Differential Interactions of the CREB/ATF Family of Transcription Factors with p300 and Adenovirus E1A

Lee, Jeng-Shin; Zhang, Xiaolin; Shi, Yang

doi:10.1074/jbc.271.30.17666

Cited by 48Genomics and Chromatin DynamicsChromatin Remodeling and CancerProtein Kinase Regulation and GTPase Signaling

Differential Interactions of the CREB/ATF Family of Transcription Factors with p300 and Adenovirus E1A

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Lee, Jeng-Shin, Zhang, Xiaolin, Shi, Yang·1996·Journal of Biological Chemistry

DOI 10.1074/jbc.271.30.17666

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Abstract

The adenovirus E1A-associated protein p300 is a transcriptional cofactor that interacts with YY1 and mediates the relief of YY1 transcriptional repression by E1A. These observations raise the possibility that p300 may function as a bridging factor between E1A and cellular transcription factors. Here we show that p300, but not a mutant defective for binding to E1A, activated cAMP-responsive element-binding protein/activating transcription factor (CREB/ATF) binding site-mediated transcription in the presence of E1A. Among proteins that can recognize the CREB/ATF site, CREB appeared to be modulated by E1A in a p300 binding-dependent manner. This effect of E1A was correlated with a specific physical interaction between CREB and p300. These results suggest that p300 plays a crucial role in mediating the functional interplay between E1A and certain members of the CREB/ATF family. Two separate domains within p300 were identified that are capable of activating transcription. One of the domains interacted with the basal factor TFIIB, suggesting that p300 may function as a coactivator by making contacts with both sequence-specific transcription factors and the basal transcriptional machinery. This pivotal role of p300 may make it a prime target for viral proteins such as E1A in programming the cellular transcription machinery.

