Genetic Determinants of Human Health Span and Life Span: Progress and New Opportunities
Open accessAbstract
We review three approaches to the genetic analysis of the biology and pathobiology of human aging. The first and so far the best-developed is the search for the biochemical genetic basis of varying susceptibilities to major geriatric disorders. These include a range of progeroid syndromes. Collectively, they tell us much about the genetics of health span. Given that the major risk factor for virtually all geriatric disorders is biological aging, they may also serve as markers for the study of intrinsic biological aging. The second approach seeks to identify allelic contributions to exceptionally long life spans. While linkage to a locus on Chromosome 4 has not been confirmed, association studies have revealed a number of significant polymorphisms that impact upon late-life diseases and life span. The third approach remains theoretical. It would require longitudinal studies of large numbers of middle-aged sib-pairs who are extremely discordant or concordant for their rates of decline in various physiological functions. We can conclude that there are great opportunities for research on the genetics of human aging, particularly given the huge fund of information on human biology and pathobiology, and the rapidly developing knowledge of the human genome.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Genes that regulate lifespan in animal models and human studies, and multiple experimental paradigms, have demonstrated that it is possible to manipulate ageing biology to rejuvenate physiological functioning in complex model organisms.
“Genes that regulate lifespan in animal models6–9 and human studies10–14 as well as multiple experimental paradigms, such as caloric restriction, heterochronic parabiosis and partial epigenetic reprogramming, have demonstrated that it is possible to manipulate ageing biology to ‘rejuvenate’ physiological functioning in complex model organisms15–28.”
From Measuring biological age using omics data (2022) · cites this paper as [14]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Theory of Island Biogeography
MacArthur, R. H., & Wilson, E. O. (2001) · Princeton University Press eBooks · doi:10.1515/9781400881376 · Cited by 13,298 · see citing works
Pleiotropy, natural selection, and the evolution of senescence.
Williams, G. C. (1957) · Evolution · doi:10.1111/j.1558-5646.1957.tb02911.x · Cited by 4,279 · see citing works
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602 · see citing works
Wallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185 · see citing works
King, M.-C., & Wilson, A. C. (1975) · Science · doi:10.1126/science.1090005 · Cited by 2,815 · see citing works
Complement factor H variant increases the risk of age-related macular degeneration
Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424 · see citing works
Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome
Eriksson, M., Brown, W. T., Gordon, L. B., Glynn, M. W., Singer, J. I., Scott, L. J., Erdos, M. R., Robbins, C. M., Moses, T. Y., Berglund, P., et al. (2003) · Nature · doi:10.1038/nature01629 · Cited by 2,217 · see citing works
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109 · see citing works
A Century of Alzheimer's Disease
Goedert, M., & Spillantini, M. G. (2006) · Science · doi:10.1126/science.1132814 · Cited by 2,106 · see citing works
Kirkwood, T. B. L., & Austad, S. N. (2000) · Nature · doi:10.1038/35041682 · Cited by 1,774 · see citing works
Positional Cloning of the Werner's Syndrome Gene
Yu, C., Oshima, J., Fu, Y., Wijsman, E. M., Hisama, F. M., Alisch, R. S., Matthews, S., Nakura, J., Miki, T., Ouais, S. G., et al. (1996) · Science · doi:10.1126/science.272.5259.258 · Cited by 1,705 · see citing works
Self-citationGenomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6
Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M., et al. (2006) · Cell · doi:10.1016/j.cell.2005.11.044 · Cited by 1,637 · see citing works
Lin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,496 · see citing works
Longevity, senescence and the genome
(1995) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(95)90026-8 · Cited by 1,403 · see citing works
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
Rogina, B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404184101 · Cited by 1,361 · see citing works
(1991) · Choice Reviews Online · doi:10.5860/choice.28-5664 · Cited by 1,306 · see citing works
Insect dormancy: an ecological perspective.
Danks, H. V. (1987) · Medical Entomology and Zoology · Cited by 1,278 · see citing works
Lamin A-Dependent Nuclear Defects in Human Aging
Scaffidi, P., & Misteli, T. (2006) · Science · doi:10.1126/science.1127168 · Cited by 1,224 · see citing works
An RNA gene expressed during cortical development evolved rapidly in humans
Pollard, K. S., Salama, S. R., Lambert, N., Lambot, M.-A., Coppens, S., Pedersen, J. S., Katzman, S., King, B., Onodera, C., Siepel, A., et al. (2006) · Nature · doi:10.1038/nature05113 · Cited by 1,005 · see citing works
Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.
Gm, M., Sprague, C. A., & Cj, E. (1970) · PubMed · Cited by 1,003 · see citing works
DNA Repair, Genome Stability, and Aging
Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M., & Alt, F. W. (2005) · Cell · doi:10.1016/j.cell.2005.01.028 · Cited by 944 · see citing works
Ageing and vision: structure, stability and function of lens crystallins
BLOEMENDAL, H., JONG, W. W. D., Jaenicke, R., Lubsen, N. H., Slingsby, C., & Tardieu, A. (2003) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2003.11.012 · Cited by 854 · see citing works
Rivera, A., Fisher, S. A., Fritsche, L. G., Keilhauer, C. N., Lichtner, P., Meitinger, T., & Weber, B. H. F. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi353 · Cited by 788 · see citing works
Substantial Genetic Influence on Cognitive Abilities in Twins 80 or More Years Old
McClearn, G. E., Johansson, B. E. A., Berg, S., Pedersen, N. L., Ahern, F. M., Petrill, S. A., & Plomin, R. J. (1997) · Science · doi:10.1126/science.276.5318.1560 · Cited by 727 · see citing works
In Search of Methuselah: Estimating the Upper Limits to Human Longevity
Olshansky, S. J., Carnes, B. A., & Cassel, C. (1990) · Science · doi:10.1126/science.2237414 · Cited by 645 · see citing works
Genetic analysis of ageing: role of oxidative damage and environmental stresses
Martin, G. M., Austad, S. N., & Johnson, T. E. (1996) · Nature Genetics · doi:10.1038/ng0596-25 · Cited by 641 · see citing works
Self-citationPhenotypic Consequences of Promoter-Mediated Transcriptional Noise
Blake, W. J., Balázsi, G., Kohanski, M. A., Isaacs, F. J., Murphy, K. F., Kuang, Y., Cantor, C. R., Walt, D. R., & Collins, J. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.11.003 · Cited by 617 · see citing works
Unique Lipoprotein Phenotype and Genotype Associated With Exceptional Longevity
Barzilai, N. (2003) · JAMA · doi:10.1001/jama.290.15.2030 · Cited by 576 · see citing works
Self-citationWeydt, P., Pineda, V. V., Torrence, A. E., Libby, R. T., Satterfield, T. F., Lazarowski, E. R., Gilbert, M. L., Morton, G. J., Bammler, T. K., Strand, A. D., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.004 · Cited by 562 · see citing works
Extreme Discordant Sib Pairs for Mapping Quantitative Trait Loci in Humans
RISCH, N. J., & Heping Zhang, D. (1995) · Science · doi:10.1126/science.7777857 · Cited by 525 · see citing works
Forces shaping the fastest evolving regions in the human genome
Pollard, K. S., Salama, S. R., King, B., Kern, A. D., Dreszer, T., Katzman, S., Siepel, A., Pedersen, J. S., Bejerano, G., Baertsch, R., et al. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020168 · Cited by 511 · see citing works
Mechanisms of aging: public or private?
