Karin, Michael

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

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A gp130–Src–YAP module links inflammation to epithelial regeneration

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NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ

Greten, F. R., Arkan, M. C., Bollrath, J., Hsu, L.-C., Goode, J., Miething, C., Göktuna, S. I., Neuenhahn, M., Fierer, J., Paxian, S., et al. (2007) · Cell

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Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

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Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

Shalapour, S., Lin, X.-J., Bastian, I. N., Brain, J., Burt, A. D., Aksenov, A. A., Vrbanac, A. F., Li, W., Perkins, A., Matsutani, T., et al. (2017) · Nature

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

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Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E., et al. (2010) · Science

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Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

Grivennikov, S. I., & Karin, M. (2011) · Annals of the Rheumatic Diseases

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The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

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ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

Nakagawa, H., Umemura, A., Taniguchi, K., Font-Burgada, J., Dhar, D., Ogata, H., Zhong, Z., Valasek, M. A., Seki, E., Hidalgo, J., et al. (2014) · Cancer Cell

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JNK1 in Hematopoietically Derived Cells Contributes to Diet-Induced Inflammation and Insulin Resistance without Affecting Obesity

Solinas, G., Vilcu, C., Neels, J. G., Bandyopadhyay, G. K., Luo, J.-L., Naugler, W., Grivennikov, S., Wynshaw-Boris, A., Scadeng, M., Olefsky, J. M., et al. (2007) · Cell Metabolism

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Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

Zaph, C., Troy, A. E., Taylor, B. C., Berman-Booty, L. D., Guild, K. J., Du, Y., Yost, E. A., Gruber, A. D., May, M. J., Greten, F. R., et al. (2007) · Nature

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Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

Sakurai, T., He, G., Matsuzawa, A., Yu, G.-Y., Maeda, S., Hardiman, G., & Karin, M. (2008) · Cancer Cell

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Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

Font-Burgada, J., Shalapour, S., Ramaswamy, S., Hsueh, B., Rossell, D., Umemura, A., Taniguchi, K., Nakagawa, H., Valasek, M. A., Ye, L., et al. (2015) · Cell

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Expanding TRAF function: TRAF3 as a tri-faced immune regulator

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Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

Finkin, S., Yuan, D., Stein, I., Taniguchi, K., Weber, A., Unger, K., Browning, J. L., Goossens, N., Nakagawa, S., Gunasekaran, G., et al. (2015) · Nature Immunology

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Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation

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Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

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Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

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JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

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Sestrins inhibit mTORC1 kinase activation through the GATOR complex

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ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

Kim, J. Y., Garcia-Carbonell, R., Yamachika, S., Zhao, P., Dhar, D., Loomba, R., Kaufman, R. J., Saltiel, A. R., & Karin, M. (2018) · Cell

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Fructose stimulated de novo lipogenesis is promoted by inflammation

Todoric, J., Di Caro, G., Reibe, S., Henstridge, D. C., Green, C. R., Vrbanac, A., Ceteci, F., Conche, C., McNulty, R., Shalapour, S., et al. (2020) · Nature Metabolism

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NF-κB signaling, liver disease and hepatoprotective agents

Sun, B., & Karin, M. (2008) · Oncogene

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Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3

Lee, J. H., Budanov, A. V., Talukdar, S., Park, E. J., Park, H. L., Park, H.-W., Bandyopadhyay, G., Li, N., Aghajan, M., Jang, I., et al. (2012) · Cell Metabolism

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