Stressin’ Sestrins take an aging fight

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works

p53, the cellular gatekeeper for growth and division

Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693 · see citing works

Signal integration in the endoplasmic reticulum unfolded protein response

Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,308 · see citing works

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787 · see citing works

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649 · see citing works

Alzheimer’s disease

Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works

Autophagy regulates lipid metabolism

Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975 · see citing works

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914 · see citing works

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882 · see citing works

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849 · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

Blinded by the Light: The Growing Complexity of p53

Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163 · see citing works

Defining the role of mTOR in cancer

Guertin, D. A., & Sabatini, D. M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.05.008 · Cited by 2,833 · see citing works

A model for p53-induced apoptosis

Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500 · see citing works

T antigen is bound to a host protein in SY40-transformed cells

Lane, D. P., & Crawford, L. V. (1979) · Nature · doi:10.1038/278261a0 · Cited by 2,443 · see citing works

Cellular response to oxidative stress: Signaling for suicide and survival *

Martindale, J., & Holbrook, N. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10119 · Cited by 2,392 · see citing works

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347 · see citing works

mTOR signaling at a glance

Laplante, M., & Sabatini, D. (2009) · Journal of Cell Science · doi:10.1242/jcs.051011 · Cited by 2,317 · see citing works

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277 · see citing works

p53 in health and disease

Vousden, K. H., & Lane, D. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2147 · Cited by 2,275 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., et al. (2008) · Autophagy · doi:10.4161/auto.5338 · Cited by 2,230 · see citing works

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S.-I., Natsume, T., Takehana, K., Yamada, N., et al. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1248 · Cited by 2,076 · see citing works

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

Jung, C. H., Jun, C. B., Ro, S.-H., Kim, Y.-M., Otto, N. M., Cao, J., Kundu, M., & Kim, D.-H. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1249 · Cited by 2,025 · see citing works

TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N. C., Nakano, K., Bartrons, R., Gottlieb, E., & Vousden, K. H. (2006) · Cell · doi:10.1016/j.cell.2006.05.036 · Cited by 2,019 · see citing works

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulatorsPreprint

Morimoto, R. I. (1998) · Genes & Development · doi:10.1101/gad.12.24.3788 · Cited by 1,898 · see citing works

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., & Guo, M. (2006) · Nature · doi:10.1038/nature04779 · Cited by 1,788 · see citing works

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

Park, J., Lee, S. B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.-M., et al. (2006) · Nature · doi:10.1038/nature04788 · Cited by 1,705 · see citing works

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., & Goldschmidt-Clermont, P. J. (1997) · Science · doi:10.1126/science.275.5306.1649 · Cited by 1,588 · see citing works

Oxidant signals and oxidative stress

Finkel, T. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00002-4 · Cited by 1,393 · see citing works

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

Budanov, A. V., & Karin, M. (2008) · Cell · doi:10.1016/j.cell.2008.06.028 · Cited by 1,326 · see citing works

Intrinsic tumour suppression

Lowe, S. W., Cepero, E., & Evan, G. I. (2004) · Nature · doi:10.1038/nature03098 · Cited by 1,309 · see citing works

Diversity of gene expression in adenocarcinoma of the lung

Garber, M. E., Troyanskaya, O. G., Schlüns, K., Petersen, S., Thäsler, Z., Pacyna-Gengelbach, M., van de Rijn, M., Rosen, G., Perou, C. M., Whyte, R. I., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241500798 · Cited by 1,301 · see citing works

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293 · see citing works

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005) · Science · doi:10.1126/science.1115535 · Cited by 1,293 · see citing works

The coordinate regulation of the p53 and mTOR pathways in cells

Feng, Z., Zhang, H., Levine, A. J., & Jin, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502857102 · Cited by 1,235 · see citing works

Mitochondrial pathology and apoptotic muscle degeneration in <i>Drosophila parkin</i> mutants

Greene, J. C., Whitworth, A. J., Kuo, I., Andrews, L. A., Feany, M. B., & Pallanck, L. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737556100 · Cited by 1,203 · see citing works

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120 · see citing works

The antioxidant function of the p53 tumor suppressor

Sablina, A. A., Budanov, A. V., Ilyinskaya, G. V., Agapova, L. S., Kravchenko, J. E., & Chumakov, P. M. (2005) · Nature Medicine · doi:10.1038/nm1320 · Cited by 1,110 · see citing works

Tumor suppressors and cell metabolism: a recipe for cancer growth

Jones, R. G., & Thompson, C. B. (2009) · Genes &amp; Development · doi:10.1101/gad.1756509 · Cited by 1,085 · see citing works

Current development of mTOR inhibitors as anticancer agents

Faivre, S. J., Kroemer, G., & Raymond, É. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2062 · Cited by 998 · see citing works

ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin

Biteau, B., Labarre, J., & Tolédano, M. B. (2003) · Nature · doi:10.1038/nature02075 · Cited by 970 · see citing works

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

Hu, W., Zhang, C., Wu, R., Sun, Y., Levine, A., & Feng, Z. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001006107 · Cited by 862 · see citing works

DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein

Tran, H. G., Brunet, A., Grenier, J. M., Datta, S. R., Fornace, A. J., DiStefano, P. S., Chiang, L. W., & Greenberg, M. E. (2002) · Science · doi:10.1126/science.1068712 · Cited by 860 · see citing works

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

Nogueira, V., Park, Y., Chen, C.-C., Xu, P.-Z., Chen, M.-L., Tonic, I., Unterman, T., & Hay, N. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.11.003 · Cited by 780 · see citing works

Autophagy regulates adipose mass and differentiation in mice

Singh, R., Xiang, Y., Wang, Y., Baikati, K., Cuervo, A. M., Luu, Y. K., Tang, Y., Pessin, J. E., Schwartz, G. J., & Czaja, M. J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39228 · Cited by 748 · see citing works

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

Budanov, A. V., Sablina, A. A., Feinstein, E., Koonin, E. V., & Chumakov, P. M. (2004) · Science · doi:10.1126/science.1095569 · Cited by 731 · see citing works