Partridge, L., & Gems, D. (2002) · Nature Reviews Genetics · doi:10.1038/nrg753 · Cited by 510 · see citing works
Genetic influence on human lifespan and longevity
Hjelmborg, J., Iachine, I. A., Skytthe, A., Vaupel, J. W., McGue, M. K., Koskenvuo, M. J., Kaprio, J. A., Pedersen, N. L., & Christensen, K. (2006) · Human Genetics · doi:10.1007/s00439-006-0144-y · Cited by 496 · see citing works
Finch, C. E., & Tanzi, R. E. (1997) · Science · doi:10.1126/science.278.5337.407 · Cited by 490 · see citing works
Susceptibility genes for age-related maculopathy on chromosome 10q26
Jakobsdottir, J., Conley, Y. P., Weeks, D. E., Mah, T. S., Ferrell, R. E., & Gorin, M. B. (2005) · The American Journal of Human Genetics · doi:10.1086/444437 · Cited by 470 · see citing works
Excess of rare cancers in Werner syndrome (adult progeria).
Goto, M., Miller, R. W., Ishikawa, Y., & Sugano, H. (1996) · PubMed · Cited by 434 · see citing works
A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans
Rea, S. L., Wu, D., Cypser, J. R., Vaupel, J. W., & Johnson, T. E. (2005) · Nature Genetics · doi:10.1038/ng1608 · Cited by 411 · see citing works
Mitochondrial point mutations do not limit the natural lifespan of mice
Vermulst, M., Bielas, J. H., Kujoth, G. C., Ladiges, W. C., Rabinovitch, P. S., Prolla, T. A., & Loeb, L. A. (2007) · Nature Genetics · doi:10.1038/ng1988 · Cited by 404 · see citing works
Life-long sustained mortality advantage of siblings of centenarians
Perls, T. T., Wilmoth, J. R., Levenson, R., Shea-Drinkwater, M., Cohen, M., Bogan, H., Joyce, E., Brewster, S. J., Kunkel, L. M., & Puca, A. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122587599 · Cited by 383 · see citing works
Schoenmaker, M., de Craen, A. J. M., de Meijer, P. H. E. M., Beekman, M., Blauw, G. J., Slagboom, P. E., & Westendorp, R. G. J. (2005) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201508 · Cited by 368 · see citing works
The case for negative senescence
Vaupel, J. W., Baudisch, A., Dölling, M., Roach, D. A., & Gampe, J. (2004) · Theoretical Population Biology · doi:10.1016/j.tpb.2003.12.003 · Cited by 364 · see citing works
A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4
Puca, A. A., Daly, M. J., Brewster, S. J., Matise, T. C., Barrett, J. C., Shea-Drinkwater, M., Kang, S., Joyce, E., Nicoli, J., Benson, E. K., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181337598 · Cited by 347 · see citing works
Reduced insulin/IGF‐1 signalling and human longevity
van Heemst, D., Beekman, M., Mooijaart, S. P., Heijmans, B. T., Brandt, B. W., Zwaan, B. J., Slagboom, P. E., & Westendorp, R. G. J. (2005) · Aging Cell · doi:10.1111/j.1474-9728.2005.00148.x · Cited by 338 · see citing works
Telomeres: Cancer to Human Aging
Stewart, S. A., & Weinberg, R. A. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104518 · Cited by 336 · see citing works
Diapause and life cycle strategies in insects.
BROWN, V. K., & Hodek, I. (1983) · Medical Entomology and Zoology · Cited by 327 · see citing works
Bonafè, M., Barbieri, M., Marchegiani, F., Olivieri, F., Ragno, E., Giampieri, C., Mugianesi, E., Centurelli, M., Franceschi, C., & Paolisso, G. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021810 · Cited by 312 · see citing works
Plasma antioxidants and longevity: a study on healthy centenarians
Mecocci, P., Polidori, M. C., Troiano, L., Cherubini, A., Cecchetti, R., Pini, G., Straatman, M., Monti, D., Stahl, W., Sies, H., et al. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00246-x · Cited by 306 · see citing works
Genetic syndromes in man with potential relevance to the pathobiology of aging.
