FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications

Diagnostic and Statistical Manual of Mental Disorders

Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works

Adjusting batch effects in microarray expression data using empirical Bayes methods

Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658 · see citing works

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244 · see citing works

Network medicine: a network-based approach to human disease

Barabási, A.-L., Gulbahce, N., & Loscalzo, J. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2918 · Cited by 5,034 · see citing works

Stress and the brain: from adaptation to disease

de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621 · see citing works

Variance stabilization applied to microarray data calibration and to the quantification of differential expression

Huber, W., von Heydebreck, A., Sültmann, H., Poustka, A., & Vingron, M. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.suppl_1.s96 · Cited by 2,440 · see citing works

Five Years of GWAS Discovery

Visscher, P. M., Brown, M. A., McCarthy, M. I., & Yang, J. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.11.029 · Cited by 2,425 · see citing works

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works

GSK-3: tricks of the trade for a multi-tasking kinase

Doble, B. W., & Woodgett, J. R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00384 · Cited by 2,084 · see citing works

Animal models of neuropsychiatric disorders

Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works

The renaissance of GSK3

Cohen, P., & Frame, S. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096075 · Cited by 1,478 · see citing works

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447 · see citing works

SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

Jacinto, E., Facchinetti, V., Liu, D., Soto, N., Wei, S., Jung, S. Y., Huang, Q., Qin, J., & Su, B. (2006) · Cell · doi:10.1016/j.cell.2006.08.033 · Cited by 1,407 · see citing works

Association of <emph type="ital">FKBP5</emph> Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults

Binder, E. B. (2008) · JAMA · doi:10.1001/jama.299.11.1291 · Cited by 1,362 · see citing works

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

van den Heuvel, S., & Harlow, E. (1993) · Science · doi:10.1126/science.8266103 · Cited by 1,092 · see citing works

Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

Binder, E. B., Salyakina, D., Lichtner, P., Wochnik, G. M., Ising, M., Pütz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M. A., et al. (2004) · Nature Genetics · doi:10.1038/ng1479 · Cited by 977 · see citing works

Zebrafish Prickle, a Modulator of Noncanonical Wnt/Fz Signaling, Regulates Gastrulation Movements

Veeman, M. T., Slusarski, D. C., Kaykas, A., Louie, S. H., & Moon, R. T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00240-9 · Cited by 945 · see citing works

AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011

Hiemke, C., Baumann, P., Bergemann, N., Conca, A., Dietmaier, O., Egberts, K. M., Fric, M., Gerlach, M., Greiner, C., Gründer, G., et al. (2011) · Pharmacopsychiatry · doi:10.1055/s-0031-1286287 · Cited by 862 · see citing works

GSK3 signalling in neural development

Hur, E., & Zhou, F. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2870 · Cited by 828 · see citing works

FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt

Pei, H., Li, L., Fridley, B. L., Jenkins, G. D., Kalari, K. R., Lingle, W., Petersen, G., Lou, Z., & Wang, L. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.07.016 · Cited by 709 · see citing works

FK506-binding Proteins 51 and 52 Differentially Regulate Dynein Interaction and Nuclear Translocation of the Glucocorticoid Receptor in Mammalian Cells

Wochnik, G. M., Rüegg, J., Abel, G. A., Schmidt, U., Holsboer, F., & Rein, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m407498200 · Cited by 638 · see citing works

Trauma exposure and stress-related disorders in inner city primary care patients

Gillespie, C. F., Bradley, B., Mercer, K., Smith, A. K., Conneely, K. N., Gapen, M., Weiss, T., Schwartz, A. C., Cubells, J. F., & Ressler, K. J. (2009) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2009.05.003 · Cited by 504 · see citing works

Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes

Jope, R. S. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00206-2 · Cited by 501 · see citing works

Glycogen Synthase Kinase-3β Haploinsufficiency Mimics the Behavioral and Molecular Effects of Lithium

O'Brien, W. T., Harper, A. D., Jove, F. A., Woodgett, J. R., Maretto, S., Piccolo, S., & Klein, P. S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4753-03.2004 · Cited by 415 · see citing works

Paroxetine: A Review

Bourin, M., Chue, P. S., & Guillon, Y. (2001) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2001.tb00189.x · Cited by 412 · see citing works

Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes.

