Rabinowitz, Joshua D.

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

Zhang, J., Fan, J., Venneti, S., Cross, J. R., Takagi, T., Bhinder, B., Djaballah, H., Kanai, M., Cheng, E. H., Judkins, A. R., et al. (2014) · Molecular Cell

Amino Acid Enzymes and MetabolismCancer, Hypoxia, and Metabolism

Cited by 439

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation

Ron-Harel, N., Santos, D., Ghergurovich, J. M., Sage, P. T., Reddy, A., Lovitch, S. B., Dephoure, N., Satterstrom, F. K., Sheffer, M., Spinelli, J. B., et al. (2016) · Cell Metabolism

Mitochondrial Function and PathologyT-cell and B-cell Immunology

Cited by 429

Glutamine‐driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

Fan, J., Kamphorst, J. J., Mathew, R., Chung, M. K., White, E., Shlomi, T., & Rabinowitz, J. D. (2013) · Molecular Systems Biology

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 428

Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway

Ducker, G. S., Chen, L., Morscher, R. J., Ghergurovich, J. M., Esposito, M., Teng, X., Kang, Y., & Rabinowitz, J. D. (2016) · Cell Metabolism

Folate and B Vitamins ResearchCancer, Hypoxia, and Metabolism

Cited by 419

Itaconic acid is a mammalian metabolite induced during macrophage activation

Strelko, C. L., Lu, W., Dufort, F. J., Seyfried, T. N., Chiles, T. C., Rabinowitz, J. D., & Roberts, M. F. (2011) · Journal of the American Chemical Society

Immune cells in cancerMetabolomics and Mass Spectrometry Studies

Cited by 391

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

Wellen, K. E., Lu, C., Mancuso, A., Lemons, J. M. S., Ryczko, M., Dennis, J. W., Rabinowitz, J. D., Coller, H. A., & Thompson, C. B. (2010) · Genes & Development

Cancer, Hypoxia, and MetabolismGlycosylation and Glycoproteins Research

Cited by 377

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

Frederick, D. W., Loro, E., Liu, L., Davila, A., Chellappa, K., Silverman, I. M., Quinn, W. J., Gosai, S. J., Tichy, E. D., Davis, J. G., et al. (2016) · Cell Metabolism

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 367

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

Chini, C. C. S., Peclat, T. R., Warner, G. M., Kashyap, S., Espindola-Netto, J. M., de Oliveira, G. C., Gomez, L. S., Hogan, K. A., Tarragó, M. G., Puranik, A. S., et al. (2020) · Nature Metabolism

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 349

As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid

Pavlova, N. N., Hui, S., Ghergurovich, J. M., Fan, J., Intlekofer, A. M., White, R. M., Rabinowitz, J. D., Thompson, C. B., & Zhang, J. (2018) · Cell Metabolism

Amino Acid Enzymes and MetabolismCancer, Hypoxia, and Metabolism

Cited by 341

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

Davidson, S. M., Jonas, O., Keibler, M. A., Hou, H. W., Luengo, A., Mayers, J. R., Wyckoff, J., Del Rosario, A. M., Whitman, M., Chin, C. R., et al. (2017) · Nature Medicine

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 331

SLC25A51 is a mammalian mitochondrial NAD(+) transporter

Luongo, T. S., Eller, J. M., Lu, M.-J., Niere, M., Raith, F., Perry, C., Bornstein, M. R., Oliphint, P., Wang, L., McReynolds, M. R., et al. (2020) · Nature

Mitochondrial Function and PathologySirtuins and Resveratrol in Medicine

Cited by 308

Slow TCA flux and ATP production in primary solid tumours but not metastases

Bartman, C. R., Weilandt, D. R., Shen, Y., Lee, W. D., Han, Y., TeSlaa, T., Jankowski, C. S. R., Samarah, L., Park, N. R., da Silva-Diz, V., et al. (2023) · Nature

