishra, L., & Deng, C.-X. (2018) · International Journal of Biological Sciences

TGF-β signaling in diseasesSignaling Pathways in Disease

Cited by 631

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

Wang, R.-H., Li, C., Xu, X., Zheng, Y., Xiao, C., Zerfas, P., Cooperman, S., Eckhaus, M., Rouault, T., Mishra, L., et al. (2005) · Cell Metabolism

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 614

Bmi1 regulates mitochondrial function and the DNA damage response pathway

Liu, J., Cao, L., Chen, J., Song, S., Lee, I. H., Quijano, C., Liu, H., Keyvanfar, K., Chen, H., Cao, L.-Y., et al. (2009) · Nature

Epigenetics and DNA MethylationMitochondrial Function and Pathology

Cited by 474

Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1

Lijam, N., Paylor, R., McDonald, M. P., Crawley, J. N., Deng, C.-X., Herrup, K., Stevens, K. E., Maccaferri, G., McBain, C. J., Sussman, D. J., et al. (1997) · Cell

Genetics and Neurodevelopmental DisordersSchizophrenia research and treatment

Cited by 470

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

Jeong, S. M., Xiao, C., Finley, L. W. S., Lahusen, T., Souza, A. L., Pierce, K., Li, Y.-H., Wang, X., Laurent, G., German, N. J., et al. (2013) · Cancer Cell

Sirtuins and Resveratrol in MedicineCancer, Hypoxia, and Metabolism

Cited by 445

KrasG12D and Smad4/Dpc4 Haploinsufficiency Cooperate to Induce Mucinous Cystic Neoplasms and Invasive Adenocarcinoma of the Pancreas

Izeradjene, K., Combs, C., Best, M., Gopinathan, A., Wagner, A., Grady, W. M., Deng, C.-X., Hruban, R. H., Adsay, N. V., Tuveson, D. A., et al. (2007) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 379

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

Cao, L., Li, W., Kim, S., Brodie, S. G., & Deng, C.-X. (2003) · Genes & Development

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 293

Current Progresses of Exosomes as Cancer Diagnostic and Prognostic Biomarkers

Huang, T., & Deng, C.-X. (2019) · International Journal of Biological Sciences

Extracellular vesicles in diseaseNanoparticle-Based Drug Delivery

Cited by 228

SIRT3 Deacetylates ATP Synthase F 1 Complex Proteins in Response to Nutrient- and Exercise-Induced Stress

Vassilopoulos, A., Pennington, J. D., Andresson, T., Rees, D. M., Bosley, A. D., Fearnley, I. M., Ham, A., Flynn, C. R., Hill, S., Rose, K. L., et al. (2014) · Antioxidants & Redox Signaling

Sirtuins and Resveratrol in MedicineMitochondrial Function and Pathology

Cited by 173

Sirt3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions

Kim, T. S., Jin, Y. B., Kim, Y. S., Kim, S., Kim, J. K., Lee, H.-M., Suh, H.-W., Choe, J. H., Kim, Y. J., Koo, B.-S., et al. (2019) · Autophagy

Tuberculosis Research and EpidemiologySirtuins and Resveratrol in Medicine

Cited by 172

Fibroblast Growth Factor Receptor-1 is Required for Long-Term Potentiation, Memory Consolidation, and Neurogenesis

Zhao, M., Li, D., Shimazu, K., Zhou, Y.-X., Lu, B., & Deng, C.-X. (2007) · Biological Psychiatry

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 171

Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology

Holmes, G., Rothschild, G., Roy, U. B., Deng, C.-X., Mansukhani, A., & Basilico, C. (2009) · Developmental Biology

Craniofacial Disorders and TreatmentsBone Metabolism and Diseases

Cited by 104

Characterization of potential driver mutations involved in human breast cancer by computational approaches

Rajendran, B. K., & Deng, C.-X. (2017) · Oncotarget

Cancer Genomics and DiagnosticsBioinformatics and Genomic Networks

Cited by 73

A comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis

Rajendran, B. K., & Deng, C.-X. (2017) · Oncotarget

Cancer Genomics and DiagnosticsBRCA gene mutations in cancer

Cited by 32

MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBP β and C/EBP δ

Lee, J.-E., Cho, Y.-W., Deng, C.-X., & Ge, K. (2020) · Molecular and Cellular Biology

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 26