Goode, N. T., Hughes, K., Woodgett, J. R., & Parker, P. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41866-2 · Cited by 397 · see citing works

Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: A review

Silva, M. F. B., Aires, C. C. P., Luis, P. B., Ruiter, J. P. N., IJlst, L., Durán, M., Wanders, R. J. A., & de Almeida, I. T. (2008) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-008-0841-x · Cited by 385 · see citing works

Glycogen Synthase Kinase-3: a Putative Molecular Target for Lithium Mimetic Drugs

Gould, T. D., & Manji, H. K. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300731 · Cited by 377 · see citing works

Cyclic AMP Promotes Neuronal Survival by Phosphorylation of Glycogen Synthase Kinase 3β

Li, M., Wang, X., Meintzer, M. K., Laessig, T. A., Birnbaum, M. J., & Heidenreich, K. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.24.9356-9363.2000 · Cited by 363 · see citing works

A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior

Beaulieu, J., Marion, S., Rodriguiz, R. M., Medvedev, I. O., Sotnikova, T. D., Ghisi, V., Wetsel, W. C., Lefkowitz, R. J., Gainetdinov, R. R., & Caron, M. G. (2008) · Cell · doi:10.1016/j.cell.2007.11.041 · Cited by 362 · see citing works

The Hsp90‐binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo

Riggs, D. L., Roberts, P. J., Chirillo, S. C., Cheung‐Flynn, J., Prapapanich, V., Ratajczak, T., Gaber, R., Picard, D., & Smith, D. F. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg108 · Cited by 353 · see citing works

The Roles of Cyclin-dependent Kinase 5 and Glycogen Synthase Kinase 3 in Tau Hyperphosphorylation

Plattner, F., Angelo, M., & Giese, K. P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603469200 · Cited by 340 · see citing works

Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?

Li, X., & Jope, R. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.105 · Cited by 294 · see citing works

Regulation of GSK-3

Harwood, A. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00412-3 · Cited by 291 · see citing works

The FKBP5 gene in depression and treatment response – an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) cohort

Lekman, M., Laje, G., Charney, D., Rush, A. J., Wilson, A. F., Sorant, A. J. M., Lipsky, R., Wisniewski, S. R., Manji, H., McMahon, F. J., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.026 · Cited by 284 · see citing works

FK506 Binding Protein 5 Shapes Stress Responsiveness: Modulation of Neuroendocrine Reactivity and Coping Behavior

Touma, C., Gassen, N. C., Herrmann, L., Cheung‐Flynn, J., Büll, D., Ionescu, I. A., Heinzmann, J.-M., Knapman, A., Siebertz, A., Depping, A., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.023 · Cited by 270 · see citing works

A novel CDK5‐dependent pathway for regulating GSK3 activity and kinesin‐driven motility in neurons

Morfini, G. A., Szebenyi, G., Brown, H. J., Pant, H. C., Pigino, G. F., DeBoer, S. R., Beffert, U., & Brady, S. T. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600237 · Cited by 268 · see citing works

Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters

Burkard, G. S., Jutzi, P., & Roditi, I. J. (2010) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2010.09.002 · Cited by 268 · see citing works

Selective inhibitors of the FK506-binding protein 51 by induced fit

Gaali, S., Kirschner, A., Cuboni, S., Hartmann, J., Kozany, C., Balsevich, G., Namendorf, C., Fernandez-Vizarra, P., Sippel, C., Zannas, A. S., et al. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1699 · Cited by 245 · see citing works

Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation

Tranguch, S., Cheung-Flynn, J., Daikoku, T., Prapapanich, V., Cox, M. B., Xie, H., Wang, H., Das, S. K., Smith, D. F., & Dey, S. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505775102 · Cited by 232 · see citing works

Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances

Polter, A., Beurel, E., Yang, S., Garner, R., Song, L., Miller, C. A., Sweatt, J. D., McMahon, L., Bartolucci, A. A., Li, X., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.43 · Cited by 225 · see citing works

The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress

Hartmann, J., Wagner, K. V., Liebl, C., Scharf, S. H., Wang, X.-D., Wolf, M., Hausch, F., Rein, T., Schmidt, U., Touma, C., et al. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.041 · Cited by 224 · see citing works

The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules

Jinwal, U. K., Koren, J., Borysov, S. I., Schmid, A. B., Abisambra, J. F., Blair, L. J., Johnson, A. G., Jones, J. R., Shults, C. L., O'Leary, J. C., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4815-09.2010 · Cited by 214 · see citing works

Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3β/β-catenin signaling

Garza, J. C., Guo, M., Zhang, W., & Lu, X.-Y. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.161 · Cited by 209 · see citing works

