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Reward Network Immediate Early Gene Expression in Mood Disorders

Manning, C., WILLIAMS, E. S., & Robison, A. J. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00077 · Cited by 36 · see citing works

The Homer1 family of proteins at the crossroad of dopamine-glutamate signaling: An emerging molecular “Lego” in the pathophysiology of psychiatric disorders. A systematic review and translational insight

de Bartolomeis, A., Barone, A., Buonaguro, E. F., Tomasetti, C., Vellucci, L., & Iasevoli, F. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104596 · Cited by 37 · see citing works

Recent insights into antidepressant therapy: Distinct pathways and potential common mechanisms in the treatment of depressive syndromes

van Calker, D., Serchov, T., Normann, C., & Biber, K. P. H. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.014 · Cited by 35 · see citing works

Phenotypes, mechanisms and therapeutics: insights from bipolar disorder GWAS findings

Li, M., Li, T., Xiao, X., Chen, J., Hu, Z., & Fang, Y. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01523-9 · Cited by 35 · see citing works

Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress

Liu, C., Chen, J., Liu, Y., Zhou, X., Zhang, M., Jiang, Y.-M., Ma, Q., Xue, Z., Zhao, Z., Li, X., et al. (2022) · Chinese Medicine · doi:10.1186/s13020-022-00621-8 · Cited by 33 · see citing works

Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses

Lim, J., Kim, E., Noh, H. J., Kang, S., Phillips, B. U., Kim, D. G., Bussey, T. J., Saksida, L. M., Heath, C. J., & Kim, C. H. (2019) · Molecular Brain · doi:10.1186/s13041-019-0441-8 · Cited by 27 · see citing works

Neonatal maternal separation affects metabotropic glutamate receptor 5 expression and anxiety‐related behavior of adult rats

Tsotsokou, G., Νικολακοπούλου, Μ., Kouvelas, E. D., & Mitsacos, A. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15358 · Cited by 25 · see citing works

Re-arrangements of gene transcripts at glutamatergic synapses after prolonged treatments with antipsychotics: A putative link with synaptic remodeling

Buonaguro, E. F., Iasevoli, F., Marmo, F., Eramo, A., Latte, G., Avagliano, C., Tomasetti, C., & de Bartolomeis, A. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.02.012 · Cited by 25 · see citing works

Sleep-mediated regulation of reward circuits: implications in substance use disorders

Guo, R., Vaughan, D. T., Rojo, A. L. A., & Huang, Y. H. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01356-8 · Cited by 24 · see citing works

Behavioral and Neurochemical Phenotyping of Mice Incapable of Homer1a Induction

Datko, M., Hu, J. H., Williams, M. L., Reyes, C. M., Lominac, K. D., von Jonquières, G., Klugmann, M., Worley, P. F., & Szumlinski, K. K. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00208 · Cited by 21 · see citing works

Translating preclinical findings in clinically relevant new antipsychotic targets: focus on the glutamatergic postsynaptic density. Implications for treatment resistant schizophrenia.

de Bartolomeis, A., Avagliano, C., Vellucci, L., D'Ambrosio, L., Manchia, M., D'Urso, G., Buonaguro, E., & Iasevoli, F. (2019) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.08.019 · Cited by 17 · see citing works

mGluR5-Mediated eCB Signaling in the Nucleus Accumbens Controls Vulnerability to Depressive-Like Behaviors and Pain After Chronic Social Defeat Stress

Xu, X., Wu, K., Ma, X., Wang, W., Wang, H., Huang, M., Luo, L., Su, C., Yuan, T., Shi, H., et al. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02469-9 · Cited by 18 · see citing works

Stress resilience-associated behaviors following predator scent stress are accompanied by upregulated nucleus accumbens mGlu5 transcription in female Sprague Dawley rats

Blount, H. L., Dee, J., Wu, L., Schwendt, M., & Knackstedt, L. A. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114090 · Cited by 19 · see citing works

Harnessing the Neurobiology of Resilience to Protect the Mental Well-Being of Healthcare Workers During the COVID-19 Pandemic

Rajkumar, R. P. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.621853 · Cited by 18 · see citing works

Blocking metabotropic glutamate receptor subtype 5 relieves maladaptive chronic stress consequences

