Hyde, Thomas M.

Developmental regulation of human cortex transcription and its clinical relevance at single base resolution

Jaffe, A. E., Shin, J., Collado-Torres, L., Leek, J. T., Tao, R., Li, C., Gao, Y., Jia, Y., Maher, B. J., Hyde, T. M., et al. (2015) · Nature Neuroscience

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 156

Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy

Law, A. J., Wang, Y., Sei, Y., O’Donnell, P., Piantadosi, P., Papaleo, F., Straub, R. E., Huang, W., Thomas, C. J., Vakkalanka, R., et al. (2012) · Proceedings of the National Academy of Sciences

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 147

Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder

Rutten, B. P. F., Vermetten, E., Vinkers, C. H., Ursini, G., Daskalakis, N. P., Pishva, E., de Nijs, L., Houtepen, L. C., Eijssen, L., Jaffe, A. E., et al. (2018) · Molecular Psychiatry

Posttraumatic Stress Disorder ResearchEpigenetics and DNA Methylation

Cited by 142

Myelin, myelin-related disorders, and psychosis

Mighdoll, M. I., Tao, R., Kleinman, J. E., & Hyde, T. M. (2015) · Schizophrenia Research

Schizophrenia research and treatmentAdvanced Neuroimaging Techniques and Applications

Cited by 135

Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain

Kaalund, S. S., Newburn, E. N., Ye, T., Tao, R., Li, C., Deep-Soboslay, A., Herman, M. M., Hyde, T. M., Weinberger, D. R., Lipska, B. K., et al. (2014) · Molecular Psychiatry

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 132

qSVA framework for RNA quality correction in differential expression analysis

Jaffe, A. E., Tao, R., Norris, A. L., Kealhofer, M., Nellore, A., Shin, J. H., Kim, D., Jia, Y., Hyde, T. M., Kleinman, J. E., et al. (2017) · Proceedings of the National Academy of Sciences

Gene expression and cancer classificationSingle-cell and spatial transcriptomics

Cited by 114

Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders

Hu, B., Won, H., Mah, W., Park, R. B., Kassim, B., Spiess, K., Kozlenkov, A., Crowley, C. A., Pochareddy, S., The PsychENCODE Consortium, et al. (2021) · Nature Communications

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 103

Prenatal Expression Patterns of Genes Associated With Neuropsychiatric Disorders

Birnbaum, R., Jaffe, A. E., Hyde, T. M., Kleinman, J. E., & Weinberger, D. R. (2014) · American Journal of Psychiatry

Genetics and Neurodevelopmental DisordersSchizophrenia research and treatment

Cited by 97

Somatic LINE-1 retrotransposition in cortical neurons and non-brain tissues of Rett patients and healthy individuals

Zhao, B., Wu, Q., Ye, A. Y., Guo, J., Zheng, X., Yang, X., Yan, L., Liu, Q.-R., Hyde, T. M., Wei, L., et al. (2019) · PLOS Genetics

Genetics and Neurodevelopmental DisordersChromosomal and Genetic Variations

Cited by 83

A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan

Su, Y., Zhou, Y., Bennett, M. L., Li, S., Carceles-Cordon, M., Lu, L., Huh, S., Jimenez-Cyrus, D., Kennedy, B. C., Kessler, S. K., et al. (2022) · Cell Stem Cell

Single-cell and spatial transcriptomicsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 75

Prodynorphin mRNA expression is increased in the patch vs matrix compartment of the caudate nucleus in suicide subjects

Hurd, Y. L., Herman, M. M., Hyde, T. M., Bigelow, L. B., Weinberger, D. R., & Kleinman, J. E. (1997) · Molecular Psychiatry

Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Cited by 75

Characterizing the dynamic and functional DNA methylation landscape in the developing human cortex

Perzel Mandell, K. A., Price, A. J., Wilton, R., Collado-Torres, L., Tao, R., Eagles, N. J., Szalay, A. S., Hyde, T. M., Weinberger, D. R., Kleinman, J. E., et al. (2021) · Epigenetics

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 21