Alteration in Kinase Activity But Not in Protein Levels of Protein Kinase B and Glycogen Synthase Kinase-3β in Ventral Prefrontal Cortex of Depressed Suicide Victims

Karege, F., Perroud, N. A., Burkhardt, S., Schwald, M., Ballmann, E., Harpe, R. L., & Malafosse, A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.036 · Cited by 208 · see citing works

Clinical characteristics and treatment outcome in a representative sample of depressed inpatients – Findings from the Munich Antidepressant Response Signature (MARS) project

Hennings, J. M., Owashi, T., Binder, E. B., Horstmann, S., Menke, A., Kloiber, S. M., Dose, T., Wollweber, B., Spieler, D., Messer, T., et al. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.05.002 · Cited by 191 · see citing works

Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

Gassen, N. C., Hartmann, J., Zschocke, J., Stepan, J., Hafner, K., Zellner, A., Kirmeier, T., Kollmannsberger, L. K., Wagner, K. V., Dedic, N., et al. (2014) · PLoS Medicine · doi:10.1371/journal.pmed.1001755 · Cited by 177 · see citing works

Glycogen Synthase Kinase-3 in the Etiology and Treatment of Mood Disorders

Jope, R. S. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00016 · Cited by 174 · see citing works

Family-based association of FKBP5 in bipolar disorder

Willour, V. L., Chen, H., Toolan, J., Belmonte, P. L., Cutler, D. J., Goes, F. S., Zandi, P. P., Lee, R. S., MacKinnon, D. F., Mondimore, F. M., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002141 · Cited by 159 · see citing works

Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling

Wang, X., Chen, Y., Wolf, M., Wagner, K. V., Liebl, C., Scharf, S. H., Harbich, D., Mayer, B., Wurst, W., Holsboer, F., et al. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.020 · Cited by 157 · see citing works

A role for FKBP52 in tau protein function

Chambraud, B., Sardin, E., Giustiniani, J., Dounane, O., Schumacher, M., Goedert, M., & Baulieu, E.-E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914957107 · Cited by 140 · see citing works

Valproate and Amitriptyline Exert Common and Divergent Influences on Global and Gene Promoter-Specific Chromatin Modifications in Rat Primary Astrocytes

Perišić, T., Zimmermann, N., Kirmeier, T., Asmus, M., Tuorto, F., Uhr, M., Holsboer, F., Rein, T., & Zschocke, J. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.188 · Cited by 133 · see citing works

Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice

Rosa, A. O., Kaster, M. P., Binfaré, R. W., Morales, S., Martı́n-Aparicio, E., Navarro-Rico, M. L., Martı́nez, A., Medina, M., Garcı́a, A. G., López, M. G., et al. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.05.020 · Cited by 130 · see citing works

Cdk5: Multitasking between physiological and pathological conditions

Lopes, J. P., & Agostinho, P. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.03.006 · Cited by 129 · see citing works

A New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51

O’Leary, J. C., Dharia, S. P., Blair, L. J., Brady, S., Johnson, A. G., Peters, M. M., Cheung‐Flynn, J., Cox, M. B., de Erausquin, G. A., Weeber, E. J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024840 · Cited by 123 · see citing works

Mice lacking phosphatase PP2A subunit PR61/B’δ ( <i>Ppp2r5d</i> ) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β

Louis, J. V., Martens, E., Borghgraef, P., Lambrecht, C., Sents, W., Longin, S., Zwaenepoel, K., Pijnenborg, R., Landrieu, I., Lippens, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018777108 · Cited by 112 · see citing works

Decreased Cyclin-Dependent Kinase 5 (cdk5) Activity Is Accompanied by Redistribution of cdk5 and Cytoskeletal Proteins and Increased Cytoskeletal Protein Phosphorylation in p35 Null Mice

Hallows, J. L., Chen, K., DePinho, R. A., & Vincent, I. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-33-10633.2003 · Cited by 111 · see citing works

Differential Impact of Tetratricopeptide Repeat Proteins on the Steroid Hormone Receptors

Schülke, J.-P., Wochnik, G. M., Lang‐Rollin, I., Gassen, N. C., Knapp, R., Berning, B., Yassouridis, A., & Rein, T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011717 · Cited by 106 · see citing works

Subcellular Rearrangement of Hsp90-binding Immunophilins Accompanies Neuronal Differentiation and Neurite Outgrowth

