Köhrle, Josef

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

Wirth, E. K., Conrad, M., Winterer, J., Wozny, C., Carlson, B. A., Roth, S., Schmitz, D., Bornkamm, G. W., Coppola, V., Tessarollo, L., et al. (2010) · The FASEB Journal

Selenium in Biological SystemsOrganoselenium and organotellurium chemistry

Cited by 237

Selenium and the Thyroid

Köhrle, J. (2015) · Current Opinion in Endocrinology, Diabetes & Obesity

Selenium in Biological SystemsThyroid Disorders and Treatments

Cited by 195

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

Finan, B., Clemmensen, C., Zhu, Z., Stemmer, K., Gauthier, K., Müller, L., De Angelis, M., Moreth, K., Neff, F., Perez-Tilve, D., et al. (2016) · Cell

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 191

Selenium, Iodine and Iron–Essential Trace Elements for Thyroid Hormone Synthesis and Metabolism

Köhrle, J. (2023) · International Journal of Molecular Sciences

Thyroid Disorders and TreatmentsSelenium in Biological Systems

Cited by 163

Deiodinases control local cellular and systemic thyroid hormone availability

Köhrle, J., & Frädrich, C. (2022) · Free Radical Biology and Medicine

Thyroid Disorders and TreatmentsSelenium in Biological Systems

Cited by 133

Thyroxine transport to the brain: role of protein synthesis by the choroid plexus

Southwell, B. R., Duan, W., Alcorn, D., Brack, C., Richardson, S. J., Köhrle, J., & Schreiber, G. (1993) · Endocrinology

Barrier Structure and Function StudiesCerebrospinal fluid and hydrocephalus

Cited by 105

Tyrosine kinase inhibitors noncompetitively inhibit MCT8-mediated iodothyronine transport

Braun, D., Kim, T. D., le Coutre, P., Köhrle, J., Hershman, J. M., & Schweizer, U. (2012) · The Journal of Clinical Endocrinology & Metabolism

Thyroid Disorders and TreatmentsDrug Transport and Resistance Mechanisms

Cited by 102

Thyroid Stimulating Hormone and Thyroid Hormones (Triiodothyronine and Thyroxine): An American Thyroid Association-Commissioned Review of Current Clinical and Laboratory Status

Van Uytfanghe, K., Ehrenkranz, J., Halsall, D., Hoff, K., Loh, T. P., Spencer, C. A., Köhrle, J., & ATA Thyroid Function Tests Writing Group (2023) · Thyroid®

Thyroid Disorders and TreatmentsClinical Laboratory Practices and Quality Control

Cited by 100

3,5-Diiodo-L-Thyronine (3,5-T2) Exerts Thyromimetic Effects on Hypothalamus-Pituitary-Thyroid Axis, Body Composition, and Energy Metabolism in Male Diet-Induced Obese Mice

Jonas, W., Lietzow, J., Wohlgemuth, F., Hoefig, C. S., Wiedmer, P., Schweizer, U., Köhrle, J., & Schürmann, A. (2015) · Endocrinology

Thyroid Disorders and TreatmentsRegulation of Appetite and Obesity

Cited by 90

The Promoter of the Human Type I 5′‐Deiodinase Gene — Mapping of the Transcription Start Site and Identification of a DR+4 Thyroid‐Hormone‐Responsive Element

Jakobs, T. C., Schmutzler, C., Meissner, J., & Köhrle, J. (1997) · European Journal of Biochemistry

Thyroid Disorders and TreatmentsGenomics and Chromatin Dynamics

Cited by 90

Evidence for extrathyroidal formation of 3-iodothyronamine in humans as provided by a novel monoclonal antibody-based chemiluminescent serum immunoassay

Hoefig, C. S., Köhrle, J., Brabant, G., Dixit, K., Yap, B., Strasburger, C. J., & Wu, Z. (2011) · The Journal of Clinical Endocrinology & Metabolism

Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and Treatment

Cited by 78

Nonthyroidal illness syndrome in cardiac illness involves elevated concentrations of 3,5-diiodothyronine and correlates with atrial remodeling

Dietrich, J. W., Müller, P., Schiedat, F., Schlömicher, M., Strauch, J., Chatzitomaris, A., Klein, H. H., Mügge, A., Köhrle, J., Rijntjes, E., et al. (2015) · European Thyroid Journal