Martin, G. M. (1978) · PubMed · Cited by 297 · see citing works
Self-citationAPOE Genotype Effects on Alzheimer's Disease Onset and Epidemiology
Ashford, J. W. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:3:157 · Cited by 233 · see citing works
Curb, J. D., Abbott, R. D., Rodríguez, B. L., Masaki, K., Chen, R., Sharp, D. S., & Tall, A. R. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300520-jlr200 · Cited by 228 · see citing works
Lipoprotein Genotype and Conserved Pathway for Exceptional Longevity in Humans
Atzmon, G., Rincon, M., Schechter, C. B., Shuldiner, A. R., Lipton, R. B., Bergman, A., & Barzilai, N. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040113 · Cited by 222 · see citing works
Self-citationMeat‐Adaptive Genes and the Evolution of Slower Aging in Humans
Finch, C. E., & Stanford, C. B. (2004) · The Quarterly Review of Biology · doi:10.1086/381662 · Cited by 214 · see citing works
Franceschi, C., Olivieri, F., Marchegiani, F., Cardelli, M., Cavallone, L., Capri, M., Salvioli, S., Valensin, S., Benedictis, G. D., Iorio, A. D., et al. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.028 · Cited by 211 · see citing works
POT1 Stimulates RecQ Helicases WRN and BLM to Unwind Telomeric DNA Substrates
Opresko, P. L., Mason, P. A., Podell, E. R., Lei, M., Hickson, I. D., Cech, T. R., & Bohr, V. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505211200 · Cited by 202 · see citing works
Epigenetic drift in aging identical twins
Martin, G. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504743102 · Cited by 195 · see citing works
Self-citationCognitive Impairment: Dementia And Alzheimer's Disease
Larson, E. B., Kukull, W. A., & Katzman, R. (1992) · Annual Review of Public Health · doi:10.1146/annurev.pu.13.050192.002243 · Cited by 193 · see citing works
Schaumberg, D. A. (2007) · Archives of Ophthalmology · doi:10.1001/archopht.125.1.55 · Cited by 191 · see citing works
Clinical Phenotype of Families with Longevity
Atzmon, G., Schechter, C. B., Greiner, W., Davidson, D. E., Rennert, G., & Barzilai, N. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52068.x · Cited by 190 · see citing works
Self-citationMaster’s performance in the New York City Marathon 1983–1999
Jokl, P., Sethi, P. M., & Cooper, A. J. (2004) · British Journal of Sports Medicine · doi:10.1136/bjsm.2002.003566 · Cited by 183 · see citing works
What Can Progeroid Syndromes Tell Us About Human Aging?
Kipling, D., Davis, T., Ostler, E. L., & Faragher, R. (2004) · Science · doi:10.1126/science.1102587 · Cited by 182 · see citing works
Paolisso, G., Ammendola, S., Buono, A. D., Gambardella, A., Riondino, M., Tagliamonte, M. R., Rizzo, M. R., Carella, C., & Varricchio, M. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4087 · Cited by 181 · see citing works
Hamilton's indicators of the force of selection
Baudisch, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502155102 · Cited by 175 · see citing works
Genetic Modulation of Senescent Phenotypes in Homo sapiens
Martin, G. M. (2005) · Cell · doi:10.1016/j.cell.2005.01.031 · Cited by 171 · see citing works
Self-citationPlasma HDL Levels Highly Correlate With Cognitive Function in Exceptional Longevity
Atzmon, G., Gabriely, I., Greiner, W., Davidson, D., Schechter, C. B., & Barzilai, N. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.11.m712 · Cited by 164 · see citing works
Self-citationCigarette smoke – an aging accelerator?
Bernhard, D., Moser, C. E., Backović, A., & Wick, G. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.09.016 · Cited by 155 · see citing works
Geesaman, B. J., Benson, E. K., Brewster, S. J., Kunkel, L. M., Blanché, H., Thomas, G. D., Perls, T. T., Daly, M. J., & Puca, A. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1936249100 · Cited by 149 · see citing works
TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA
Machwe, A., Xiao, L., & Orren, D. K. (2004) · Oncogene · doi:10.1038/sj.onc.1206906 · Cited by 130 · see citing works
Offspring of Centenarians Have a Favorable Lipid Profile
Barzilai, N., Gabriely, I., Gabriely, M., Iankowitz, N., & Sorkin, J. D. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49013.x · Cited by 119 · see citing works
Self-citationSumi, S. M., Bird, T. D., Nochlin, D., & Raskind, M. A. (1992) · Neurology · doi:10.1212/wnl.42.1.120 · Cited by 118 · see citing works
Buffering Mechanisms in Aging: A Systems Approach Toward Uncovering the Genetic Component of Aging
Bergman, A., Atzmon, G., Ye, K. Q., MacCarthy, T., & Barzilai, N. (2005) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030170 · Cited by 117 · see citing works
Self-citationA genotype of exceptional longevity is associated with preservation of cognitive function
Barzilai, N., Atzmon, G., Derby, C. A., Bauman, J., & Lipton, R. B. (2006) · Neurology · doi:10.1212/01.wnl.0000249116.50854.65 · Cited by 111 · see citing works
Self-citationBrain weight throughout the life span of the chimpanzee
Herndon, J. G., Tigges, J., Anderson, D. C., Klumpp, S. A., & McClure, H. M. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990712)409:4 · Cited by 110 · see citing works
Kojima, T., Kamei, H., Aizu, T., Arai, Y., Takayama, M., Nakazawa, S., Ebihara, Y., Inagaki, H., Masui, Y., Gondo, Y., et al. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.05.007 · Cited by 104 · see citing works
Genetics of Healthy Aging in Europe
Franceschi, C., Bezrukov, V. V., Blanché, H., Bolund, L., Christensen, K., Benedictis, G. D., Deiana, L., GONOS, E., Hervonen, A., YANG, H., et al. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.003 · Cited by 101 · see citing works
Patnaik, B. K., Mahapatro, N., & Jena, B. S. (2009) · Gerontology · doi:10.1159/000213582 · Cited by 98 · see citing works
Tang, Y., Manfredi, G., Hirano, M., & Schon, E. A. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.7.2349 · Cited by 91 · see citing works
Genes, ageing and longevity in humans: Problems, advantages and perspectives
