Shi, Yang

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 4,051

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science

Cancer-related molecular mechanisms researchGenomics and Chromatin Dynamics

Cited by 3,290

Histone methylation: a dynamic mark in health, disease and inheritance

Greer, E. L., & Shi, Y. (2012) · Nature Reviews Genetics

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 2,241

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

Sheng, W., LaFleur, M. W., Nguyen, T. H., Chen, S., Chakravarthy, A., Conway, J. R., Li, Y., Chen, H., Yang, H., Hsu, P.-H., et al. (2018) · Cell

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 693

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

Greer, E. L., Maures, T. J., Ucar, D., Hauswirth, A. G., Mancini, E., Lim, J. P., Benayoun, B. A., Shi, Y., & Brunet, A. (2011) · Nature

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 660

Roles and regulation of histone methylation in animal development

Jambhekar, A., Dhall, A., & Shi, Y. (2019) · Nature Reviews Molecular Cell Biology

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 556

The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3

Rahman, S., Sowa, M. E., Ottinger, M., Smith, J. A., Shi, Y., Harper, J. W., & Howley, P. M. (2011) · Molecular and Cellular Biology

Protein Degradation and InhibitorsGenomics and Chromatin Dynamics

Cited by 532

Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer

Wu, D., Hu, D., Chen, H., Shi, G., Fetahu, I. S., Wu, F., Rabidou, K., Fang, R., Tan, L., Xu, S., et al. (2018) · Nature

Metabolism, Diabetes, and CancerEpigenetics and DNA Methylation

Cited by 477

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

Horton, J. R., Upadhyay, A. K., Qi, H. H., Zhang, X., Shi, Y., & Cheng, X. (2010) · Nature Structural & Molecular Biology

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 389

Mutations in CHD7, Encoding a Chromatin-Remodeling Protein, Cause Idiopathic Hypogonadotropic Hypogonadism and Kallmann Syndrome

Kim, H.-G., Kurth, I., Lan, F., Meliciani, I., Wenzel, W., Eom, S. H., Kang, G. B., Rosenberger, G., Tekin, M., Ozata, M., et al. (2008) · The American Journal of Human Genetics

Congenital Ear and Nasal AnomaliesHypothalamic control of reproductive hormones

Cited by 338

SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation

Westbrook, T. F., Hu, G., Ang, X. L., Mulligan, P., Pavlova, N. N., Liang, A., Leng, Y., Maehr, R., Shi, Y., Harper, J. W., et al. (2008) · Nature

Ubiquitin and proteasome pathwaysDevelopmental Biology and Gene Regulation

Cited by 311

Emerging roles for chromatin as a signal integration and storage platform

Badeaux, A. I., & Shi, Y. (2013) · Nature Reviews Molecular Cell Biology

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 291

DNA N6-methyladenine: a new epigenetic mark in eukaryotes?

Luo, G.-Z., Blanco, M. A., Greer, E. L., He, C., & Shi, Y. (2015) · Nature Reviews Molecular Cell Biology

Epigenetics and DNA MethylationRNA modifications and cancer

Cited by 252

Mechanisms involved in the regulation of histone lysine demethylases

Lan, F., Nottke, A. C., & Shi, Y. (2008) · Current Opinion in Cell Biology

Epigenetics and DNA MethylationCancer-related gene regulation

Cited by 241

DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation

Dango, S., Mosammaparast, N., Sowa, M. E., Xiong, L.-J., Wu, F., Park, K., Rubin, M., Gygi, S., Harper, J. W., & Shi, Y. (2011) · Molecular Cell

DNA Repair MechanismsEpigenetics and DNA Methylation

Cited by 216

Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex

Shen, H., Xu, W., Guo, R., Rong, B., Gu, L., Wang, Z., He, C., Zheng, L., Hu, X., Hu, Z., et al. (2016) · Cell

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 184

Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation

Yang, Y. J., Baltus, A. E., Mathew, R. S., Murphy, E. A., Evrony, G. D., Gonzalez, D. M., Wang, E. P., Marshall-Walker, C. A., Barry, B. J., Murn, J., et al. (2012) · Cell

Neurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental Disorders

Cited by 176

Phosphorylation by the β-Catenin/MAPK Complex Promotes 14-3-3-Mediated Nuclear Export of TCF/POP-1 in Signal-Responsive Cells in C. elegans

Lo, M.-C., Gay, F., Odom, R., Shi, Y., & Lin, R. (2004) · Cell

Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

Cited by 138

Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming

Tan, L., Ke, Z., Tombline, G., Macoretta, N., Hayes, K., Tian, X., Lv, R., Ablaeva, J., Gilbert, M., Bhanu, N. V., et al. (2017) · Stem Cell Reports

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 88

Differential Interactions of the CREB/ATF Family of Transcription Factors with p300 and Adenovirus E1A

Lee, J.-S., Zhang, X., & Shi, Y. (1996) · Journal of Biological Chemistry

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 48

Chromatin-state barriers enforce an irreversible mammalian cell fate decision

Blanco, M. A., Sykes, D. B., Gu, L., Wu, M., Petroni, R., Karnik, R., Wawer, M., Rico, J., Li, H., Jacobus, W. D., et al. (2021) · Cell Reports

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 45