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Alexander, A., Cai, S.-L., Kim, J., Nanez, A., Sahin, M., MacLean, K. H., Inoki, K., Guan, K.-L., Shen, J., Person, M. D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913860107 · Cited by 717 · see citing works

Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins

Rhee, S. G., Kang, S. W., Jeong, W., Chang, T.-S., Yang, K., & Woo, H. A. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.02.004 · Cited by 709 · see citing works

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

Kapahi, P., Chen, D., Rogers, A. N., Katewa, S. D., Li, P. W.-L., Thomas, E., & Kockel, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.001 · Cited by 663 · see citing works

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

Shaw, R. J. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01972.x · Cited by 644 · see citing works

Adipose-specific deletion of <i>autophagy-related gene 7</i> ( <i>atg7</i> ) in mice reveals a role in adipogenesis

Zhang, Y., Goldman, S., Baerga, R., Zhao, Y., Komatsu, M., & Jin, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906048106 · Cited by 634 · see citing works

An Emerging Role of mTOR in Lipid Biosynthesis

Laplante, M., & Sabatini, D. M. (2009) · Current Biology · doi:10.1016/j.cub.2009.09.058 · Cited by 614 · see citing works

FoxO transcription factors in the maintenance of cellular homeostasis during aging

Salih, D. A., & Brunet, A. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.02.005 · Cited by 604 · see citing works

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E., et al. (2010) · Science · doi:10.1126/science.1182228 · Cited by 570 · see citing works

JNK Extends Life Span and Limits Growth by Antagonizing Cellular and Organism-Wide Responses to Insulin Signaling

Wang, M. C., Bohmann, D., & Jasper, H. (2005) · Cell · doi:10.1016/j.cell.2005.02.030 · Cited by 537 · see citing works

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

Papadia, S., Soriano, F. X., Léveillé, F., Martel, M.-A., Dakin, K. A., Hansen, H. H., Kaindl, A., Sifringer, M., Fowler, J., Stefovska, V., et al. (2008) · Nature Neuroscience · doi:10.1038/nn2071 · Cited by 498 · see citing works

mTOR Complex1–S6K1 signaling: at the crossroads of obesity, diabetes and cancer

Dann, S. G., Selvaraj, A., & Thomas, G. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.04.002 · Cited by 481 · see citing works

Delayed ageing through damage protection by the Arf/p53 pathway

Matheu, A., Maraver, A., Klatt, P., Flores, I., Garcia-Cao, I., Borras, C., Flores, J. M., Viña, J., Blasco, M. A., & Serrano, M. (2007) · Nature · doi:10.1038/nature05949 · Cited by 466 · see citing works

Rapamycin Protects against Neuron Death inIn VitroandIn VivoModels of Parkinson's Disease

Malagelada, C., Jin, Z. H., Jackson-Lewis, V. R., Przedborski, S., & Greene, L. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3944-09.2010 · Cited by 458 · see citing works

Metallothioneins: Proteins in search of function

Karin, M. (1985) · Cell · doi:10.1016/0092-8674(85)90051-0 · Cited by 442 · see citing works

Metabolic Enzymes of Mycobacteria Linked to Antioxidant Defense by a Thioredoxin-Like Protein

Bryk, R., Lima, C. D., Erdjument‐Bromage, H., Tempst, P., & Nathan, C. (2002) · Science · doi:10.1126/science.1067798 · Cited by 400 · see citing works

Characterization of Mammalian Sulfiredoxin and Its Reactivation of Hyperoxidized Peroxiredoxin through Reduction of Cysteine Sulfinic Acid in the Active Site to Cysteine

Chang, T.-S., Jeong, W., Woo, H. A., Lee, S. M., Park, S., & Rhee, S. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409482200 · Cited by 388 · see citing works

AMPK alterations in cardiac physiology and pathology: enemy or ally?

Dyck, J. R. B., & Lopaschuk, G. D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.109389 · Cited by 386 · see citing works

p53-Induced Up-Regulation of MnSOD and GPx but not Catalase Increases Oxidative Stress and Apoptosis

Hussain, S. P., Amstad, P., He, P., Robles, A. I., Lupold, S. E., Kaneko, I., Ichimiya, M., Sengupta, S., Mechanic, L. E., Okamura, S., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-2287-2 · Cited by 385 · see citing works

Aging: ROS or TOR

Blagosklonny, M. V. (2008) · Cell Cycle · doi:10.4161/cc.7.21.6965 · Cited by 375 · see citing works

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

Chen, C.-C., Jeon, S., Bhaskar, P. T., Nogueira, V., Sundararajan, D., Tonic, I., Park, Y., & Hay, N. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.03.008 · Cited by 369 · see citing works

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

Singh, A. K., Riederer, B., Krabbenhöft, A., Rausch, B., Bonhagen, J., Lehmann, U., de Jonge, H. R., Donowitz, M., Yun, C. C., Weinman, E. J., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35541 · Cited by 364 · see citing works

Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

Budanov, A. V., Shoshani, T., Faerman, A., Zelin, E., Kamer, I., Kalinski, H., Gorodin, S., Fishman, A., Chajut, A., Einat, P., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205877 · Cited by 363 · see citing works

The TOR pathway comes of age

Stanfel, M. N., Shamieh, L. S., Kaeberlein, M. R., & Kennedy, B. K. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.007 · Cited by 339 · see citing works

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

Tain, L. S., Mortiboys, H., Tao, R. N., Ziviani, E., Bandmann, O., & Whitworth, A. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2372 · Cited by 323 · see citing works

Insulin regulation of heart function in aging fruit flies

Wessells, R. J., Fitzgerald, E., Cypser, J. R., Tatar, M., & Bodmer, R. (2004) · Nature Genetics · doi:10.1038/ng1476 · Cited by 319 · see citing works

Stimulation of autophagy by the p53 target gene Sestrin2

Maiuri, M. C., Malik, S. A., Morselli, E., Kepp, O., Criollo, A., Mouchel, P., Carnuccio, R., & Kroemer, G. (2009) · Cell Cycle · doi:10.4161/cc.8.10.8498 · Cited by 278 · see citing works