Salvioli, S., Olivieri, F., Marchegiani, F., Cardelli, M., Santoro, A., Bellavista, E., Mishto, M., Invidia, L., Capri, M., Valensin, S., et al. (2006) · Free Radical Research · doi:10.1080/10715760600917136 · Cited by 77 · see citing works
PARP-1: A Regulator of Genomic Stability Linked with Mammalian Longevity
Bürkle, A. (2001) · ChemBioChem · doi:10.1002/1439-7633(20011001)2:10 · Cited by 73 · see citing works
Vanfleteren, J. R., Vreese, A. D., & Braeckman, B. P. (1998) · The Journals of Gerontology Series A · doi:10.1093/gerona/53a.6.b393 · Cited by 73 · see citing works
Uka, J., Tamura, H., Kobayashi, T., Yamane, K., Kawakami, H., Minamoto, A., & Mishima, H. K. (2006) · Retina · doi:10.1097/01.iae.0000244068.18520.3e · Cited by 72 · see citing works
Rea, I. M., McKeown, P., McMaster, D., Young, I. S., Patterson, C. C., Savage, M., Belton, C., Marchegiani, F., Olivieri, F., Bonafè, M., et al. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.11.019 · Cited by 71 · see citing works
Bonafè, M., Marchegiani, F., Cardelli, M., Olivieri, F., Cavallone, L., Giovagnetti, S., Pieri, C., Marra, M., Antonicelli, R., Troiano, L., et al. (2002) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200806 · Cited by 69 · see citing works
Age-related changes of the 3′APOB-VNTR genotype pool in ageing cohorts
BENEDICTIS, G. D., Carotenuto, L., Carrieri, G., Luca, M. D., FALCONE, E., Rose, G., Yashin, A. I., Bonafè, M., & Franceschi, C. (1998) · Annals of Human Genetics · doi:10.1046/j.1469-1809.1998.6220115.x · Cited by 65 · see citing works
Vijg, J. (2007) · doi:10.1093/acprof:oso/9780198569237.001.0001 · Cited by 63 · see citing works
Characteristics of Framingham Offspring Participants With Long-lived Parents
Terry, D. F. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.5.438 · Cited by 61 · see citing works
Cottet, F., Blanché, H., Verasdonck, P., Gall, I. L., Schächter, F., Bürkle, A., & Muiras, M.-L. (2000) · Journal of Molecular Medicine · doi:10.1007/s001090000132 · Cited by 61 · see citing works
Rodríguez‐Rodríguez, E., Mateo, I., Infante, J., Llorca, J., Berciano, J., & Combarros, O. (2005) · Journal of Neurology · doi:10.1007/s00415-005-0945-2 · Cited by 60 · see citing works
Genetic Contribution to Biological Aging: The Framingham Study
Karasik, D., Hannan, M. T., Cupples, L. A., Felson, D. T., & Kiel, D. P. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.3.b218 · Cited by 55 · see citing works
Norton, M. C., Skoog, I. G., Franklin, L. M., Corcoran, C. D., Tschanz, J. T., Zandi, P. P., Breitner, J. C. S., Welsh-Bohmer, K. A., & Steffens, D. C. (2006) · The Journals of Gerontology Series B · doi:10.1093/geronb/61.3.p129 · Cited by 55 · see citing works
Tanimoto, S., Tamura, H., Ue, T., Yamane, K., Maruyama, H., Kawakami, H., & Kiuchi, Y. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.12.011 · Cited by 53 · see citing works
Beekman, M., Blauw, G. J., Houwing‐Duistermaat, J. J., Brandt, B. W., Westendorp, R. G. J., & Slagboom, P. E. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.4.355 · Cited by 48 · see citing works
Prospects and pitfalls in whole genome association studies
Lawrence, R., Evans, D. M., & Cardon, L. R. (2005) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2005.1689 · Cited by 48 · see citing works
Andersen, H. R., Jeune, B., Nybo, H., Nielsen, J. B., Andersen‐Ranberg, K., & Grandjean, P. (1998) · Age and Ageing · doi:10.1093/ageing/27.5.643 · Cited by 47 · see citing works
Paraoxonase Activity and Genotype Predispose to Successful Aging
Marchegiani, F., Marra, M., Spazzafumo, L., James, R. W., Boemi, M., Olivieri, F., Cardelli, M., Cavallone, L., Bonfigli, A. R., & Franceschi, C. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.6.541 · Cited by 40 · see citing works
Interactions of aging and environmental agents: the gerontological perspective.
Gm, M. (1987) · PubMed · Cited by 34 · see citing works
Parental longevity and mortality amongst Japanese men and women: the JACC Study
Ikeda, A., Iso, H., Toyoshima, H., Kondo, T., Mizoue, T., Koizumi, A., Inaba, Y., Tamakoshi, A., & JACC STUDY GROUP (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01609.x · Cited by 33 · see citing works
Heritability and Validity of Healthy Physical Aging (Wellness) in Elderly Male Twins
Reed, T., & Dick, D. M. (2003) · Twin Research · doi:10.1375/136905203765693889 · Cited by 27 · see citing works
Genetic modulation of the senescent phenotype in Homo sapiens
Martin, G. M. (1989) · Genome · doi:10.1139/g89-059 · Cited by 25 · see citing works
Self-citationMaintaining Genetic Integrity in Aging: A Zero Sum Game
Suh, Y., & Vijg, J. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.559 · Cited by 24 · see citing works
Gene action in the aging brain: an evolutionary biological perspective
MARTIN, G. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00341-4 · Cited by 24 · see citing works
Self-citationTan, Q., Christiansen, L., Bathum, L., Li, S., Kruse, T. A., & Christensen, K. (2005) · Genetics · doi:10.1534/genetics.105.050914 · Cited by 24 · see citing works
Martin, G. M. (2001) · Science · doi:10.1126/science.294.5540.13 · Cited by 23 · see citing works
Self-citationFrontotemporal lobar degeneration through loss of progranulin function
Goedert, M., & Spillantini, M. G. (2006) · Brain · doi:10.1093/brain/awl291 · Cited by 22 · see citing works
Model Systems for the Genetic Analysis of Mechanisms of Aging
Martin, G. M., & Turker, M. S. (1988) · Journal of Gerontology · doi:10.1093/geronj/43.2.b33 · Cited by 21 · see citing works
Self-citationReplication studies in longevity: puzzling findings in Danish centenarians at the 3′APOB–VNTR locus
Varcasia, O., Garasto, S., Rizza, T., Andersen-Ranberg, K., Jeune, B., Bathum, L., Andreev, K., Tan, Q., Yashin, A., Bonafè, M., et al. (2001) · Annals of Human Genetics · doi:10.1046/j.1469-1809.2001.6540371.x · Cited by 19 · see citing works
Replication studies in longevity: puzzling findings in Danish centenarians at the 3'APOB-VNTR locus.
