Cited by 207Telomeres, Telomerase, and SenescenceDNA Repair MechanismsGenetics, Aging, and Longevity in Model Organisms

Impact of genomic damage and ageing on stem cell function

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Behrens, Axel, van Deursen, Jan M., Rudolph, K. Lenhard, Schumacher, Björn·2014·Nature Cell Biology

Abstract

Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell microenvironment are partly responsible for stem cell dysfunction with ageing. Here, we review the impact of the various types of DNA damage that accumulate with ageing on stem cell functionality, as well as the development of cancer. We discuss DNA-damage-induced cell intrinsic and extrinsic alterations that influence these processes, and review recent advances in understanding systemic adjustments to DNA damage and how they affect stem cells.

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  1. [62]Krishnamurthy J Ink4a/Arf expression is a biomarker of aging J. Clin. Invest 2004 114 1299 1307 15520862 PMC524230

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Authors
Behrens, A., van Deursen, J. M., Rudolph, K. L., & Schumacher, B.
Affiliations
  • King's College London (GB)
  • Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) (DE)
  • University of Cologne (DE)
Corresponding author
  • Behrens, Axel
  • Rudolph, K. Lenhard
  • Schumacher, Björn
Venue
Nature Cell Biology
Published
2014-02-28
Volume
16
Issue
3
Pages
201-207
ISSN
  • 1465-7392 (ISSN-L)
  • 1476-4679
OpenAlex
W2054525725
Cited by
207
References
98
Citations by year
2026: 7 · 2025: 8 · 2024: 11 · 2023: 12 · 2022: 10 · 2021: 17 · 2020: 19 · 2019: 27 · 2018: 13 · 2017: 18 · 2016: 20 · 2015: 32 · 2014: 13
FWCI
3.24
Type
journal article
Language
en
Open access
Locations
  • Nature Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Funders
  • Cancer Research UK (15679)
  • National Cancer Institute (R01CA126828)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
genomic instability, aging, stem cell function, DNA damage, stem cell niche, tissue maintenance, tissue repair, carcinogenesis
MeSH terms
Aneuploidy, Animals, Cells, Cultured, DNA Damage, DNA Repair, Humans, Neoplasms, Genome, Human, Cellular Senescence, Adult Stem Cells

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