Utility of genetic determinants of lipids and cardiovascular events in assessing risk

Holmes, Michael V.; Harrison, Seamus; Talmud, Philippa J.; Hingorani, Aroon D.; Humphries, Steve E.

doi:10.1038/nrcardio.2011.6

Cited by 44Lipoproteins and Cardiovascular HealthGenetic Associations and EpidemiologyNutrition, Genetics, and Disease

Utility of genetic determinants of lipids and cardiovascular events in assessing risk

Holmes, Michael V., Harrison, Seamus, Talmud, Philippa J., Hingorani, Aroon D., Humphries, Steve E.·2011·Nature Reviews Cardiology

DOI 10.1038/nrcardio.2011.6

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Abstract

The prevention of coronary heart disease (CHD) is a major public-health goal, but disease architecture is such that a larger proportion of clinical events occur among the average majority than among the high-risk minority--the prevention paradox. Genetic findings over the past few years have resulted in the reopening of the old debate on whether an individualized or a population-based approach to prevention is preferable. Genetic testing is an attractive tool for CHD risk prediction because it is a low-cost, high-fidelity technology with multiplex capability. Moreover, by contrast with nongenetic markers, genotype is invariant and determined from conception, which eliminates biological variability and makes prediction from early life possible. Mindful of the prevention paradox, this Review examines the potential applications and challenges of using genetic information for predicting CHD, focusing on lipid risk factors and drawing on experience in the evaluation of nongenetic risk factors as screening tests for CHD. Many of the issues we discuss hold true for any late-onset common disease with modifiable risk factors and proven preventative strategies.

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From Integrating genomics with biomarkers and therapeutic targets to invigorate cardiovascular drug development (2021) · cites this paper as [11]

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Authors: Holmes, M. V., Harrison, S., Talmud, P. J., Hingorani, A. D., & Humphries, S. E.
Affiliations: University College London (GB)
Corresponding author: Hingorani, Aroon D.
Humphries, Steve E.
ORCID: Holmes, Michael V.
Harrison, Seamus
Talmud, Philippa J.
Hingorani, Aroon D.
Humphries, Steve E.
Venue: Nature Reviews Cardiology
Publisher: Springer Science and Business Media LLC
Published: 2011-02-15
Volume: 8
Issue: 4
Pages: 207-221
ISSN: 1759-5002 (ISSN-L)
1759-5010
DOI: 10.1038/nrcardio.2011.6
OpenAlex: W2027805811
Cited by: 44
References: 167
Citations by year: 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 3 · 2012: 13
FWCI: 1.56
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Cardiology (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: British Heart Foundation (FS/11/16/28696, FS05/125, RG 08/008, PG/07/133/24)
Topics: Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords: coronary artery disease, genetic risk prediction, genetic testing, prevention paradox, cardiovascular risk assessment, lipid screening, modifiable risk factors
MeSH terms: Coronary Artery Disease, Ethnicity, Genetic Testing, Humans, Lipids, Risk Factors, Genetic Variation, Genome, Human, Risk Assessment, Genome-Wide Association Study

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Utility of genetic determinants of lipids and cardiovascular events in assessing risk

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