Varcasia, O., Garasto, S., Rizza, T., et al. (2001) · PubMed · doi:10.1017/s0003480001008715 · Cited by 17 · see citing works
A Novel Framework for Sib Pair Linkage Analysis
Poznik, G. D., Adamska, K., Xu, X. P., Królewski, A. S., & Rogus, J. J. (2006) · The American Journal of Human Genetics · doi:10.1086/499827 · Cited by 15 · see citing works
Help Wanted: Physiologists for Research on Aging
Martin, G. M. (2002) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.9.vp2 · Cited by 14 · see citing works
Self-citationConstitutional genetic markers of aging
Martin, G. M. (1988) · Experimental Gerontology · doi:10.1016/0531-5565(88)90028-9 · Cited by 13 · see citing works
Self-citationThe Evolutionary Substrate of Aging
Martin, G. M. (2002) · Archives of Neurology · doi:10.1001/archneur.59.11.1702 · Cited by 12 · see citing works
Self-citationKeynote lecture: An update on the what, why and how questions of ageing
MARTIN, G. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.03.009 · Cited by 10 · see citing works
Self-citationNeuropathology of the Werner Syndrome
Sumi, S. M. (1985) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-7853-2_8 · Cited by 9 · see citing works
Lucchi, T. A., Arosio, B., Caloni, M., Ceconi, I., Calabresi, C., Scurati, S., & Vergani, C. (2005) · PubMed · Cited by 8 · see citing works
Buffering Mechanisms in Aging: A systems approach towards uncovering the genetic component of aging
Bergman, A., Atzmon, G., Ye, K. Q., et al. (2005) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030170.eor · Cited by 3 · see citing works
Self-citation
Flagged first, then by citations
1 of the 115 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Suh Y Cho M Cohen P Barzilai N 2007 The IGF-1 axis, SNPs and human longevity The 3rd international conference on Functional Genomics of Aging Palermo [Italy].
Cited by
Sorted by citations
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
Jurk, D., Wilson, C., Passos, J. F., Oakley, F., Correia-Melo, C., Greaves, L., Saretzki, G., Fox, C., Lawless, C., Anderson, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5172 · Cited by 814 · see citing works
Measuring biological age using omics data
Rutledge, J., Oh, H., & Wyss-Coray, T. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00511-7 · Cited by 570 · see citing works
Progeria syndromes and ageing: what is the connection?
Burtner, C. R., & Kennedy, B. K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2944 · Cited by 386 · see citing works
Goldman, D. P., Cutler, D., Rowe, J. W., Michaud, P., Sullivan, J. H., Peneva, D., & Olshansky, S. J. (2013) · Health Affairs · doi:10.1377/hlthaff.2013.0052 · Cited by 312 · see citing works
Hayflick, L. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030220 · Cited by 260 · see citing works
Lifestyle Factors of People with Exceptional Longevity
Rajpathak, S. N., Liu, Y., Ben‐David, O., Reddy, S., Atzmon, G., Crandall, J. P., & Barzilai, N. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03498.x · Cited by 187 · see citing works
Self-citationOlshansky, S. J., Goldman, D. P., Zheng, Y., & Rowe, J. W. (2009) · Milbank Quarterly · doi:10.1111/j.1468-0009.2009.00581.x · Cited by 178 · see citing works
New model of health promotion and disease prevention for the 21st century
Butler, R. N., Miller, R. A., Perry, D. P., Carnes, B. A., Williams, T. F., Cassel, C. K., Brody, J. A., Bernard, M., Partridge, L., Kirkwood, T. B. L., et al. (2008) · BMJ · doi:10.1136/bmj.a399 · Cited by 162 · see citing works
Self-citationSeven knowledge gaps in modern biogerontology
Rattan, S. I. S. (2024) · Biogerontology · doi:10.1007/s10522-023-10089-0 · Cited by 129 · see citing works
Asynchrony of senescence among phenotypic traits in a wild mammal population
Hayward, A. D., Moorad, J. A., Regan, C. E., Bérénos, C., Pilkington, J. G., Pemberton, J. M., & Nussey, D. H. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.08.003 · Cited by 127 · see citing works
The Epidemiology of Human Telomeres: Faults and Promises
Aviv, A. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.9.979 · Cited by 121 · see citing works
Rodríguez‐Rodero, S., Fernández-Morera, J. L., Torre, E. L. M., Calvanese, V., Fernández, A. F., & Fraga, M. F. (2011) · Europe PMC (PubMed Central) · Cited by 117 · see citing works
Genetic and epigenetic regulation of aging
Fraga, M. F. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.04.003 · Cited by 112 · see citing works
Kishi, S., Slack, B. E., Uchiyama, J., & Zhdanova, I. V. (2009) · Gerontology · doi:10.1159/000228892 · Cited by 108 · see citing works
Sanders, A. E. (2010) · JAMA · doi:10.1001/jama.2009.1988 · Cited by 107 · see citing works
Subjective Wellbeing and Longevity: A Co-Twin Control Study
Sadler, M. E., Miller, C. J., Christensen, K., & McGue, M. K. (2011) · Twin Research and Human Genetics · doi:10.1375/twin.14.3.249 · Cited by 96 · see citing works
Prospects for Life Span Extension
Sierra, F., Hadley, E., Suzman, R., & Hodes, R. J. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.60.061607.220533 · Cited by 90 · see citing works
Lipidomics in longevity and healthy aging
González-Covarrubias, V. (2013) · Biogerontology · doi:10.1007/s10522-013-9450-7 · Cited by 86 · see citing works
Optimizing aging: A call for a new narrative.
Diehl, M. K., Smyer, M. A., & Mehrotra, C. M. N. (2020) · American Psychologist · doi:10.1037/amp0000598 · Cited by 84 · see citing works
Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing
Gombar, S., Jung, H. J., Dong, F., Calder, B. R., Atzmon, G., Barzilai, N., Tian, X., Pothof, J., Hoeijmakers, J. H. J., Campisi, J., et al. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-353 · Cited by 80 · see citing works
Self-citationSzabó, D., Gee, N. R., & Miklósi, Á. (2015) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2015.08.003 · Cited by 69 · see citing works
Cruz-Jentoft, A. J., Franco, A., Sommer, P., Baeyens, J., Jankowska, E. A., Maggi, A. C., Ponikowski, P. P., Ryś, A., Szczerbińska, K. E., Michel, J., et al. (2009) · Aging Clinical and Experimental Research · doi:10.1007/bf03327452 · Cited by 66 · see citing works
DRD4 Genotype Predicts Longevity in Mouse and Human
Grady, D. L., Thanos, P. K., Corrada, M. M., Barnett, J. C., Ciobanu, V., Shustarovich, D., Napoli, A., Moyzis, A. G., Grandy, D. K., Rubinstein, M., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3515-12.2013 · Cited by 62 · see citing works
Developmental Drift and the Role of Wnt Signaling in Aging
Gruber, J., Yee, Z., & Tolwinski, N. S. (2016) · Cancers · doi:10.3390/cancers8080073 · Cited by 60 · see citing works
Aging and stress: past hypotheses, present approaches and perspectives.