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 299

Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma

Ducker, G. S., Ghergurovich, J. M., Mainolfi, N., Suri, V., Jeong, S. K., Hsin-Jung Li, S., Friedman, A., Manfredi, M. G., Gitai, Z., Kim, H., et al. (2017) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismFolate and B Vitamins Research

Cited by 261

Metabolite exchange between mammalian organs quantified in pigs

Jang, C., Hui, S., Zeng, X., Cowan, A. J., Wang, L., Chen, L., Morscher, R. J., Reyes, J., Frezza, C., Hwang, H. Y., et al. (2019) · Cell Metabolism

Metabolomics and Mass Spectrometry StudiesDiet, Metabolism, and Disease

Cited by 256

Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate

Kamphorst, J. J., Chung, M. K., Fan, J., & Rabinowitz, J. D. (2014) · Cancer & Metabolism

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 227

Metabolomics-driven quantitative analysis of ammonia assimilation in E. coli

Yuan, J., Doucette, C. D., Fowler, W. U., Feng, X., Piazza, M., Rabitz, H. A., Wingreen, N. S., & Rabinowitz, J. D. (2009) · Molecular Systems Biology

Microbial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

Cited by 178

Therapeutic targeting of the Warburg effect in pancreatic cancer relies on an absence of p53 function

Rajeshkumar, N. V., Dutta, P., Yabuuchi, S., de Wilde, R. F., Martinez, G. V., Le, A., Kamphorst, J. J., Rabinowitz, J. D., Jain, S. K., Hidalgo, M., et al. (2015) · Cancer Research

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 158

NAD precursors cycle between host tissues and the gut microbiome

Chellappa, K., McReynolds, M. R., Lu, W., Zeng, X., Makarov, M., Hayat, F., Mukherjee, S., Bhat, Y. R., Lingala, S. R., Shima, R. T., et al. (2022) · Cell Metabolism

Sirtuins and Resveratrol in MedicineGut microbiota and health

Cited by 146

Nicotinamide adenine dinucleotide is transported into mammalian mitochondria

Davila, A., Liu, L., Chellappa, K., Redpath, P., Nakamaru-Ogiso, E., Paolella, L. M., Zhang, Z., Migaud, M. E., Rabinowitz, J. D., & Baur, J. A. (2018) · eLife

Sirtuins and Resveratrol in MedicineMitochondrial Function and Pathology

Cited by 142

Absence of Detectable Arsenate in DNA from Arsenate-Grown GFAJ-1 Cells

Reaves, M. L., Sinha, S., Rabinowitz, J. D., Kruglyak, L., & Redfield, R. J. (2012) · Science

Arsenic contamination and mitigationOrigins and Evolution of Life

Cited by 125

Kinetic flux profiling of nitrogen assimilation in Escherichia coli

Yuan, J., Fowler, W. U., Kimball, E., Lu, W., & Rabinowitz, J. D. (2006) · Nature Chemical Biology

Microbial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

Cited by 125

Saturated Very Long Chain Fatty Acids Are Required for the Production of Infectious Human Cytomegalovirus Progeny

Koyuncu, E., Purdy, J. G., Rabinowitz, J. D., & Shenk, T. (2013) · PLoS Pathogens

Cytomegalovirus and herpesvirus researchCancer, Lipids, and Metabolism

Cited by 114

NAD+ flux is maintained in aged mice despite lower tissue concentrations

McReynolds, M. R., Chellappa, K., Chiles, E., Jankowski, C., Shen, Y., Chen, L., Descamps, H. C., Mukherjee, S., Bhat, Y. R., Lingala, S. R., et al. (2021) · Cell Systems

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 112

Fatty Acid Elongase 7 Catalyzes Lipidome Remodeling Essential for Human Cytomegalovirus Replication

Purdy, J. G., Shenk, T., & Rabinowitz, J. D. (2015) · Cell Reports

Cytomegalovirus and herpesvirus researchCancer, Lipids, and Metabolism

Cited by 103