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NADPH and Mitochondrial Quality Control as Targets for a Circadian-Based Fasting and Exercise Therapy for the Treatment of Parkinson’s Disease

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Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD+

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Roadmap for alleviating the manifestations of ageing in the cardiovascular system

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A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells

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Age-Dependent Decline of NAD+—Universal Truth or Confounded Consensus?

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How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span

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Exosomes based advancements for application in medical aesthetics

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Association of Human Whole Blood NAD+ Contents With Aging

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Roles of NAD + in Health and AgingPreprint

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Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study

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Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns

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NAD+ Precursors: A Questionable Redundancy

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NAMPT-dependent NAD + biosynthesis controls circadian metabolism in a tissue-specific manner

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Epithelial NAD+ depletion drives mitochondrial dysfunction and contributes to intestinal inflammation

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Targeting NAD Metabolism for the Therapy of Age-Related Neurodegenerative Diseases

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NAD + Precursors in Human Health and Disease: Current Status and Future Prospects

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NAD+ precursor supplementation in human ageing: clinical evidence and challenges

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NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control

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Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration

Liu, S., Deshmukh, V., Meng, F., Wang, Y., Morikawa, Y., Steimle, J. D., Li, G., Wang, J., & Martin, J. F. (2024) · Circulation · doi:10.1161/circulationaha.123.067646 · Cited by 29 · see citing works

Acidic Methanol Treatment Facilitates Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry Imaging of Energy Metabolism

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Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury

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NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging

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Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD+ without impacting respiratory capacity or insulin sensitivity

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Towards personalized nicotinamide mononucleotide (NMN) supplementation: Nicotinamide adenine dinucleotide (NAD) concentration

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Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics

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Defining NAD(P)(H) Catabolism

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DNA aptamer-based sensitive electrochemical biosensor for NAD(H) detection

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Aged mice exhibit widespread metabolic changes but preserved major fluxes

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The NAMPT enzyme employs a switch that directly senses AMP/ATP and regulates cellular responses to energy stress

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Source of nicotinamide governs its metabolic fate in cultured cells, mice, and humans

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Effects of Aging on Glucose and Lipid Metabolism in Mice

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Targeting the Electron Transport System for Enhanced Longevity

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Fingerstick blood assay maps real‐world NAD + disparity across gender and age

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The Roles of White Adipose Tissue and Liver NADPH in Dietary Restriction-Induced Longevity

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Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent mannerPreprint

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Using mass spectrometry imaging to visualize age-related subcellular disruption

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The immunosenescence clock: A new method for evaluating biological age and predicting mortality risk

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Nicotinamide adenine dinucleotide metabolism: driving or counterbalancing inflammatory bowel disease?

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Combining Metabolomics and Experimental Evolution Reveals Key Mechanisms Underlying Longevity Differences in Laboratory Evolved Drosophila melanogaster Populations

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Regular exercise effectively protects against the aging-associated decline in skeletal muscle NAD content

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Beyond Pellagra—Research Models and Strategies Addressing the Enduring Clinical Relevance of NAD Deficiency in Aging and Disease

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Potential implications of natural compounds on aging and metabolic regulation

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Circadian cardiac NAD+ metabolism, from transcriptional regulation to healthy aging

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Evolution, mechanism and limits of dietary restriction induced health benefits & longevity

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Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide)

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Dysregulated nicotinamide adenine dinucleotide metabolome in patients hospitalized with COVID ‐19

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Cancer progression through the lens of age-induced metabolic reprogramming

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Sleep deprivation and aging are metabolically linked across tissues

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Sexually dimorphic effects of SARM1 deletion on cardiac NAD + metabolism and function

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Potential Therapeutic Interventions Targeting NAD+ Metabolism for ALS

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CD38 mediates nicotinamide mononucleotide base exchange to yield nicotinic acid mononucleotide

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Perturbation of NAD(P)H metabolism with the Lb NOX xenotopic tool extends lifespan and mitigates age-related changes

Yadav, S., Pan, X., Li, S., Martin, P. L., Hoang, N., Chen, K., Karhadkar, A., Malhotra, J., Zuckerman, A. L., Munan, S., et al. (2026) · Science Advances · doi:10.1126/sciadv.ady0628 · Cited by 8 · see citing works

Senescence-associated metabolic alterations aggravate calcific aortic valve disease

Qian, X., Xu, L., Zheng, Y., Fan, Z., Jiang, C., Liu, Y., Tong, F., Fan, P., Chen, M., Chen, Z., et al. (2026) · European Heart Journal · doi:10.1093/eurheartj/ehag191 · Cited by 8 · see citing works

Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive review

Zhao, X., Lv, P., Cai, Z., Dong, J., Chen, W., Sun, L., & Yang, R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1579924 · Cited by 8 · see citing works

