Thompson, Craig B.

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

Lindsten, T., Ross, A. J., King, A., Zong, W.-X., Rathmell, J. C., Shiels, H. A., Ulrich, E., Waymire, K. G., Mahar, P., Frauwirth, K., et al. (2000) · Molecular Cell

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 1,489

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

Lum, J. J., Bauer, D. E., Kong, M., Harris, M. H., Li, C., Lindsten, T., & Thompson, C. B. (2005) · Cell

Autophagy in Disease and TherapyCell death mechanisms and regulation

Cited by 1,487

Structure of Bcl-x L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

Sattler, M., Liang, H., Nettesheim, D., Meadows, R. P., Harlan, J. E., Eberstadt, M., Yoon, H. S., Shuker, S. B., Chang, B. S., Minn, A. J., et al. (1997) · Science

Cell death mechanisms and regulationProtein Structure and Dynamics

Cited by 1,476

The CD28 Signaling Pathway Regulates Glucose Metabolism

Frauwirth, K. A., Riley, J. L., Harris, M. H., Parry, R. V., Rathmell, J. C., Plas, D. R., Elstrom, R. L., June, C. H., & Thompson, C. B. (2002) · Immunity

T-cell and B-cell ImmunologyMetabolism, Diabetes, and Cancer

Cited by 1,475

Akt Stimulates Aerobic Glycolysis in Cancer Cells

Elstrom, R. L., Bauer, D. E., Buzzai, M., Karnauskas, R., Harris, M. H., Plas, D. R., Zhuang, H., Cinalli, R. M., Alavi, A., Rudin, C. M., et al. (2004) · Cancer Research

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,454

The hallmarks of cancer metabolism: still emerging

Pavlova, N. N., Zhu, J., & Thompson, C. B. (2022) · Cell Metabolism

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,418

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

Shimizu, S., Kanaseki, T., Mizushima, N., Mizuta, T., Arakawa-Kobayashi, S., Thompson, C. B., & Tsujimoto, Y. (2004) · Nature Cell Biology

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 1,358

Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation

Krawczyk, C. M., Holowka, T., Sun, J., Blagih, J., Amiel, E., DeBerardinis, R. J., Cross, J. R., Jung, E., Thompson, C. B., Jones, R. G., et al. (2010) · Blood

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 1,246

Quantitative flux analysis reveals folate-dependent NADPH production

Fan, J., Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B., & Rabinowitz, J. D. (2014) · Nature

Folate and B Vitamins ResearchCancer, Hypoxia, and Metabolism

Cited by 1,114

ATP citrate lyase inhibition can suppress tumor cell growth

Hatzivassiliou, G., Zhao, F., Bauer, D. E., Andreadis, C., Shaw, A. N., Dhanak, D., Hingorani, S. R., Tuveson, D. A., & Thompson, C. B. (2005) · Cancer Cell

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 1,086

Tumor suppressors and cell metabolism: a recipe for cancer growth

Jones, R. G., & Thompson, C. B. (2009) · Genes & Development

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,085

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

Cárdenas, C., Miller, R. A., Smith, I., Bui, T., Molgó, J., Müller, M., Vais, H., Cheung, K.-H., Yang, J., Parker, I., et al. (2010) · Cell

Mitochondrial Function and PathologyCalcium signaling and nucleotide metabolism

Cited by 1,026

Brick by brick: metabolism and tumor cell growth

DeBerardinis, R. J., Sayed, N., Ditsworth, D., & Thompson, C. B. (2008) · Current Opinion in Genetics & Development

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 1,018

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

Carey, B. W., Finley, L. W. S., Cross, J. R., Allis, C. D., & Thompson, C. B. (2015) · Nature

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 1,007

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

Wise, D. R., Ward, P. S., Shay, J. E. S., Cross, J. R., Gruber, J. J., Sachdeva, U. M., Platt, J. M., DeMatteo, R. G., Simon, M. C., & Thompson, C. B. (2011) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 975

AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation

Lamia, K. A., Sachdeva, U. M., DiTacchio, L., Williams, E. C., Alvarez, J. G., Egan, D. F., Vasquez, D. S., Juguilon, H., Panda, S., Shaw, R. J., et al. (2009) · Science

Circadian rhythm and melatoninMetabolism, Diabetes, and Cancer

Cited by 958

Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein

Kamphorst, J. J., Nofal, M., Commisso, C., Hackett, S. R., Lu, W., Grabocka, E., Vander Heiden, M. G., Miller, G., Drebin, J. A., Bar-Sagi, D., et al. (2015) · Cancer Research

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 893

Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

DeBerardinis, R. J., & Thompson, C. B. (2012) · Cell

Cancer, Hypoxia, and MetabolismCancer and biochemical research

Cited by 858

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

Kamphorst, J. J., Cross, J. R., Fan, J., de Stanchina, E., Mathew, R., White, E. P., Thompson, C. B., & Rabinowitz, J. D. (2013) · Proceedings of the National Academy of Sciences

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 726

Metabolic Regulation of Epigenetics

Lu, C., & Thompson, C. B. (2012) · Cell Metabolism

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 699

Molecular Basis of T Cell Inactivation by CTLA-4

Lee, K.-M., Chuang, E., Griffin, M., Khattri, R., Hong, D. K., Zhang, W., Straus, D., Samelson, L. E., Thompson, C. B., & Bluestone, J. A. (1998) · Science

T-cell and B-cell ImmunologyProtein Tyrosine Phosphatases

Cited by 684

Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine

Zhang, J., Pavlova, N. N., & Thompson, C. B. (2017) · The EMBO Journal

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 651

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2010) · Nature

Cancer, Hypoxia, and MetabolismMetabolism and Genetic Disorders

Cited by 613

Hypoxia-induced energy stress regulates mRNA translation and cell growth

Liu, L., Cash, T. P., Jones, R. G., Keith, B., Thompson, C. B., & Simon, M. C. (2006) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerCancer, Hypoxia, and Metabolism

Cited by 607