Barzilai, Nir

Intracerebroventricular Leptin Regulates Hepatic but Not Peripheral Glucose Fluxes

Liu, L., Karkanias, G. B., Morales, J. C., Hawkins, M., Barzilai, N., Wang, J., & Rossetti, L. (1998) · Journal of Biological Chemistry

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 222

Role of visceral adipose tissue in aging

Huffman, D. M., & Barzilai, N. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 220

Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies

Hwang, J.-H., Stein, D. T., Barzilai, N., Cui, M.-H., Tonelli, J., Kishore, P., & Hawkins, M. (2007) · American Journal of Physiology-Endocrinology and Metabolism

Liver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 188

Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins

Carmi, S., Hui, K. Y., Kochav, E., Liu, X., Xue, J., Grady, F., Guha, S., Upadhyay, K., Ben-Avraham, D., Mukherjee, S., et al. (2014) · Nature Communications

Forensic and Genetic ResearchGenetic Associations and Epidemiology

Cited by 188

Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults

Kulkarni, A. S., Brutsaert, E. F., Anghel, V., Zhang, K., Bloomgarden, N., Pollak, M., Mar, J. C., Hawkins, M., Crandall, J. P., & Barzilai, N. (2018) · Aging Cell

Metabolism, Diabetes, and CancerGenetics, Aging, and Longevity in Model Organisms

Cited by 183

Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

Mao, K., Quipildor, G. F., Tabrizian, T., Novaj, A., Guan, F., Walters, R. O., Delahaye, F., Hubbard, G. B., Ikeno, Y., Ejima, K., et al. (2018) · Nature Communications

Genetics, Aging, and Longevity in Model OrganismsGrowth Hormone and Insulin-like Growth Factors

Cited by 167

Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats

Thompson, R. F., Fazzari, M. J., Niu, H., Barzilai, N., Simmons, R. A., & Greally, J. M. (2010) · Journal of Biological Chemistry

Birth, Development, and HealthEpigenetics and DNA Methylation

Cited by 154

The somatotropic axis in human aging: framework for the current state of knowledge and future research

Milman, S., Huffman, D. M., & Barzilai, N. (2016) · Cell Metabolism

Growth Hormone and Insulin-like Growth FactorsGenetics, Aging, and Longevity in Model Organisms

Cited by 150

Genetic Predisposition to Elevated Serum Thyrotropin Is Associated with Exceptional Longevity

Atzmon, G., Barzilai, N., Surks, M. I., & Gabriely, I. (2009) · The Journal of Clinical Endocrinology & Metabolism

Thyroid Disorders and TreatmentsGenetic Associations and Epidemiology

Cited by 145

Disease drivers of aging

Hodes, R. J., Sierra, F., Austad, S. N., Epel, E., Neigh, G. N., Erlandson, K. M., Schafer, M. J., LeBrasseur, N. K., Wiley, C., Campisi, J., et al. (2016) · Annals of the New York Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 132

Genetics, lifestyle and longevity: Lessons from centenarians

Govindaraju, D., Atzmon, G., & Barzilai, N. (2015) · Applied & Translational Genomics

Genetics, Aging, and Longevity in Model OrganismsEvolution and Genetic Dynamics

Cited by 128

A deep catalogue of protein-coding variation in 983,578 individuals

Sun, K. Y., Bai, X., Chen, S., Bao, S., Zhang, C., Kapoor, M., Backman, J., Joseph, T., Maxwell, E., Mitra, G., et al. (2024) · Nature

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 127

Caloric restriction, body fat and ageing in experimental models

Das, M., Gabriely, I., & Barzilai, N. (2004) · Obesity Reviews

Genetics, Aging, and Longevity in Model OrganismsAdipokines, Inflammation, and Metabolic Diseases

Cited by 121

Genetic Determinants of Human Health Span and Life Span: Progress and New Opportunities

Martin, G. M., Bergman, A., & Barzilai, N. (2007) · PLoS Genetics

Genetics, Aging, and Longevity in Model OrganismsGenetic Associations and Epidemiology

Cited by 120

Screening Human Embryos for Polygenic Traits Has Limited Utility

Karavani, E., Zuk, O., Zeevi, D., Barzilai, N., Stefanis, N. C., Hatzimanolis, A., Smyrnis, N., Avramopoulos, D., Kruglyak, L., Atzmon, G., et al. (2019) · Cell

Prenatal Screening and DiagnosticsAssisted Reproductive Technology and Twin Pregnancy

Cited by 111

The paradox of the insulin/IGF-1 signaling pathway in longevity

Rincon, M., Muzumdar, R. H., Atzmon, G., & Barzilai, N. (2004) · Mechanisms of Ageing and Development

Genetics, Aging, and Longevity in Model OrganismsGrowth Hormone and Insulin-like Growth Factors

Cited by 102

Frameworks for proof-of-concept clinical trials of interventions that target fundamental aging processes

Justice, J., Miller, J. D., Newman, J. C., Hashmi, S. K., Halter, J., Austad, S. N., Barzilai, N., & Kirkland, J. L. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 96

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population

Rivas, M. A., Avila, B. E., Koskela, J., Huang, H., Stevens, C., Pirinen, M., Haritunians, T., Neale, B. M., Kurki, M., Ganna, A., et al. (2018) · PLoS Genetics

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 87

Development of clinical trials to extend healthy lifespan

Justice, J. N., Niedernhofer, L., Robbins, P. D., Aroda, V. R., Espeland, M. A., Kritchevsky, S. B., Kuchel, G. A., & Barzilai, N. (2018) · Cardiovascular Endocrinology & Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 84

Positive attitude toward life, emotional expression, self-rated health, and depressive symptoms among centenarians and near-centenarians

Kato, K., Zweig, R., Schechter, C. B., Barzilai, N., & Atzmon, G. (2016) · Aging & Mental Health

Aging and Gerontology ResearchAging, Health, and Disability

Cited by 71

Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience

Huffman, D. M., Justice, J. N., Stout, M. B., Kirkland, J. L., Barzilai, N., & Austad, S. N. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 52

TARGETING AGING WITH METFORMIN (TAME)

Barzilai, N. R. (2017) · Innovation in Aging

Metabolism, Diabetes, and CancerGenetics, Aging, and Longevity in Model Organisms

Cited by 30

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms: Table 1.

Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N., & Kirkland, J. L. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 28

Insulin Resistance in Cushing's Syndrome

Karnieli, E., Cohen, P., Barzilai, N., Ish-Shalom, Z., Armoni, M., Rafaelov, R., & Barzilai, D. (1985) · Hormone and Metabolic Research

Pituitary Gland Disorders and TreatmentsPancreatic function and diabetes

Cited by 17