Quintá, H., Maschi, D., Gomez-Sanchez, C., Piwien-Pilipuk, G., & Galigniana, M. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06970.x · Cited by 86 · see citing works

Glucocorticoid-Induced Degradation of Glycogen Synthase Kinase-3 Protein Is Triggered by Serum- and Glucocorticoid-Induced Protein Kinase and Akt Signaling and Controls β-Catenin Dynamics and Tight Junction Formation in Mammary Epithelial Tumor Cells

Failor, K. L., Desyatnikov, Y., Finger, L. A., & Firestone, G. L. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0143 · Cited by 76 · see citing works

Lithium: Still a Cornerstone in the Long-Term Treatment in Bipolar Disorder?

Nivoli, A., Murru, A., & Vieta, E. (2010) · Neuropsychobiology · doi:10.1159/000314307 · Cited by 76 · see citing works

Protein phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-type potassium channel activity

Kapfhamer, D., Berger, K. H., Hopf, F. W., Seif, T., Kharazia, V., Bonci, A., & Heberlein, U. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1292-10.2010 · Cited by 71 · see citing works

Pituitary glucocorticoid receptor deletion reduces vulnerability to chronic stress

Wagner, K. V., Wang, X., Liebl, C., Scharf, S. H., Müller, M. B., & Schmidt, M. V. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.09.007 · Cited by 69 · see citing works

Functional significance of glycogen synthase kinase-3 regulation by serotonin

Polter, A. M., Yang, S., Jope, R. S., & Li, X. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.09.009 · Cited by 66 · see citing works

Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition

Schmidt, M. V., Schülke, J.-P., Liebl, C., Stieß, M., Avrabos, C., Bock, J., Wochnik, G. M., Davies, H. A., Zimmermann, N., Scharf, S. H., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103318108 · Cited by 64 · see citing works

Differences in FKBP51 Regulation Following Chronic Social Defeat Stress Correlate with Individual Stress Sensitivity: Influence of Paroxetine Treatment

Wagner, K. V., Marinescu, D., Hartmann, J., Wang, X., Labermaier, C., Scharf, S. H., Liebl, C., Uhr, M., Holsboer, F., Müller, M. B., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.150 · Cited by 63 · see citing works

Lentivirally mediated GSK-3β silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice

Omata, N., Chiu, C., Moya, P. R., Leng, Y., Wang, Z., Hunsberger, J. G., Leeds, P. R., & Chuang, D. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000726 · Cited by 51 · see citing works

ENPP1 Affects Insulin Action and Secretion: Evidences from In Vitro Studies

Paola, R. D., Caporarello, N., Marucci, A., Dimatteo, C., Iadicicco, C., Guerra, S. D., Prudente, S., Sudano, D., Miele, C., Parrino, C., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019462 · Cited by 46 · see citing works

CNS glia are targets for GDNF and neurturin

Franke, B., Figiel, M., & Engele, J. (1998) · Histochemistry and Cell Biology · doi:10.1007/s004180050322 · Cited by 44 · see citing works

Kainic Acid-Induced Seizures Modulate Akt (SER473) Phosphorylation in the Hippocampus of Dopamine D2 Receptor Knockout Mice

Dunleavy, M., Provenzano, G., Henshall, D. C., & Bozzi, Y. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9927-x · Cited by 36 · see citing works

Use of the Hamilton rating scale for classification of depressive disorders

Overall, J. E., & Rhoades, H. M. (1982) · Comprehensive Psychiatry · doi:10.1016/0010-440x(82)90087-6 · Cited by 28 · see citing works

A novel mass spectrometry-based assay for GSK-3β activity

Bowley, E., Mulvihill, E. E., Howard, J. C., Pak, B. J., Gan, B. S., & O’Gorman, D. B. (2005) · BMC Biochemistry · doi:10.1186/1471-2091-6-29 · Cited by 13 · see citing works

P.1.024 The epigenetic machinery of neural cells is modulated by psychoactive drugs

Zimmermann, N., Perišić, T., Hafner, K., Uhr, M., Holsboer, F., Zschocke, J., & Rein, T. (2011) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(11)70025-6 · Cited by 1 · see citing works

Gene–Stress–Epigenetic regulation of FKBP5: clinical and translational implications

Zannas, A. S., Wiechmann, T., Gassen, N. C., & Binder, E. B. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.235 · Cited by 622 · see citing works

