Blacklow, Stephen C.

Direct inhibition of the NOTCH transcription factor complex

Moellering, R. E., Cornejo, M., Davis, T. N., Bianco, C. D., Aster, J. C., Blacklow, S. C., Kung, A. L., Gilliland, D. G., Verdine, G. L., & Bradner, J. E. (2009) · Nature

Chemical Synthesis and AnalysisRNA Interference and Gene Delivery

Cited by 752

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers

Wang, H., Zang, C., Taing, L., Arnett, K. L., Wong, Y. J., Pear, W. S., Blacklow, S. C., Liu, X. S., & Aster, J. C. (2014) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 252

Structure of an LDLR-RAP Complex Reveals a General Mode for Ligand Recognition by Lipoprotein Receptors

Fisher, C., Beglova, N., & Blacklow, S. C. (2006) · Molecular Cell

Cholesterol and Lipid MetabolismProtein Structure and Dynamics

Cited by 185

Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition

LaRochelle, J. R., Fodor, M., Vemulapalli, V., Mohseni, M., Wang, P., Stams, T., LaMarche, M. J., Chopra, R., Acker, M. G., & Blacklow, S. C. (2018) · Nature Communications

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 167

The LDL receptor: how acid pulls the trigger

Beglova, N., & Blacklow, S. C. (2005) · Trends in Biochemical Sciences

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 120

Origins of Peptide Selectivity and Phosphoinositide Binding Revealed by Structures of Disabled-1 PTB Domain Complexes

Stolt, P. C., Jeon, H., Song, H. K., Herz, J., Eck, M. J., & Blacklow, S. C. (2003) · Structure

Protein Kinase Regulation and GTPase SignalingAxon Guidance and Neuronal Signaling

Cited by 117

Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2

LaRochelle, J. R., Fodor, M., Xu, X., Durzynska, I., Fan, L., Stams, T., Chan, H. M., LaMarche, M. J., Chopra, R., Wang, P., et al. (2016) · Biochemistry

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 70

Versatility in ligand recognition by LDL receptor family proteins: advances and frontiers

Blacklow, S. C. (2007) · Current Opinion in Structural Biology

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 68

Targeted Degradation of the Oncogenic Phosphatase SHP2

Vemulapalli, V., Donovan, K. A., Seegar, T. C. M., Rogers, J. M., Bae, M., Lumpkin, R. J., Cao, R., Henke, M. T., Ray, S. S., Fischer, E. S., et al. (2021) · Biochemistry

Protein Tyrosine PhosphatasesProtein Degradation and Inhibitors

Cited by 43

Heterogeneity of Tethered Agonist Signaling in Adhesion G Protein-Coupled Receptors

Dates, A. N., Jones, D. T. D., Smith, J. S., Skiba, M. A., Rich, M. F., Burruss, M. M., Kruse, A. C., & Blacklow, S. C. (2022) · Cell chemical biology

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 37

DNA binding analysis of rare variants in homeodomains reveals homeodomain specificity-determining residues

Kock, K. H., Kimes, P. K., Gisselbrecht, S. S., Inukai, S., Phanor, S. K., Anderson, J. T., Ramakrishnan, G., Lipper, C. H., Song, D., Kurland, J. V., et al. (2024) · Nature Communications

Genomics and Rare DiseasesProtein Structure and Dynamics

Cited by 24

Structural requirements for activity of Mind bomb1 in Notch signaling

Cao, R., Gozlan, O., Airich, A., Tveriakhina, L., Zhou, H., Jiang, H., Cole, P. A., Aster, J. C., Klein, T., Sprinzak, D., et al. (2024) · Structure

Ubiquitin and proteasome pathwaysDevelopmental Biology and Gene Regulation

Cited by 7

Structural Requirements for Activity of Mind bomb1 in Notch Signaling

Cao, R., Gozlan, O., Tveriakhina, L., Zhou, H., Jiang, H., Cole, P. A., Aster, J. C., Sprinzak, D., & Blacklow, S. C. (2024) · Structure

Ubiquitin and proteasome pathwaysDevelopmental Biology and Gene Regulation

Cited by 7

Molecular mechanism of PP2A/B55α phosphatase inhibition by IER5

Cao, R., Jones, D. T. D., Pan, L., Yang, A., Wang, S., Padi, S. K. R., Rawson, S., Aster, J. C., & Blacklow, S. C. (2025) · Cell Chemical Biology

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 7