Garrido, P. (2011) · Europe PMC (PubMed Central) · Cited by 59 · see citing works
The ApoE Gene Is Related with Exceptional Longevity: A Systematic Review and Meta-Analysis
Garatachea, N., Marin, P. J., Santos‐Lozano, A., Sanchis‐Gomar, F., Emanuele, E., & Lucía, A. (2014) · Rejuvenation Research · doi:10.1089/rej.2014.1605 · Cited by 59 · see citing works
Biogerontology: research status, challenges and opportunities.
Rattan, S. I. S. (2018) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · doi:10.23750/abm.v89i2.7403 · Cited by 54 · see citing works
Common gene signature of cancer and longevity
Budovsky, A., Tăcutu, R., Yanai, H., Abramovich, A., Wolfson, M., & Fraifeld, V. E. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.04.002 · Cited by 52 · see citing works
Cytogenetic perspective of ageing and longevity in men and women
Ziętkiewicz, E., Wojda, A., & Witt, M. (2009) · Journal of Applied Genetics · doi:10.1007/bf03195682 · Cited by 50 · see citing works
Kulminski, A. M., Culminskaya, I. V., Ukraintseva, S. V., Arbeev, K. G., Arbeeva, L. S., Wu, D., Akushevich, I. V., Land, K. C., & Yashin, A. I. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00689.x · Cited by 49 · see citing works
From cellular senescence to age-associated diseases: the miRNA connection
Schraml, E., & Grillari, J. (2012) · Longevity & Healthspan · doi:10.1186/2046-2395-1-10 · Cited by 46 · see citing works
Age-associated vulval integrity is an important marker of nematode healthspan
Leiser, S. F., Jafari, G., Primitivo, M., Sutphin, G. L., Dong, J., Leonard, A., Fletcher, M., & Kaeberlein, M. R. (2016) · AGE · doi:10.1007/s11357-016-9936-8 · Cited by 44 · see citing works
The Economic Promise of Delayed AgingPreprint
Goldman, D. P. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025072 · Cited by 43 · see citing works
Mood, Memory and Movement: An Age-Related Neurodegenerative Complex?
Granholm, A., Boger, H. A., & Emborg, M. E. (2008) · Current Aging Science · doi:10.2174/1874609810801020133 · Cited by 41 · see citing works
Fahy, G. M. (2010) · Springer eBooks · doi:10.1007/978-90-481-3999-6_6 · Cited by 39 · see citing works
Arum, O., Rasche, Z. A., Rickman, D. J., & Bartke, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072255 · Cited by 38 · see citing works
Genetics and Pharmacology of Longevity
Castillo-Quan, J. I., Kinghorn, K. J., & Bjedov, I. (2015) · Advances in genetics · doi:10.1016/bs.adgen.2015.06.002 · Cited by 37 · see citing works
Are ‘Endurance’ Alleles ‘Survival’ Alleles? Insights from the ACTN3 R577X Polymorphism
Fiuza‐Luces, C., Ruiz, J. R., Rodríguez‐Romo, G., Santiago, C., Gómez‐Gallego, F., Yvert, T. P., Cano-Nieto, A., Garatachea, N., Morán, M., & Lucía, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017558 · Cited by 37 · see citing works
Definitions of healthspan: A systematic review
Masfiah, S., Kurnialandi, A., Meij, H. J., & Maier, A. B. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102806 · Cited by 35 · see citing works
Dietary polyphenols as geroprotective compounds: From Blue Zones to hallmarks of ageing
Davinelli, S., Medoro, A., Hu, F. B., & Scapagnini, G. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102733 · Cited by 33 · see citing works
Rattan, S. I. S. (2019) · Biogerontology · doi:10.1007/s10522-019-09851-0 · Cited by 33 · see citing works
The ACE DD genotype and D-allele are associated with exceptional longevity: A meta-analysis
Garatachea, N., Marin, P. J., & Lucía, A. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.04.001 · Cited by 32 · see citing works
Toward a Systems Biology Framework for Understanding Aging and Health Span
West, G. B., & Bergman, A. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln066 · Cited by 32 · see citing works
Self-citationKulminski, A. M., Raghavachari, N., Arbeev, K. G., Culminskaya, I. V., Arbeeva, L. S., Wu, D., Ukraintseva, S. V., Christensen, K., & Yashin, A. I. (2016) · Biogerontology · doi:10.1007/s10522-016-9659-3 · Cited by 31 · see citing works
Mutation and the evolution of ageing: from biometrics to system genetics
Hughes, K. A. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2009.0265 · Cited by 31 · see citing works
Inside out: Relations between the microbiome, nutrition, and eye health
Grant, M. B., Bernstein, P. S., Boesze‐Battaglia, K., Chew, E. Y., Curcio, C. A., Kenney, M. C., Klaver, C. C. W., Philp, N. J., Rowan, S., Sparrow, J. R., et al. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109216 · Cited by 30 · see citing works
Boyden, S. E., & Kunkel, L. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012432 · Cited by 29 · see citing works
Yashin, A. I., Arbeev, K. G., Arbeeva, L. S., Wu, D., Akushevich, I. V., Kovtun, M., Yashkin, A. P., Kulminski, A. M., Culminskaya, I. V., Stallard, E., et al. (2015) · Biogerontology · doi:10.1007/s10522-015-9594-8 · Cited by 27 · see citing works
Are mitochondrial haplogroups associated with extreme longevity? A study on a Spanish cohort
Pinós, T., Nogales‐Gadea, G., Ruiz, J. R., Rodríguez‐Romo, G., Santiago, C., Fiuza‐Luces, C., Gómez‐Gallego, F., Cano-Nieto, A., Garatachea, N., Morán, M., et al. (2011) · AGE · doi:10.1007/s11357-011-9209-5 · Cited by 25 · see citing works
Progress & Prospects: Gene therapy in aging
Rattan, S. I. S., & Singh, R. (2008) · Gene Therapy · doi:10.1038/gt.2008.166 · Cited by 24 · see citing works
Bretman, A. J., & Fricke, C. (2019) · Functional Ecology · doi:10.1111/1365-2435.13339 · Cited by 24 · see citing works
Genetic determinants of ageing processes and diseases in later life