Phosphoproteome Analysis of Drosophila melanogaster Embryos

Zhai, B., Villén, J., Beausoleil, S. A., Mintseris, J., & Gygi, S. P. (2008) · Journal of Proteome Research · doi:10.1021/pr700696a · Cited by 271 · see citing works

Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations

Feng, Z., Hu, W., Teresky, A. K., Hernando, E., Cordon-Cardo, C., & Levine, A. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708043104 · Cited by 264 · see citing works

Disruption of the gene encoding the latent transforming growth factor-β binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancerPreprint

Sterner‐Kock, A., Thorey, I. S., Koli, K. M., Wempe, F., Otte, J., Bangsow, T., Kuhlmeier, K., Kirchner, T., Jin, S., Keski‐Oja, J., et al. (2002) · Genes & Development · doi:10.1101/gad.229102 · Cited by 255 · see citing works

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

Velasco-Miguel, S., Buckbinder, L., Jean, P., Gelbert, L., Talbott, R. L., Laidlaw, J. L., Seizinger, B. R., & Kley, N. (1999) · Oncogene · doi:10.1038/sj.onc.1202274 · Cited by 249 · see citing works

Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

Chen, L., Xu, B., Liu, L., Luo, Y., Yin, J., Zhou, H., Chen, W., Shen, T., Han, X., & Huang, S. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.36 · Cited by 236 · see citing works

Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses

Yoon, K., Nakamura, Y., & Arakawa, H. (2004) · Journal of Human Genetics · doi:10.1007/s10038-003-0122-3 · Cited by 236 · see citing works

Autophagy in health and disease. 5. Mitophagy as a way of life

Gottlieb, R. A., & Carreira, R. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00097.2010 · Cited by 228 · see citing works

A New Fork for Clinical Application: Targeting Forkhead Transcription Factors in Cancer

Yang, J.-Y., & Hung, M. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0124 · Cited by 227 · see citing works

Huntington’s disease: degradation of mutant huntingtin by autophagy

Sarkar, S., & Rubinsztein, D. C. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06562.x · Cited by 207 · see citing works

Molecular and clinical prodrome of Parkinson disease: implications for treatment

Schapira, A. H. V., & TOLOSA, E. S. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.52 · Cited by 199 · see citing works

Antioxidants protect PINK1 -dependent dopaminergic neurons in Drosophila

Wang, D., Li, Q., Xiong, H., Liu, J., Neckameyer, W. S., Oldham, S., Xia, K., Wang, J., Bodmer, R., & Zhang, Z. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604661103 · Cited by 196 · see citing works

Rapamycin confers preconditioning-like protection against ischemia–reperfusion injury in isolated mouse heart and cardiomyocytes

Khan, S. A., Salloum, F. N., Das, A., Xi, L., Vetrovec, G. W., & Kukreja, R. C. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.04.014 · Cited by 189 · see citing works

The mTOR pathway and its role in human genetic diseases

ROSNER, M., Hanneder, M., Siegel, N., Valli, A., Fuchs, C., & HENGSTSCHLAGER, M. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.06.001 · Cited by 182 · see citing works

Autophagy genes and ageing

Vellai, T. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.126 · Cited by 169 · see citing works

Converging Pathways in Lifespan Regulation

Narasimhan, S. D., Yen, K., & Tissenbaum, H. A. (2009) · Current Biology · doi:10.1016/j.cub.2009.06.013 · Cited by 165 · see citing works

AMP‐activated protein kinase and cancer

Wang, W., & Guan, K. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01980.x · Cited by 163 · see citing works

Loss of heterozygosity at chromosome 1p in different solid human tumours: association with survival

Ragnarsson, G., Eiriksdottir, G., Johannsdottir, J. T., Jonasson, J. G., Egilsson, V., & Ingvarsson, S. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690234 · Cited by 159 · see citing works

Tumor Protein 53–Induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function

Cano, C. E., Gommeaux, J., Pietri, S., Culcasi, M., Garcia, S., Seux, M., Barelier, S., Vasseur, S., Spoto, R. P., Pébusque, M., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2320 · Cited by 153 · see citing works

Rapamycin Protects Against High Fat Diet–Induced Obesity in C57BL/6J Mice

Chang, G., Chiu, Y., Wu, Y., Chen, W., Liao, J., Chao, T., & Mao, F. C. (2009) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08215fp · Cited by 146 · see citing works

Repression of Sestrin Family Genes Contributes to Oncogenic Ras-Induced Reactive Oxygen Species Up-regulation and Genetic Instability

Kopnin, P., Agapova, L. S., Kopnin, B. P., & Chumakov, P. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2466 · Cited by 146 · see citing works

KSR2 Is an Essential Regulator of AMP Kinase, Energy Expenditure, and Insulin Sensitivity

Costanzo-Garvey, D. L., Pfluger, P. T., Dougherty, M. K., Stock, J. L., Boehm, M. B., Chaika, O. V., Fernandez, M. R., Fisher, K. W., Kortum, R. L., Hong, E., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.010 · Cited by 145 · see citing works

Regulation of Protein Synthesis by Ionizing Radiation

Braunstein, S. E., Badura, M. L., Xi, Q., Formenti, S. C., & Schneider, R. J. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00711-09 · Cited by 138 · see citing works

Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen.

Oren, M., & Levine, A. J. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.1.56 · Cited by 130 · see citing works

PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse

Peeters, H., Debeer, P., Bairoch, A., Wilquet, V., Huysmans, C., Parthoens, E., Fryns, J. P., Gewillig, M. H. M. L., Nakamura, Y., Niikawa, N., et al. (2003) · Human Genetics · doi:10.1007/s00439-003-0917-5 · Cited by 117 · see citing works

Transforming Growth Factor-β Signaling across Ages: From Distorted Lung Development to Chronic Obstructive Pulmonary Disease

Morty, R. E., Königshoff, M., & Eickelberg, O. (2009) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200908-087rm · Cited by 114 · see citing works

Sestrin 2 Is Not a Reductase for Cysteine Sulfinic Acid of Peroxiredoxins

Woo, H. A., Bae, S. H., Park, S., & Rhee, S. G. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2360 · Cited by 96 · see citing works

Role of sestrin2 in peroxide signaling in macrophages

Essler, S., Dehne, N., & Brüne, B. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.017 · Cited by 90 · see citing works

d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila

Wessells, R. J., Fitzgerald, E., Piazza, N., Ocorr, K. A., Morley, S., Davies, C. R., Lim, H., Elmeń, L., Hayes, M., Oldham, S., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00504.x · Cited by 89 · see citing works

Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes.