Peterlik, D., Stangl, C., Bauer, A., Bludau, A., Keller, J., Grabski, D., Killian, T., Schmidt, D., Zajicek, F., Jaeschke, G., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.08.007 · Cited by 18 · see citing works

Gene by environment interaction mouse model reveals a functional role for 5-hydroxymethylcytosine in neurodevelopmental disordersPreprint

Papale, L. A., Madrid, A., Zhang, Q., Chen, K., Sak, L., Keleş, S., & Alisch, R. S. (2021) · Genome Research · doi:10.1101/gr.276137.121 · Cited by 18 · see citing works

Neurobiological Mechanisms of Electroconvulsive Therapy: Molecular Perspectives of Brain Stimulation

Fetahović, E., Janjic, V. S., Muric, M. D., Jovicic, N. U., Radmanović, B., Rosic, G. L., Selaković, D., Filipovic, M., & Muric, N. N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125905 · Cited by 16 · see citing works

Chronic Stress Reduces Nectin-1 mRNA Levels and Disrupts Dendritic Spine Plasticity in the Adult Mouse Perirhinal Cortex

Gong, Q., Su, Y., Wu, C., Si, T., Deussing, J. M., Schmidt, M. V., & Wang, X. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00067 · Cited by 16 · see citing works

oReduced astrocytic mGluR5 in the hippocampus is associated with stress-induced depressive-like behaviors in mice.

Liu, C., Yang, T.-Q., Zhou, Y.-D., & Shen, Y. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136766 · Cited by 13 · see citing works

Glutamatergic postsynaptic density in early life stress programming: Topographic gene expression of mGlu5 receptors and Homer proteins

Buonaguro, E. F., Morley‐Fletcher, S., Avagliano, C., Vellucci, L., Iasevoli, F., Bouwalerh, H., Camp, G. V., Nicoletti, F., Maccari, S., & de Bartolomeis, A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109725 · Cited by 15 · see citing works

Association of social defeat stress-induced anhedonia-like symptoms with mGluR1-dependent decrease in membrane-bound AMPA-GluR1 in the mouse ventral midbrain

Yashiro, S., & Seki, K. (2017) · Stress · doi:10.1080/10253890.2017.1336534 · Cited by 15 · see citing works

Targeting the dysfunction of glutamate receptors for the development of novel antidepressants

Xia, C., He, J., Du, L., Yan, Y., Lian, W., Xu, J., & Zhang, W. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107875 · Cited by 14 · see citing works

Pushing the threshold: How NMDAR antagonists induce homeostasis through protein synthesis to remedy depression

Raab‐Graham, K. F., Workman, E. R., Namjoshi, S. V., & Niere, F. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.020 · Cited by 13 · see citing works

Alterations of BDNF, mGluR5, Homer1a, p11 and excitatory/inhibitory balance in corticolimbic brain regions of suicide decedents

García‐Gutiérrez, M. S., Navarro, D., Torregrosa, A. B., Viudez‐Martínez, A., Giner, S., & Manzanares, J. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.07.003 · Cited by 14 · see citing works

Pharmacology, Signaling and Therapeutic Potential of Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators

Kos, J. A., Langiu, M., Hellyer, S. D., & Gregory, K. J. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00213 · Cited by 12 · see citing works

Systemic neuro-dysregulation in depression: Evidence from genome-wide association

Tubbs, J. D., Ding, J., Baum, L., & Sham, P. C. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.08.007 · Cited by 12 · see citing works

Frontal cortex genetic ablation of metabotropic glutamate receptor subtype 3 (mGlu3) impairs postsynaptic plasticity and modulates affective behaviors

Joffe, M. E., Santiago, C. I., Vermudez, S. A. D., Fisher, N. M., Dogra, S., Niswender, C. M., & Conn, P. J. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01041-2 · Cited by 12 · see citing works

The Role of Stress-Induced Changes of Homer1 Expression in Stress Susceptibility

Reshetnikov, V. V., & Bondar, N. P. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921060018 · Cited by 12 · see citing works

The role of mGlu receptors in susceptibility to stress-induced anhedonia, fear, and anxiety-like behavior

Modrak, C. G., Wilkinson, C. S., Blount, H. L., Schwendt, M., & Knackstedt, L. A. (2022) · International review of neurobiology · doi:10.1016/bs.irn.2022.10.006 · Cited by 11 · see citing works

