Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088 · see citing works

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905 · see citing works

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

Harding, H. P., Zhang, Y., Zeng, H., Novoa, I., Lu, P. D., Calfon, M. A., Sadri, N., Yun, C., Popko, B., Paules, R. S., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00105-9 · Cited by 3,336 · see citing works

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333 · see citing works

International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors

Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Klotz, K.-N., & Linden, J. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01511-4 · Cited by 2,585 · see citing works

Cellular and developmental control of O ₂ homeostasis by hypoxia-inducible factor 1α

Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476 · see citing works

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267 · see citing works

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124 · see citing works

Cellular Fatty Acid Metabolism and Cancer

Currie, E., Schulze, A., Zechner, R., Walther, T. C., & Farese, R. V. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.017 · Cited by 2,123 · see citing works

From Krebs to clinic: glutamine metabolism to cancer therapy

Altman, B. J., Stine, Z. E., & Dang, C. V. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.71 · Cited by 2,119 · see citing works

Inhibitory effect of tumor cell-derived lactic acid on human T cells

Fischer, K., Hoffmann, P., Voelkl, S., Meidenbauer, N., Ammer, J., Edinger, M., Gottfried, E., Schwarz, S., Rothe, G., Hoves, S., et al. (2007) · Blood · doi:10.1182/blood-2006-07-035972 · Cited by 1,946 · see citing works

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., Jewell, C. M., Johnson, Z. R., Irvine, D. J., Guarente, L., et al. (2012) · Nature · doi:10.1038/nature10602 · Cited by 1,791 · see citing works

Glutamine addiction: a new therapeutic target in cancer

Wise, D. R., & Thompson, C. B. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.003 · Cited by 1,770 · see citing works

Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1

Semenza, G. L., Jiang, B.-H., Leung, S. W., Passantino, R., Concordet, J.-P., Maire, P., & Giallongo, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32529 · Cited by 1,752 · see citing works

Hypoxia, HIF1 and glucose metabolism in the solid tumour

Denko, N. C. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2468 · Cited by 1,707 · see citing works

Serine, glycine and one-carbon units: cancer metabolism in full circle

Locasale, J. W. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3557 · Cited by 1,669 · see citing works

The multifaceted roles of fatty acid synthesis in cancer

Röhrig, F., & Schulze, A. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.89 · Cited by 1,651 · see citing works

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

Dang, E. V., Barbi, J., Yang, H.-Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H.-R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.033 · Cited by 1,595 · see citing works

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., & Bruick, R. K. (2002) · Genes & Development · doi:10.1101/gad.991402 · Cited by 1,550 · see citing works

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

Luo, W., Hu, H., Chang, R., Zhong, J., Knabel, M., O'Meally, R., Cole, R. N., Pandey, A., & Semenza, G. L. (2011) · Cell · doi:10.1016/j.cell.2011.03.054 · Cited by 1,463 · see citing works

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

Ho, P.-C., Bihuniak, J. D., Macintyre, A. N., Staron, M., Liu, X., Amezquita, R., Tsui, Y.-C., Cui, G., Micevic, G., Perales, J. C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.012 · Cited by 1,462 · see citing works

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

Mahon, P. C., Hirota, K., & Semenza, G. L. (2001) · Genes & Development · doi:10.1101/gad.924501 · Cited by 1,385 · see citing works

Lactate Metabolism in Human Lung Tumors

Faubert, B., Li, K. Y., Cai, L., Hensley, C. T., Kim, J., Zacharias, L. G., Yang, C., Do, Q. N., Doucette, S., Burguete, D., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.019 · Cited by 1,343 · see citing works

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

Semenza, G. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67230 · Cited by 1,335 · see citing works

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

Corzo, C. A., Condamine, T., Lu, L., Cotter, M. J., Youn, J.-I., Cheng, P., Cho, H.-I., Celis, E., Quiceno, D. G., Padhya, T., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100587 · Cited by 1,173 · see citing works

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Locasale, J. W., Grassian, A. R., Melman, T., Lyssiotis, C. A., Mattaini, K. R., Bass, A. J., Heffron, G., Metallo, C. M., Muranen, T., Sharfi, H., et al. (2011) · Nature Genetics · doi:10.1038/ng.890 · Cited by 1,120 · see citing works

Quantitative flux analysis reveals folate-dependent NADPH production

Fan, J., Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B., & Rabinowitz, J. D. (2014) · Nature · doi:10.1038/nature13236 · Cited by 1,114 · see citing works

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

Le, A., Lane, A. N., Hamaker, M., Bose, S., Gouw, A., Barbi, J., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Zhang, H., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.009 · Cited by 1,095 · see citing works

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

Maxwell, P. H., Dachs, G. U., Gleadle, J. M., Nicholls, L. G., Harris, A. L., Stratford, I. J., Hankinson, O., Pugh, C. W., & Ratcliffe, P. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8104 · Cited by 1,084 · see citing works

A2A adenosine receptor protects tumors from antitumor T cells

Ohta, A., Gorelik, E., Prasad, S. J., Ronchese, F., Lukashev, D. E., Wong, M. K. K., Huang, X., Caldwell, S. A., Liu, K., Smith, P. T., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605251103 · Cited by 1,066 · see citing works

Tumour acidosis: from the passenger to the driver's seat

Corbet, C., & Féron, O. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.77 · Cited by 1,000 · see citing works

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

Wise, D. R., Ward, P. S., Shay, J. E. S., Cross, J. R., Gruber, J. J., Sachdeva, U. M., Platt, J. M., DeMatteo, R. G., Simon, M. C., & Thompson, C. B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117773108 · Cited by 975 · see citing works

Endoplasmic Reticulum Stress Triggers Autophagy

Yorimitsu, T., Nair, U., Yang, Z., & Klionsky, D. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607007200 · Cited by 941 · see citing works

Targeting immunosuppressive adenosine in cancer

Vijayan, D., Young, A., Teng, M. W. L., & Smyth, M. J. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.86 · Cited by 852 · see citing works

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

Schug, Z. T., Peck, B., Jones, D. T., Zhang, Q., Grosskurth, S., Alam, I. S., Goodwin, L. M., Smethurst, E., Mason, S., Blyth, K., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.12.002 · Cited by 820 · see citing works

Purinergic regulation of the immune system

Cekic, C., & Linden, J. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.4 · Cited by 787 · see citing works

NRF2 regulates serine biosynthesis in non–small cell lung cancer

DeNicola, G. M., Chen, P.-H., Mullarky, E., Sudderth, J., Hu, Z., Wu, D., Tang, H., Xie, Y., Asara, J. M., Huffman, K. E., et al. (2015) · Nature Genetics · doi:10.1038/ng.3421 · Cited by 747 · see citing works