Thyroid Disorders and TreatmentsAtrial Fibrillation Management and Outcomes

Cited by 68

The colorful diversity of thyroid hormone metabolites

Köhrle, J. (2019) · European Thyroid Journal

Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and Treatment

Cited by 67

Detection of 3,5-diiodothyronine in sera of patients with altered thyroid status using a new monoclonal antibody-based chemiluminescence immunoassay

Lehmphul, I., Brabant, G., Wallaschofski, H., Ruchala, M., Strasburger, C. J., Köhrle, J., & Wu, Z. (2014) · Thyroid®

Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and Treatment

Cited by 58

Thyroid hormone and its metabolites in relation to quality of life in patients treated for differentiated thyroid cancer

Massolt, E. T., van der Windt, M., Korevaar, T. I. M., Kam, B. L. R., Burger, J. W., Franssen, G. J. H., Lehmphul, I., Köhrle, J., Visser, W. E., & Peeters, R. P. (2016) · Clinical Endocrinology

Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and Treatment

Cited by 47

Thyroid hormones and derivatives: endogenous thyroid hormones and their targets

Köhrle, J. (2018) · Methods in Molecular Biology

Thyroid Disorders and TreatmentsChemical Analysis and Environmental Impact

Cited by 47

3,5-Diiodo-l-Thyronine Stimulates Type 1 5′Deiodinase Activity in Rat Anterior Pituitaries in Vivo and in Reaggregate Cultures and GH3 Cells in Vitro1

Baur, A., Bauer, K., Jarry, H., & Köhrle, J. (1997) · Endocrinology

Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth Factors

Cited by 42

Quantitative analysis of thyroid hormone metabolites in cell culture samples using LC-MS/MS

Rathmann, D., Rijntjes, E., Lietzow, J., & Köhrle, J. (2015) · European Thyroid Journal

Thyroid Disorders and TreatmentsAnalytical chemistry methods development

Cited by 34

Translating pharmacological findings from hypothyroid rodents to euthyroid humans: is there a functional role of endogenous 3,5-T2?

Pietzner, M., Lehmphul, I., Friedrich, N., Schurmann, C., Ittermann, T., Dörr, M., Nauck, M., Laqua, R., Völker, U., Brabant, G., et al. (2015) · Thyroid

Thyroid Disorders and TreatmentsFatty Acid Research and Health

Cited by 31

3,5-T2 alters murine genes relevant for xenobiotic, steroid, and thyroid hormone metabolism

Lietzow, J., Golchert, J., Homuth, G., Völker, U., Jonas, W., & Köhrle, J. (2016) · Journal of Molecular Endocrinology

Pharmacogenetics and Drug MetabolismThyroid Disorders and Treatments

Cited by 28

A combined LC-MS/MS and LC-MS3 multi-method for the quantification of iodothyronines in human blood serum

Richards, K. H., Monk, R., Renko, K., Rathmann, D., Rijntjes, E., & Köhrle, J. (2019) · Analytical and Bioanalytical Chemistry

Thyroid Disorders and TreatmentsAnalytical Methods in Pharmaceuticals

Cited by 27

Avoiding the pitfalls when quantifying thyroid hormones and their metabolites using mass spectrometric methods: the role of quality assurance

Richards, K., Rijntjes, E., Rathmann, D., & Köhrle, J. (2017) · Molecular and Cellular Endocrinology

Thyroid Disorders and TreatmentsAnalytical Methods in Pharmaceuticals

Cited by 23

3,5-T2—A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine and Intracrine Hepatic Action

Köhrle, J., Lehmphul, I., Pietzner, M., Renko, K., Rijntjes, E., Richards, K., Anselmo, J., Danielsen, M., & Jonklaas, J. (2020) · Frontiers in Endocrinology

Thyroid Disorders and TreatmentsHormonal and reproductive studies

Cited by 23

Circulating 3-T1AM and 3,5-T2 in critically ill patients: a cross-sectional observational study

Langouche, L., Lehmphul, I., Perre, S. V., Köhrle, J., & Van den Berghe, G. (2016) · Thyroid®

Thyroid Disorders and TreatmentsAdrenal Hormones and Disorders

Cited by 23