Rein, Theo

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

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Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience

Epigenetics and DNA MethylationStress Responses and Cortisol

Cited by 1,447

Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

Binder, E. B., Salyakina, D., Lichtner, P., Wochnik, G. M., Ising, M., Pütz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M. A., et al. (2004) · Nature Genetics

Stress Responses and CortisolGenetic Associations and Epidemiology

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FK506-binding Proteins 51 and 52 Differentially Regulate Dynein Interaction and Nuclear Translocation of the Glucocorticoid Receptor in Mammalian Cells

Wochnik, G. M., Rüegg, J., Abel, G. A., Schmidt, U., Holsboer, F., & Rein, T. (2005) · Journal of Biological Chemistry

Signaling Pathways in DiseaseEstrogen and related hormone effects

Cited by 638

Molecular pathways of major depressive disorder converge on the synapse

Fries, G. R., Saldana, V. A., Finnstein, J., & Rein, T. (2023) · Molecular Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

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SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

Gassen, N. C., Niemeyer, D., Muth, D., Corman, V. M., Martinelli, S., Gassen, A., Hafner, K., Papies, J., Mösbauer, K., Zellner, A., et al. (2019) · Nature Communications

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

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Gene Expression Patterns Associated with Posttraumatic Stress Disorder Following Exposure to the World Trade Center Attacks

Yehuda, R., Cai, G., Golier, J. A., Sarapas, C., Galea, S., Ising, M., Rein, T., Schmeidler, J., Müller-Myhsok, B., Holsboer, F., et al. (2009) · Biological Psychiatry

Posttraumatic Stress Disorder ResearchStress Responses and Cortisol

Cited by 294

FKBP51 and FKBP52 in signaling and disease

Storer, C. L., Dickey, C. A., Galigniana, M. D., Rein, T., & Cox, M. B. (2011) · Trends in Endocrinology & Metabolism

Heat shock proteins researchSignaling Pathways in Disease

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The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress

Hartmann, J., Wagner, K. V., Liebl, C., Scharf, S. H., Wang, X.-D., Wolf, M., Hausch, F., Rein, T., Schmidt, U., Touma, C., et al. (2012) · Neuropharmacology

Stress Responses and CortisolNeuropeptides and Animal Physiology

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Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks

Sarapas, C., Cai, G., Bierer, L. M., Golier, J. A., Galea, S., Ising, M., Rein, T., Schmeidler, J., Müller-Myhsok, B., Uhr, M., et al. (2011) · Disease Markers

Posttraumatic Stress Disorder ResearchStress Responses and Cortisol

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Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function

Balsevich, G., Häusl, A. S., Meyer, C. W., Karamihalev, S., Feng, X., Pöhlmann, M. L., Dournes, C., Uribe-Marino, A., Santarelli, S., Labermaier, C., et al. (2017) · Nature Communications

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

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Homer1/mGluR5 Activity Moderates Vulnerability to Chronic Social Stress

Wagner, K. V., Hartmann, J., Labermaier, C., Häusl, A. S., Zhao, G., Harbich, D., Schmid, B., Wang, X.-D., Santarelli, S., Kohl, C., et al. (2015) · Neuropsychopharmacology

Neuroscience and Neuropharmacology ResearchStress Responses and Cortisol

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FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications

Gassen, N. C., Hartmann, J., Zannas, A. S., Kretzschmar, A., Zschocke, J., Maccarrone, G., Hafner, K., Zellner, A., Kollmannsberger, L. K., Wagner, K. V., et al. (2016) · Molecular Psychiatry

Treatment of Major DepressionBipolar Disorder and Treatment

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Epigenetic aspects of posttraumatic stress disorder

Schmidt, U., Holsboer, F., & Rein, T. (2011) · Disease Markers

Posttraumatic Stress Disorder ResearchEpigenetics and DNA Methylation

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Impact of Lipid Raft Integrity on 5-HT3 Receptor Function and its Modulation by Antidepressants

Nothdurfter, C., Tanasic, S., Di Benedetto, B., Rammes, G., Wagner, E.-M., Kirmeier, T., Ganal, V., Kessler, J. S., Rein, T., Holsboer, F., et al. (2010) · Neuropsychopharmacology

Neuroscience and Neuropharmacology ResearchLipid Membrane Structure and Behavior

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Peptidylprolylisomerases, Protein Folders, or Scaffolders? The Example of FKBP51 and FKBP52

Rein, T. (2020) · BioEssays

Signaling Pathways in DiseaseProtein Structure and Dynamics

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Tricyclic antidepressants target FKBP51 SUMOylation to restore glucocorticoid receptor activity

Budziñski, M. L., Sokn, C., Gobbini, R., Ugo, B., Antunica-Noguerol, M., Senin, S., Bajaj, T., Gassen, N. C., Rein, T., Schmidt, M. V., et al. (2022) · Molecular Psychiatry

Stress Responses and CortisolTreatment of Major Depression

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