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

Schödel, J., Oikonomopoulos, S., Ragoussis, J., Pugh, C. W., Ratcliffe, P. J., & Mole, D. R. (2011) · Blood · doi:10.1182/blood-2010-10-314427 · Cited by 724 · see citing works

The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

Ye, J., Kumanova, M., Hart, L. S., Sloane, K. L., Zhang, H., Panis, D. N. D., Bobrovnikova-Marjon, E. V., Diehl, J. A., Ron, D., & Koumenis, C. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.81 · Cited by 709 · see citing works

Targeting renal cell carcinoma with a HIF-2 antagonist

Chen, W., Hill, H., Christie, A., Kim, M. S., Holloman, E., Pavia-Jimenez, A., Homayoun, F., Ma, Y., Patel, N., Yell, P., et al. (2016) · Nature · doi:10.1038/nature19796 · Cited by 709 · see citing works

Ecto-5′-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia

Synnestvedt, K., Furuta, G. T., Comerford, K. M., Louis, N. A., Karhausen, J., Eltzschig, H. K., Hansen, K. R., Thompson, L. F., & Colgan, S. P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15337 · Cited by 679 · see citing works

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

Chiche, J., Brahimi-Horn, M. C., & Pouysségur, J. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00994.x · Cited by 671 · see citing works

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway

Isaacs, J. S., Jung, Y.-J., Mimnaugh, E. G., Martinez, A., Cuttitta, F., & Neckers, L. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204733200 · Cited by 663 · see citing works

Ecto-5′-Nucleotidase (CD73) Regulation by Hypoxia-Inducible Factor-1 Mediates Permeability Changes in Intestinal Epithelia

Synnestvedt, K., Furuta, G. T., Comerford, K. M., Louis, N., Karhausen, J., Eltzschig, H. K., Hansen, K. R., Thompson, L. F., & Colgan, S. P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215337 · Cited by 660 · see citing works

Serine is an essential metabolite for effector T cell expansion

Ma, E. H., Bantug, G., Griss, T., Condotta, S., Johnson, R. M., Samborska, B., Mainolfi, N., Suri, V., Guak, H., Balmer, M. L., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.011 · Cited by 657 · see citing works

Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells

Seagroves, T. N., Ryan, H. E., Lu, H., Wouters, B. G., Knapp, M., Thibault, P., Laderoute, K. R., & Johnson, R. S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3436-3444.2001 · Cited by 634 · see citing works

Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth

Zhang, H., Qian, D. Z., Tan, Y. S., Lee, K., Gao, P., Ren, Y. R., Rey, S., Hammers, H., Chang, D., Pili, R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809763105 · Cited by 624 · see citing works

Immunological mechanisms of the antitumor effects of supplemental oxygenation

Hatfield, S. M., Kjaergaard, J., Lukashev, D., Schreiber, T. H., Belikoff, B., Abbott, R., Sethumadhavan, S., Philbrook, P., Ko, K., Cannici, R., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa1260 · Cited by 600 · see citing works

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

Stagg, J., Divisekera, U., McLaughlin, N. M., Sharkey, J., Pommey, S., Denoyer, D., Dwyer, K. M., & Smyth, M. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908801107 · Cited by 570 · see citing works

Regulatory circuits of T cell function in cancer

Speiser, D. E., Ho, P., & Verdeil, G. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.80 · Cited by 559 · see citing works

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

Mole, D. R., Blancher, C., Copley, R. R., Pollard, P. J., Gleadle, J. M., Ragoussis, J., & Ratcliffe, P. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901790200 · Cited by 552 · see citing works

The hypoxic tumor microenvironment: A driving force for breast cancer progression

Semenza, G. L. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.05.036 · Cited by 535 · see citing works

RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1α

Liu, Y. V., Baek, J. H., Zhang, H., Diez, R., Cole, R. N., & Semenza, G. L. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.001 · Cited by 477 · see citing works

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

Du, W., Zhang, L., Brett-Morris, A., Aguila, B., Kerner, J., Hoppel, C. L., Puchowicz, M., Serra, D., Herrero, L., Rini, B. I., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01965-8 · Cited by 468 · see citing works

CD73 on Tumor Cells Impairs Antitumor T-Cell Responses: A Novel Mechanism of Tumor-Induced Immune Suppression

Jin, D., Fan, J., Wang, L., Thompson, L. F., Liu, A., Daniel, B. J., Shin, T., Curiel, T. J., & Zhang, B. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3109 · Cited by 433 · see citing works

Untitled work

(1997) · PubMed · Cited by 433 · see citing works

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

Xia, X., Lemieux, M. E., Li, W., Carroll, J. S., Brown, M., Liu, X. S., & Kung, A. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810067106 · Cited by 410 · see citing works

Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes

Dietl, K., Renner, K., Dettmer, K., Timischl, B., Eberhart, K., Dorn, C., Hellerbrand, C., Kastenberger, M., Kunz‐Schughart, L. A., Oefner, P. J., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902584 · Cited by 402 · see citing works

CD73-Deficient Mice Have Increased Antitumor Immunity and Are Resistant to Experimental Metastasis

Stagg, J., Divisekera, U., Duret, H., Sparwasser, T. D., Teng, M. W. L., Darcy, P. K., & Smyth, M. J. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4246 · Cited by 401 · see citing works

Fatty Acid Synthase Gene Is Up-regulated by Hypoxia via Activation of Akt and Sterol Regulatory Element Binding Protein-1

Furuta, E., Pai, S. K., Zhan, R., Bandyopadhyay, S., Watabe, M., Mo, Y., Hirota, S., Hosobe, S., Tsukada, T., Miura, K., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2489 · Cited by 392 · see citing works

Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells

Favaro, E., Bensaad, K., Chong, M., Tennant, D. A., Ferguson, D. J. P., Snell, C. E., Steers, G., Turley, H., Li, J., Günther, U. L., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.017 · Cited by 389 · see citing works

A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

Ohta, A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00109 · Cited by 385 · see citing works

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

Qing, G., Li, B., Vu, A., Skuli, N., Walton, Z. E., Liu, X., Mayes, P. A., Wise, D. R., Thompson, C. B., Maris, J. M., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.09.021 · Cited by 375 · see citing works

Role of monocarboxylate transporters in human cancers: state of the art

Pinheiro, C., Longatto-Filho, A., Azevedo-Silva, J., Casal, M., Schmitt, F. C., & Baltazar, F. (2012) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-012-9428-1 · Cited by 368 · see citing works

Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer

Chouaı̈b, S., Noman, M. Z., Kosmatopoulos, K., & Curran, M. A. (2016) · Oncogene · doi:10.1038/onc.2016.225 · Cited by 366 · see citing works

Carbonic anhydrase IX, MN/CA IX: Analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts

Pastoreková, S., Parkkila, S., Parkkila, A. K., Opavský, R., Zelnı́k, V., Saarnio, J., & Pastorek, J. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.pm9024293 · Cited by 354 · see citing works

HIF-1–dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia

Eltzschig, H. K., ABDULLA, P. R., Hoffman, E., Hamilton, K. E., Daniels, D., Schönfeld, C., Löffler, M., Reyes, G., Duszenko, M., Karhausen, J., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050177 · Cited by 352 · see citing works

HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression

Huang, D., Li, T., Li, X., Zhang, L., Sun, L., He, X., Zhong, X., Jia, D., Song, L., Semenza, G. L., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.028 · Cited by 352 · see citing works

Structural integration in hypoxia-inducible factors

Wu, D., Potluri, N., Lu, J., Kim, Y., & Rastinejad, F. (2015) · Nature · doi:10.1038/nature14883 · Cited by 346 · see citing works

Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth

Sun, R. C., & Denko, N. C. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.022 · Cited by 344 · see citing works

Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: From biology to clinical use

Pastorek, J., & Pastoreková, S. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.08.002 · Cited by 331 · see citing works

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

Scheuermann, T. H., Li, Q., Ma, H.-W., Key, J., Zhang, L., Chen, R., Garcia, J. A., Naidoo, J., Longgood, J., Frantz, D. E., et al. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1185 · Cited by 315 · see citing works

T cell metabolic fitness in antitumor immunity

Siska, P. J., & Rathmell, J. C. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.02.007 · Cited by 315 · see citing works

Myeloid Expression of Adenosine A2A Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment

Cekic, C., Day, Y., Sağ, D., & Linden, J. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3583 · Cited by 305 · see citing works

Hypoxia Promotes Glycogen Accumulation through Hypoxia Inducible Factor (HIF)-Mediated Induction of Glycogen Synthase 1

Pescador, N., Villar, D., Cifuentes, D., Garcı́a-Rocha, M., Ortiz-Barahona, A., Vázquez, S., Ordóñez, Á., Cuevas, Y., Saez-Morales, D., García‐Bermejo, L., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009644 · Cited by 265 · see citing works

Hypoxia controls CD4+CD25+ regulatory T‐cell homeostasis via hypoxia‐inducible factor‐1α

Ben‐Shoshan, J., Maysel-Auslender, S., Mor, A., Keren, G., & George, J. (2008) · European Journal of Immunology · doi:10.1002/eji.200838318 · Cited by 260 · see citing works

Ectonucleotidases as Regulators of Purinergic Signaling in Thrombosis, Inflammation, and Immunity

Deaglio, S., & Robson, S. C. (2011) · Advances in pharmacology · doi:10.1016/b978-0-12-385526-8.00010-2 · Cited by 251 · see citing works

Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments

Wojtkowiak, J. W., Rothberg, J. M., Kumar, V., Schramm, K. J., Haller, E. M., Proemsey, J. B., Lloyd, M. C., Sloane, B. F., & Gillies, R. J. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3881 · Cited by 251 · see citing works

A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy

Leone, R. D., Lo, Y.-C., & Powell, J. D. (2015) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2015.03.008 · Cited by 224 · see citing works

Oxygen Sensing and Homeostasis

Prabhakar, N. R., & Semenza, G. L. (2015) · Physiology · doi:10.1152/physiol.00022.2015 · Cited by 222 · see citing works

Lactate Boosts TLR4 Signaling and NF-κB Pathway-Mediated Gene Transcription in Macrophages via Monocarboxylate Transporters and MD-2 Up-Regulation

Samuvel, D. J., Sundararaj, K. P., Nareika, A., Lopes-Virella, M. F., & Huang, Y. Q. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802059 · Cited by 220 · see citing works

Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway

Payen, V. L., Porporato, P. E., Baselet, B., & Sonveaux, P. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2098-5 · Cited by 219 · see citing works

Tumor-associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-dimensional Multicellular Growths

Swietach, P., Wigfield, S., Cobden, P. M., Supuran, C. T., Harris, A. L., & Vaughan‐Jones, R. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801330200 · Cited by 216 · see citing works

HIF-1–dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak

Morote–Garcia, J. C., Rosenberger, P., Kuhlicke, J., & Eltzschig, H. K. (2008) · Blood · doi:10.1182/blood-2007-11-126763 · Cited by 211 · see citing works

Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival

Pelletier, J., Bellot, G. L., Gounon, P., Lacas‐Gervais, S., Pouysségur, J., & Mazure, N. M. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00018 · Cited by 203 · see citing works

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity

Häusler, S. F., del Barrio, I. M., Strohschein, J., Chandran, P. A., Engel, J. B., Hönig, A., Ossadnik, M., Horn, E., Fischer, B., Krockenberger, M., et al. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1040-4 · Cited by 193 · see citing works

Hypoxia‐inducible factor‐1α (HIF‐1α) escapes O2‐driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm

Berra, E., Roux, D., Richard, D. E., & Pouysségur, J. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve130 · Cited by 183 · see citing works

Glucose, glycolysis and lymphocyte responses

Donnelly, R. P., & Finlay, D. K. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.07.034 · Cited by 181 · see citing works

Pathway Signature and Cellular Differentiation in Clear Cell Renal Cell Carcinoma

Tun, H. W., Marlow, L. A., Roemeling, C. A. V., Cooper, S. J., Kreinest, P. A., Wu, K. J., Luxon, B. A., Sinha, M., Anastasiadis, P. Z., & Copland, J. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010696 · Cited by 178 · see citing works

HIF‐1α and HIF‐2α have divergent roles in colon cancer

Imamura, T., Kikuchi, H., Herráiz, M., Park, D., Mizukami, Y., Mino-Kenudson, M. A., Lynch, M. P., Rueda, B. R., Benita, Y., Xavier, R. J., et al. (2008) · International Journal of Cancer · doi:10.1002/ijc.24032 · Cited by 159 · see citing works

Sphingosine Kinase 1: A New Modulator of Hypoxia Inducible Factor 1α during Hypoxia in Human Cancer Cells

Ader, I., Brizuela, L., Bouquerel, P., Malavaud, B. A., & Cuvillier, O. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0917 · Cited by 152 · see citing works

Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor

Davis, S. R., Stacpoole, P. W., Williamson, J., Kick, L. S., Quinlivan, E. P., Coats, B. S., Shane, B., Bailey, L. B., & Gregory, J. F. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00351.2003 · Cited by 149 · see citing works

Redox control of glutamine utilization in cancer

Alberghina, L., & Gaglio, D. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.513 · Cited by 147 · see citing works

Adenosine-Mediated Inhibition of the Cytotoxic Activity and Cytokine Production by Activated Natural Killer Cells

Lokshin, A. E., Raskovalova, T., Huang, X., Zacharia, L. C., Jackson, E. K., & Gorelik, E. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0478 · Cited by 138 · see citing works

Hypoxia causes triglyceride accumulation via HIF-1-mediated stimulation of lipin 1 expression

Mylonis, I., Sembongi, H., Befani, C. D., Liakos, P., Siniossoglou, S., & Simos, G. (2012) · Journal of Cell Science · doi:10.1242/jcs.106682 · Cited by 137 · see citing works

Chronic Hypoxia Enhances Adenosine Release in Rat PC12 Cells by Altering Adenosine Metabolism and Membrane Transport

Kobayashi, S., Zimmermann, H., & Millhorn, D. E. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740621.x · Cited by 128 · see citing works

Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer

Xiang, L., Gilkes, D. M., Chaturvedi, P., Luo, W., Hu, H., Takano, N., Liang, H., & Semenza, G. L. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1102-5 · Cited by 114 · see citing works

Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion.

Häusler, S. F., del Barrio, I. M., Diessner, J., Stein, R. G., Strohschein, J., Hönig, A., Dietl, J., & Wischhusen, J. (2014) · Europe PMC (PubMed Central) · Cited by 110 · see citing works

Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers

Okazaki, A., Gameiro, P. A., Christodoulou, D. C., Laviolette, L. A., Schneider, M., Chaves, F. L., Stemmer-Rachamimov, A. O., Yazinski, S. A., Lee, R. E., Jr., Stephanopoulos, G. N., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci87800 · Cited by 108 · see citing works

Proteasomal Inhibition Attenuates Transcriptional Activity of Hypoxia-Inducible Factor 1 (HIF-1) via Specific Effect on the HIF-1α C-Terminal Activation Domain

Kaluz, S., Kaluzová, M., & Stanbridge, E. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00552-06 · Cited by 108 · see citing works

The Intercellular Metabolic Interplay between Tumor and Immune Cells

Wang, T., Liu, G., & Wang, R. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00358 · Cited by 95 · see citing works

Metabolic sensitivity of pancreatic tumour cell apoptosis to glycogen phosphorylase inhibitor treatment

Lee, W.-N. P., Guo, P., Lim, S., Bassilian, S., Lee, S. T., Boren, J., Cascante, M., Go, V. L. W., & Boros, L. G. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602243 · Cited by 83 · see citing works

Increased Expression of PHGDH and Prognostic Significance in Colorectal Cancer

Jia, X.-Q., Zhang, S., Zhu, H., Wang, W., Zhu, J., Wang, X., & Qiang, J. (2016) · Translational Oncology · doi:10.1016/j.tranon.2016.03.006 · Cited by 83 · see citing works

Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox

Samanta, D., & Semenza, G. L. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1730 · Cited by 74 · see citing works

Learning from PD-1 Resistance: New Combination Strategies

Bu, X., Mahoney, K. M., & Freeman, G. J. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.04.008 · Cited by 71 · see citing works

Next‐Generation Sequencing RNA‐Seq Library Construction

Podnar, J. W., Deiderick, H., Huerta, G., & Hunicke-Smith, S. (2014) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb0421s106 · Cited by 69 · see citing works

Effect of Low Glutamine/Glucose on Hypoxia-Induced Elevation of Hypoxia-Inducible Factor-1α in Human Pancreatic Cancer MiaPaCa-2 and Human Prostatic Cancer DU-145 Cells

Kwon, S., & Lee, Y. J. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2530 · Cited by 67 · see citing works

Molecular Pathways: Targeting Proteasomal Protein Degradation in Cancer

Molineaux, S. M. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0853 · Cited by 63 · see citing works

Acute L ‐glutamine deprivation compromises VEGF‐a upregulation in A549/8 human carcinoma cells

Drogat, B., Bouchecareilh, M., North, S., Petibois, C., Déléris, G., Chevet, É., Bikfalvi, A., & Moenner, M. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21044 · Cited by 57 · see citing works

12-Lipoxygenase and the regulation of hypoxia-inducible factor in prostate cancer cells

Krishnamoorthy, S., Jin, R., Cai, Y., Maddipati, K. R., Nie, D., Pagès, G., Tucker, S. C., & Honn, K. V. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.03.005 · Cited by 48 · see citing works

Growth and metastasis of B16-F10 melanoma cells is not critically dependent on host CD73 expression in mice

Burghoff, S., Gong, X., Viethen, C., Jacoby, C., Flögel, U., Bongardt, S., Schorr, A., Hippe, A., Homey, B., & Schrader, J. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-898 · Cited by 39 · see citing works

Coordinate regulation of stress signaling and epigenetic events by Acss2 and HIF-2 in cancer cells

Chen, R., Xu, M., Nagati, J. S., & Garcia, J. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0190241 · Cited by 39 · see citing works

Expression and Clinical Significance of Phosphoglycerate Dehydrogenase and Squamous Cell Carcinoma Antigen in Cervical Cancer

Zhang, J., Wei, H., Aiping, D., Qi, Y., & Shulan, Z. (2013) · International Journal of Gynecological Cancer · doi:10.1097/igc.0b013e3182a0c068 · Cited by 36 · see citing works

Differential contribution of key metabolic substrates and cellular oxygen in HIF signalling

Zhdanov, A. V., Waters, A. H. C., Golubeva, A. V., & Papkovsky, D. B. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.10.005 · Cited by 27 · see citing works

Carbonic anhydrases in meningiomas: association of endothelial carbonic anhydrase II with aggressive tumor features

Korhonen, K., Parkkila, A., Helén, P., Välimäki, R., Pastoreková, S., Pastorek, J., Parkkila, S., & Haapasalo, H. K. (2009) · Journal of neurosurgery · doi:10.3171/2008.10.17672 · Cited by 23 · see citing works

Cellular Adaptation to Hypoxia through Hypoxia Inducible Factors and beyond

Lee, P., Chandel, N. S., & Simon, M. C. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0227-y · Cited by 1,272 · see citing works

