Karin, Michael

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

Rius, J., Guma, M., Schachtrup, C., Akassoglou, K., Zinkernagel, A. S., Nizet, V., Johnson, R. S., Haddad, G. G., & Karin, M. (2008) · Nature

NF-κB Signaling PathwaysCancer, Hypoxia, and Metabolism

Cited by 1,614

The gut-liver axis and the intersection with the microbiome

Tripathi, A., Debelius, J., Brenner, D. A., Karin, M., Loomba, R., Schnabl, B., & Knight, R. (2018) · Nature Reviews Gastroenterology & Hepatology

Gut microbiota and healthLiver Disease Diagnosis and Treatment

Cited by 1,480

The IKK NF-κB system: a treasure trove for drug development

Karin, M., Yamamoto, Y., & Wang, Q. M. (2004) · Nature Reviews Drug Discovery

NF-κB Signaling PathwaysNatural Compounds in Disease Treatment

Cited by 1,364

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., & Cai, D. (2008) · Cell

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,350

Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Grivennikov, S. I., Wang, K., Mucida, D., Stewart, C. A., Schnabl, B., Jauch, D., Taniguchi, K., Yu, G.-Y., Österreicher, C. H., Hung, K. E., et al. (2012) · Nature

Cancer Immunotherapy and BiomarkersIL-33, ST2, and ILC Pathways

Cited by 1,327

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

Budanov, A. V., & Karin, M. (2008) · Cell

PI3K/AKT/mTOR signaling in cancerCancer-related Molecular Pathways

Cited by 1,326

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

Angel, P., Hattori, K., Smeal, T., & Karin, M. (1988) · Cell

Protein Kinase Regulation and GTPase SignalingGenomics and Chromatin Dynamics

Cited by 1,239

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

Zhong, Z., Liang, S., Sanchez-Lopez, E., He, F., Shalapour, S., Lin, X.-J., Wong, J., Ding, S., Seki, E., Schnabl, B., et al. (2018) · Nature

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 1,208

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

Zhong, Z., Umemura, A., Sanchez-Lopez, E., Liang, S., Shalapour, S., Wong, J., He, F., Boassa, D., Perkins, G., Ali, S. R., et al. (2016) · Cell

Inflammasome and immune disordersNF-κB Signaling Pathways

Cited by 1,197

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

Grivennikov, S. I., & Karin, M. (2010) · Cytokine & Growth Factor Reviews

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 1,160

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

Kim, S., Takahashi, H., Lin, W.-W., Descargues, P., Grivennikov, S., Kim, Y., Luo, J.-L., & Karin, M. (2009) · Nature

Immune cells in cancerProteoglycans and glycosaminoglycans research

Cited by 1,100

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

Angel, P., Allegretto, E. A., Okino, S. T., Hattori, K., Boyle, W. J., Hunter, T., & Karin, M. (1988) · Nature

Genomics and Chromatin DynamicsProtein Kinase Regulation and GTPase Signaling

Cited by 907

AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs

Chen, C.-Y., Gherzi, R., Ong, S.-E., Chan, E. L., Raijmakers, R., Pruijn, G. J. M., Stoecklin, G., Moroni, C., Mann, M., & Karin, M. (2001) · Cell

RNA Research and SplicingRNA regulation and disease

Cited by 865

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

Xian, H., Watari, K., Sanchez-Lopez, E., Offenberger, J., Onyuru, J., Sampath, H., Ying, W., Hoffman, H. M., Shadel, G. S., & Karin, M. (2022) · Immunity

Inflammasome and immune disordersMitochondrial Function and Pathology

Cited by 850

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

Smeal, T., Binetruy, B., Mercola, D. A., Birrer, M., & Karin, M. (1991) · Nature

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 789

Reparative inflammation takes charge of tissue regeneration

Karin, M., & Clevers, H. (2016) · Nature

Wound Healing and TreatmentsLiver physiology and pathology

Cited by 767

Mitogen-activated protein kinase cascades and regulation of gene expression

Su, B., & Karin, M. (1996) · Current Opinion in Immunology

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 747

Prevention of fat-induced insulin resistance by salicylate

Kim, J. K., Kim, Y.-J., Fillmore, J. J., Chen, Y., Moore, I., Lee, J., Yuan, M., Li, Z. W., Karin, M., Perret, P., et al. (2001) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 737

The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer

Naugler, W. E., & Karin, M. (2008) · Trends in Molecular Medicine

Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic Diseases

Cited by 730

Inhibition of JNK activation through NF-κB target genes

Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., & Lin, A. (2001) · Nature

NF-κB Signaling PathwaysCell death mechanisms and regulation

Cited by 721

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

Didonato, J., Mercurio, F., Rosette, C., Wu-Li, J., Suyang, H., Ghosh, S., & Karin, M. (1996) · Molecular and Cellular Biology

NF-κB Signaling PathwaysImmune Response and Inflammation

Cited by 707

The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover

Chang, L., Kamata, H., Solinas, G., Luo, J.-L., Maeda, S., Venuprasad, K., Liu, Y.-C., & Karin, M. (2006) · Cell

NF-κB Signaling PathwaysUbiquitin and proteasome pathways

Cited by 706

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

Wolf, M. J., Adili, A., Piotrowitz, K., Abdullah, Z., Boege, Y., Stemmer, K., Ringelhan, M., Simonavicius, N., Egger, M., Wohlleber, D., et al. (2014) · Cancer Cell

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 678

Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression

Doedens, A. L., Stockmann, C., Rubinstein, M. P., Liao, D., Zhang, N., DeNardo, D. G., Coussens, L. M., Karin, M., Goldrath, A. W., & Johnson, R. S. (2010) · Cancer Research

Immune cells in cancerCancer, Hypoxia, and Metabolism

Cited by 652