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CBP is a ubiquitous adapter protein that links transcription factors to the basal transcription machinery and is thought to stimulate transcription through contact with RNA polymerase II and histone acetylation.
“CBP is a ubiquitous adapter protein that mediates contacts between transcription factors and the basal transcription machinery (1,26,33) and is thought to stimulate transcription both by physical contact with the RNA polymerase II complex and through intrinsic histone acetylation activity (4, 33, 52).”
From Multiple Functional Domains of AML1: PU.1 and C/EBPα Synergize with Different Regions of AML1 (1998) · cites this paper as [33]
The discussion reports that CBP interacts with the basal transcription factor TFIIB, supporting the proposed link between transcription factors and basal machinery; the paper primarily investigates this bridging role in p300. Our copy does not establish that CBP is ubiquitous or that it stimulates transcription through contact with the RNA polymerase II complex or intrinsic histone acetylation. The indexed passages provide no page number. (LLM, conf=0.88)
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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262 · see citing works
A novel genetic system to detect protein–protein interactions
Fields, S., & Song, O.-K. (1989) · Nature · doi:10.1038/340245a0 · Cited by 6,152 · see citing works
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
Gonzalez, G. A., & Montminy, M. (1989) · Cell · doi:10.1016/0092-8674(89)90013-5 · Cited by 2,464 · see citing works
Phosphorylated CREB binds specifically to the nuclear protein CBP
Chrivia, J. C., Kwok, R. P. S., Lamb, N., Hagiwara, M., Montminy, M. R., & Goodman, R. H. (1993) · Nature · doi:10.1038/365855a0 · Cited by 2,052 · see citing works
E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins
Nevins, J. R. (1992) · Science · doi:10.1126/science.1411535 · Cited by 1,506 · see citing works
CREB: a Ca 2+ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases
Sheng, M., Thompson, M. A., & Greenberg, M. E. (1991) · Science · doi:10.1126/science.1646483 · Cited by 1,498 · see citing works
Nuclear protein CBP is a coactivator for the transcription factor CREB
Kwok, R. P. S., Lundblad, J. R., Chrivia, J. C., Richards, J. P., Bächinger, H. P., Brennan, R. G., Roberts, S. G. E., Green, M. R., & Goodman, R. H. (1994) · Nature · doi:10.1038/370223a0 · Cited by 1,443 · see citing works
Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.
Hai, T., & Curran, T. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3720 · Cited by 1,321 · see citing works
Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture
Ruley, H. E. (1983) · Nature · doi:10.1038/304602a0 · Cited by 1,248 · see citing works
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.Preprint
Eckner, R., Ewen, M. E., Newsome, D., Gerdes, M., DeCaprio, J. A., Lawrence, J. B., & Livingston, D. M. (1994) · Genes & Development · doi:10.1101/gad.8.8.869 · Cited by 1,045 · see citing works
Transcriptional repression by YY1, a human GLI-Krüippel-related protein, and relief of repression by adenovirus E1A protein
Shi, Y., Seto, E., Chang, L., & Shenk, T. E. (1991) · Cell · doi:10.1016/0092-8674(91)90189-6 · Cited by 1,035 · see citing works
Self-citation
Cellular targets for transformation by the adenovirus E1A proteins
Whyte, P., Williamson, N. M., & Harlow, E. (1989) · Cell · doi:10.1016/0092-8674(89)90984-7 · Cited by 729 · see citing works
Mechanism of activation of early viral transcription by the adenovirus E1A gene product
Nevins, J. R. (1981) · Cell · doi:10.1016/0092-8674(81)90304-4 · Cited by 606 · see citing works
Structure of the adenovirus 2 early mRNAs
Berk, A. J., & Sharp, P. A. (1978) · Cell · doi:10.1016/0092-8674(78)90252-0 · Cited by 592 · see citing works
Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP
Lundblad, J. R., Kwok, R. P. S., Laurance, M. E., Harter, M. L., & Goodman, R. H. (1995) · Nature · doi:10.1038/374085a0 · Cited by 585 · see citing works
A vector for expressing GAL4(1–147) fusions tn mammalian cells
Sadowski, I., & Ptashne, M. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.18.7539 · Cited by 556 · see citing works
Complex splicing patterns of RNAs from the early regions of adenovirus-2
Chow, L. T., Broker, T. R., & Lewis, J. B. (1979) · Journal of Molecular Biology · doi:10.1016/0022-2836(79)90036-6 · Cited by 551 · see citing works
A family of transcriptional adaptor proteins targeted by the E1A oncoprotein
Arany, Z., Newsome, D., Oldread, E., Livingston, D. M., & Eckner, R. (1995) · Nature · doi:10.1038/374081a0 · Cited by 533 · see citing works
E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators
Arany, Z. (1994) · Cell · doi:10.1016/0092-8674(94)90127-9 · Cited by 444 · see citing works
Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA
Houweling, A., van den Elsen, P. J., & van der Eb, A. J. (1980) · Virology · doi:10.1016/0042-6822(80)90054-9 · Cited by 417 · see citing works
Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription
Borrelli, E., Hen, R., & Chambon, P. (1984) · Nature · doi:10.1038/312608a0 · Cited by 404 · see citing works
A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein
Liu, F., & Green, M. R. (1990) · Cell · doi:10.1016/0092-8674(90)90686-9 · Cited by 376 · see citing works
Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products
Harlow, E., Franza, B. R., & Schley, C. (1985) · Journal of Virology · doi:10.1128/jvi.55.3.533-546.1985 · Cited by 374 · see citing works
Association of Adenovirus Early-Region 1A Proteins with Cellular Polypeptides
Harlow, E., Whyte, P., Franza, B. R., & Schley, C. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.5.1579 · Cited by 369 · see citing works
Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses
Perricaudet, M., Akusjärvi, G., Virtanen, A., & Pettersson, U. (1979) · Nature · doi:10.1038/281694a0 · Cited by 365 · see citing works
Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor
Lee, W. S., Kao, C. C., Bryant, G. O., Liu, X., & Berk, A. J. (1991) · Cell · doi:10.1016/0092-8674(91)90188-5 · Cited by 365 · see citing works
Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation
Bagchi, S., Raychaudhuri, P., & Nevins, J. R. (1990) · Cell · doi:10.1016/0092-8674(90)90112-r · Cited by 341 · see citing works
Adenovirus E1a proteins repress transcription from the SV40 early promoter
Velcich, A., & Ziff, E. B. (1985) · Cell · doi:10.1016/0092-8674(85)90219-3 · Cited by 325 · see citing works
Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300.Preprint
Lee, J. S., Galvin, K. M., See, R. H., Eckner, R., Livingston, D. M., Moran, E. M., & Shi, Y. (1995) · Genes & Development · doi:10.1101/gad.9.10.1188 · Cited by 311 · see citing works
Self-citation
An adenovirus E1a protein region required for transformation and transcriptional repression
Lillie, J. W., Green, M. R., & Green, M. R. (1986) · Cell · doi:10.1016/0092-8674(86)90704-x · Cited by 308 · see citing works
Interaction of a common cellular transcription factor, ATF, with regulatory elements in both E1a- and cyclic AMP-inducible promoters.
Lin, Y. S., & Green, M. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.10.3396 · Cited by 290 · see citing works
Definition of multiple, functionally distinct TATA elements, one of which is a target in the hsp70 promoter for E1A regulation
Simon, M. C., Fisch, T. M., Benecke, B. J., Nevins, J. R., & Heintz, N. (1988) · Cell · doi:10.1016/0092-8674(88)90410-2 · Cited by 279 · see citing works
Functional domains of adenovirus type 5 E1a proteins
Lillie, J. W., Loewenstein, P. M., Green, M. R., & Green, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90175-9 · Cited by 266 · see citing works
A cellular protein, activating transcription factor, activates transcription of multiple E1A-inducible adenovirus early promoters.
Lee, K. A. W., Hai, T. Y., Sivaraman, L., Thimmappaya, B., Hurst, H. C., Jones, N., & Green, M. R. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8355 · Cited by 257 · see citing works
Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth
Wang, H. G., Rikitake, Y., Carter, M. C., Yaciuk, P., Abraham, S., Zerler, B. R., & Moran, E. M. (1993) · Journal of Virology · doi:10.1128/jvi.67.1.476-488.1993 · Cited by 254 · see citing works
Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domains
Liu, F., & Green, M. R. (1994) · Nature · doi:10.1038/368520a0 · Cited by 254 · see citing works
A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1.Preprint
Hai, T., Liu, F., Allegretto, E. A., Karin, M., & Green, M. R. (1988) · Genes & Development · doi:10.1101/gad.2.10.1216 · Cited by 251 · see citing works
Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity
Stein, R. W., Corrigan, M. W., Yaciuk, P., Whelan, J., & Moran, E. M. (1990) · Journal of Virology · doi:10.1128/jvi.64.9.4421-4427.1990 · Cited by 241 · see citing works
Direct interaction between adenovirus E1A protein and the TATA box binding transcription factor IID.
Horikoshi, N., Maguire, K., Kralli, A., Maldonado, E., Reinberg, D., & Weinmann, R. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.12.5124 · Cited by 231 · see citing works
Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides
Yee, S., & Branton, P. E. (1985) · Virology · doi:10.1016/0042-6822(85)90234-x · Cited by 228 · see citing works
The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A.
Rehfuss, R. P., Walton, K. M., Loriaux, M., & Goodman, R. H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55078-x · Cited by 226 · see citing works
Repression of the Immunoglobulin Heavy Chain Enhancer by the Adenovirus-2 E1A Products
Hen, R., Borrelli, E., & Chambon, P. (1985) · Science · doi:10.1126/science.2999984 · Cited by 204 · see citing works
Both the basic region and the ‘leucine zipper’ domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation.
Dwarki, V., Montminy, M., & Verma, I. M. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08099.x · Cited by 198 · see citing works
Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer
Wefald, F. C., Devlin, B. H., & Williams, R. S. (1990) · Nature · doi:10.1038/344260a0 · Cited by 191 · see citing works
E1A 13S and 12S mRNA Products Made in Escherichia coli Both Function as Nucleus-Localized Transcription Activators but Do Not Directly Bind DNA
Ferguson, B., Krippl, B., ANDRISANI, O. M., Jones, N. C., Westphal, H., & Rosenberg, M. J. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.10.2653-2661.1985 · Cited by 185 · see citing works
ADENOVIRUS E1A PROTEIN PARADIGM VIRAL TRANSACTIVATOR
Flint, J., & Shenk, T. E. (1989) · Annual Review of Genetics · doi:10.1146/annurev.ge.23.120189.001041 · Cited by 184 · see citing works
Control of adenovirus early gene expression: A class of immediate early products
Lewis, J. B., & Mathews, M. B. (1980) · Cell · doi:10.1016/0092-8674(80)90138-5 · Cited by 182 · see citing works
Different Functional Domains of the Adenovirus E1A Gene are Involved in Regulation of Host Cell Cycle Products
Zerler, B. R., Roberts, R. J., Mathews, M. B., & Moran, E. M. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.2.821 · Cited by 169 · see citing works
The release of growth arrest by microinjection of adenovirus E1A DNA.
Stabel, S., Argos, P., & Philipson, L. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03934.x · Cited by 142 · see citing works
Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation.
Liu, F., Thompson, M., Wagner, S., Greenberg, M. E., & Green, M. R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53308-1 · Cited by 141 · see citing works
Sequences in E1A proteins of human adenovirus 5 required for cell transformation, repression of a transcriptional enhancer, and induction of proliferating cell nuclear antigen
Jelsma, T. N., Howe, J. A., Mymryk, J. S., Evelegh, C. M., Cunniff, N. F. A., & Bayley, S. T. (1989) · Virology · doi:10.1016/0042-6822(89)90518-7 · Cited by 141 · see citing works