Molecular pathways of major depressive disorder converge on the synapse

Fries, G. R., Saldana, V. A., Finnstein, J., & Rein, T. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01806-1 · Cited by 504 · see citing works

Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility

Gjerstad, J. K., Lightman, S. L., & Spiga, F. (2018) · Stress · doi:10.1080/10253890.2018.1470238 · Cited by 437 · see citing works

SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

Gassen, N. C., Niemeyer, D., Muth, D., Corman, V. M., Martinelli, S., Gassen, A., Hafner, K., Papies, J., Mösbauer, K., Zellner, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13659-4 · Cited by 356 · see citing works

Understanding the Molecular Mechanisms Underpinning Gene by Environment Interactions in Psychiatric Disorders: The FKBP5 Model

Matosin, N., Halldorsdottir, T., & Binder, E. B. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.021 · Cited by 226 · see citing works

The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease

Fries, G. R., Gassen, N. C., & Rein, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122614 · Cited by 167 · see citing works

Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function

Balsevich, G., Häusl, A. S., Meyer, C. W., Karamihalev, S., Feng, X., Pöhlmann, M. L., Dournes, C., Uribe-Marino, A., Santarelli, S., Labermaier, C., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01783-y · Cited by 134 · see citing works

The HPA Axis as Target for Depression

Menke, A. (2024) · Current Neuropharmacology · doi:10.2174/1570159x21666230811141557 · Cited by 131 · see citing works

Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion

Martinelli, S., Anderzhanova, E. A., Bajaj, T., Wiechmann, S., Dethloff, F., Weckmann, K., Heinz, D. E., Ebert, T., Hartmann, J., Geiger, T. M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24810-5 · Cited by 130 · see citing works

The Many Faces of FKBP51

Hähle, A., Merz, S., Meyners, C., & Hausch, F. (2019) · Biomolecules · doi:10.3390/biom9010035 · Cited by 119 · see citing works

The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice

Häusl, A. S., Brix, L. M., Hartmann, J., Pöhlmann, M. L., López, J. P., Menegaz, D., Brivio, E., Engelhardt, C., Roeh, S., Bajaj, T., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01044-x · Cited by 109 · see citing works

Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine

Gassen, N. C., Fries, G. R., Zannas, A. S., Hartmann, J., Zschocke, J., Hafner, K., Carrillo‐Roa, T., Steinbacher, J., Preißinger, S. N., Hoeijmakers, L., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aac7695 · Cited by 106 · see citing works

Genetics of Resilience: Gene-by-Environment Interaction Studies as a Tool to Dissect Mechanisms of Resilience.

Elbau, I., Cruceanu, C., & Binder, E. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.025 · Cited by 91 · see citing works

Wnt Signaling in the Central Nervous System: New Insights in Health and Disease

Oliva, C. A., Montecinos-Oliva, C., & Inestrosa, N. C. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.11.018 · Cited by 97 · see citing works

Biological Actions of the Hsp90-binding Immunophilins FKBP51 and FKBP52

Zgajnar, N. R., Leo, S. A. D., Lotufo, C. M., Erlejman, A. G., Piwien‐Pilipuk, G., & Galigniana, M. D. (2019) · Biomolecules · doi:10.3390/biom9020052 · Cited by 94 · see citing works

GSK3β: a master player in depressive disorder pathogenesis and treatment responsiveness

Duda, P., Hajka, D., Wójcicka, O., Rakus, D., & Gizak, A. (2020) · Cells · doi:10.3390/cells9030727 · Cited by 84 · see citing works

The role of DNA methylation in the pathophysiology and treatment of bipolar disorder

Fries, G. R., Li, Q., McAlpin, B. R., Rein, T., Walss‐Bass, C., Soares, J. C., & Quevedo, J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.010 · Cited by 82 · see citing works

Focus on FKBP51: A molecular link between stress and metabolic disorders

Häusl, A. S., Balsevich, G., Gassen, N. C., & Schmidt, M. V. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.003 · Cited by 71 · see citing works

FK506 binding protein 51 integrates pathways of adaptation

Rein, T. (2016) · BioEssays · doi:10.1002/bies.201600050 · Cited by 65 · see citing works

FKBP5 Gene Expression Predicts Antidepressant Treatment Outcome in Depression

Ising, M., Maccarrone, G., Brückl, T., Scheuer, S., Hennings, J., Holsboer, F., Turck, C. W., Uhr, M., & Lucae, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030485 · Cited by 60 · see citing works