Increased [³H]quisqualic acid binding density in the dorsal striatum and anterior insula of alcoholics: A post-mortem whole-hemisphere autoradiography study

Laukkanen, V., Kärkkäinen, O. K., Kautiainen, H., Tiihonen, J., & Storvik, M. (2019) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2019.04.002 · Cited by 9 · see citing works

Reduced mGluR5 Activity Modulates Mitochondrial Function

Gonzalez‐Lozano, M. A., Wortel, J., van der Loo, R. J., van Weering, J. R. T., Smit, A. B., & Li, K. W. (2021) · Cells · doi:10.3390/cells10061375 · Cited by 8 · see citing works

Preventive effect of a Kampo medicine, kososan, on recurrent depression in a mouse model of repeated social defeat stress

Ito, N., Sasaki, K., Hirose, E., Nagai, T., Isoda, H., & Odaguchi, H. (2021) · Gene · doi:10.1016/j.gene.2021.145920 · Cited by 7 · see citing works

Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice

Kovářová, V., Bordes, J., Mitra, S., Narayan, S. V., Springer, M., Brix, L. M., Deussing, J. M., & Schmidt, M. V. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-02008-9 · Cited by 6 · see citing works

Rare Pathogenic Variants in Genes Implicated in Glutamatergic Neurotransmission Pathway Segregate with Schizophrenia in Pakistani Families

Fatima, A., Abdullah, U., Farooq, M., Mang, Y., Mehrjouy, M. M., Asif, M., Ali, Z., Tommerup, N., & Baig, S. M. (2021) · Genes · doi:10.3390/genes12121899 · Cited by 6 · see citing works

Differential mGluR5 expression in response to the same stress causes individually adapted hippocampal network activity

Yim, Y. S., Han, W., Seo, J., Kim, C. H., & Kim, D. G. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.11.172 · Cited by 6 · see citing works

Targeting Homer1a for Rapid Antidepressant Effects

Albert, P. R. (2019) · Neuron · doi:10.1016/j.neuron.2019.10.003 · Cited by 6 · see citing works

A single 24 h maternal separation at PND 9 promotes behavioral resilience of female C57BL/6J mice and the possible role of hippocampal Homer1a

Hao, Y., Niu, Y., Shi, F., Zhang, L., Peng, C., Yan, Z., Chen, X., & Xu, H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27037 · Cited by 5 · see citing works

mGlu5: A double-edged sword for aversive learning related therapeutics

Tan, S., & Kim, J. (2021) · Neuroanatomy and Behaviour · doi:10.35430/nab.2021.e16 · Cited by 4 · see citing works

Omega-3 fatty acid normalizes postsynaptic density related miRNAs and proteins in hippocampus and prevents DEHP-induced impairment of learning and memory in mice

Ding, M., Ma, H., Du, H., Yang, Y., Yu, M., & Zhang, C. (2025) · PLoS ONE · doi:10.1371/journal.pone.0313233 · Cited by 5 · see citing works

Differences in mGluR5 Availability Depending on the Level of Social Avoidance in Drug-Naïve Young Patients with Major Depressive Disorder

Kim, J.-H., Joo, Y., Son, Y., Kim, H.-K., & Kim, J. (2022) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s379395 · Cited by 4 · see citing works

Role of Glutamatergic Neurotransmission in the Pathophysiology of Stress-Related Disorders and Chronic Stress Response

Réus, G. Z., Abelaira, H. M., Coutellier, L. D., Manosso, L. M., & Pavlovic, Z. M. (2022) · Springer eBooks · doi:10.1007/978-3-030-87480-3_3 · Cited by 4 · see citing works

Evidence for Phosphorylation-Dependent, Dynamic, Regulation of mGlu5 and Homer2 in Expression of Cocaine Aversion in Mice

Szumlinski, K. K., Beltran, J., Doren, E. V., Chavez, C. L. J., Domingo-Gonzalez, R. D., Reyes, C. M., Ary, A. W., Lang, A., Guo, W., Worley, P. F., et al. (2023) · eNeuro · doi:10.1523/eneuro.0423-22.2023 · Cited by 1 · see citing works

An In Vivo Examination of the Relationship Between Metabotropic Glutamate 5 Receptor and Suicide Attempts in People With Borderline Personality Disorder