Dissection of overlapping functions within the adenovirus type 5 E1A gene.
Winberg, G., & Shenk, T. E. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb02066.x · Cited by 132 · see citing works
A novel function of the transforming domain of E1a: Repression of AP-1 activity
Offringa, R., Gebel, S., van Dam, H., Timmers, H. T. M., de Vries-Smits, A. M. M., Zwart, R., Stein, B., Bos, J. L., van der Eb, A. J., & Herrlich, P. A. (1990) · Cell · doi:10.1016/0092-8674(90)90017-9 · Cited by 132 · see citing works
Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate viral EIIa and EIII expression at the transcriptional level.
Leff, T., Elkaïm, R., Goding, C. R., Jalinot, P., Sassone‐Corsi, P., Perricaudet, M., Kédinger, C., & Chambon, P. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.14.4381 · Cited by 128 · see citing works
Selective Induction of Human Heat Shock Gene Transcription by the Adenovirus E1A Gene Products, Including the 12S E1A Product
Simon, M. C., Kitchener, K., Kao, H., Hickey, E. D., Weber, L. E., Voellmy, R. W., Heintz, N., & Nevins, J. R. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.8.2884-2890.1987 · Cited by 123 · see citing works
p300, and p300-associated proteins, are components of TATA-binding protein (TBP) complexes.
Abraham, S., Lobo, S. M., Yaciuk, P., Wang, H.-G. H., & Moran, E. M. (1993) · PubMed · Cited by 120 · see citing works
Identification of human adenovirus early region 1 products by using antisera against synthetic peptides corresponding to the predicted carboxy termini
Yee, S., Rowe, D., Tremblay, M. L., McDermott, M. R., & Branton, P. E. (1983) · Journal of Virology · doi:10.1128/jvi.46.3.1003-1013.1983 · Cited by 110 · see citing works
Structure and Function of the Transforming Genes of Human Adenoviruses and SV40Preprint
van der Eb, A. J., van Ormondt, H., Schrier, P. I., Lupker, J. H., Jochemsen, H., van den Elsen, P. J., Deleys, R., Maat, J., van Beveren, C. P., Dijkema, R., et al. (1980) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1980.044.01.043 · Cited by 105 · see citing works
Transcriptional Activation by the Adenovirus Larger E1a Product is Mediated by Members of the Cellular Transcription Factor ATF Family Which Can Directly Associate with E1a
Chatton, B., Bocco, J. L., Gaire, M., Hauss, C., Reimund, B., Goetz, J., & Kédinger, C. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.561-570.1993 · Cited by 100 · see citing works
Cloning and analysis of the promotor region of the human fibronectin gene.
Dean, D. C., Bowlus, C. L., & Bourgeois, S. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.7.1876 · Cited by 98 · see citing works
Forskolin Inducibility and Tissue-Specific Expression of the Fibronectin Promoter
Dean, D. C., Blakeley, M. S., Newby, R. F., Ghazal, P., Hennighausen, L. G., & Bourgeois, S. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.4.1498 · Cited by 92 · see citing works
Repression of Insulin Gene Expression by Adenovirus Type 5 Ela Proteins
Stein, R. W., & Ziff, E. B. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.3.1164 · Cited by 90 · see citing works
The relationship between region E1a and E1b of human adenoviruses in cell transformation
van den Elsen, P. J., de Pater, S., Houweling, A., van der Veer, J., & van der Eb, A. J. (1982) · Gene · doi:10.1016/0378-1119(82)90115-9 · Cited by 90 · see citing works
Functional interactions between YY1 and adenovirus E1A
Lee, J.-S., See, R. H., Galvin, K. M., Wang, J., & Shi, Y. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.6.925 · Cited by 88 · see citing works
Self-citation
DNA-binding properties of the E1A-associated 300-kilodalton protein.
Rikitake, Y., & Morán, E. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2826 · Cited by 85 · see citing works
General repression of enhanson activity by the adenovirus-2 E1A proteins.Preprint
Rochette‐Egly, C., Fromental-Ramain, C., & Chambon, P. (1990) · Genes & Development · doi:10.1101/gad.4.1.137 · Cited by 83 · see citing works
DNA‐binding properties of an adenovirus 289R E1A protein.
Chatterjee, P. K., Bruner, M. W., Flint, S. J., & Harter, M. L. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02882.x · Cited by 77 · see citing works
Promoter-Specific Zrans-Activation by the Adenovirus E1A12S Product Involves Separate E1A Domains
Kraus, V. B., Moran, E. M., & Nevins, J. R. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.10.4391 · Cited by 73 · see citing works
Induction of cellular DNA synthesis by purified adenovirus E1A proteins
Kaczmarek, L., Ferguson, B., Rosenberg, M. J., & Baserga, R. (1986) · Virology · doi:10.1016/0042-6822(86)90366-1 · Cited by 69 · see citing works
myc and E1A oncogenes alter the responses of PC12 cells to nerve growth factor and block differentiation.
Maruyama, K., Schiavi, S. C., Huse, W. D., Johnson, G. L., & Ruley, H. E. (1987) · PubMed · Cited by 66 · see citing works
E1A-Mediated Inhibition of Myogenesis Correlates with a Direct Physical Interaction of E1A 12S and Basic Helix-Loop-Helix Proteins
Taylor, D. A., Kraus, V. B., Schwarz, J. J., Olson, E. N., & Kraus, W. E. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.8.4714 · Cited by 56 · see citing works
Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active.
Loriaux, M., Rehfuss, R. P., Brennan, R. G., & Goodman, R. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.9046 · Cited by 54 · see citing works
Morphological transformation of human adenoviruses is determined to a large extent by gene products of region E1A
van den Elsen, P. J., Houweling, A., & van der Eb, A. J. (1983) · Virology · doi:10.1016/0042-6822(83)90549-4 · Cited by 52 · see citing works
Interaction of a Common Factor with ATF, Spl, or TATAA Promoter Elements Is Required for These Sequences To Mediate Transactivation by the Adenoviral Oncogene E1a
Weintraub, S. J., & Dean, D. C. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.2.512-517.1992 · Cited by 32 · see citing works