Hypoxia-inducible factors: cancer progression and clinical translation

Wicks, E. E., & Semenza, G. L. (2022) · Journal of Clinical Investigation · doi:10.1172/jci159839 · Cited by 600 · see citing works

The effect of HIF on metabolism and immunity

Taylor, C. T., & Scholz, C. C. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00587-8 · Cited by 517 · see citing works

Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target

Infantino, V., Santarsiero, A., Convertini, P., Todisco, S., & Iacobazzi, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115703 · Cited by 510 · see citing works

A guide to plasma membrane solute carrier proteins

Pizzagalli, M. D., Bensimon, A., & Superti‐Furga, G. (2020) · FEBS Journal · doi:10.1111/febs.15531 · Cited by 380 · see citing works

Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine

Singhal, R., & Shah, Y. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.011188 · Cited by 379 · see citing works

Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer

Labrie, M., Brugge, J. S., Mills, G. B., & Zervantonakis, I. K. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00454-5 · Cited by 388 · see citing works

HIFs, angiogenesis, and metabolism: Elusive enemies in breast cancer

de Heer, E. C., Jalving, M., & Harris, A. L. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137552 · Cited by 372 · see citing works

Hypoxia-inducible factors and the regulation of lipid metabolism

Mylonis, I., Simos, G., & Paraskeva, E. (2019) · Cells · doi:10.3390/cells8030214 · Cited by 316 · see citing works

The role of hypoxia‐inducible factor 1 in tumor immune evasion

Li, Y., Wu, W., Wang, X., Fang, L., Adam, V., Nepovimová, E., Wu, Q., & Kuča, K. (2020) · Medicinal Research Reviews · doi:10.1002/med.21771 · Cited by 273 · see citing works

AMPK–mTOR Signaling and Cellular Adaptations in Hypoxia

Chun, Y., & Kim, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189765 · Cited by 224 · see citing works

Hypoxia Compromises Anti-Cancer Immune Responses

Multhoff, G., & Vaupel, P. W. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34461-0_18 · Cited by 179 · see citing works

Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons

Akman, M., Belisario, D. C., Salaroglio, I. C., Kopecka, J., Donadelli, M., Smaele, E. D., & Riganti, C. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01824-3 · Cited by 176 · see citing works

Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier

Bensard, C., Wisidagama, D. R., Olson, K. A., Berg, J. A., Krah, N. M., Schell, J. C., Nowinski, S. M., Fogarty, S., Bott, A. J., Wei, P., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.002 · Cited by 170 · see citing works

Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion

Kreuzaler, P. A., Panina, Y., Segal, J., & Yuneva, M. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.08.021 · Cited by 151 · see citing works

Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer

Matés, J. M., Paola, F. J. D., Campos-Sandoval, J. A., Mazurek, S., & Márquez, J. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.012 · Cited by 164 · see citing works

Metabolism of Dendritic Cells in Tumor Microenvironment: For Immunotherapy

Peng, X., He, Y., Huang, J. X., Tao, Y., & Liu, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.613492 · Cited by 146 · see citing works

Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876

Ma, Y., Wang, W., Idowu, M. O., Oh, U., Wang, X.-Y., Temkin, S. M., & Fang, X. (2018) · Cancers · doi:10.3390/cancers11010033 · Cited by 145 · see citing works

The Genomics and Genetics of Oxygen Homeostasis

Semenza, G. L. (2020) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-111119-073356 · Cited by 134 · see citing works

Role of hypoxia in the tumor microenvironment and targeted therapy

Chen, G., Wu, K., Li, H., Xia, D., & He, T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.961637 · Cited by 141 · see citing works

Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance

Belisario, D. C., Kopecka, J., Pasino, M., Akman, M., De Smaele, E., Donadelli, M., & Riganti, C. (2020) · Cells · doi:10.3390/cells9122598 · Cited by 133 · see citing works

Redox signaling at the crossroads of human health and disease

Zuo, J., Zhang, Z., Luo, M., Zhou, L., Nice, E., Zhang, W., Wang, C., & Huang, C.-H. (2022) · MedComm · doi:10.1002/mco2.127 · Cited by 107 · see citing works

Signaling, metabolism, and cancer: An important relationship for therapeutic intervention

Vaghari‐Tabari, M., Ferns, G. A., Qujeq, D., Andevari, A. N., Sabahi, Z., & Moein, S. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30276 · Cited by 117 · see citing works

HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy

Salman, S., Meyers, D. J., Wicks, E. E., Lee, S. N., Datan, E., Thomas, A. M., Anders, N. M., Hwang, Y., Lyu, Y., Yang, Y., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci156774 · Cited by 111 · see citing works

Anti-VEGF Treatment Enhances CD8+ T-cell Antitumor Activity by Amplifying Hypoxia

de Almeida, P. E., Mak, J., Hernandez, G., Jesudason, R., Hérault, A., Javinal, V., Borneo, J., Kim, J. M., & Walsh, K. B. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-19-0360 · Cited by 103 · see citing works

Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting Genetically Driven Tumor Hypoxia

Toledo, R. A., Jiménez, C., Armaiz-Peña, G., Arenillas, C., Capdevila, J., & Dahia, P. L. M. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac025 · Cited by 98 · see citing works

The Effect of Hypoxia and Hypoxia-Associated Pathways in the Regulation of Antitumor Response: Friends or Foes?

Khouzam, R. A., Zaarour, R. F., Brodaczewska, K. K., Azakir, B., Venkatesh, G. H., Thiery, J., Terry, S., & Chouaı̈b, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.828875 · Cited by 80 · see citing works

Turning the Oxygen Dial: Balancing the Highs and Lows

Baik, A. H., & Jain, I. H. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.04.005 · Cited by 69 · see citing works

The role of HIF-1α in hypoxic metabolic reprogramming in osteoarthritis

Zhang, J., Gao, P., Chang, W.-R., Song, J., An, F.-Y., Wang, Y., Xiao, Z.-P., Jin, H., Zhang, X., & Yan, C. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107649 · Cited by 77 · see citing works

New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma

Chang, X., Ma, Z., Zhu, G., Lu, Y., & Yang, J. (2021) · Journal of Bone Oncology · doi:10.1016/j.jbo.2021.100372 · Cited by 70 · see citing works

Energy metabolism in anaerobic eukaryotes and Earth's late oxygenation

Zimorski, V., Mentel, M., Tielens, A. G. M., & Martin, W. F. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.03.030 · Cited by 66 · see citing works

Regulation of the phosphoprotein phosphatase 2A system and its modulation during oxidative stress: A potential therapeutic target?

