Semenza, Gregg L.

Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice

Kojima, H., Gu, H., Nomura, S., Caldwell, C. C., Kobata, T., Carmeliet, P., Semenza, G. L., & Sitkovsky, M. V. (2002) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologySystemic Lupus Erythematosus Research

Cited by 224

Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells

Schito, L., Rey, S., Tafani, M., Zhang, H., Wong, C. C.-L., Russo, A., Russo, M. A., & Semenza, G. L. (2012) · Proceedings of the National Academy of Sciences

Lymphatic System and DiseasesCancer, Hypoxia, and Metabolism

Cited by 224

Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization

Xiang, L., Mou, J., Shao, B., Wei, Y., Liang, H., Takano, N., Semenza, G. L., & Xie, G. (2019) · Cell Death & Disease

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 223

Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors

Samanta, D., & Semenza, G. L. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 190

RETRACTED: Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells

Gilkes, D. M., Xiang, L., Lee, S. J., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingCancer, Hypoxia, and Metabolism

Cited by 184

Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis

Chaturvedi, P., Gilkes, D. M., Wong, C. C. L., Kshitiz, K., Luo, W., Zhang, H., Wei, H., Takano, N., Schito, L., Levchenko, A., et al. (2013) · Journal of Clinical Investigation

Cancer Cells and MetastasisCancer, Hypoxia, and Metabolism

Cited by 181

The Human Hypoxia-Inducible Factor 1α Gene:HIF1AStructure and Evolutionary Conservation

Iyer, N. V., Leung, S. W., & Semenza, G. L. (1998) · Genomics

Cancer, Hypoxia, and MetabolismGenomics and Chromatin Dynamics

Cited by 176

Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4

Drager, L. F., Yao, Q., Hernandez, K. L., Shin, M.-K., Bevans-Fonti, S., Gay, J., Sussan, T. E., Jun, J. C., Myers, A. C., Olivecrona, G., et al. (2013) · American Journal of Respiratory and Critical Care Medicine

Obstructive Sleep Apnea ResearchLipid metabolism and disorders

Cited by 175

Maintenance of redox homeostasis by hypoxia-inducible factors

Samanta, D., & Semenza, G. L. (2017) · Redox Biology

Redox biology and oxidative stressCancer, Hypoxia, and Metabolism

Cited by 127

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

Xiang, L., Gilkes, D. M., Hu, H., Takano, N., Luo, W., Lu, H., Bullen, J. W., Samanta, D., Liang, H., & Semenza, G. L. (2014) · Oncotarget

Cancer, Hypoxia, and MetabolismCancer Cells and Metastasis

Cited by 119

HIF-1 Inhibitors for Cancer Therapy: From Gene Expression to Drug Discovery

Semenza, G. (2009) · Current Pharmaceutical Design

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 116

A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication

Hubbi, M. E., Kshitiz, Gilkes, D. M., Rey, S., Wong, C. C., Luo, W., Kim, D.-H., Dang, C. V., Levchenko, A., & Semenza, G. L. (2013) · Science Signaling

Cancer, Hypoxia, and MetabolismCancer-related Molecular Pathways

Cited by 116

Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer

Xiang, L., Gilkes, D. M., Chaturvedi, P., Luo, W., Hu, H., Takano, N., Liang, H., & Semenza, G. L. (2014) · Journal of Molecular Medicine

Cancer, Hypoxia, and MetabolismHeat shock proteins research

Cited by 114

HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease

Zhang, J., Qin, Y., Martinez, M., Flores-Bellver, M., Rodrigues, M., Dinabandhu, A., Cao, X., Deshpande, M., Qin, Y., Aparicio-Domingo, S., et al. (2021) · Journal of Clinical Investigation

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 95

HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells

Xiang, L., Gilkes, D. M., Hu, H., Luo, W., Bullen, J. W., Liang, H., & Semenza, G. L. (2015) · Oncotarget

Hippo pathway signaling and YAP/TAZCancer, Hypoxia, and Metabolism

Cited by 73

Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy

Xiang, L., & Semenza, G. L. (2019) · Advances in Cancer Research

Cancer, Hypoxia, and MetabolismCancer Cells and Metastasis

Cited by 71

Intratumoral hypoxia and mechanisms of immune evasion mediated by hypoxia-inducible factors

Semenza, G. L. (2021) · Physiology

Cancer, Hypoxia, and MetabolismCancer Immunotherapy and Biomarkers

Cited by 64

BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy

Samanta, D., Huang, T. Y.-T., Shah, R., Yang, Y., Pan, F., & Semenza, G. L. (2020) · Cell Reports

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 49

Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway

Pang, Y., Yang, C., Schovanek, J., Wang, H., Bullova, P., Caisova, V., Gupta, G., Wolf, K. I., Semenza, G. L., Zhuang, Z., et al. (2017) · Oncotarget

Adrenal and Paraganglionic TumorsNeuroblastoma Research and Treatments

Cited by 37

Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation

Fu, C., Tyagi, R., Chin, A. C., Rojas, T., Li, R.-J., Guha, P., Bernstein, I. A., Rao, F., Xu, R., Cha, J. Y., et al. (2018) · Circulation Research

Angiogenesis and VEGF in CancerCancer, Hypoxia, and Metabolism

Cited by 28

Daily administration of low-dose daunorubicin or doxorubicin inhibits hypoxia-inducible factor 1 and tumor vascularization

Yang, Y., Qian, D. Z., Rey, S., Liu, J. O., & Semenza, G. L. (2022) · bioRxiv (Cold Spring Harbor Laboratory)

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 2