Flagged first, then by citations

Research works printed but not linked: 8

Horikoshi, N., Maguire, K., Krelli, A., Maldanado, E., Reinberg, D., and Weinmann, R. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 5124 -5128
Lee, K. A. W., Hai, T.-Y., SivaRaman, L., Thimmappaya, B., Hurst, H. C., Jones, N. C., and Grenn, M. R. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 8355-8359
Lin, Y.-S., and Green, M. R. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 3396 -3400
Hai, T., and Curran, T. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 3720 -3724
Dean, D. C., Bowlus, C. L., and Bourgeois, S. (1987) Proc. Natl. Acad. Sci.
Leff, T., Elkaim, R., Goding, C. R., Jalinot, P., Sassone-Corsi, P., Perricaudet, M., Kedinger, C., and Chambon, P. (1984) Proc. Natl. Acad. Sci. U. S. A. 81, 4381-4385
Lee, J.-S., See, R. H., Deng, T., and Shi, Y. (1996) Mol. Cell. Biol., in press
Loriaux, M. M., Rehfuss, R. P., Brennan, R. G., and Goodman, R. H. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 9046 -9050

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Gerritsen, M. E., Williams, A. J., Neish, A. S., Moore, S., Shi, Y., & Collins, T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2927 · Cited by 811 · see citing works
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CBP and p300: HATs for different occasions
Kalkhoven, E. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.03.045 · Cited by 499 · see citing works
Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?
Thomas, M. J. N., & Seto, E. (1999) · Gene · doi:10.1016/s0378-1119(99)00261-9 · Cited by 463 · see citing works
CREB Activation Induces Adipogenesis in 3T3-L1 Cells
Reusch, J. E. B., Colton, L. A., & Klemm, D. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.1008-1020.2000 · Cited by 341 · see citing works
Ca2+-dependent regulation in neuronal gene expression
Bito, H., Deisseroth, K. A., & Tsien, R. W. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80072-4 · Cited by 300 · see citing works
Multiple Functional Domains of AML1: PU.1 and C/EBPα Synergize with Different Regions of AML1
Petrovick, M. S., Hiebert, S. W., Friedman, A. D., Hetherington, C. J., Tenen, D. G., & Zhang, D.-E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.3915 · Cited by 223 · see citing works
Activation of the cyclin D1 Gene by the E1A-associated Protein p300 through AP-1 Inhibits Cellular Apoptosis
Albanese, C., D’Amico, M., Reutens, A. T., Fu, M., Watanabe, G., Lee, R. J., Kitsis, R. N., Henglein, B., Avantaggiati, M. L., Somasundaram, K., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.34186 · Cited by 189 · see citing works
Multiple Mechanisms of Transcriptional Repression by YY1
Galvin, K. M., & Shi, Y. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.7.3723 · Cited by 183 · see citing works
Self-citation
Down Regulation of the Interleukin-8 Promoter by Human Papillomavirus Type 16 E6 and E7 through Effects on CREB Binding Protein/p300 and P/CAF
Huang, S.-M. A., & McCance, D. J. (2002) · Journal of Virology · doi:10.1128/jvi.76.17.8710-8721.2002 · Cited by 176 · see citing works
p300 Functions as a Coactivator for the Peroxisome Proliferator-activated Receptor α
Dowell, P., Ishmael, J. E., Avram, D., Peterson, V. J., Nevrivy, D. J., & Leid, M. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.33435 · Cited by 174 · see citing works
A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegansPreprint
Shi, Y., & Mello, C. C. (1998) · Genes & Development · doi:10.1101/gad.12.7.943 · Cited by 166 · see citing works
Self-citation
Adenovirus E1A Downregulates cJun- and JunB-Mediated Transcription by Targeting Their Coactivator p300
Lee, J.-S., See, R. H., Deng, T., & Shi, Y. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4312 · Cited by 153 · see citing works
Self-citation
Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation
Billon, N., Carlisi, D., Datto, M., van Grunsven, L. A., Watt, A. J., Wang, X., & Rudkin, B. B. (1999) · Oncogene · doi:10.1038/sj.onc.1202712 · Cited by 151 · see citing works
Regulation of the human P450scc gene by steroidogenic factor 1 is mediated by CBP/p300
Monté, D., DeWitte, F., & Hum, D. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.8.4585 · Cited by 147 · see citing works
The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cellsPreprint
Mutoh, H., Naya, F. J., Tsai, M., & Leiter, A. B. (1998) · Genes & Development · doi:10.1101/gad.12.6.820 · Cited by 139 · see citing works
p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6
Gingras, S., Simard, J., Groner, B., & Pfitzner, E. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.13.2722 · Cited by 129 · see citing works
Characterization of Human Activating Transcription Factor 4, a Transcriptional Activator That Interacts with Multiple Domains of cAMP-responsive Element-binding Protein (CREB)-binding Protein (CBP)
Liang, G., & Hai, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.24088 · Cited by 114 · see citing works
Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes
Dallas, P. B., Yaciuk, P., & Moran, E. M. (1997) · Journal of Virology · doi:10.1128/jvi.71.2.1726-1731.1997 · Cited by 102 · see citing works
The Viral Oncoprotein E1A Blocks Transforming Growth Factor β-Mediated Induction of p21/WAF1/Cip1 and p15/INK4B
Datto, M., Hu, P. P.-C., Kowalik, T. F., Yingling, J. M., & Wang, X. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.2030 · Cited by 98 · see citing works
Loricrin Expression in Cultured Human Keratinocytes Is Controlled by a Complex Interplay between Transcription Factors of the Sp1, CREB, AP1, and AP2 Families
Jang, S.-I., & Steinert, P. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205593200 · Cited by 94 · see citing works
Murine Double Minute (MDM2) Blocks p53-coactivator Interaction, a New Mechanism for Inhibition of p53-dependent Gene Expression
Wadgaonkar, R., & Collins, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.13760 · Cited by 93 · see citing works
cAMP Responsive Element Modulator (CREM) α Mediates Chromatin Remodeling of CD8 during the Generation of CD3+CD4−CD8− T Cells
Hedrich, C. M., Crispín, J. C., Rauen, T., Ioannidis, C., Koga, T., Rodríguez‐Rodríguez, N., Apostolidis, S. A., Kyttaris, V. C., & Tsokos, G. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.523605 · Cited by 82 · see citing works
Metabolic Reprogramming of the Host Cell by Human Adenovirus Infection