Elgenaidi, I. S., & Spiers, P. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.02.011 · Cited by 65 · see citing works

Fatal Alliance of Hypoxia-/HIF-1α-Driven Microenvironmental Traits Promoting Cancer Progression

Vaupel, P. W., & Multhoff, G. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34461-0_21 · Cited by 64 · see citing works

Intratumoral hypoxia and mechanisms of immune evasion mediated by hypoxia-inducible factors

Semenza, G. L. (2021) · Physiology · doi:10.1152/physiol.00034.2020 · Cited by 64 · see citing works

Oxidative Stress Induced by Lipotoxicity and Renal Hypoxia in Diabetic Kidney Disease and Possible Therapeutic Interventions: Targeting the Lipid Metabolism and Hypoxia

Chae, S. Y., Kim, Y., & Park, C. W. (2023) · Antioxidants · doi:10.3390/antiox12122083 · Cited by 63 · see citing works

Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions

Martí, J. M., García-Díaz, Á., Delgado‐Bellido, D., O’Valle, F., González-Flores, A., Carlevaris, O., Rodríguez-Vargas, J. M., Amé, J., Dantzer, F., King, G. L., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101885 · Cited by 62 · see citing works

Tumor Hypoxia Drives Genomic Instability

Tang, M., Bolderson, E., O'Byrne, K. J., & Richard, D. J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.626229 · Cited by 63 · see citing works

Epithelial-to-Mesenchymal Transition in the Light of Plasticity and Hybrid E/M States

Bornes, L., Belthier, G., & van Rheenen, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112403 · Cited by 59 · see citing works

The small members of the JMJD protein family: Enzymatic jewels or jinxes?

Oh, S., Shin, S., & Janknecht, R. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.04.002 · Cited by 60 · see citing works

The metabolic signature of T cells in rheumatoid arthritis

Weyand, C. M., Wu, B., & Goronzy, J. J. (2019) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000683 · Cited by 59 · see citing works

Regulation of Oxygen Homeostasis at the Intestinal Epithelial Barrier Site

Konjar, Š., Pavšič, M., & Veldhoen, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179170 · Cited by 58 · see citing works

Lipidomic landscape in cancer: Actionable insights for membrane‐based therapy and diagnoses

Agarwala, P. K., Aneja, R., & Kapoor, S. (2021) · Medicinal Research Reviews · doi:10.1002/med.21868 · Cited by 55 · see citing works

Enhancing Tumor Therapy of Fe(III)-Shikonin Supramolecular Nanomedicine via Triple Ferroptosis Amplification

Feng, W., Shi, W., Wang, Z., Cui, Y., Shao, X., Liu, S., Li, R., Liu, Y., & Zhang, H. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c11130 · Cited by 54 · see citing works

The Multifactorial Role of PARP-1 in Tumor Microenvironment

Martí, J. M., Fernández‐Cortés, M., Serrano-Sáenz, S., Zamudio-Martínez, E., Delgado‐Bellido, D., García-Díaz, Á., & Oliver, F. J. (2020) · Cancers · doi:10.3390/cancers12030739 · Cited by 51 · see citing works

Hydrogen Sulfide Metabolism and Signaling in the Tumor Microenvironment

Giuffrè, A., Tomé, C. S., Fernandes, D., Zuhra, K., & Vicente, J. B. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34025-4_17 · Cited by 50 · see citing works

Sleep Apnoea Adverse Effects on Cancer: True, False, or Too Many Confounders?

Gozal, D., Almendros, I., Phipps, A. I., Campos‐Rodríguez, F., Martínez‐García, M. Á., & Farré, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228779 · Cited by 53 · see citing works

Immune Escape Mechanisms and Their Clinical Relevance in Head and Neck Squamous Cell Carcinoma

Seliger, B., Massa, C., Yang, B., Bethmann, D., Kappler, M., Eckert, A. W., & Wickenhauser, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197032 · Cited by 48 · see citing works

NF-κB mediated regulation of tumor cell proliferation in hypoxic microenvironment

Rastogi, S., Aldosary, S., Saeedan, A. S., Ansari, M. N., Singh, M., & Kaithwas, G. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1108915 · Cited by 50 · see citing works

Association of obstructive sleep apnea and nocturnal hypoxemia with all-cancer incidence and mortality: a systematic review and meta-analysis

Tan, B. K. J., Teo, Y. H., Tan, N. K. W., Yap, D. W. T., Sundar, R., Lee, C., See, A., & Toh, S. T. (2021) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.9772 · Cited by 47 · see citing works

Hypoxia upregulating ACSS2 enhances lipid metabolism reprogramming through HMGCS1 mediated PI3K/AKT/mTOR pathway to promote the progression of pancreatic neuroendocrine neoplasms

Gu, D., Ye, M., Zhu, G., Bai, J., Chen, J., Yan, L., Yu, P., Lu, F., Hu, C., Zhong, Y., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04870-z · Cited by 47 · see citing works

The dynamics between in vitro culture and metabolism: embryonic adaptation to environmental changes

de Lima, C. B., dos Santos, É. C., Ispada, J., Fontes, P. K., Nogueira, M. F. G., Santos, C. M. D., & Milazzotto, M. P. (2020) · Scientific Reports · doi:10.1038/s41598-020-72221-1 · Cited by 47 · see citing works

Does Hypoxia Decrease the Metabolic Rate?

Gu, C., & Jun, J. C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00668 · Cited by 45 · see citing works

Microvesicles derived from human bone marrow mesenchymal stem cells promote U2OS cell growth under hypoxia: the role of PI3K/AKT and HIF-1α

Lin, S., Zhu, B., Huang, G., Zeng, Q., & Wang, C. (2018) · Human Cell · doi:10.1007/s13577-018-0224-z · Cited by 45 · see citing works

Beyond glycolysis: Hypoxia signaling as a master regulator of alternative metabolic pathways and the implications in clear cell renal cell carcinoma

Bacigalupa, Z. A., & Rathmell, W. K. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.05.034 · Cited by 45 · see citing works

Hypoxia-induced SKA3 promoted cholangiocarcinoma progression and chemoresistance by enhancing fatty acid synthesis via the regulation of PAR-dependent HIF-1a deubiquitylation

Chen, Y., Xu, X., Wang, Y., Zhang, Y., Zhou, T., Jiang, W., Wang, Z., Chang, J., Liu, S., Chen, R., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02842-7 · Cited by 44 · see citing works

Role of oxygen and the HIF-pathway in polycystic kidney disease

Buchholz, B., & Eckardt, K. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109524 · Cited by 42 · see citing works

