Karin, Michael

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

Maeda, S., Chang, L., Li, Z.-W., Luo, J.-L., Leffert, H., & Karin, M. (2003) · Immunity

NF-κB Signaling PathwaysCell death mechanisms and regulation

Cited by 286

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

Solinas, G., Naugler, W., Galimi, F., Lee, M.-S., & Karin, M. (2006) · Proceedings of the National Academy of Sciences

Pancreatic function and diabetesAdipokines, Inflammation, and Metabolic Diseases

Cited by 284

A sestrin-dependent Erk–Jnk–p38 MAPK activation complex inhibits immunity during aging

Lanna, A., Gomes, D. C. O., Muller-Durovic, B., McDonnell, T., Escors, D., Gilroy, D. W., Lee, J. H., Karin, M., & Akbar, A. N. (2017) · Nature Immunology

T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

Cited by 284

IκB kinase (IKK)β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss

Ruocco, M. G., Maeda, S., Park, J. M., Lawrence, T., Hsu, L.-C., Cao, Y., Schett, G., Wagner, E. F., & Karin, M. (2005) · The Journal of Experimental Medicine

Bone Metabolism and DiseasesNF-κB Signaling Pathways

Cited by 252

Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis

Gao, H., Jin, Z., Bandyopadhyay, G., Wang, G., Zhang, D., Rocha, K. C. E., Liu, X., Zhao, H., Kisseleva, T., Brenner, D. A., et al. (2022) · Cell Metabolism

Liver Disease Diagnosis and TreatmentIron Metabolism and Disorders

Cited by 224

Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome

Su, H., Yang, F., Fu, R., Trinh, B., Sun, N., Liu, J., Kumar, A., Baglieri, J., Siruno, J., Le, M., et al. (2022) · Nature

Pancreatic and Hepatic Oncology ResearchProtease and Inhibitor Mechanisms

Cited by 221

IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease

Ma, H.-Y., Yamamoto, G., Xu, J., Liu, X., Karin, D., Kim, J. Y., Alexandrov, L. B., Koyama, Y., Nishio, T., Benner, C., et al. (2020) · Journal of Hepatology

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 216

IκB kinase-α acts in the epidermis to control skeletal and craniofacial morphogenesis

Sil, A. K., Maeda, S., Sano, Y., Roop, D. R., & Karin, M. (2004) · Nature

Developmental Biology and Gene RegulationNF-κB Signaling Pathways

Cited by 211

Stressin’ Sestrins take an aging fight

Budanov, A. V., Lee, J. H., & Karin, M. (2010) · EMBO Molecular Medicine

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 208

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

Stebbins, J. L., De, S. K., Machleidt, T., Becattini, B., Vazquez, J., Kuntzen, C., Chen, L.-H., Cellitti, J. F., Riel-Mehan, M., Emdadi, A., et al. (2008) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 186

A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse

Moles, A., Murphy, L., Wilson, C. L., Chakraborty, J. B., Fox, C., Park, E. J., Mann, J., Oakley, F., Howarth, R., Brain, J., et al. (2014) · Journal of Hepatology

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 169

NF-κB: a double-edged sword controlling inflammation

Liu, D., Zhong, Z., & Karin, M. (2022) · Biomedicines

NF-κB Signaling PathwaysImmune Response and Inflammation

Cited by 157

Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals

Segalés, J., Perdiguero, E., Serrano, A. L., Sousa-Victor, P., Ortet, L., Jardí, M., Budanov, A. V., Garcia-Prat, L., Sandri, M., Thomson, D. M., et al. (2020) · Nature Communications

Muscle Physiology and DisordersNutrition and Health in Aging

Cited by 153

The Chemokine CXCL16 and Its Receptor, CXCR6, as Markers and Promoters of Inflammation-Associated Cancers

Darash-Yahana, M., Gillespie, J. W., Hewitt, S. M., Chen, Y.-Y. K., Maeda, S., Stein, I., Singh, S. P., Bedolla, R. B., Peled, A., Troyer, D. A., et al. (2009) · PLoS ONE

Chemokine receptors and signalingInflammatory Biomarkers in Disease Prognosis

Cited by 143

Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer

McLoed, A. G., Sherrill, T. P., Cheng, D.-S., Han, W., Saxon, J. A., Gleaves, L. A., Wu, P., Polosukhin, V. V., Karin, M., Yull, F. E., et al. (2016) · Cell Reports

NF-κB Signaling PathwaysImmune cells in cancer

Cited by 107

Nadph oxidase 1 in liver macrophages promotes inflammation and tumor development in mice

Liang, S., Ma, H.-Y., Zhong, Z., Dhar, D., Liu, X., Xu, J., Koyama, Y., Nishio, T., Karin, D., Karin, G., et al. (2019) · Gastroenterology

Redox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 92

Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression

Guma, M., Rius, J., Duong-Polk, K. X., Haddad, G. G., Lindsey, J. D., & Karin, M. (2009) · Proceedings of the National Academy of Sciences

Retinopathy of Prematurity StudiesRetinal Diseases and Treatments

Cited by 80

JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration

Du, H., Sun, X., Guma, M., Luo, J., Ouyang, H., Zhang, X., Zeng, J., Quach, J., Nguyen, D. H., Shaw, P. X., et al. (2013) · Proceedings of the National Academy of Sciences

Retinal Diseases and TreatmentsOcular Diseases and Behçet’s Syndrome

Cited by 74

The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-β production

Mahieu, T., Park, J. M., Revets, H., Pasche, B., Lengeling, A., Staelens, J., Wullaert, A., Vanlaere, I., Hochepied, T., van Roy, F., et al. (2006) · Proceedings of the National Academy of Sciences

Immune Response and Inflammationinterferon and immune responses

Cited by 70

Publisher Correction: The gut–liver axis and the intersection with the microbiome

Tripathi, A., Debelius, J., Brenner, D. A., Karin, M., Loomba, R., Schnabl, B., & Knight, R. (2018) · Nature Reviews Gastroenterology & Hepatology

Gut microbiota and healthAlcohol Consumption and Health Effects

Cited by 70

Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC

Boslem, E., Reibe, S., Carlessi, R., Smeuninx, B., Tegegne, S., Egan, C. L., McLennan, E., Terry, L. V., Nobis, M., Mu, A., et al. (2023) · Science Advances

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 39

Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR3

Wilson, C. L., Mann, J., Walsh, M., Perrugoria, M. J., Oakley, F., Wright, M. C., Brignole, C., Di Paolo, D., Perri, P., Ponzoni, M., et al. (2014) · PLoS ONE

Immune Response and InflammationLiver physiology and pathology

Cited by 31

Metabolic injury of hepatocytes promotes progression of NAFLD and AALD

Carvalho-Gontijo, R., Han, C., Zhang, L., Zhang, V., Hosseini, M., Mekeel, K., Schnabl, B., Loomba, R., Karin, M., Brenner, D. A., et al. (2022) · Seminars in Liver Disease

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 23