Prusinkiewicz, M. A., & Mymryk, J. S. (2019) · Viruses · doi:10.3390/v11020141 · Cited by 72 · see citing works
Histone Deacetylase Inhibitors Synergize p300 Autoacetylation that Regulates Its Transactivation Activity and Complex Formation
Stiehl, D. P., Fath, D. M., Liang, D., Jiang, Y., & Sang, N. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3985 · Cited by 65 · see citing works
Transcriptional Regulation of the Transforming Growth Factor-β2 Promoter by cAMP-responsive Element-binding Protein (CREB) and Activating Transcription Factor-1 (ATF-1) Is Modulated by Protein Kinases and the Coactivators p300 and CREB-binding Protein
Kingsley-Kallesen, M. L., Kelly, D., & Rizzino, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.34020 · Cited by 61 · see citing works
Differential role for CBP and p300 CREB-binding domain in motor skill learning.
Oliveira, A. M. M., Abel, T. G., Brindle, P. K., & Wood, M. A. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.3.724 · Cited by 56 · see citing works
Stimulation of p300-mediated Transcription by the Kinase MEKK1
See, R. H., Calvo, D., Shi, Y. G., Kawa, H., Luke, M. P.-S., Yuan, Z., & Shi, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008113200 · Cited by 55 · see citing works
Self-citation
YY1AP, A Novel Co-activator of YY1
Wang, C., Liang, Y., Lin, Y.-S., Shih, H., Jou, Y., & Yu, W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310532200 · Cited by 50 · see citing works
KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer
Kim, K., Kabra, A., Kim, D. W., Xue, Y., Huang, Y., Hou, P., Zhou, Y., Miranda, L. J., Park, J., Shi, X., et al. (2022) · Science Advances · doi:10.1126/sciadv.abl4618 · Cited by 36 · see citing works
cAMP-independent Activation of the Adenovirus Type 12 E2 Promoter Correlates with the Recruitment of CREB-1/ATF-1, E1A12S, and CBP to the E2-CRE
Fax, P., Lipinski, K. S., Esche, H., & Brockmann, D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8911 · Cited by 34 · see citing works
The N-terminal transactivation domain of ATF2 is a target for the co-operative activation of the c-jun promoter by p300 and 12S E1A
Duyndam, M. C. A., van Dam, H., Smits, P. H. M., Verlaan, M., van der Eb, A. J., & ZANTEMA, A. (1999) · Oncogene · doi:10.1038/sj.onc.1202584 · Cited by 33 · see citing works
The NH(2)-terminal and conserved region 2 domains of adenovirus E1A mediate two distinct mechanisms of tumor suppression.
Deng, J., Kloosterbooer, F., Xia, W., & Hung, M. (2002) · PubMed · Cited by 26 · see citing works
Transcriptional activation of the F1F0 ATP synthase α-subunit initiator element by USF2 is mediated by p300
Breen, G. A. M., & Jordan, E. M. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(99)00061-6 · Cited by 23 · see citing works
Transcriptional Up-regulation of the Delayed Early GeneHRS/SRp40during Liver Regeneration
Du, K., Leu, J. I.-J., Peng, Y., & Taub, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.35208 · Cited by 21 · see citing works
Upstream stimulatory factor 2 stimulates transcription through an initiator element in the mouse cytochrome c oxidase subunit Vb promoter
Breen, G. A. M., & Jordan, E. M. (2000) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00269-4 · Cited by 19 · see citing works
Aberrant Forms of Histone Acetyltransferases in Human Disease
van Beekum, O., & Kalkhoven, E. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/1-4020-5466-1_11 · Cited by 16 · see citing works
D-site Binding Protein Transactivation Requires the Proline- and Acid-rich Domain and Involves the Coactivator p300
Lamprecht, C., & Mueller, C. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17643 · Cited by 14 · see citing works
Thrombin Induces CCL2 Expression in Human Lung Fibroblasts via p300 Mediated Histone Acetylation and NF‐KappaB Activation
Deng, X., Zhou, X., Deng, Y., Liu, F., Feng, X., Yin, Q., Gu, Y., Shi, S., & Xu, M. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26057 · Cited by 12 · see citing works
Identification of N-terminal minimal transactivation domain of CBP, p300 and Caenorhabditis elegans homologues
Yoshida, E., Nakajima, T., Murakamia, K., & Fukamizu, A. (1998) · Gene · doi:10.1016/s0378-1119(98)00008-0 · Cited by 11 · see citing works
Dual action of the adenovirus E1A 243R oncoprotein on the human proliferating cell nuclear antigen promoter: repression of transcriptional activation by p53
Kannabiran, C., Morris, G. F., & Mathews, M. B. (1999) · Oncogene · doi:10.1038/sj.onc.1203294 · Cited by 11 · see citing works
CREB (cAMP response element binding protein) and C/EBPα (CCAAT/enhancer binding protein) are required for the superstimulation of phosphoenolpyruvate carboxykinase gene transcription by adenoviral E1a and cAMP
Routes, J. M., Colton, L. A., Ryan, S., & Klemm, D. J. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3520335 · Cited by 10 · see citing works
Yin Yang 1
Liu, H., & Shi, Y. (2007) · Springer eBooks · doi:10.1007/0-387-27421-9_25 · Cited by 10 · see citing works
Self-citation
Expression of the transcriptional coactivators CBP and p300 in the hamster suprachiasmatic nucleus: possible molecular components of the mammalian circadian clock
Fiore, P., & Gannon, R. L. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00663-0 · Cited by 9 · see citing works
IRF2BP2 counteracts the ATF7/JDP2 AP-1 heterodimer to prevent inflammatory overactivation in acute myeloid leukemia (AML) cells
Fischer, S., Weber, L. M., Stielow, B., Frech, M., Simon, C., Geller, M., Könnecke, J., Finkernagel, F., Forné, I., Nist, A., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae437 · Cited by 10 · see citing works
Minireview
(1996) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1996.377.11.685 · Cited by 5 · see citing works
Funktionelle Interaktion von E1A-Onkoproteinen mit Chromatin-remodellierenden Faktoren bei der Transkriptionsregulation des zellulären PCNA-Gens
Schwan, A. (2010) · DuEPublico (University of Duisburg-Essen)
Leptin vermittelte Signalübertragung und Proinsulingen- Regulation in β-Zellen des endokrinen Pankreas
Einsele, H. (2005)
Viral exploitation of p300/CBP at the virus-cancer interface: Chromatin regulation, oncogenesis, immune evasion, and therapeutic targeting
Atoom, A. M., Rizaev, J., Polatova, D., Patel, P. N., Jamuna, K. V., Maharana, L., Bainsal, N., & Singhal, D. (2026) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2026.101448