Tumor microenvironment, immune response and post-radiotherapy tumor clearance

Koukourakis, M. I., & Giatromanolaki, A. N. (2020) · Clinical & Translational Oncology · doi:10.1007/s12094-020-02378-8 · Cited by 42 · see citing works

Molecular basis and clinical implications of HIFs in cardiovascular diseases

Hu, Y., Lu, H., Li, H., & Ge, J. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.09.004 · Cited by 40 · see citing works

Insight into Hypoxia Stemness Control

Mattia, M. D., Mauro, A., Citeroni, M. R., Dufrusine, B., Peserico, A., Russo, V., Berardinelli, P., Dainese, E., Cimini, A., & Barboni, B. (2021) · Cells · doi:10.3390/cells10082161 · Cited by 40 · see citing works

LOXL2-enriched small extracellular vesicles mediate hypoxia-induced premetastatic niche and indicates poor outcome of head and neck cancer

Zhu, G., Wang, L., Meng, W., Lu, S., Cao, B., Liang, X., He, C., Hao, Y., Du, X., Wang, X., et al. (2021) · Theranostics · doi:10.7150/thno.62455 · Cited by 39 · see citing works

Hypoxia-inducible factors: roles in cardiovascular disease progression, prevention, and treatment

Semenza, G. L. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac089 · Cited by 39 · see citing works

Role of T Cells in the Pathogenesis of Rheumatoid Arthritis: Focus on Immunometabolism Dysfunctions

Masoumi, M., Alesaeidi, ‬., Khorramdelazad, H., Behzadi, M., Baharlou, R., Alizadeh‐Fanalou, S., & Karami, J. (2022) · Inflammation · doi:10.1007/s10753-022-01751-9 · Cited by 38 · see citing works

Hypoxia and panvascular diseases: exploring the role of hypoxia-inducible factors in vascular smooth muscle cells under panvascular pathologies

Hu, Y., Zhao, Y., Li, P., Lu, H., Li, H., & Ge, J. (2023) · 中国科学通报：英文版 · doi:10.1016/j.scib.2023.07.032 · Cited by 37 · see citing works

Hydrogen Sulfide Oxidation: Adaptive Changes in Mitochondria of SW480 Colorectal Cancer Cells upon Exposure to Hypoxia

Malagrinò, F., Zuhra, K., Mascolo, L., Mastronicola, D., Vicente, J. B., Forte, E., & Giuffrè, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8102936 · Cited by 36 · see citing works

The role of HIF in angiogenesis, lymphangiogenesis, and tumor microenvironment in urological cancers

Shen, L., Chai, Y., Zheng, X., & Xu, X. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08931-2 · Cited by 35 · see citing works

Obstructive sleep apnea and cancer: a complex relationship

Marrone, O., & Bonsignore, M. R. (2020) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000729 · Cited by 35 · see citing works

TIGIT signaling and its influence on T cell metabolism and immune cell function in the tumor microenvironment

Jantz-Naeem, N., Loschinski, R., Borucki, K., Mitchell-Flack, M., Böttcher, M., Schraven, B. L., Mougiakakos, D., & Kahlfuß, S. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1060112 · Cited by 35 · see citing works

The Role of Imaging Biomarkers to Guide Pharmacological Interventions Targeting Tumor Hypoxia

Gallez, B. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.853568 · Cited by 34 · see citing works

Effects of Hypoxia in Intestinal Tumors on Immune Cell Behavior in the Tumor Microenvironment

Zhang, L., Wang, S., Wang, Y., Zhao, W., Zhang, Y., Zhang, N., & Xu, H. W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.645320 · Cited by 33 · see citing works

Immunometabolism modulation, a new trick of edible and medicinal plants in cancer treatment

Tan, W., Pan, T., Wang, S., Li, P., Men, Y., Tan, R., Zhong, Z., & Wang, Y. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.131860 · Cited by 35 · see citing works

Hypoxia, a Targetable Culprit to Counter Pancreatic Cancer Resistance to Therapy

Khouzam, R. A., Lehn, J., Mayr, H., Clavien, P., Wallace, M. B., Ducreux, M. P., Limani, P., & Chouaı̈b, S. (2023) · Cancers · doi:10.3390/cancers15041235 · Cited by 31 · see citing works

HIF1α-dependent uncoupling of glycolysis suppresses tumor cell proliferation

Urrutia, A. A., Mesa‐Ciller, C., Guajardo-Grence, A., Alkan, H. F., Soro-Arnáiz, I., Vandekeere, A., Campos, A. M. F., Igelmann, S., Fernández-Arroyo, L., Rinaldi, G., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114103 · Cited by 31 · see citing works

Lipid droplet velocity is a microenvironmental sensor of aggressive tumors regulated by V-ATPase and PEDF

Nardi, F., Fitchev, P., Brooks, K. M., Franco, O. E., Cheng, K. L., Hayward, S. W., Welte, M. A., & Crawford, S. E. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0296-8 · Cited by 30 · see citing works

EMT signaling: potential contribution of CRISPR/Cas gene editing

Mohammadinejad, R., Biagioni, A., Arunkumar, G., Shapiro, R. S., Chang, K., Sedeeq, M., Taiyab, A., Hashemabadi, M., Pardakhty, A., Mandegary, A., et al. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03449-3 · Cited by 30 · see citing works

Hypoxia Inducible Factors’ Signaling in Pediatric High-Grade Gliomas: Role, Modelization and Innovative Targeted Approaches

Fuchs, Q., Pierrevelcin, M., Messé, M., Lhermitte, B., Blandin, A.-F., Papin, C., Coca, A. H., Dontenwill, M., & Entz‐Werlé, N. (2020) · Cancers · doi:10.3390/cancers12040979 · Cited by 30 · see citing works

Novel insights into the interaction between long non-coding RNAs and microRNAs in glioma

Ebrahimpour, A., Sarfi, M., Rezatabar, S., & Tehrani, S. S. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04080-x · Cited by 29 · see citing works

Interplay of Carbonic Anhydrase IX With Amino Acid and Acid/Base Transporters in the Hypoxic Tumor Microenvironment

Venkateswaran, G., & Dedhar, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.602668 · Cited by 28 · see citing works

More Than Meets the Eye Regarding Cancer Metabolism

Kubicka, A., Matczak, K., & Łabieniec-Watała, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179507 · Cited by 30 · see citing works

Engineering nanomedicines to inhibit hypoxia-inducible Factor-1 for cancer therapy

Zhang, X., He, C., & Xiang, G. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.01.012 · Cited by 28 · see citing works