NAD+ glycohydrolases-CD38 as a therapeutic target in aging: physiological roles, molecular mechanisms, and future opportunities in anti-aging research

Sun, J.-Y., Wang, Z., Xu, W., & Zhao, J. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117050 · Cited by 7 · see citing works

Effects of aging and anti-aging dietary restriction on regulators of the [NADPH]/[NADP+] in different neural cell types and brain regions

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NNMT inhibition counteracts tubular senescence and fibrosis in early stages of chronic kidney disease

Chanvillard, L., Lantermans, H. C., Wall, C., Thévenet, J., Butter, L. M., Tauzin, L., Claessen, N., Christen, S., Holzwarth, J. A., Karaz, S., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116823 · Cited by 7 · see citing works

Kinetic proteomics identifies targeted changes in liver metabolism and the ribo-interactome by dietary sulfur amino acid restriction

Jonsson, W. O., Borowik, A., Pranay, A., Kinter, M. T., Mirek, E. T., Levy, J. L., Snyder, E. M., Miller, B. F., & Anthony, T. G. (2023) · GeroScience · doi:10.1007/s11357-023-00758-w · Cited by 6 · see citing works

Randomized, placebo-controlled, pilot clinical study evaluating acute Niagen®+ IV and NAD+ IV in healthy adultsPreprint

Hawkins, J., Idoine, R., Kwon, J., Shao, A. E., Dunne, E., Hawkins, E. M., Dawson, K., & Nkrumah-Elie, Y. M. (2024) · medRxiv · doi:10.1101/2024.06.06.24308565 · Cited by 7 · see citing works

Nicotinamide mononucleotide combined with PJ-34 protects microglial cells from lipopolysaccharide-induced mitochondrial impairment through NMNAT3-PARP1 axis

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The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age‐Dependent Structural Deficits in the Kidney

Katti, P., Prasad, P., Masenga, S. K., Venkhatesh, P., Vue, Z., Marshall, A. G., Rodriguez, B., Le, H., Lopez, E. G., Murphy, A. C., et al. (2026) · Aging Cell · doi:10.1111/acel.70534 · Cited by 6 · see citing works

Changes in the brain [NAD+]/[NADH] and [NADPH]/[NADP+] with aging and anti-aging dietary restriction

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Review article: Improving mitochondrial function: Current therapeutic perspectives in neurodegenerative diseases

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The Role of NAD+ Metabolism in Cardiovascular Diseases: Mechanisms and Prospects

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[Vitamins and Immune System Health].

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Nicotinamide riboside functions during development while beta-hydroxybutyrate functions during adulthood to extend C. elegans lifespan

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Circadian biology of cardiac aging

Bettadapura, S. S., Todd, W. D., McGinnis, G. R., & Bruns, D. R. (2025) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2024.12.001 · Cited by 4 · see citing works

Downregulation of NAD Kinase Expression in β‐Cells Contributes to the Aging‐Associated Decline in Glucose‐Stimulated Insulin Secretion

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Deletion of Nmnat1 in Skeletal Muscle Leads to the Reduction of NAD+ Levels but Has No Impact on Skeletal Muscle Morphology and Fiber Types

Karim, M., Iqbal, T., Nawaz, A., Yaku, K., & Nakagawa, T. (2023) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.69.184 · Cited by 4 · see citing works

Effects of Nicotinamide Mononucleotide Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zhang, M., Chen, Y., Jiang, N., Zeng, J., Zhang, J., Wu, C., Liu, Y., Nie, Z., Yang, J., & Han, S. (2026) · Nutrients · doi:10.3390/nu18060890 · Cited by 3 · see citing works

Metabolic Activation of PARP as a SARS-CoV-2 Therapeutic Target—Is It a Bait for the Virus or the Best Deal We Could Ever Make with the Virus? Is AMBICA the Potential Cure?

Puthanveetil, P. (2023) · Biomolecules · doi:10.3390/biom13020374 · Cited by 3 · see citing works

Metabolic Pathway Tracing for NAD+ Synthesis and Consumption

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Clinical evidence for the use of NAD+ precursors to slow aging

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Mechanisms of NAD+ Homeostasis in Aging and Disease

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Metabolic pathway analysis of tumors using stable isotopes

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Synergistic Strategies to Accelerate the Development of Function-Promoting Therapies: Lessons From Operation Warp Speed and Oncology Drug Development

Araujo, R. C.-D., Evans, W. J., Fielding, R. A., Krishnan, V., Carter, R. H., Appleby, J. C., Guralnik, J. M., Klickstein, L. B., Marks, P. W., Moore, A. A., et al. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad028 · Cited by 2 · see citing works

Synthesis, Detection, and Metabolism of Pyridone Ribosides, Products of NAD Overoxidation

