Semenza, Gregg L.

Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1

Jiang, B.-H., Rue, E., Wang, G. L., Roe, R., & Semenza, G. L. (1996) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 1,106

Oncogenic alterations of metabolism

Dang, C. V., & Semenza, G. L. (1999) · Trends in Biochemical Sciences

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,106

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

Semenza, G. L. (1998) · Current Opinion in Genetics & Development

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 1,092

HIF-1 and tumor progression: pathophysiology and therapeutics

Semenza, G. L. (2002) · Trends in Molecular Medicine

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 1,060

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.

Semenza, G. L., Nejfelt, M. K., Chi, S. M., & Antonarakis, S. E. (1991) · Proceedings of the National Academy of Sciences

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 990

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α

Ravi, R., Mookerjee, B., Bhujwalla, Z. M., Sutter, C. H., Artemov, D., Zeng, Q., Dillehay, L. E., Madan, A., Semenza, G. L., & Bedi, A. (2000) · Genes & Development

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 967

Hypoxia-Inducible Factors: Master Regulators of Cancer Progression

Schito, L., & Semenza, G. L. (2016) · Trends in Cancer

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 962

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

Semenza, G. L. (2001) · Trends in Molecular Medicine

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 930

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

Semenza, G. L. (2009) · Physiology

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 926

HIF-1 and human disease: one highly involved factor

Semenza, G. L. (2000) · Genes & Development

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 909

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V., & Semenza, G. L. (2007) · Cancer Cell

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 885

Signal transduction to hypoxia-inducible factor 1

Semenza, G. L. (2002) · Biochemical Pharmacology

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 860

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

Suda, T., Takubo, K., & Semenza, G. L. (2011) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationCancer, Hypoxia, and Metabolism

Cited by 844

Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia

Lee, P. J., Jiang, B.-H., Chin, B. Y., Iyer, N. V., Alam, J., Semenza, G. L., & Choi, A. K. (1997) · Journal of Biological Chemistry

Heme Oxygenase-1 and Carbon MonoxideCancer, Hypoxia, and Metabolism

Cited by 782

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

Kim, J.-W., Gao, P., Liu, Y.-C., Semenza, G. L., & Dang, C. V. (2007) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 658

Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2

Prabhakar, N. R., & Semenza, G. L. (2012) · Physiological Reviews

Obstructive Sleep Apnea ResearchNeuroscience of respiration and sleep

Cited by 641

Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α

Jiang, B.-H., Zheng, J. Z., Leung, S. W., Roe, R., & Semenza, G. L. (1997) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 629

Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth

Zhang, H., Qian, D. Z., Tan, Y. S., Lee, K., Gao, P., Ren, Y. R., Rey, S., Hammers, H., Chang, D., Pili, R., et al. (2008) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 624

Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1

Kelly, B. D., Hackett, S. F., Hirota, K., Oshima, Y., Cai, Z., Berg-Dixon, S., Rowan, A., Yan, Z., Campochiaro, P. A., & Semenza, G. L. (2003) · Circulation Research

Angiogenesis and VEGF in CancerCancer, Hypoxia, and Metabolism

Cited by 611

Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1

Semenza, G. L. (2007) · Biochemical Journal

Cancer, Hypoxia, and MetabolismMitochondrial Function and Pathology

Cited by 541

The hypoxic tumor microenvironment: A driving force for breast cancer progression

Semenza, G. L. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 535

HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo

Gao, P., Zhang, H., Dinavahi, R., Li, F., Xiang, Y., Raman, V., Bhujwalla, Z. M., Felsher, D. W., Cheng, L., Pevsner, J., et al. (2007) · Cancer Cell

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 523

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

Ang, S. O., Chen, H., Hirota, K., Gordeuk, V. R., Jelinek, J., Guan, Y., Liu, E., Sergueeva, A. I., Miasnikova, G. Y., Mole, D., et al. (2002) · Nature Genetics

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 510

Levels of hypoxia‐inducible factor‐1α independently predict prognosis in patients with lymph node negative breast carcinoma

Bos, R., van der Groep, P., Greijer, A. E., Shvarts, A., Meijer, S., Pinedo, H. M., Semenza, G. L., van Diest, P. J., & van der Wall, E. (2003) · Cancer

Cancer, Hypoxia, and MetabolismBreast Cancer Treatment Studies

Cited by 500