Somatic LINE-1 retrotransposition in cortical neurons and non-brain tissues of Rett patients and healthy individuals

Zhao, Boxun; Wu, Qixi; Ye, Adam Yongxin; Guo, Jing; Zheng, Xianing; Yang, Xiaoxu; Yan, Linlin; Liu, Qing-Rong; Hyde, Thomas M.; Wei, Liping; Huang, August Yue

doi:10.1371/journal.pgen.1008043

Somatic LINE-1 retrotransposition in cortical neurons and non-brain tissues of Rett patients and healthy individuals

Mounting evidence supports that LINE-1 (L1) retrotransposition can occur postzygotically in healthy and diseased human tissues, contributing to genomic mosaicism in the brain and other somatic tissues of an individual. However, the genomic distribution of somatic human-specific LINE-1 (L1Hs) inse…