Bostock, C. V., Soiza, R. L., & Whalley, L. J. (2009) · Maturitas · doi:10.1016/j.maturitas.2008.12.012 · Cited by 24 · see citing works
Unraveling Genetic Origin of Aging-Related Traits: Evolving Concepts
Kulminski, A. M. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1441 · Cited by 23 · see citing works
Association of the K153R polymorphism in the myostatin gene and extreme longevity
Garatachea, N., Pinós, T., Cámara, Y., Rodríguez‐Romo, G., Emanuele, E., Ricevuti, G., Venturini, L., Santos‐Lozano, A., Santiago, C., Fiuza‐Luces, C., et al. (2013) · AGE · doi:10.1007/s11357-013-9513-3 · Cited by 23 · see citing works
How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging
Karasik, D. (2010) · AGE · doi:10.1007/s11357-010-9159-3 · Cited by 23 · see citing works
Gall, J. L., & Ardaillou, R. (2009) · PubMed · Cited by 22 · see citing works
Molecular and chemical genetic approaches to developmental origins of aging and disease in zebrafish
Sasaki, T., & Kishi, S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.04.030 · Cited by 21 · see citing works
Genomics of human health and aging
Kulminski, A. M., & Culminskaya, I. V. (2011) · AGE · doi:10.1007/s11357-011-9362-x · Cited by 21 · see citing works
Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort
Fiuza‐Luces, C., Ruiz, J. R., Rodríguez‐Romo, G., Santiago, C., Gómez‐Gallego, F., Cano-Nieto, A., Garatachea, N., Rodríguez-Moreno, I., Morán, M., & Lucía, A. (2011) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320310391505 · Cited by 19 · see citing works
Yashin, A. I., Arbeev, K. G., Kulminski, A. M., Borecki, I. B., Christensen, K., Barmada, M. M., Hadley, E., Rossi, W. K., Lee, J. H., Cheng, R., et al. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.02.001 · Cited by 18 · see citing works
A brief history of modern aging research
Zainabadi, K. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.01.018 · Cited by 18 · see citing works
Contemporary human genetic strategies in aging research
Bloss, C. S., Pawlikowska, L., & Schork, N. J. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.07.005 · Cited by 17 · see citing works
Kulminski, A. M., Arbeev, K. G., Culminskaya, I. V., Ukraintseva, S. V., Stallard, E., Province, M. A., & Yashin, A. I. (2014) · Rejuvenation Research · doi:10.1089/rej.2014.1616 · Cited by 17 · see citing works
Genetic interplay between human longevity and metabolic pathways — a large‐scale eQTL study
Häsler, R., Venkatesh, G., Tan, Q., Flachsbart, F., Sinha, A. N., Rosenstiel, P. C., Lieb, W., Schreiber, S., Christensen, K., Christiansen, L., et al. (2017) · Aging Cell · doi:10.1111/acel.12598 · Cited by 17 · see citing works
Möller, S., Saul, N., Cohen, A. A., Köhling, R., Sender, S., Escobar, H. M., Junghanß, C., Cirulli, F., Berry, A., Antal, P., et al. (2020) · Aging · doi:10.18632/aging.103514 · Cited by 17 · see citing works
Evolutionary Genetic Bases of Longevity and Senescence
Govindaraju, D. R. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2404-2_1 · Cited by 16 · see citing works
Are centenarians genetically predisposed to lower disease risk?
Ruiz, J. R., Fiuza‐Luces, C., Buxens, A., Cano-Nieto, A., Gómez‐Gallego, F., Santiago, C., Rodríguez‐Romo, G., Garatachea, N., Lao, J. I., Morán, M., et al. (2011) · AGE · doi:10.1007/s11357-011-9296-3 · Cited by 16 · see citing works
Pharmacogenetics and Pharmagenomics, Trends in Normal and Pathological Aging Studies: Focus on p53
Lanni, C., Racchi, M., Uberti, D. L., Mazzini, G., Stanga, S., Sinforiani, E., Memo, M., & Govoni, S. M. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786264133 · Cited by 16 · see citing works
Genetic Polymorphisms and Human Aging: Association Studies Deliver
Melzer, D. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0684 · Cited by 15 · see citing works
Molecular Basis and Emerging Strategies for Anti-aging Interventions
Rattan, S. (2018) · Springer eBooks · doi:10.1007/978-981-13-1699-9 · Cited by 15 · see citing works
Gender-Specific DNA Methylome Analysis of a Han Chinese Longevity Population
Sun, L., Lin, J., Du, H., Hu, C., Huang, Z., Lv, Z., Zheng, C., Shi, X., Zhang, Y., & Yang, Z. (2014) · BioMed Research International · doi:10.1155/2014/396727 · Cited by 14 · see citing works
Aging trajectories are trait- and sex-specific in the long-lived Alpine swift
Moullec, H., Reichert, S., & Bize, P. (2023) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2023.983266 · Cited by 14 · see citing works
Kishi, S. (2011) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20217 · Cited by 14 · see citing works
Kulminski, A. M. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.08.010 · Cited by 13 · see citing works
Kishi, S. (2013) · Translational research · doi:10.1016/j.trsl.2013.10.004 · Cited by 12 · see citing works
The polymorphism of the serotonin-2A receptor T102C is associated with age
Jobim, P. F. C., do Prado‐Lima, P. A. S., Schwanke, C. H. A., Giugliani, R., & da Cruz, I. B. M. (2008) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2008005000045 · Cited by 12 · see citing works
Kulminski, A. M., Loika, Y., Huang, J. V., Arbeev, K. G., Bagley, O., Ukraintseva, S. V., Yashin, A. I., & Culminskaya, I. V. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00433 · Cited by 12 · see citing works
Biased survival expectations and behaviours: Does domain specific information matter?
Costa‐Font, J., & Vilaplana‐Prieto, C. (2022) · Journal of Risk and Uncertainty · doi:10.1007/s11166-022-09382-z · Cited by 11 · see citing works
Has the time come to take on time itself?