Davis, M. T., Asch, R., Weiss, E. R., Wagner, A., Fineberg, S. K., Nabulsi, N., Matuskey, D., Carson, R. E., & Esterlis, I. (2024) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2024.11.014 · Cited by 1 · see citing works

Molecular and topographic mapping of antipsychotic effects: a meta-analysis of postsynaptic density proteins in animal models with translational implications

Simone, G. D., Prisco, M. D., Oliva, V., Vellucci, L., Ciccarelli, M., Mazza, B., Fico, G., Fornaro, M., Iasevoli, F., Vieta, E., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03351-z · Cited by 2 · see citing works

Resilience to Anxiety and Anhedonia after Predator Scent Stress is Accompanied by Increased Nucleus Accumbens mGlu5 in Female RatsPreprint

Blount, H. L., Dee, J., Wu, L., Schwendt, M., & Knackstedt, L. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.2139/ssrn.4089351 · Cited by 1 · see citing works

Omega-3 fatty acid normalizes postsynaptic density proteins via miRNAs regulation in hippocampus and prevents DEHP-induced impairment of learning and memory in micePreprint

Ding, M., Ma, H., Du, H., Yang, Y., Yu, M., & Zhang, C. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.23.619821 · Cited by 1 · see citing works

Роль изменений экспрессии Homer1 в чувствительности к стрессу

Reshetnikov, V. V., & Bondar, N. P. (2021) · Biochemistry (Moscow) · doi:10.31857/s0320972521060014

Effects of chronic stress on nectin1 levels in the mouse primary somatosensory cortex

Xu, X., & Wang, X. (2022) · Stress and Brain · doi:10.26599/sab.2022.9060013

mGluR5 in Pyramidal Neurons in the Hippocampus Mediates Chronic Stress‐Induced Memory Deficits

Lu, H., Du, Z., Chen, H. H., Guo, T., Yang, S. C., & Li, X. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70477

Additional file 1 of Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress

Liu, C.-Y., Chen, J., Liu, Y., Zhou, X.-M., Zhang, M., Jiang, Y.-M., Ma, Q.-Y., Xue, Z., Zhao, Z.-Y., Li, X.-J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19863026

A female-specific role for Slit1 in prenatal stress-induced depression vulnerability

Xu, K., Chen, T., Yang, Y., Liu, W., Guo, H., Gong, Z., Ma, X., Liu, J., Lu, Y., Zhang, H., et al. (2026) · Neurotherapeutics · doi:10.1016/j.neurot.2026.e00916

Increased Homer1-mGluR5 mediates chronic stress-induced depressive-like behaviors and glutamatergic dysregulation via activation of PERK-eIF2α

Li, M., Li, Q., Sun, X., Luo, C., Li, Y., Wang, Y., Chen, J., Gong, C.-Z., Li, Y., Shi, L.-P., et al. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109682 · Cited by 65 · see citing works

Homer1 Mediates Acute Stress-Induced Cognitive Deficits in the Dorsal Hippocampus

Wagner, K. V., Hartmann, J., Mangold, K., Wang, X., Labermaier, C., Liebl, C., Wolf, M., Gassen, N. C., Holsboer, F., Rein, T., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4333-12.2013 · Cited by 61 · see citing works

The role of different Homer1 isoforms in acute and chronic social stress

Wagner, K., Hartmann, J., Wang, X. D., Liebl, C., Wolf, M., Scharf, S. H., Kohl, C., Marinescu, D., Müller, M., & Schmidt, M. V. (2011) · Pharmacopsychiatry · doi:10.1055/s-0031-1292557

Metabotropic Glutamate Receptor 5/Homer Interactions Underlie Stress Effects on Fear

Tronson, N. C., Guzmán, Y. F., Guedea, A. L., Huh, K. H., Gao, C., Schwarz, M. K., & Radulović, J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.004 · Cited by 75 · see citing works

Blocking metabotropic glutamate receptor subtype 5 relieves maladaptive chronic stress consequences

Peterlik, D., Stangl, C., Bauer, A., Bludau, A., Keller, J., Grabski, D., Killian, T., Schmidt, D., Zajicek, F., Jaeschke, G., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.08.007 · Cited by 18 · see citing works