Buckbinder, L., Talbott, R. L., Seizinger, B. R., & Kley, N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10640 · Cited by 81 · see citing works

Identification of amyloid β-peptide responsive genes by cDNA microarray technology: Involvement of RTP801 in amyloid β-peptide toxicity

Kim, J.-R., Lee, S.-R., Chung, H. J., Kim, S., Baek, S.-H., Kim, J. H., & Kim, Y.-S. (2003) · Experimental &amp; Molecular Medicine · doi:10.1038/emm.2003.53 · Cited by 78 · see citing works

Cellular context‐dependent “colors” of transforming growth factor‐β signaling

Ikushima, H., & Miyazono, K. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01441.x · Cited by 77 · see citing works

ROS up-regulation mediates Ras-induced changes of cell morphology and motility

Alexandrova, A. Y., Kopnin, P., Vasiliev, J. M., & Kopnin, B. P. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.03.004 · Cited by 77 · see citing works

Rapamycin inhibits hepatic fibrosis in rats by attenuating multiple profibrogenic pathways

Bridle, K. R., Popa, C., Morgan, M. L., Sobbe, A. L., Clouston, A. D., Fletcher, L. M., & Crawford, D. H. (2009) · Liver Transplantation · doi:10.1002/lt.21804 · Cited by 75 · see citing works

Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans

Hashimoto, Y., Ookuma, S., & Nishida, E. (2009) · Genes to Cells · doi:10.1111/j.1365-2443.2009.01306.x · Cited by 71 · see citing works

A Novel Antioxidant Function for the Tumor-Suppressor Gene p53 in the Retinal Ganglion Cell

O'Connor, J. C., Wallace, D., O'Brien, C. J., & Cotter, T. G. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1963 · Cited by 60 · see citing works

Electron Microscope Studies on Aging Drosophila melanogaster III. Flight Muscle

Takahashi, A., Philpott, D. E., & Miquel, J. (1970) · Journal of Gerontology · doi:10.1093/geronj/25.3.222 · Cited by 55 · see citing works

Inactivation of sestrin 2 induces TGF-β signaling and partially rescues pulmonary emphysema in a mouse model of COPD

Wempe, F., De-Zolt, S., Koli, K. M., Bangsow, T., Parajuli, N., Dumitrascu, R., Sterner‐Kock, A., Weißmann, N., Keski‐Oja, J., & von Melchner, H. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.004234 · Cited by 50 · see citing works

Differential Methylation Hybridization Array of Endometrial Cancers Reveals Two Novel Cancer-Specific Methylation Markers

Zighelboim, I., Goodfellow, P. J., Schmidt, A. P., Walls, K. C., Mallon, M. A., Mutch, D. G., Yan, P. S., Huang, T. H. ‐., & Powell, M. A. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2367 · Cited by 40 · see citing works

Role of p53 in antioxidant defense of HPV-positive cervical carcinoma cells following H2O2 exposure

Ding, B., Chi, S., Kim, S. H., Kang, S., Cho, J., Kim, D. S., & Cho, N. H. (2007) · Journal of Cell Science · doi:10.1242/jcs.002345 · Cited by 39 · see citing works

Rosiglitazone acts as a neuroprotectant in retinal cells via up‐regulation of sestrin‐1 and SOD‐2

Doonan, F., Wallace, D., O’Driscoll, C., & Cotter, T. G. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05995.x · Cited by 38 · see citing works

Electron microscope studies on aging Drosophila melanogaster. I

Miquel, J., Philpott, D. E., & Takahashi, A. (1970) · NASA Technical Reports Server (NASA) · Cited by 18 · see citing works

Burn Out or Fade Away?

Topisirović, I., & Sonenberg, N. (2010) · Science · doi:10.1126/science.1187497 · Cited by 13 · see citing works

A Xenopus homolog of a human p53-activated gene, PA26, is specifically expressed in the notochord

Hikasa, H., & Taira, M. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00519-0 · Cited by 12 · see citing works

[Isolation of a plasmid clone containing the mRNA sequence for mouse nonviral T-antigen].

Chumakov, P. M., Iotsova, V., & Georgiev, G. P. (1982) · PubMed · Cited by 10 · see citing works

Antioxidants put Parkinson flies back in the PINK

Bier, E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606288103 · Cited by 4 · see citing works

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

Robida-Stubbs, S., Glover-Cutter, K., Lamming, D. W., Mizunuma, M., Narasimhan, S. D., Neumann-Haefelin, E., Sabatini, D. M., & Blackwell, T. K. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.007 · Cited by 648 · see citing works

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

Demine, S., Renard, P., & Arnould, T. (2019) · Cells · doi:10.3390/cells8080795 · Cited by 476 · see citing works

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

Chantranupong, L., Wolfson, R. L., Orozco, J. M., Saxton, R. A., Scaria, S. M., Bar-Peled, L., Spooner, E., Isasa, M., Gygi, S. P., & Sabatini, D. M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.014 · Cited by 466 · see citing works

Metabolic regulation by p53

Maddocks, O. D. K., & Vousden, K. H. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0735-5 · Cited by 359 · see citing works

Sestrins inhibit mTORC1 kinase activation through the GATOR complex

Parmigiani, A., Nourbakhsh, A., Ding, B., Wang, W., Kim, Y. C., Akopiants, K., Guan, K.-L., Karin, M., & Budanov, A. V. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.019 · Cited by 336 · see citing works

Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Lee, J. H., Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H.-W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.004 · Cited by 295 · see citing works

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling

Peng, M., Yin, N., & Li, M. O. (2014) · Cell · doi:10.1016/j.cell.2014.08.038 · Cited by 220 · see citing works

Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

Kim, J. S., Ro, S.-H., Kim, M., Park, H.-W., Semple, I. A., Park, H., Cho, U., Wang, W., Guan, K., Karin, M., et al. (2015) · Scientific Reports · doi:10.1038/srep09502 · Cited by 177 · see citing works

GSK-3α is a central regulator of age-related pathologies in mice

Zhou, J., Freeman, T. A., Ahmad, F., Shang, X., Mangano, E. N., Gao, E., Farber, J. L., Wang, Y., Ma, X.-L., Woodgett, J. R., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64398 · Cited by 167 · see citing works

Sestrin2 promotes LKB1‐mediated AMPK activation in the ischemic heart

Morrison, A., Chen, L., Wang, J., Zhang, M., Yang, H. M., Ma, Y., Budanov, A. V., Lee, J. H., Karin, M., & Li, J. (2014) · The FASEB Journal · doi:10.1096/fj.14-258814 · Cited by 167 · see citing works

The role of tumor suppressor p53 in the antioxidant defense and metabolism

Budanov, A. V. (2014) · Subcellular Biochemistry · doi:10.1007/978-94-017-9211-0_18 · Cited by 157 · see citing works

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

Kim, H., An, S., Ro, S.-H., Teixeira, F., Park, G. J., Kim, C., Cho, C., Kim, J.-S., Jakob, U., Lee, J.-H., et al. (2015) · Nature Communications · doi:10.1038/ncomms10025 · Cited by 152 · see citing works

Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases

Pasha, M., Eid, A. H., Eid, A. A., Gorin, Y. C., & Munusamy, S. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3296294 · Cited by 154 · see citing works

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

Li, L., Ishdorj, G., & Gibson, S. B. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.011 · Cited by 153 · see citing works

Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner

Kim, G. T., Lee, S. H., Kim, J., & Kim, Y. M. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1658 · Cited by 146 · see citing works

The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1

Rhee, S. G., & Bae, S. H. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.007 · Cited by 141 · see citing works

Glucocorticoids, genes and brain function

Juszczak, G. R., & Stankiewicz, A. M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.11.020 · Cited by 135 · see citing works

<scp>TOR</scp>‐mediated regulation of metabolism in aging

Antikainen, H., Driscoll, M., Haspel, G., & Dobrowolski, R. (2017) · Aging Cell · doi:10.1111/acel.12689 · Cited by 122 · see citing works

Sestrin2 Modulates AMPK Subunit Expression and Its Response to Ionizing Radiation in Breast Cancer Cells

Sanli, T., Linher‐Melville, K., Tsakiridis, T. K., & Singh, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032035 · Cited by 130 · see citing works

A longer and healthier life with TOR down-regulation: genetics and drugs

Bjedov, I., & Partridge, L. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390460 · Cited by 128 · see citing works

The cytoplasmic side of p53's oncosuppressive activities

Comel, A., Sorrentino, G., Capaci, V., & Sal, G. D. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.04.015 · Cited by 126 · see citing works

Sestrin2 promotes Unc‐51‐like kinase 1 mediated phosphorylation of p62/sequestosome‐1

Ro, S., Semple, I. A., Park, H., Park, H., Park, H., Kim, M., Kim, J. S., & Lee, J. H. (2014) · FEBS Journal · doi:10.1111/febs.12905 · Cited by 123 · see citing works

Sestrin2 prevents age‐related intolerance to ischemia and reperfusion injury by modulating substrate metabolism

Quan, N., Sun, W., Wang, L., Xu, C., Bogan, J. S., Zhou, X., Cates, C. A., Liu, Q., Zheng, Y., & Li, J. (2017) · The FASEB Journal · doi:10.1096/fj.201700063r · Cited by 124 · see citing works

Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by integrating multi-hierarchical regulatory networks

Hu, S., Feng, J., Wang, M., Wufuer, R., Liu, K., Zhang, Z., & Zhang, Y. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102470 · Cited by 118 · see citing works

AMPK binds to Sestrins and mediates the effect of exercise to increase insulin-sensitivity through autophagy

Liu, X., Niu, Y., Yuan, H., Huang, J. Y., & Fu, L. (2015) · Metabolism · doi:10.1016/j.metabol.2015.01.015 · Cited by 116 · see citing works

Sestrins are evolutionarily conserved mediators of exercise benefits

Kim, M., Sujkowski, A. L., Namkoong, S., Gu, B., Cobb, T., Kim, B. Y., Kowalsky, A. H., Cho, C., Semple, I. A., Ro, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13442-5 · Cited by 116 · see citing works

Biochemical Basis Underlying Sestrins’ Physiological Activities

Ho, A., Cho, C., Namkoong, S., Cho, U., & Lee, J.-H. (2016) · TIBS -Trends in Biochemical Sciences. Regular ed · doi:10.1016/j.tibs.2016.04.005 · Cited by 110 · see citing works

NRF2 and p53: Januses in cancer?

Rotblat, B., Melino, G., & Knight, R. A. (2012) · Oncotarget · doi:10.18632/oncotarget.754 · Cited by 109 · see citing works

Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death

Ding, B., Parmigiani, A., Divakaruni, A. S., Archer, K. J., Murphy, A. N., & Budanov, A. V. (2016) · Scientific Reports · doi:10.1038/srep22538 · Cited by 108 · see citing works

SESN2/sestrin 2 induction-mediated autophagy and inhibitory effect of isorhapontigenin (ISO) on human bladder cancers

Liang, Y., Zhu, J., Huang, H., Xiang, D., Yang, L., Zhang, D., Li, J., Wang, Y., Jin, H., Jiang, G., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1179403 · Cited by 98 · see citing works

Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway

Quan, N., Wang, L., Chen, X., Luckett, C., Cates, C. A., Rousselle, T. V., Zheng, Y., & Li, J. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.01.005 · Cited by 94 · see citing works

mTORC1 and p53

Hasty, P., Sharp, Z. D., Curiel, T. J., & Campisi, J. (2012) · Cell Cycle · doi:10.4161/cc.22912 · Cited by 94 · see citing works

Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species

Ro, S., Nam, M., Jang, I., Park, H., Park, H., Semple, I. A., Kim, M., Kim, J. S., Park, H., Einat, P., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401787111 · Cited by 89 · see citing works

