Alessi, Dario R.

New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

Zagórska, A., Deak, M., Campbell, D. G., Banerjee, S., Hirano, M., Aizawa, S., Prescott, A. R., & Alessi, D. R. (2010) · Science Signaling

Protein Kinase Regulation and GTPase SignalingHippo pathway signaling and YAP/TAZ

Cited by 193

Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

Kalogeropulou, A. F., Purlyte, E., Tonelli, F., Lange, S. M., Wightman, M., Prescott, A. R., Padmanabhan, S., Sammler, E., & Alessi, D. R. (2022) · Biochemical Journal

Parkinson's Disease Mechanisms and TreatmentsProtein Kinase Regulation and GTPase Signaling

Cited by 129

RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses

Gustavsson, E. K., Follett, J., Trinh, J., Barodia, S. K., Real, R., Liu, Z., Grant-Peters, M., Fox, J. D., Appel-Cresswell, S., Stoessl, A. J., et al. (2024) · The Lancet Neurology

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 114

Phenformin as prophylaxis and therapy in breast cancer xenografts

Appleyard, M. V. C. L., Murray, K. E., Coates, P. J., Wullschleger, S., Bray, S. E., Kernohan, N. M., Fleming, S., Alessi, D. R., & Thompson, A. M. (2012) · British Journal of Cancer

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 108

Structural basis of human LRRK2 membrane recruitment and activation

Zhu, H., Tonelli, F., Alessi, D. R., & Sun, J. (2022) · Science

Parkinson's Disease Mechanisms and TreatmentsProtein Kinase Regulation and GTPase Signaling

Cited by 108

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

Khan, S. S., Sobu, Y., Dhekne, H. S., Tonelli, F., Berndsen, K., Alessi, D. R., & Pfeffer, S. R. (2021) · eLife

Parkinson's Disease Mechanisms and TreatmentsGenetic and Kidney Cyst Diseases

Cited by 93

Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

Dhekne, H. S., Tonelli, F., Yeshaw, W. M., Chiang, C. Y., Limouse, C., Jaimon, E., Purlyte, E., Alessi, D. R., & Pfeffer, S. R. (2023) · eLife

Parkinson's Disease Mechanisms and TreatmentsCellular transport and secretion

Cited by 76

Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation

Schumacher, F.-R., Sorrell, F. J., Alessi, D. R., Bullock, A. N., & Kurz, T. (2014) · Biochemical Journal

Ubiquitin and proteasome pathwaysIon Transport and Channel Regulation

Cited by 76

Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1

Zhang, N., Gordon, S. L., Fritsch, M. J., Esoof, N., Campbell, D. G., Gourlay, R., Velupillai, S., Macartney, T., Peggie, M., van Aalten, D. M. F., et al. (2015) · The Journal of Neuroscience

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 72

A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

Vides, E. G., Adhikari, A., Chiang, C. Y., Lis, P., Purlyte, E., Limouse, C., Shumate, J. L., Spínola-Lasso, E., Dhekne, H. S., Alessi, D. R., et al. (2022) · eLife

Parkinson's Disease Mechanisms and TreatmentsCellular transport and secretion

Cited by 63

A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation

Vides, E. G., Adhikari, A., Chiang, C. Y., Lis, P., Purlyte, E., Limouse, C., Shumate, J. L., Spínola-Lasso, E., Dhekne, H. S., Alessi, D. R., et al. (2022) · eLife

Parkinson's Disease Mechanisms and TreatmentsCellular transport and secretion

Cited by 63

Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease

Khan, S. S., Jaimon, E., Lin, Y.-E., Nikoloff, J., Tonelli, F., Alessi, D. R., & Pfeffer, S. R. (2024) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsGenetic and Kidney Cyst Diseases

Cited by 61

Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5

Gilbert, A. S., Seoane, P. I., Sephton-Clark, P., Bojarczuk, A., Hotham, R., Giurisato, E., Sarhan, A. R., Hillen, A., Velde, G. V., Gray, N. S., et al. (2017) · Science Advances

Cellular transport and secretionFungal Infections and Studies

Cited by 54

Parkinson’s VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B

Pal, P., Taylor, M., Lam, P. Y., Tonelli, F., Hecht, C. A., Lis, P., Nirujogi, R. S., Phung, T. K., Yeshaw, W. M., Jaimon, E., et al. (2023) · Science Advances

Parkinson's Disease Mechanisms and TreatmentsCellular transport and secretion

Cited by 36

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase

Banerjee, S., Zagórska, A., Deak, M., Campbell, D. G., Prescott, A. R., & Alessi, D. R. (2014) · Biochemical Journal

Ubiquitin and proteasome pathwaysMicrotubule and mitosis dynamics

Cited by 32

CURTAIN – A Unique Web-based tool for exploration and sharing of MS-based proteomics data

Phung, T. K., Berndsen, K., Phan, T. L. C. H. B., Muqit, M. M. K., Alessi, D. R., & Nirujogi, R. S. (2023) · Proceedings of the National Academy of Sciences

Advanced Proteomics Techniques and ApplicationsBioinformatics and Genomic Networks

Cited by 18

CURTAIN—A unique web-based tool for exploration and sharing of MS-based proteomics data

Phung, T. K., Berndsen, K., Shastry, R., Phan, T. L. C. H. B., Muqit, M. M. K., Alessi, D. R., & Nirujogi, R. S. (2024) · Proceedings of the National Academy of Sciences

Advanced Proteomics Techniques and ApplicationsBioinformatics and Genomic Networks

Cited by 18

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain

Malik, A. U., Karapetsas, A., Nirujogi, R. S., Chatterjee, D., Phung, T. K., Wightman, M., Gourlay, R., Morrice, N., Mathea, S., Knapp, S., et al. (2022) · Biochemical Journal

Protein Kinase Regulation and GTPase SignalingParkinson's Disease Mechanisms and Treatments

Cited by 13

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain

Malik, A. U., Karapetsas, A., Nirujogi, R. S., Chatterjee, D., Phung, T. K., Wightman, M., Gourlay, R., Morrice, N., Mathea, S., Knapp, S., et al. (2022) · Biochemical Journal

Protein Kinase Regulation and GTPase SignalingParkinson's Disease Mechanisms and Treatments

Cited by 13

A Functional Genetic Atlas of Parkin Resolves Variants of Uncertain Significance and Predicts Parkinson’s Disease Age at Onset

Aslanzadeh, V., Glendinning, S., Sari, Y., Clarke, M., Rodger, C. J., Lin, X., Lenka, D. R., Richardson, L., Liang, J. R., Kleinz, T., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory)

Parkinson's Disease Mechanisms and TreatmentsGenomics and Rare Diseases

Cited by 1