Unpacking Major Depressive Disorder: From Classification to Treatment Selection

Kennedy, S. H., & Ceniti, A. K. (2017) · The Canadian Journal of Psychiatry · doi:10.1177/0706743717748883 · Cited by 47 · see citing works

Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus

Criado‐Marrero, M., Gebru, N. T., Gould, L. A., Smith, T. M., Kim, S., Blackburn, R. J., Dickey, C. A., & Blair, L. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112738 · Cited by 44 · see citing works

Δ 9 -Tetrahydrocannabinol changes the brain lipidome and transcriptome differentially in the adolescent and the adult

Leishman, E., Murphy, M., Mackie, K., & Bradshaw, H. B. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.02.001 · Cited by 42 · see citing works

Stress‐Responsive Gene FK506‐Binding Protein 51 Mediates Alcohol‐Induced Liver Injury Through the Hippo Pathway and Chemokine (C‐X‐C Motif) Ligand 1 Signaling

Kusumanchi, P., Liang, T., Zhang, T., Ross, R. A., Han, S., Chandler, K., Oshodi, A., Jiang, Y., Dent, A. L., Skill, N. J., et al. (2021) · Hepatology · doi:10.1002/hep.31800 · Cited by 39 · see citing works

SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration

Hartmann, J., Bajaj, T., Otten, J., Klengel, C., Ebert, T., Gellner, A., Junglas, E., Hafner, K., Anderzhanova, E. A., Tang, F., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46953-x · Cited by 34 · see citing works

The stress susceptibility factor FKBP51 controls S-ketamine-evoked release of mBDNF in the prefrontal cortex of mice

Anderzhanova, E., Hafner, K., Genewsky, A. J., Soliman, A., Pöhlmann, M. L., Schmidt, M. V., Blum, R., Wotjak, C. T., & Gassen, N. C. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100239 · Cited by 29 · see citing works

Friend or foe: role of pathological tau in neuronal death

Wu, M., Chen, Z., Jiang, M. H., Bao, B., Li, D., Yin, X., Wang, X., Liu, D., & Zhu, L. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02024-z · Cited by 28 · see citing works

P21-activated kinase 7 (PAK7) interacts with and activates Wnt/β-catenin signaling pathway in breast cancer

Li, K., Xu, X., He, Y., Tian, Y., Pan, W., Liu, X., Ma, Y., Gao, Y., Gao, J., Qi, Y., et al. (2018) · Journal of Cancer · doi:10.7150/jca.24934 · Cited by 27 · see citing works

Peptidylprolylisomerases, Protein Folders, or Scaffolders? The Example of FKBP51 and FKBP52

Rein, T. (2020) · BioEssays · doi:10.1002/bies.201900250 · Cited by 25 · see citing works

Circ-GSK3B up-regulates GSK3B to suppress the progression of lung adenocarcinoma

Zhu, M., Zhang, Y., Xiong, P., Fan, X., Li, G.-L., & Zhu, M. (2022) · Cancer Gene Therapy · doi:10.1038/s41417-022-00489-8 · Cited by 20 · see citing works

Tricyclic antidepressants target FKBP51 SUMOylation to restore glucocorticoid receptor activity

Budziñski, M. L., Sokn, C., Gobbini, R., Ugo, B., Antunica-Noguerol, M., Senin, S., Bajaj, T., Gassen, N. C., Rein, T., Schmidt, M. V., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01491-0 · Cited by 17 · see citing works

Post-translational modifications and stress adaptation: the paradigm of FKBP51

Rein, T. (2020) · Biochemical Society Transactions · doi:10.1042/bst20190332 · Cited by 15 · see citing works

Genetically engineered mouse models of FK506‐binding protein 5

Gebru, N. T., Hill, S. E., & Blair, L. J. (2023) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30374 · Cited by 15 · see citing works

Stress, mental disorder and ketamine as a novel, rapid acting treatment

Dutton, M., Can, A., Lagopoulos, J., & Hermens, D. F. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.09.006 · Cited by 15 · see citing works

Structural and biochemical insights into FKBP51 as a Hsp90 co‐chaperone

Baischew, A., Engel, S., Geiger, T. M., Taubert, M. C., & Hausch, F. (2023) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30384 · Cited by 13 · see citing works

FKBP5/FKBP51-mediated signaling pathways in neuropsychiatric diseases: Insights for biomarker development and targeted therapies

