Semenza, Gregg L.

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

Wang, T., Gilkes, D. M., Takano, N., Xiang, L., Luo, W., Bishop, C. J., Chaturvedi, P., Green, J. J., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences

Extracellular vesicles in diseaseCellular transport and secretion

Cited by 493

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

Semenza, G. L. (2009) · Seminars in Cancer Biology

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 469

RETRACTED: Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

Samanta, D., Gilkes, D. M., Chaturvedi, P., Xiang, L., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismCancer Cells and Metastasis

Cited by 460

RETRACTED: Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

Lee, K., Zhang, H., Qian, D. Z., Rey, S., Liu, J. O., & Semenza, G. L. (2009) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 451

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

Wong, C. C.-L., Gilkes, D. M., Zhang, H., Chen, J., Wei, H., Chaturvedi, P., Fraley, S. I., Wong, C.-M., Khoo, U.-S., Ng, I. O.-L., et al. (2011) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismCancer Cells and Metastasis

Cited by 437

HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells

Zhang, H., Lu, H., Xiang, L., Bullen, J. W., Zhang, C., Samanta, D., Gilkes, D. M., He, J., & Semenza, G. L. (2015) · Proceedings of the National Academy of Sciences

Phagocytosis and Immune RegulationCancer, Hypoxia, and Metabolism

Cited by 420

Hypoxia-Inducible Factor-1-Dependent Repression of E-cadherin in von Hippel-Lindau Tumor Suppressor–Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B

Krishnamachary, B., Zagzag, D., Nagasawa, H., Rainey, K., Okuyama, H., Baek, J. H., & Semenza, G. L. (2006) · Cancer Research

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 415

Perspectives on Oxygen Sensing

Semenza, G. L. (1999) · Cell

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 385

Evaluation of HIF-1 inhibitors as anticancer agents

Semenza, G. L. (2007) · Drug Discovery Today

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 363

HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression

Huang, D., Li, T., Li, X., Zhang, L., Sun, L., He, X., Zhong, X., Jia, D., Song, L., Semenza, G. L., et al. (2014) · Cell Reports

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 352

Regulation of Metabolism by Hypoxia-Inducible Factor 1

Semenza, G. L. (2011) · Cold Spring Harbor Symposia on Quantitative Biology

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 342

RETRACTED ARTICLE: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

Zhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., et al. (2012) · Oncogene

Angiogenesis and VEGF in CancerCancer, Hypoxia, and Metabolism

Cited by 326

Oxygen sensing in the body

Lahiri, S., Roy, A., Baby, S. M., Hoshi, T., Semenza, G. L., & Prabhakar, N. R. (2006) · Progress in Biophysics and Molecular Biology

Neuroscience of respiration and sleepCancer, Hypoxia, and Metabolism

Cited by 312

Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells

Samanta, D., Park, Y., Ni, X., Li, H., Zahnow, C. A., Gabrielson, E., Pan, F., & Semenza, G. L. (2018) · Proceedings of the National Academy of Sciences

Cancer Immunotherapy and BiomarkersCancer, Hypoxia, and Metabolism

Cited by 302

RETRACTED: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis

Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Cancer Research

Cancer, Hypoxia, and MetabolismMechanisms of cancer metastasis

Cited by 296

RETRACTED: Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

Lee, K., Qian, D. Z., Rey, S., Wei, H., Liu, J. O., & Semenza, G. L. (2009) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 289

Pharmacologic Targeting of Hypoxia-Inducible Factors

Semenza, G. L. (2019) · Annual Review of Pharmacology and Toxicology

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 288

Role of hypoxia-inducible factors in breast cancer metastasis

Gilkes, D. M., & Semenza, G. L. (2013) · Future Oncology

Cancer, Hypoxia, and MetabolismMechanisms of cancer metastasis

Cited by 274

Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis

Gilkes, D. M., Bajpai, S., Wong, C. C., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Molecular Cancer Research

Cancer, Hypoxia, and MetabolismMechanisms of cancer metastasis

Cited by 252

Hypoxia, HIF-1, and the Pathophysiologi of Common Human Diseases

Semenza, G. L., Agani, F., Feldser, D., Lyer, N., Kotch, L., Laughner, E., & Yu, 1. (2006) · Advances in Experimental Medicine and Biology

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 241

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

Elgogary, A., Xu, Q., Poore, B., Alt, J., Zimmermann, S. C., Zhao, L., Fu, J., Chen, B., Xia, S., Liu, Y., et al. (2016) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 234

Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1α but not HIF-2α

Luo, W., Zhong, J., Chang, R., Hu, H., Pandey, A., & Semenza, G. L. (2010) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismHeat shock proteins research

Cited by 232

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression

Luo, W., Chang, R., Zhong, J., Pandey, A., & Semenza, G. L. (2012) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation

Cited by 228

Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment

Chaturvedi, P., Gilkes, D. M., Takano, N., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences

Immune cells in cancerCancer Cells and Metastasis

Cited by 226