Sestrin2 protects dopaminergic cells against rotenone toxicity through AMPK-Dependent autophagy activation

Hou, Y.-S., Guan, J.-J., Xu, H.-D., Wu, F., Sheng, R., & Qin, Z.-H. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00285-15 · Cited by 87 · see citing works

P53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing

Deng, W., Cha, J., Yuan, J., Haraguchi, H., Bartos, A., Leishman, E., Viollet, B., Bradshaw, H. B., Hirota, Y., & Dey, S. K. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87715 · Cited by 85 · see citing works

The functions and roles of sestrins in regulating human diseases

Chen, Y., Huang, T., Yu, Z., Yu, Q., Wang, Y., Hu, J., Shi, J., & Yang, G. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-021-00302-8 · Cited by 85 · see citing works

The Emerging Role of Sestrin2 in Cell Metabolism, and Cardiovascular and Age-Related Diseases

Wanqing, S., Wang, Y., Yang, Z., & Quan, N. (2020) · Aging and Disease · doi:10.14336/ad.2019.0320 · Cited by 80 · see citing works

Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups

Shi, X.-D., Xu, L., Doycheva, D., Tang, J.-P., Yan, M., & Zhang, J. H. (2017) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1177/0271678x16656201 · Cited by 72 · see citing works

Cold atmospheric plasma induces apoptosis of melanoma cells via Sestrin2‐mediated nitric oxide synthase signaling

Xia, J., Zeng, W., Xia, Y., Wang, B., Xu, D., Liu, D., Kong, M. G., & Dong, Y. (2018) · Journal of Biophotonics · doi:10.1002/jbio.201800046 · Cited by 78 · see citing works

Age‐related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration

Álvarez-García, Ó., Matsuzaki, T., Olmer, M., Masuda, K., & Lotz, M. (2017) · Journal of Orthopaedic Research® · doi:10.1002/jor.23583 · Cited by 73 · see citing works

Crosstalk Between ROS and Autophagy in Tumorigenesis: Understanding the Multifaceted Paradox

Hasan, A., Rizvi, S. F., Parveen, S., Pathak, N., Nazir, A., & Mir, S. S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.852424 · Cited by 71 · see citing works

Mechanisms involved in alternariol-induced cell cycle arrest

Solhaug, A., Vines, L. L., Ivanova, L., Spilsberg, B., Holme, J. A., Pestka, J. J., Collins, A. R., & Eriksen, G. S. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2012.09.001 · Cited by 72 · see citing works

Drosophila melanogasteras a Model for Diabetes Type 2 Progression

Álvarez-Rendón, J. P., Salceda, R., & Riesgo‐Escovar, J. R. (2018) · BioMed Research International · doi:10.1155/2018/1417528 · Cited by 69 · see citing works

Knockdown of sestrin2 increases pro-inflammatory reactions and ER stress in the endothelium via an AMPK dependent mechanism

Hwang, H., Jung, T. W., Choi, J.-H., Lee, H. J., Chung, H. S., Seo, J. A., Kim, S. G., Kim, N. H., Choi, K. M., Choi, D. S., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.02.018 · Cited by 65 · see citing works

Sestrin2: Its Potential Role and Regulatory Mechanism in Host Immune Response in Diseases

Wang, L., Zhu, X.-M., & Yao, Y.-M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02797 · Cited by 68 · see citing works

Antioxidant Activity of Sestrin 2 Controls Neuropathic Pain After Peripheral Nerve Injury

Kallenborn-Gerhardt, W., Lu, R., Syhr, K. M. J., Heidler, J., von Melchner, H., Geißlinger, G., Bangsow, T., & Schmidtko, A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4958 · Cited by 66 · see citing works

SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation

Kumar, A. A., & Shaha, C. (2018) · Scientific Reports · doi:10.1038/s41598-017-19102-2 · Cited by 67 · see citing works

Sestrin2 Protein Positively Regulates AKT Enzyme Signaling and Survival in Human Squamous Cell Carcinoma and Melanoma Cells

Zhao, B., Shah, P., Budanov, A. V., Qiang, L., Ming, M., Aplin, A., Sims, D. M., & He, Y.-Y. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.595397 · Cited by 61 · see citing works

More targets, more pathways and more clues for mutant p53

Garritano, S., Inga, A., Gemignani, F., & Landi, S. (2013) · Oncogenesis · doi:10.1038/oncsis.2013.15 · Cited by 63 · see citing works

Sestrins in Physiological Stress Responses

Kim, M., Kowalsky, A. H., & Lee, J. H. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-031620-092317 · Cited by 62 · see citing works

Investigating the Role of Reactive Oxygen Species in Regulating Autophagy

Gibson, S. B. (2013) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-405881-1.00013-6 · Cited by 63 · see citing works

Gerosuppressant Metformin: less is more

Menéndez, J. A., Cufí, S., Oliveras‐Ferraros, C., Vellón, L., Joven, J., & Vázquez‐Martín, A. (2011) · Aging · doi:10.18632/aging.100316 · Cited by 57 · see citing works

Emerging Roles of Sestrins in Neurodegenerative Diseases: Counteracting Oxidative Stress and Beyond

Chen, S., Yang, J., Lin, T., & Yang, D. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8071001 · Cited by 55 · see citing works

Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1pathways

Zamkova, M. A., Хромова, Н. В., Kopnin, B. P., & Kopnin, P. (2013) · Cell Cycle · doi:10.4161/cc.23723 · Cited by 56 · see citing works

Sestrin2–AMPK activation protects mitochondrial function against glucose deprivation-induced cytotoxicity

Seo, K., Ki, S. H., & Shin, S. M. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.03.003 · Cited by 55 · see citing works

The GATOR2–mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation

Kowalsky, A. H., Namkoong, S., Mettetal, E., Park, H.-W., Kazyken, D., Fingar, D., & Lee, J.-H. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010857 · Cited by 52 · see citing works

A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity

Livshits, G., & Kalinkovich, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101852 · Cited by 55 · see citing works

Metabolic parameters and oxidative balance in juvenile Rhamdia quelen exposed to rice paddy herbicides: Roundup®, Primoleo®, and Facet®