Liu, Y., Lian, J., Fu, Y., Wang, S., Liu, Y., Zhang, R., & Han, H. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100762 · Cited by 12 · see citing works

Stress Molecular Signaling in Interaction With Cognition

Lugenbühl, J. F., Viho, E. M. G., Binder, E. B., & Daskalakis, N. P. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.09.023 · Cited by 12 · see citing works

Leveraging genetics to enhance the efficacy of PTSD pharmacotherapies

Miller, M. W. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.04.039 · Cited by 12 · see citing works

The Role of HSP90 Molecular Chaperones in Depression: Potential Mechanisms

Fan, X., Sun, L., Qin, Y., Liu, Y., Wu, S., & Du, L. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04284-4 · Cited by 11 · see citing works

FKBP51-Hsp90 Interaction-Deficient Mice Exhibit Altered Endocrine Stress Response and Sex Differences Under High-Fat Diet

Wang, L., Wojcieszak, J., Kumar, R., Zhao, Z., Sun, X., Xie, S., Winblad, B. G., & Pavlov, P. F. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03627-x · Cited by 10 · see citing works

Serine/threonine phosphatase 5 (PP5C/PPP5C) regulates the ISOC channel through a PP5C‐FKBP51 axis

Hamilton, C. L., Abney, K. A., Vasauskas, A. A., ALEXEYEV, M. F., Ni, L., Honkanen, R. E., Scammell, J. G., & Cioffi, D. L. (2017) · Pulmonary Circulation · doi:10.1177/2045893217753156 · Cited by 10 · see citing works

The molecular mechanism of polysaccharides in combating major depressive disorder: A comprehensive review

Kong, H., Xu, T., Wang, S., Zhang, Z., Li, M., Qu, S., Li, Q., Gao, P., & Cong, Z. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.129067 · Cited by 9 · see citing works

Knocking out Fkbp51 decreases CCl4-induced liver injury through enhancement of mitochondrial function and Parkin activity

Qiu, B., Zhong, Z., Dou, L., Xu, Y., Zou, Y., Weldon, K. S., Wang, J., Zhang, L., Liu, M., Williams, K. E., et al. (2024) · Cell & Bioscience · doi:10.1186/s13578-023-01184-3 · Cited by 10 · see citing works

FK506 binding protein 51: Its role in the adipose organ and beyond

Galigniana, N. M., Ruiz, M. C., & Piwien‐Pilipuk, G. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30351 · Cited by 9 · see citing works

Paroxetine ameliorates corticosterone-induced myelin damage by promoting the proliferation and differentiation of oligodendrocyte precursor cells

Bu, J., Liu, Y., Zhao, Y., Liu, L., Shen, J.-D., & Li, Y. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.03.065 · Cited by 6 · see citing works

Relationships between sarcopenia and Alzheimer’s disease: screening for mitochondria-related biomarkers

He, Q., Xia, Y., Shen, Q., Huang, C., Nie, X., Hu, X., & Tang, X. (2025) · Computer Methods in Biomechanics & Biomedical Engineering · doi:10.1080/10255842.2025.2598656 · Cited by 5 · see citing works

A depression-associated protein FKBP5 functions in autophagy initiation through scaffolding the VPS34 complex

Park, H., Park, J., Kim, T., Heo, H., Chang, J., Blackstone, C. D., & Lee, S. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04897-3 · Cited by 5 · see citing works

Sex-Specific Impact of Fkbp5 on Hippocampal Response to Acute Alcohol Injection: Involvement in Alterations of Metabolism-Related Pathways

Williams, K. E., Zou, Y., Qiu, B., Kono, T., Guo, C., Garcia, D. K., Chen, H., Graves, T. J., Lai, Z., Evans‐Molina, C., et al. (2023) · Cells · doi:10.3390/cells13010089 · Cited by 5 · see citing works

FK-binding protein 5: Possible relevance to the pathogenesis of metabolic dysfunction and alcohol-associated liver disease

Ma, J., Yang, Z., Gao, H., Huda, N., Jiang, Y., & Liangpunsakul, S. (2023) · Journal of Investigative Medicine · doi:10.1177/10815589231207793 · Cited by 3 · see citing works

Convergence of glycogen synthase kinase 3β and GR signaling in response to fluoxetine treatment in chronically stressed female and male rats

Mitić, M., Brkic, Z., Lukić, I., & Adžić, M. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.07.014 · Cited by 4 · see citing works