Farrelly, C. (2008) · BMJ · doi:10.1136/bmj.a414 · Cited by 11 · see citing works
Ottenheim, N. R., Kromhout, D., de Craen, A. J. M., Geleijnse, J. M., van der Mast, R. C., Zitman, F. G., Westendorp, R. G. J., Slagboom, P. E., & Giltay, E. J. (2011) · AGE · doi:10.1007/s11357-011-9236-2 · Cited by 11 · see citing works
Protective Effects of Familial Longevity Decrease With Age and Become Negligible for Centenarians
Gavrilova, N. S., & Gavrilov, L. A. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab380 · Cited by 11 · see citing works
Bortz, W. M. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp164 · Cited by 11 · see citing works
Health-Related Phenotypes and Longevity in Danish Twins
Kulminski, A. M., Arbeev, K. G., Culminskaya, I. V., Ukraintseva, S. V., Christensen, K., & Yashin, A. I. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln051 · Cited by 10 · see citing works
Gall, J. L., & Ardaillou, R. (2009) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/s0001-4079(19)32590-7 · Cited by 10 · see citing works
Physical Activity and Sedentary Behavior at the End of the Human Lifespan
Hernández‐Vicente, A., Santos‐Lozano, A., Mayolas-Pi, C., Rodríguez‐Romo, G., Pareja-Galeano, H., Bustamante, N., Gómez-Trullén, E. M., Lucía, A., & Garatachea, N. (2019) · Journal of Aging and Physical Activity · doi:10.1123/japa.2018-0122 · Cited by 9 · see citing works
Less functional variants of TLR-1/-6/-10 genes are associated with age
Hamann, L., Kupčinskas, J., Berrocal-Almanza, L. C., Skiecevičienė, J., Franke, A., Nöthlings, U., & Schumann, R. R. (2015) · Immunity & Ageing · doi:10.1186/s12979-015-0034-z · Cited by 9 · see citing works
Absorption of orally administered gentamicin in infants with diarrhea.
Gemer, O., Zaltztein, E., & Gorodischer, R. (1983) · PubMed · Cited by 9 · see citing works
Genome integrity as a potential index of longevity in Ashkenazi Centenarian’s families
Andrawus, M., David, G. B., Terziyska, I., Sharvit, L. E., Bergman, A., Barzilai, N., Raj, S. M., Govindaraju, D. R., & Atzmon, G. (2024) · GeroScience · doi:10.1007/s11357-024-01178-0 · Cited by 8 · see citing works
Self-citationGoldman, D. P., Gaudette, É., & Cheng, W. (2016) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2015.12.005 · Cited by 8 · see citing works
Zebrafish Aging Models and Possible Interventions
Celebi-Birand, D., Erbaba, B., Ozdemir, A. T., Kafalıgönül, H., & Adams, M. M. (2018) · InTech eBooks · doi:10.5772/intechopen.75554 · Cited by 8 · see citing works
Inter-chromosomal level of genome organization and longevity-related phenotypes in humans
Kulminski, A. M., Culminskaya, I. V., & Yashin, A. I. (2012) · AGE · doi:10.1007/s11357-011-9374-6 · Cited by 6 · see citing works
Tanguay, R. M., & Morrow, G. (2008) · Springer eBooks · doi:10.1007/978-1-4020-8231-3_16 · Cited by 6 · see citing works
Targeted protein degradation: from small molecules to complex organelles—a Keystone Symposia report
Cable, J., Weber-Ban, E. U., Clausen, T., Walters, K. J., Sharon, M., Finley, D. J., Gu, Y., Hanna, J. W., Feng, Y., Martens, S., et al. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14745 · Cited by 6 · see citing works
Rattan, S. I. S. (2018) · Wiley eBooks · doi:10.1002/9780470015902.a0003059.pub3 · Cited by 6 · see citing works
Mitochondriogenesis Genes and Extreme Longevity
Santiago, C., Garatachea, N., Yvert, T. P., Rodríguez‐Romo, G., Santos‐Lozano, A., Fiuza‐Luces, C., & Lucía, A. (2012) · Rejuvenation Research · doi:10.1089/rej.2012.1382 · Cited by 5 · see citing works
Boutwell, B. B., Narvey, C. S., Helton, J. J., & Piquero, A. R. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03440-6 · Cited by 4 · see citing works
Ossification timeline of sesamoid bones at metatarsophalangeal joints
Sun, T., Li, Q., Wang, L., Hou, X., Zhao, H., Niu, M., Zhang, T., & Wu, W. (2020) · Anatomical Science International · doi:10.1007/s12565-020-00556-w · Cited by 3 · see citing works
The transformative promise of aging science
Stipp, D. (2012) · Cell Cycle · doi:10.4161/cc.22211 · Cited by 3 · see citing works
Liu, Y., Zhang, J., Zeng, Y., Liu, Y., & Shidujamam, M. (2024) · Lecture notes in computer science · doi:10.1007/978-3-031-76809-5_9 · Cited by 2 · see citing works
Kulminski, A. M., Arbeev, K. G., Christensen, K., Stallard, E., Miljkovic, I., Barmada, M. M., & Yashin, A. I. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls243 · Cited by 2 · see citing works
- Authors
- Martin, G. M., Bergman, A., & Barzilai, N.
- Affiliations
- University of Washington (US)
- Johns Hopkins University (US)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Martin, George M
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2007-07-27
- Volume
- 3
- Issue
- 7
- Pages
- e125
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- PMC
- PMC1934400
- OpenAlex
- W2084026374
- Cited by
- 120
- References
- 115
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 1 · 2016: 5 · 2015: 8 · 2014: 5 · 2013: 10 · 2012: 6
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- PLoS Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P01AG021654, P01AG001751, P30 AG01751, R01AG018381, P50 AG05136-17, U01AG007198, P50AG005136, R01AG019711)
- National Cancer Institute (R24CA078088)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- human aging, healthspan, lifespan, progeroid syndromes, geriatric disorders, genetic susceptibility, longevity, chromosome 4, genetic polymorphism, physiological decline, genetic determinants of aging
- MeSH terms
- Aging, Alleles, Chromosome Mapping, Health, Health Status, Humans, Life Expectancy, Genetic Linkage, Longevity, Models, Genetic, Polymorphism, Genetic, Progeria, Risk Factors, Syndrome, Genome, Human
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
