Thompson, Craig B.

Revving the Engine: Signal Transduction Fuels T Cell Activation

Jones, R. G., & Thompson, C. B. (2007) · Immunity

T-cell and B-cell ImmunologyImmune Response and Inflammation

Cited by 349

As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid

Pavlova, N. N., Hui, S., Ghergurovich, J. M., Fan, J., Intlekofer, A. M., White, R. M., Rabinowitz, J. D., Thompson, C. B., & Zhang, J. (2018) · Cell Metabolism

Amino Acid Enzymes and MetabolismCancer, Hypoxia, and Metabolism

Cited by 341

Regulation of surface and intracellular expression of CTLA4 on mouse T cells

Alegre, M. L., Noel, P. J., Eisfelder, B. J., Chuang, E., Clark, M. R., Reiner, S. L., & Thompson, C. B. (1996) · The Journal of Immunology

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 338

The CD28 and CTLA-4 Receptors Associate with the Serine/Threonine Phosphatase PP2A

Chuang, E., Fisher, T. S., Morgan, R. W., Robbins, M. D., Duerr, J. M., Vander Heiden, M. G., Gardner, J. P., Hambor, J. E., Neveu, M. J., & Thompson, C. B. (2000) · Immunity

T-cell and B-cell ImmunologyProtein Tyrosine Phosphatases

Cited by 303

α-Ketoglutarate links p53 to cell fate during tumour suppression

Morris, J. P., Yashinskie, J. J., Koche, R., Chandwani, R., Tian, S., Chen, C.-C., Baslan, T., Marinkovic, Z. S., Sánchez-Rivera, F. J., Leach, S. D., et al. (2019) · Nature

Cancer-related Molecular PathwaysCancer, Hypoxia, and Metabolism

Cited by 296

Bax regulates primary necrosis through mitochondrial dynamics

Whelan, R. S., Konstantinidis, K., Wei, A.-C., Chen, Y., Reyna, D. E., Jha, S., Yang, Y., Calvert, J. W., Lindsten, T., Thompson, C. B., et al. (2012) · Proceedings of the National Academy of Sciences

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 290

Cellular ATP demand creates metabolically distinct subpopulations of mitochondria

Ryu, K. W., Fung, T. S., Baker, D. C., Saoi, M., Park, J., Febres-Aldana, C. A., Aly, R. G., Cui, R., Sharma, A., Fu, Y., et al. (2024) · Nature

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 284

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations

Intlekofer, A. M., Shih, A. H., Wang, B., Nazir, A., Rustenburg, A. S., Albanese, S. K., Patel, M., Famulare, C., Correa, F. M., Takemoto, N., et al. (2018) · Nature

Acute Myeloid Leukemia ResearchGlioma Diagnosis and Treatment

Cited by 281

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

Intlekofer, A. M., Wang, B., Liu, H., Shah, H., Carmona-Fontaine, C., Rustenburg, A. S., Salah, S., Gunner, M. R., Chodera, J. D., Cross, J. R., et al. (2017) · Nature Chemical Biology

Cancer, Hypoxia, and MetabolismBiochemical Acid Research Studies

Cited by 268

Structural Analysis of CTLA-4 Function In Vivo

Masteller, E. L., Chuang, E., Mullen, A. C., Reiner, S. L., & Thompson, C. B. (2000) · The Journal of Immunology

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 252

Metabolic regulation of chromatin modifications and gene expression

Schvartzman, J. M., Thompson, C. B., & Finley, L. W. S. (2018) · Journal of Cell Biology

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 233

Phosphatidylinositol 3-Kinase-dependent Modulation of Carnitine Palmitoyltransferase 1A Expression Regulates Lipid Metabolism during Hematopoietic Cell Growth

DeBerardinis, R. J., Lum, J. J., & Thompson, C. B. (2006) · Journal of Biological Chemistry