SUMO regulation of FKBP51 activity and the stress response

Gobbini, R. P., Velardo, V. G., Sokn, C., Liberman, A. C., & ARZT, E. S. (2023) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30411 · Cited by 3 · see citing works

Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigmEpistemology of the origin of cancer”

Brücher, B. L. D. M., & Jamall, I. S. (2019) · 4open · doi:10.1051/fopen/2019023 · Cited by 4 · see citing works

Novel treatment targets for COVID-19: Contribution from molecular psychiatry

Schmidt, U., & Rein, T. (2020) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2020.1779344 · Cited by 2 · see citing works

Inhibition of FKBP51 alleviates depressive-like behaviors via AKT/mTOR-dependent autophagy and synaptic plasticity

Li, C., Huang, J., Ge, H., Si, L., Wu, L., Xie, Y., Xiao, L., & Wang, G. (2026) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyag018 · Cited by 1 · see citing works

Roles of GR Isoforms and Hsp90-binding Immunophilins in the Modulation of Glucocorticoid Biological Responses

Galigniana, M. D., Ciucci, S. M., & Mazaira, G. I. (2022) · Current Clinical Pharmacology · doi:10.2174/2772432817666220428135138 · Cited by 1 · see citing works

Associations of psychiatric disease and aging on FKBP5 expression converge on cortical supragranular neuronsPreprint

Matosin, N., Arloth, J., Czamara, D., Edmond, K. Z., Maitra, M., Fröhlich, A. S., Martinelli, S., Kaul, D., Bartlett, R., Curry, A. R., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.27.428487 · Cited by 1 · see citing works

Elimination of FKBP51 attenuates CCl4-induced liver injury via enhancement of mitochondrial function by increased Parkin activityPreprint

Qiu, B., Zhong, Z., Dou, L., Xu, Y., Zou, Y., Weldon, K. S., Wang, J., Zhang, L., Liu, M., Williams, K. E., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2679397/v1 · Cited by 1 · see citing works

Valorisation des bases médico-administratives de l'assurance maladie pour identifier et suivre la progression d'une pathologie, en étudier la prise en charge et estimer l'impact de l'implémentation d'une politique de santé grâce à leur utilisation dans un modèle médico-économique : Application au diabète de type 2 au Luxembourg

Renard, L. (2012) · doi:10.70675/8addae69z0b0fz4f69zb3fbzc44b2f89021a

Contenido y liberación de serotonina en el hipocampo ventral de ratas estresadas prenatalmente y su relación con conductas tipo depresivas: participación de los glucocorticoides

Vásquez, F. D. J. J. (2021) · doi:10.24275/uami.xk81jk655

Additional file 2 of Knocking out Fkbp51 decreases CCl4-induced liver injury through enhancement of mitochondrial function and Parkin activity

Qiu, B., Zhong, Z., Dou, L., Xu, Y., Zou, Y., Weldon, K., Wang, J., Zhang, L., Liu, M., Williams, K. E., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26659447

Additional file 1 of Knocking out Fkbp51 decreases CCl4-induced liver injury through enhancement of mitochondrial function and Parkin activity

Qiu, B., Zhong, Z., Dou, L., Xu, Y., Zou, Y., Weldon, K., Wang, J., Zhang, L., Liu, M., Williams, K. E., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26659444

FKBP51 inhibits GSK3 beta and augments the effects of distinct psychotropic medications

Gassen, N., Hartmann, J., Zannas, A., Kretzschmar, A., Zschocke, J., Maccarrone, G., Hafner, K., Zellner, A., Kollmannsberger, L. K., Wag, K., et al. (2016) · Max Planck Digital Library · Cited by 2 · see citing works

Cracking the bell jar

Brennand, K. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aab3128 · Cited by 1 · see citing works

Psychotropic drugs affect Ser9-phosphorylated GSK-3β protein levels in rodent frontal cortex

Kozlovsky, N., Amar, S., Belmaker, R. H., & Agam, G. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705006097 · Cited by 65 · see citing works

GSK3β: a master player in depressive disorder pathogenesis and treatment responsiveness

Duda, P., Hajka, D., Wójcicka, O., Rakus, D., & Gizak, A. (2020) · Cells · doi:10.3390/cells9030727 · Cited by 84 · see citing works

Akt/GSK3 Signaling in the Action of Psychotropic Drugs

Beaulieu, J., Gainetdinov, R. R., & Caron, M. G. (2008) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.011008.145634 · Cited by 523 · see citing works