The transcriptional co‐activator proteins p300 and CBP stimulate adenovirus E1A conserved region 1 transactivation‐independent of a direct interaction
Mannervik, M., & Akusjärvi, G. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00982-4 · Cited by 4 · see citing works
A family of transcriptional adaptor proteins targeted by the E1A oncoprotein
Arany, Z., Newsome, D., Oldread, E., Livingston, D. M., & Eckner, R. (1995) · Nature · doi:10.1038/374081a0 · Cited by 533 · see citing works
The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.
Dorsman, J. C., Teunisse, A. F. A. S., ZANTEMA, A., & van der Eb, A. J. (1997) · Journal of General Virology · doi:10.1099/0022-1317-78-2-423 · Cited by 25 · see citing works
Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP
Lundblad, J. R., Kwok, R. P. S., Laurance, M. E., Harter, M. L., & Goodman, R. H. (1995) · Nature · doi:10.1038/374085a0 · Cited by 585 · see citing works
Factor-specific modulation of CREB-binding protein acetyltransferase activity (p300/CBP interacting proteinyp300/CBP associated factoryE1A)
Perissi, V., Dasen, J. S., Kurokawa, R., Wang, Z. H., Korzus, E., Rose, D. W., Glass, H. K., & Rosenfeld, M. G. (1999) · Cited by 1 · see citing works