Hayat, F., Deason, J. T., Liu‐Bryan, R., Terkeltaub, R. A., Song, W., Kraus, W. L., Pluth, J. M., Gassman, N. R., & Migaud, M. E. (2024) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.3c00264 · Cited by 2 · see citing works

Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the LiverPreprint

Masenga, S. K., Murphy, A. C., Venkhatesh, P., Vue, Z., Kadam, A. A., Marshall, A. G., Rodriguez, B., Scudese, E., Jenkins, B. C., Crabtree, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.20.599846 · Cited by 2 · see citing works

HIV persists in late coronary atheroma and is associated with increased local inflammation and disease progressionPreprint

Wanjalla, C. N., Obare, L. M., Bailin, S. S., Zhang, X., Nthenge, K., Priest, S., Liu, Q., Stolze, L. K., Sheng, Q., Gangula, R., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-5125826/v1 · Cited by 2 · see citing works

NNMT promotes tubular senescence and fibrosis in chronic kidney diseasePreprint

Chanvillard, L., Lantermans, H. C., Wall, C., Thévenet, J., Butter, L. M., Tauzin, L., Claessen, N., Christen, S., Karaz, S., Lassueur, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.06.631437 · Cited by 2 · see citing works

NAD+ Metabolism in Aging

Palikhe, S., & Nakagawa, T. (2022) · Springer eBooks · doi:10.1007/978-981-16-7977-3_8 · Cited by 1 · see citing works

Tracing NAD+ metabolism uncovers adaptive coordination between host and microbiome during colitis

Alsaadi, A. I., Wehkamp, L., Pothakamury, A. A., Yahia, M. S., Prasad, P., Gilloteau, C., Sadler, J., Smith, J. D., Jenkins, B. C., Diven, G. S., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117730 · Cited by 1 · see citing works

Circadian Clocks in Ageing

Zhu, P., & Peek, C. B. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781839167553-00505 · Cited by 1 · see citing works

The Rate of NAD+ Breakdown Is Maintained Constant against Deletion or Overexpression of NAD+-Degrading Enzymes in Mammalian Cells

Hara, N., Osago, H., Hiyoshi, M., & Kobayashi‐Miura, M. (2024) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.70.295 · Cited by 1 · see citing works

Tissue-specific effects of bacterial PncA overexpression on NAD+ metabolism and aging in mice: implications for tissue-specific aging interventions

Huo, F., Zhao, M., Liu, Y., Lv, S., Feng, S., Guo, L., Wang, N., Zhang, S., Liu, Q., Mi, T., et al. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1546017 · Cited by 1 · see citing works

Long-Term NMN Treatment Increases Lifespan and Healthspan in Mice in a Sex Dependent MannerPreprint

Kane, A. E., Chellappa, K., S, M., Arnold, M. W., Li, J., Amorim, J. A., Diener, C., Zhu, D., Mitchell, S. J., Griffin, P. T., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4857461 · Cited by 1 · see citing works

Endogenous Metabolism in Endothelial and Immune Cells Is the Main Source of Tissue Levels of the Vitamin B 3 NicotinamidePreprint

Zeidler, J. D., Chini, C. C. S., Kanamori, K. S., Kashyap, S., Espíndola‐Netto, J. M., Thompson, K. D., Warner, G. M., Cabral, F. S., Peclat, T., Gomez, L. S., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4054845

Impact of the NAD+ salvage pathway on the motor system and bioenergetics

Lundt, S. (2023) · doi:10.32469/10355/96990

Multifactorial microbial networks shape aging and neurodegeneration

Kara, N. Z., Savaliya, J. H., & Blacher, E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18979-1.00002-2

NAD + Flux and Resiliency in Aged Mice

McReynolds, M. R. (2022) · The FASEB Journal · doi:10.1096/fasebj.2022.36.s1.r6281 · Cited by 1 · see citing works

NAD+ flux is maintained in aged micePreprint

McReynolds, M. R., Chellappa, K., Chiles, E. N., Jankowski, C. S. R., Shen, Y., Chen, L., Descamps, H. C., Mukherjee, S., Bhat, Y. R., Chu, Q., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-86538/v1 · Cited by 2 · see citing works

Quantitative Survey of NAD + Flux in Aged Mice

McReynolds, M. R., Chellappa, K., Chu, Q., Baur, J. A., & Rabinowitz, J. D. (2019) · The FASEB Journal · doi:10.1096/fasebj.2019.33.1_supplement.794.14

Age-related NAD+ decline

McReynolds, M. R., Chellappa, K., & Baur, J. A. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110888 · Cited by 169 · see citing works

TRACING THE COORDINATED CONTROL OF NAD+ HOMEOSTASIS USING C. ELEGANS

McReynolds, M. R. (2023) · Innovation in Aging · doi:10.1093/geroni/igad104.0595