Indispensable role of microbes in anticancer drugs and discovery trends

Kapoor, R., Saini, A., & Sharma, D. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-12046-2 · Cited by 27 · see citing works

Lipid Peroxidation-Related Redox Signaling in Osteosarcoma

Šunjić, S. B., Jaganjac, M., Vlainić, J., Halasz, M., & Žarković, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084559 · Cited by 23 · see citing works

Cycling hypoxia selects for constitutive HIF stabilization

Pressley, M., Gallaher, J. A., Brown, J. S., Tomaszewski, M. R., Borad, P., Damaghi, M., Gillies, R. J., & Whelan, C. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-85184-8 · Cited by 23 · see citing works

Regulation of the SIAH2-HIF-1 Axis by Protein Kinases and Its Implication in Cancer Therapy

Xu, D., & Li, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.646687 · Cited by 23 · see citing works

Identifying a Hypoxia-Related Long Non-Coding RNAs Signature to Improve the Prediction of Prognosis and Immunotherapy Response in Hepatocellular Carcinoma

Tang, P., Qu, W., Wang, T., Liu, M., Wu, D., Tan, L., & Zhou, H. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.785185 · Cited by 23 · see citing works

Muscleblind-like 2 controls the hypoxia response of cancer cells

Fischer, S. E., Liddo, A. D., Taylor, K., Gerhardus, J. S., Sobczak, K., Zarnack, K., & Weigand, J. E. (2020) · RNA · doi:10.1261/rna.073353.119 · Cited by 23 · see citing works

Physiological and Genetic Basis of High-Altitude Indigenous Animals’ Adaptation to Hypoxic Environments

Zhao, P., Li, S., He, Z., & Ma, X. (2024) · Animals · doi:10.3390/ani14203031 · Cited by 22 · see citing works

PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α

Wei, Y., Zhang, D., Shi, H., Qian, H., Chen, H., Zeng, Q., Jin, F., Ye, Y., Ou, Z., Guo, M., et al. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.06.013 · Cited by 22 · see citing works

Simultaneous targeting of AMPK and mTOR is a novel therapeutic strategy against prostate cancer

Zhao, G., Forn‐Cuní, G., Scheers, M., Lindenbergh, P. P., Yin, J., van Loosen, Q. C., Passarini, L., Chen, L., & Snaar-Jagalska, E. B. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216657 · Cited by 22 · see citing works

IRF1 Negatively Regulates Oncogenic KPNA2 Expression Under Growth Stimulation and Hypoxia in Lung Cancer Cells

Huang, J., Wu, Y., Cheng, Y., Wang, C., & Yu, C. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s221832 · Cited by 21 · see citing works

Hypoxic State of Cells and Immunosenescence: A Focus on the Role of the HIF Signaling Pathway

Troise, D. E., Infante, B., Mercuri, S., Netti, G. S., Ranieri, E., Gesualdo, L., Stallone, G., & Pontrelli, P. (2023) · Biomedicines · doi:10.3390/biomedicines11082163 · Cited by 21 · see citing works

Cell stress management by the mitochondrial LonP1 protease – Insights into mitigating developmental, oncogenic and cardiac stress

Venkatesh, S., & Suzuki, C. K. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.10.004 · Cited by 20 · see citing works

Hypoxia as a modulator of cytochromes P450 : Overexpression of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in hypoxia

Cabrera‐Cano, A., Dávila‐Borja, V. M., Juárez‐Méndez, S., Marcial‐Quino, J., Gómez‐Manzo, S., & Castillo‐Rodríguez, R. A. (2020) · Cell Biochemistry and Function · doi:10.1002/cbf.3612 · Cited by 19 · see citing works

O-GlcNAcylation increases PYGL activity by promoting phosphorylation

Chen, Y., Zhu, J., Li, J., & Ye, X. (2021) · Glycobiology · doi:10.1093/glycob/cwab114 · Cited by 19 · see citing works

Targeting cellular metabolism using rapamycin and/or doxycycline enhances anti-tumour effects in human glioma cells

Petővári, G., Hujber, Z., Krencz, I., Dankó, T., Nagy, N., Tóth, F., Raffay, R. E., Mészáros, K. V., Rajnai, H., Vetlényi, E., et al. (2018) · Cancer Cell International · doi:10.1186/s12935-018-0710-0 · Cited by 19 · see citing works

Improving tumor microenvironment assessment in chip systems through next-generation technology integration

Gaebler, D., Hachey, S. J., & Hughes, C. C. W. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1462293 · Cited by 19 · see citing works

Prognostic and Clinicopathological Significance of Hypoxia-Inducible Factor-1α in Endometrial Cancer: A Meta-Analysis

Zhu, P., Shen, L., Ren, Q., Zeng, Q., & Xiaocui, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.587420 · Cited by 19 · see citing works

EPAS1 , a hypoxia‐ and f erroptosis‐related gene, promotes malignant behaviour of cervical cancer by ceRNA and super‐enhancer

Lu, X., Zhang, W., Zhang, J., Ren, D., Zhao, P., & Ying, Y. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18361 · Cited by 17 · see citing works

Immunosurveillance of cancer cell stress

Lorenzo‐Herrero, S., Sordo‐Bahamonde, C., Gonzalez, S. R., & López‐Soto, A. (2019) · Cell Stress · doi:10.15698/cst2019.09.198 · Cited by 18 · see citing works

Hypoxia-Mediated ATF4 Induction Promotes Survival in Detached Conditions in Metastatic Murine Mammary Cancer Cells

Kiesel, V. A., Sheeley, M. P., Hicks, E. M., Andolino, C. J., Donkin, S. S., Wendt, M. K., Hursting, S. D., & Teegarden, D. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.767479 · Cited by 17 · see citing works

Effects of hypoxia and HIFs on cancer metabolism

Mucaj, V., Shay, J. E. S., & Simon, M. C. (2012) · International Journal of Hematology · doi:10.1007/s12185-012-1070-5 · Cited by 137 · see citing works

Oxygen availability and metabolic reprogramming in cancer

Xie, H. J., & Simon, M. C. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.799973 · Cited by 203 · see citing works

Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment

Sormendi, S., & Wielockx, B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00040 · Cited by 141 · see citing works

Cancer Cell Metabolism in Hypoxia: Role of HIF-1 as Key Regulator and Therapeutic Target

Infantino, V., Santarsiero, A., Convertini, P., Todisco, S., & Iacobazzi, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115703 · Cited by 510 · see citing works

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

Semenza, G. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67230 · Cited by 1,335 · see citing works