Authors: Lee, J.-S., Zhang, X., & Shi, Y.
Affiliations: Harvard University (US)
Corresponding author: Shi, Yang
ORCID: Zhang, Xiaolin
Shi, Yang
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1996-07
Volume: 271
Issue: 30
Pages: 17666-17674
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.271.30.17666
OpenAlex: W2003135979
Cited by: 48
References: 74
Citations by year: 2026: 1 · 2024: 1 · 2022: 1 · 2019: 1 · 2017: 1 · 2013: 1
FWCI: 3.16
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 8871 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: American Cancer Society
National Institutes of Health (7f32gm018221-02)
National Institute of General Medical Sciences (R01GM053874)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: P300, adenovirus E1A, CREB, ATF, transcriptional coactivator, transcriptional repression, TFIIB, protein-protein interaction, transactivation domain
MeSH terms: Binding Sites, Blood Proteins, DNA Mutational Analysis, Gene Expression Regulation, Nuclear Proteins, Protein Binding, Structure-Activity Relationship, Transcription Factors, Transcription, Genetic, Trans-Activators, Cyclic AMP Response Element-Binding Protein, Adenovirus E1A Proteins, E1A-Associated p300 Protein, Activating Transcription Factors

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Differential Interactions of the CREB/ATF Family of Transcription Factors with p300 and Adenovirus E1A

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