The DNA damage response to transcription stress

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Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses

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RNA Polymerase II Elongation Control

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The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH

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Base excision repair: A critical player in many games

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Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells

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XPD Helicase Structures and Activities: Insights into the Cancer and Aging Phenotypes from XPD Mutations

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A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in Cockayne syndrome

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TFIIH: when transcription met DNA repair

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UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells.

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Cockayne syndrome group B protein enhances elongation by RNA polymerase II

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E. coli Transcription Repair Coupling Factor (Mfd Protein) Rescues Arrested Complexes by Promoting Forward Translocation

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The Oxidative DNA Lesion 8,5′-(S)-Cyclo-2′-deoxyadenosine Is Repaired by the Nucleotide Excision Repair Pathway and Blocks Gene Expression in Mammalian Cells

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Transcription Recovery after DNA Damage Requires Chromatin Priming by the H3.3 Histone Chaperone HIRA

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Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate

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CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome.

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The Cockayne syndrome B protein, involved in transcription‐coupled DNA repair, resides in an RNA polymerase II‐containing complex

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Transcription‐coupled repair removes both cyclobutane pyrimidine dimers and 6‐4 photoproducts with equal efficiency and in a sequential way from transcribed DNA in xeroderma pigmentosum group C fibroblasts.

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Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome

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Structure of hsDDB1-drDDB2 bound to a 13 bp CPD-duplex (purine at D-1 position) at 3.0 A resolution (CPD 1)

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H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase

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Damage-Induced Ubiquitylation of Human RNA Polymerase II by the Ubiquitin Ligase Nedd4, but Not Cockayne Syndrome Proteins or BRCA1

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Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair

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Malfunction of Nuclease ERCC1-XPF Results in Diverse Clinical Manifestations and Causes Cockayne Syndrome, Xeroderma Pigmentosum, and Fanconi Anemia

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Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair.

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Reprogramming transcription after DNA damage: recognition, response, repair, and restart

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Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers

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Different SWI/SNF complexes coordinately promote R-loop- and RAD52-dependent transcription-coupled homologous recombination

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R-loop Mediated DNA Damage and Impaired DNA Repair in Spinal Muscular Atrophy

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Large-scale CRISPR screening in primary human 3D gastric organoids enables comprehensive dissection of gene-drug interactions

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STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment

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Fluorescence Sheds Light on DNA Damage, DNA Repair, and Mutations

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Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation

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Interplay Among Hydrogen Sulfide, Nitric Oxide, Reactive Oxygen Species, and Mitochondrial DNA Oxidative Damage

Huang, D., Jing, G., Zhang, L., Chen, C., & Zhu, S. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.701681 · Cited by 36 · see citing works

Transcription coupled base excision repair in mammalian cells: So little is known and so much to uncover

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Nucleotide excision repair: a versatile and smart toolkit

Zhang, X., Yin, M., & Hu, J. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022054 · Cited by 36 · see citing works

Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice

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Time is ticking faster for long genes in aging

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Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1

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A unifying model for extrachromosomal circular DNA load in eukaryotic cells

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Large-scale preparation of fluorescence multiplex host cell reactivation (FM-HCR) reporters

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Different responses to DNA damage determine ageing differences between organs

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So close, no matter how far: multiple paths connecting transcription to mRNA translation in eukaryotes

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Nutritional Preconditioning in Cancer Treatment in Relation to DNA Damage and Aging

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TFIIH central activity in nucleotide excision repair to prevent disease

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Age or lifestyle-induced accumulation of genotoxicity is associated with a length-dependent decrease in gene expression

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Continuous transcription initiation guarantees robust repair of all transcribed genes and regulatory regions

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Differential processing of RNA polymerase II at DNA damage correlates with transcription-coupled repair syndrome severity

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Photorepair of Either CPD or 6-4PP DNA Lesions in Basal Keratinocytes Attenuates Ultraviolet-Induced Skin Effects in Nucleotide Excision Repair Deficient Mice

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Dynamic features of human mitochondrial DNA maintenance and transcription

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DNA damage-inducing endogenous and exogenous factors and research progress

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USP13 regulates the replication stress response by deubiquitinating TopBP1

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Transcription stress at telomeres leads to cytosolic DNA release and paracrine senescence

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Emerging mechanisms underlying formaldehyde toxicity and response

Valverde-Santiago, M., & Pontel, L. B. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.04.018 · Cited by 26 · see citing works

The Surprising Diversity of UV‐Induced Mutations

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Ganoderma lucidum triterpenoids investigating their role in medicinal applications and genomic protection

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Circadian Rhythm of NER and ATR Pathways

Kang, T. (2021) · Biomolecules · doi:10.3390/biom11050715 · Cited by 24 · see citing works

Methods and applications of genome-wide profiling of DNA damage and rare mutations

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XPG: a multitasking genome caretaker

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A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner

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Phase separation in gene transcription control

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ATR regulates neuronal activity by modulating presynaptic firing

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Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response

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Distinct roles for RSC and SWI/SNF chromatin remodelers in genomic excision repairPreprint

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Transcription Blockage by DNA Damage in Nucleotide Excision Repair-Related Neurological Dysfunctions

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Impaired Iron–Sulfur Cluster Synthesis Induces Mitochondrial PARthanatos in Diabetic Cardiomyopathy

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Polymerases and DNA Repair in Neurons: Implications in Neuronal Survival and Neurodegenerative Diseases

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DNA repair deficiencies and neurodegeneration

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Elf1 promotes Rad26’s interaction with lesion-arrested Pol II for transcription-coupled repair

Sarsam, R. D., Xu, J., Lahiri, I., Gong, W., Li, Q., Oh, J., Zhou, Z., Hou, P., Chong, J. P. C., Hao, N., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2314245121 · Cited by 21 · see citing works

Thirdhand smoke exposure causes replication stress and impaired transcription in human lung cells

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LncRNA DYNLRB2-AS1 promotes gemcitabine resistance of nasopharyngeal carcinoma by inhibiting the ubiquitination degradation of DHX9 protein

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Fludarabine increases nuclease-free AAV- and CRISPR/Cas9-mediated homologous recombination in mice

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Requirement of transcription-coupled nucleotide excision repair for the removal of a specific type of oxidatively induced DNA damage

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Tampering of Viruses and Bacteria with Host DNA Repair: Implications for Cellular Transformation

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Mechanisms of transcription-coupled repair and DNA damage surveillance in health and disease

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Dealing with transcription-blocking DNA damage: Repair mechanisms, RNA polymerase II processing and human disorders

Jia, N., Guo, C., Nakazawa, Y., van den Heuvel, D., Luijsterburg, M. S., & Ogi, T. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103192 · Cited by 50 · see citing works

What happens at the lesion does not stay at the lesion: Transcription-coupled nucleotide excision repair and the effects of DNA damage on transcription in cis and trans

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Molecular basis of transcriptional pausing, stalling, and transcription-coupled repair initiation

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Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches

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