Persch, T. S. P., Weimer, R. N., de Freitas, B. S., & Oliveira, G. T. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.01.092 · Cited by 54 · see citing works

Role of Oxidative DNA Damage and Repair in Atrial Fibrillation and Ischemic Heart Disease

Hu, L., Wang, Z., Carmone, C., Keijer, J., & Zhang, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083838 · Cited by 51 · see citing works

Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3

Huang, L.-G., Zou, J., & Lu, Q.-C. (2018) · Brain Research · doi:10.1016/j.brainres.2017.11.019 · Cited by 65 · see citing works

Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle

Nascimento, E. B. M., Osler, M. E., & Zierath, J. R. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00212.2013 · Cited by 49 · see citing works

Sestrin2 as a Potential Target for Regulating Metabolic-Related Diseases

Gong, L., Wang, Z., Wang, Z., & Zhang, Z. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.751020 · Cited by 49 · see citing works

Identification of a Novel Endoplasmic Reticulum Stress Response Element Regulated by XBP1

Misiewicz, M., Déry, M.-A. C., Foveau, B., Jodoin, J., Ruths, D. A., & LeBlanc, A. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.457242 · Cited by 49 · see citing works

Acute resistance exercise induces Sestrin2 phosphorylation and p62 dephosphorylation in human skeletal muscle

Zeng, N., D’Souza, R. F., Figueiredo, V. C., Markworth, J. F., Roberts, L. A., Peake, J. M., Mitchell, C. J., & Cameron‐Smith, D. (2017) · Physiological Reports · doi:10.14814/phy2.13526 · Cited by 47 · see citing works

Cardioprotective roles of sestrin 1 and sestrin 2 against doxorubicin cardiotoxicity

Li, R., Huang, Y., Semple, I. A., Kim, M., Zhang, Z., & Lee, J. H. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00008.2019 · Cited by 46 · see citing works

Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation

Ding, B., Parmigiani, A., Chen, Y., & Budanov, A. V. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1084447 · Cited by 45 · see citing works

Distinct Role of Sesn2 in Response to UVB‐Induced DNA Damage and UVA‐Induced Oxidative Stress in Melanocytes

Zhao, B., Shah, P., Qiang, L., He, T., Budanov, A., & He, Y. (2017) · Photochemistry and Photobiology · doi:10.1111/php.12624 · Cited by 44 · see citing works

Integrated transcriptomic and neuroimaging brain model decodes biological mechanisms in aging and Alzheimer's disease

Adewale, Q., Khan, A. F., Carbonell, F., Iturria-Medina, Y., & Initiative, A. D. N. (2021) · eLife · doi:10.7554/elife.62589 · Cited by 44 · see citing works

Gene‐expression analysis of early‐ and late‐maturation‐stage rat enamel organ

Lacruz, R. S., Smith, C. E., Chen, Y., Hubbard, M. J., Hacia, J. G., & Paine, M. L. (2011) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2011.00881.x · Cited by 43 · see citing works

Sestrin‑2 regulates podocyte mitochondrial dysfunction�and apoptosis under high‑glucose conditions via AMPK

Lin, Q., Ma, Y., Chen, Z., Hu, J., Chen, C., Fan, Y., Liang, W., & Ding, G. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4508 · Cited by 43 · see citing works

The function of miR-200 family in oxidative stress response evoked in cancer chemotherapy and radiotherapy

Kozak, J., Jonak, K. E., & Maciejewski, R. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110037 · Cited by 42 · see citing works

Sestrin2 protects dendritic cells against endoplasmic reticulum stress-related apoptosis induced by high mobility group box-1 protein

Wang, L., Zhu, X., Luo, Y., Wu, Y., Dong, N., Tong, Y., & Yao, Y.-M. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2324-4 · Cited by 44 · see citing works

Sestrin2 modulates cardiac inflammatory response through maintaining redox homeostasis during ischemia and reperfusion

Ren, D., Quan, N., Fedorova, J., Zhang, J., He, Z., & Li, J. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101556 · Cited by 41 · see citing works

Association of serum Sestrin2 level with metabolic risk factors in newly diagnosed drug-naïve type 2 diabetes

Chung, H. S., Hwang, H., Hwang, S. Y., Kim, N. H., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, K. M., & Yoo, H. J. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.07.024 · Cited by 39 · see citing works

Sensing the Environment Through Sestrins: Implications for Cellular Metabolism

Parmigiani, A., & Budanov, A. V. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.05.003 · Cited by 38 · see citing works

Defective interplay between mTORC1 activity and endoplasmic reticulum stress-unfolded protein response in uremic vascular calcification

Panda, D. K., Bai, X., Sabbagh, Y., Zhang, Y., Zaun, H. C., Karellis, A., Koromilas, A. E., Lipman, M. L., & Karaplis, A. C. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00350.2017 · Cited by 38 · see citing works

Mitochondrial localization of SESN2

Kovaleva, I., Tokarchuk, A., Zheltukhin, A. O., Dalina, A., Safronov, G. G., Evstafieva, A., Lyamzaev, K., Chumakov, P., & Budanov, A. (2019) · bioRxiv · doi:10.1371/journal.pone.0226862 · Cited by 34 · see citing works

Murine Gut Microbiota and Transcriptome Are Diet Dependent

Carlisle, E. M., Poroyko, V. A., Caplan, M. S., Alverdy, J., Morowitz, M. J., & Liu, D. (2012) · Annals of Surgery · doi:10.1097/sla.0b013e318262a6a6 · Cited by 38 · see citing works

Elucidating the underlying mechanism of amino acids to regulate muscle protein synthesis: Effect on human health

Lv, X., Zhou, C., Yan, Q., Tan, Z., Kang, J., & Tang, S. (2022) · Nutrition · doi:10.1016/j.nut.2022.111797 · Cited by 38 · see citing works

Inhibitory Effect of Sestrin 2 on Hepatic Stellate Cell Activation and Liver Fibrosis

Yang, J. H., Kim, K. M., Cho, S. S., Shin, S. M., Ka, S. O., Na, C.-S., Park, B. H., Jegal, K. H., Kim, J. K., Ku, S., et al. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7559 · Cited by 36 · see citing works

Pharmacokinetic Analysis of Carnosic Acid and Carnosol in Standardized Rosemary Extract and the Effect on the Disease Activity Index of DSS-Induced Colitis

Veenstra, J. P., Vemu, B., Tocmo, R., Nauman, M. C., & Johnson, J. J. (2021) · Nutrients · doi:10.3390/nu13030773 · Cited by 36 · see citing works

Sestrin2 expression is a favorable prognostic factor in patients with non-small cell lung cancer.