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 221

Metabolic enzymes as oncogenes or tumor suppressors

Thompson, C. B. (2009) · New England Journal of Medicine

Cancer, Hypoxia, and MetabolismGlioma Diagnosis and Treatment

Cited by 213

Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization

Pecqueur, C., Bui, T., Gelly, C., Hauchard, J., Barbot, C., Bouillaud, F., Ricquier, D., Miroux, B., & Thompson, C. B. (2008) · The FASEB Journal

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Cited by 209

Proline biosynthesis is a vent for TGFβ‐induced mitochondrial redox stress

Schwörer, S., Berisa, M., Violante, S., Qin, W., Zhu, J., Hendrickson, R. C., Cross, J. R., & Thompson, C. B. (2020) · The EMBO Journal

TGF-β signaling in diseasesRedox biology and oxidative stress

Cited by 193

Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming

Zhao, F., Mancuso, A., Bui, T. V., Tong, X., Gruber, J. J., Swider, C. R., Sanchez, P. V., Lum, J. J., Sayed, N., Melo, J. V., et al. (2010) · Oncogene

Chronic Myeloid Leukemia TreatmentsCancer, Hypoxia, and Metabolism

Cited by 179

α4 Is an Essential Regulator of PP2A Phosphatase Activity

Kong, M., Ditsworth, D., Lindsten, T., & Thompson, C. B. (2009) · Molecular Cell

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 162

The PP2A-Associated Protein α4 Is an Essential Inhibitor of Apoptosis

Kong, M., Fox, C. J., Mu, J., Solt, L., Xu, A., Cinalli, R. M., Birnbaum, M. J., Lindsten, T., & Thompson, C. B. (2004) · Science

Cell death mechanisms and regulationProtein Tyrosine Phosphatases

Cited by 149

Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers

Glass, J. L., Hassane, D., Wouters, B. J., Kunimoto, H., Avellino, R., Garrett-Bakelman, F. E., Guryanova, O. A., Bowman, R., Redlich, S., Intlekofer, A. M., et al. (2017) · Cancer Discovery

Acute Myeloid Leukemia ResearchEpigenetics and DNA Methylation

Cited by 142

PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment

Krishna, S., Palm, W., Lee, Y., Yang, W., Bandyopadhyay, U., Xu, H., Florey, O., Thompson, C. B., & Overholtzer, M. (2016) · Developmental Cell

Cellular transport and secretionCalcium signaling and nucleotide metabolism

Cited by 140

The FLI-1 and chimeric EWS-FLI-1 oncoproteins display similar DNA binding specificities.

Mao, X., Miesfeldt, S., Yang, H., Leiden, J. M., & Thompson, C. B. (1994) · Journal of Biological Chemistry

Sarcoma Diagnosis and TreatmentGenomics and Chromatin Dynamics

Cited by 132

Regulation of Cytotoxic T Lymphocyte-Associated Molecule-4 by Src Kinases

Chuang, E., Lee, K.-M., Robbins, M. D., Duerr, J. M., Alegre, M.-L., Hambor, J. E., Neveu, M. J., Bluestone, J. A., & Thompson, C. B. (1999) · The Journal of Immunology

T-cell and B-cell ImmunologyProtein Tyrosine Phosphatases

Cited by 119

The Proapoptotic Factors Bax and Bak Regulate T Cell Proliferation through Control of Endoplasmic Reticulum Ca2+ Homeostasis

Jones, R. G., Bui, T., White, C., Madesh, M., Krawczyk, C. M., Lindsten, T., Hawkins, B. J., Kubek, S., Frauwirth, K. A., Wang, Y. L., et al. (2007) · Immunity

Cell death mechanisms and regulationIon Channels and Receptors

Cited by 109

A tissue injury sensing and repair pathway distinct from host pathogen defense

Liu, S., Hur, Y. H., Cai, X., Cong, Q., Yang, Y., Xu, C., Bilate, A. M., Gonzales, K. A. U., Parigi, S. M., Cowley, C. J., et al. (2023) · Cell

Wound Healing and TreatmentsCytokine Signaling Pathways and Interactions

Cited by 108