Thompson, Craig B.

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

Vardhana, S. A., Hwee, M. A., Berisa, M., Wells, D. K., Yost, K. E., King, B., Smith, M., Herrera, P. S., Chang, H. Y., Satpathy, A. T., et al. (2020) · Nature Immunology

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 575

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

Rathmell, J. C., Fox, C. J., Plas, D. R., Hammerman, P. S., Cinalli, R. M., & Thompson, C. B. (2003) · Molecular and Cellular Biology

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 572

ATP citrate lyase is an important component of cell growth and transformation

Bauer, D. E., Hatzivassiliou, G., Zhao, F., Andreadis, C., & Thompson, C. B. (2005) · Oncogene

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 537

Growth factors can influence cell growth and survival through effects on glucose metabolism

Vander Heiden, M. G., Plas, D. R., Rathmell, J. C., Fox, C. J., Harris, M. H., & Thompson, C. B. (2001) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 536

A two-way street: reciprocal regulation of metabolism and signalling

Wellen, K. E., & Thompson, C. B. (2012) · Nature Reviews Molecular Cell Biology

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 528

Autophagy: Basic Principles and Relevance to Disease

Kundu, M., & Thompson, C. B. (2008) · Annual Review of Pathology: Mechanisms of Disease

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 523

Hypoxia Induces Production of L-2-Hydroxyglutarate

Intlekofer, A. M., Dematteo, R. G., Venneti, S., Finley, L. W. S., Lu, C., Judkins, A. R., Rustenburg, A. S., Grinaway, P. B., Chodera, J. D., Cross, J. R., et al. (2015) · Cell Metabolism

Cancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation

Cited by 513

Bcl-xL Prevents Cell Death following Growth Factor Withdrawal by Facilitating Mitochondrial ATP/ADP Exchange

Heiden, M. G. V., Chandel, N. S., Schumacker, P. T., & Thompson, C. B. (1999) · Molecular Cell

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 505

Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess

Wellen, K. E., & Thompson, C. B. (2010) · Molecular Cell

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 486

Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

Sausen, M., Phallen, J., Adleff, V., Jones, S., Leary, R. J., Barrett, M. T., Anagnostou, V., Parpart-Li, S., Murphy, D., Kay Li, Q., et al. (2015) · Nature Communications

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 484

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

Rathmell, J. C., Heiden, M. G. V., Harris, M. H., Frauwirth, K. A., & Thompson, C. B. (2000) · Molecular Cell

Cell death mechanisms and regulationT-cell and B-cell Immunology

Cited by 467

IL-7 Enhances the Survival and Maintains the Size of Naive T Cells

Rathmell, J. C., Farkash, E. A., Gao, W., & Thompson, C. B. (2001) · The Journal of Immunology

T-cell and B-cell ImmunologyCytokine Signaling Pathways and Interactions

Cited by 459

The utilization of extracellular proteins as nutrients is suppressed by mTORC1

Palm, W., Park, Y., Wright, K., Pavlova, N. N., Tuveson, D. A., & Thompson, C. B. (2015) · Cell

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 457

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Ye, J., Fan, J., Venneti, S., Wan, Y.-W., Pawel, B. R., Zhang, J., Finley, L. W. S., Lu, C., Lindsten, T., Cross, J. R., et al. (2014) · Cancer Discovery

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 452

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

Zhang, J., Fan, J., Venneti, S., Cross, J. R., Takagi, T., Bhinder, B., Djaballah, H., Kanai, M., Cheng, E. H., Judkins, A. R., et al. (2014) · Molecular Cell

Amino Acid Enzymes and MetabolismCancer, Hypoxia, and Metabolism

Cited by 439

The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

Lum, J. J., Bui, T., Gruber, M., Gordan, J. D., DeBerardinis, R. J., Covello, K. L., Simon, M. C., & Thompson, C. B. (2007) · Genes & Development

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 429

Nutrient acquisition strategies of mammalian cells

Palm, W., & Thompson, C. B. (2017) · Nature

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 388

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer

Chio, I. I. C., Jafarnejad, S. M., Ponz-Sarvise, M., Park, Y., Rivera, K., Palm, W., Wilson, J., Sangar, V., Hao, Y., Öhlund, D., et al. (2016) · Cell

Genomics, phytochemicals, and oxidative stressPancreatic and Hepatic Oncology Research

Cited by 378

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

Wellen, K. E., Lu, C., Mancuso, A., Lemons, J. M. S., Ryczko, M., Dennis, J. W., Rabinowitz, J. D., Coller, H. A., & Thompson, C. B. (2010) · Genes & Development

Cancer, Hypoxia, and MetabolismGlycosylation and Glycoproteins Research

Cited by 377

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

Qing, G., Li, B., Vu, A., Skuli, N., Walton, Z. E., Liu, X., Mayes, P. A., Wise, D. R., Thompson, C. B., Maris, J. M., et al. (2012) · Cancer Cell

Cell death mechanisms and regulationCancer, Hypoxia, and Metabolism

Cited by 375

Bcl-x Promotes the Open Configuration of the Voltage-dependent Anion Channel and Metabolite Passage through the Outer Mitochondrial Membrane

Vander Heiden, M. G., Li, X. X., Gottleib, E., Hill, R. B., Thompson, C. B., & Colombini, M. (2001) · Journal of Biological Chemistry

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 372

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation

Melino, G., Bernassola, F., Ranalli, M., Yee, K., Zong, W. X., Corazzari, M., Knight, R. A., Green, D. R., Thompson, C., & Vousden, K. H. (2004) · Journal of Biological Chemistry

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 368

The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation

Buzzai, M., Bauer, D. E., Jones, R. G., DeBerardinis, R. J., Hatzivassiliou, G., Elstrom, R. L., & Thompson, C. B. (2005) · Oncogene

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 357

The molecular determinants of de novo nucleotide biosynthesis in cancer cells

Tong, X., Zhao, F., & Thompson, C. B. (2009) · Current Opinion in Genetics & Development

Biochemical and Molecular ResearchCancer, Hypoxia, and Metabolism

Cited by 351