Chen, K.-B., Xuan, Y., Shi, W., Chi, F., Xing, R., & Zeng, Y. (2016) · PubMed Central · Cited by 36 · see citing works

Sestrins: Novel antioxidant and AMPK‐modulating functions regulated by exercise?

Sanchis‐Gomar, F. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24338 · Cited by 36 · see citing works

Relative Alterations in Blood-Based Levels of Sestrin in Alzheimer’s Disease and Mild Cognitive Impairment Patients

Rai, N., Kumar, R. K., Desai, G. R., Gunasekaran, V., Shekhar, S., Chatterjee, P., Tripathi, M., Upadhyay, A. D., Dwivedi, S. N., Dey, A. B., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160479 · Cited by 34 · see citing works

Sestrin family – the stem controlling healthy ageing

Haidurov, A., & Budanov, A. V. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111379 · Cited by 35 · see citing works

Rapamycin Attenuates Endothelial Apoptosis Induced by Low Shear Stress via mTOR and Sestrin1 Related Redox Regulation

Zhang, J., Wang, Z., Zhang, J., Zuo, G., Li, B., Mao, W., & Chen, S. (2014) · Mediators of Inflammation · doi:10.1155/2014/769608 · Cited by 35 · see citing works

SESTRINs: Emerging Dynamic Stress-Sensors in Metabolic and Environmental Health

Ro, S., Fay, J., Cyuzuzo, C. I., Jang, Y., Lee, N., Song, H., & Harris, E. N. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.603421 · Cited by 34 · see citing works

Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea

Zhang, C., Sun, W., Li, J., Xiong, B., Frye, M. D., Ding, D., Salvi, R., Kim, M., Someya, S., & Hu, B. H. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.015 · Cited by 34 · see citing works

Sestrin 2 attenuates sepsis-associated encephalopathy through the promotion of autophagy in hippocampal neurons

Luo, L., Wu, J., Qiao, L., Lu, G., Li, J., & Li, D. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15313 · Cited by 33 · see citing works

Sestrin2 maintains OXPHOS integrity to modulate cardiac substrate metabolism during ischemia and reperfusion

Ren, D., He, Z., Fedorova, J., Zhang, J., Wood, E., Zhang, X., Kang, D. E., & Li, J. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101824 · Cited by 34 · see citing works

Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration

Xu, W., Liu, C., Zheng, H., Xu, H., Yang, R., Jiang, S., & Zhu, L.-X. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.70211 · Cited by 33 · see citing works

Upregulation of sestrins protect atriums against oxidative damage and fibrosis in human and experimental atrial fibrillation

Dong, Z., Lin, C., Liu, Y., Jin, H., Wu, H., Li, Z., Sun, L., Zhang, L., Hu, X., Wei, Y., et al. (2017) · Scientific Reports · doi:10.1038/srep46307 · Cited by 32 · see citing works

Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology

Roth‐Walter, F., Adcock, I. M., Benito‐Villalvilla, C., Bianchini, R., Bjermer, L. H., Caramori, G., Cari, L., Chung, K. F., Diamant, Z., Eguíluz‐Gracia, I., et al. (2023) · Allergy · doi:10.1111/all.15977 · Cited by 31 · see citing works

Decreased Sestrin levels in patients with type 2 diabetes and dyslipidemia and their association with the severity of atherogenic index

Sundararajan, S., Jayachandran, I., Subramanian, S. C., Anjana, R. M., Balasubramanyam, M., Mohan, V., Venkatesan, B. A., & Manickam, N. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01429-9 · Cited by 31 · see citing works

Modulation of sestrin confers protection to Cr(VI) induced neuronal cell death in Drosophila melanogaster

Singh, P., & Chowdhuri, D. K. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.10.037 · Cited by 30 · see citing works

Vacuole-mediated selective regulation of TORC1-Sch9 signaling following oxidative stress

Takeda, E., Jin, N., Itakura, E., Kira, S., Kamada, Y., Weisman, L., Noda, T., & Matsuura, A. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-09-0553 · Cited by 24 · see citing works

Sesn3 deficiency promotes carcinogen-induced hepatocellular carcinoma via regulation of the hedgehog pathway

Liu, Y., Kim, H.-G., Dong, E., Dong, C., Huang, M., Liu, Y., Liangpunsakul, S., & Dong, X. C. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.07.011 · Cited by 30 · see citing works

Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control

Wu, M., Zhao, A., Yan, X., Gao, H., Zhang, C., Liu, X., Luo, Q., Xie, F., Liu, S., & Shi, D. (2022) · eLife · doi:10.7554/elife.79939 · Cited by 30 · see citing works

Sestrin-3 modulation is essential for therapeutic efficacy of cucurbitacin B in lung cancer cells

Khan, N., Jajeh, F., Khan, M. I., Mukhtar, E., Shabana, S. M., & Mukhtar, H. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw124 · Cited by 29 · see citing works

Study Advances in Stress-responsive Proteins Sestrins

Wang, X. (2013) · Medical Recapitulate

Sestrins at the crossroad between stress and aging Research Perspective

Lee, J. H., Bodmer, R., Bier, E., & Karin, M. (2013)

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E., et al. (2010) · Science · doi:10.1126/science.1182228 · Cited by 570 · see citing works

Sestrins in Aging and Metabolism

Tang, D., & Tao, S. (2014) · Else Kröner-Fresenius Symposia · doi:10.1159/000366571

Sestrins at the crossroad between stress and aging

Lee, J. H., Bodmer, R., Bier, E., & Karin, M. (2010) · Aging · doi:10.18632/aging.100157 · Cited by 64 · see citing works