Myelin, myelin-related disorders, and psychosis

Mighdoll, Michelle I.; Tao, Ran; Kleinman, Joel E.; Hyde, Thomas M.

doi:10.1016/j.schres.2014.09.040

Cited by 135Schizophrenia research and treatmentAdvanced Neuroimaging Techniques and ApplicationsMental Health and Psychiatry

Myelin, myelin-related disorders, and psychosis

Mighdoll, Michelle I., Tao, Ran, Kleinman, Joel E., Hyde, Thomas M.·2015·Schizophrenia Research

DOI 10.1016/j.schres.2014.09.040

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Abstract

The neuropathological basis of schizophrenia and related psychoses remains elusive despite intensive scientific investigation. Symptoms of psychosis have been reported in a number of conditions where normal myelin development is interrupted. The nature, location, and timing of white matter pathology seem to be key factors in the development of psychosis, especially during the critical adolescent period of association area myelination. Numerous lines of evidence implicate myelin and oligodendrocyte function as critical processes that could affect neuronal connectivity, which has been implicated as a central abnormality in schizophrenia. Phenocopies of schizophrenia with a known pathological basis involving demyelination or dysmyelination may offer insights into the biology of schizophrenia itself. This article reviews the pathological changes in white matter of patients with schizophrenia, as well as demyelinating diseases associated with psychosis. In an attempt to understand the potential role of dysmyelination in schizophrenia, we outline the evidence from a number of both clinically-based and post-mortem studies that provide evidence that OMR genes are genetically associated with increased risk for schizophrenia. To further understand the implication of white matter dysfunction and dysmyelination in schizophrenia, we examine diffusion tensor imaging (DTI), which has shown volumetric and microstructural white matter differences in patients with schizophrenia. While classical clinical-neuropathological correlations have established that disruption in myelination can produce a high fidelity phenocopy of psychosis similar to schizophrenia, the role of dysmyelination in schizophrenia remains controversial.

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Most people have sleep-wake and activity rhythms that, in the absence of environmental cues, are slightly longer than 24 hours.
“Most people have sleep–wake and activity rhythms that, in the absence of environmental cues, are slightly longer than 24 hours3,4, but the length of this period can be affected by circadian gene variants5.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [4]
Myelination defects together with PVI deficits may account for the emergence of schizophrenia pathophysiology and symptoms in early adulthood.
“Together with myelination defects 4 , this may account for the emergence of schizophrenia pathophysiology and symptoms in early adulthood.”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [4]

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Authors: Mighdoll, M. I., Tao, R., Kleinman, J. E., & Hyde, T. M.
Affiliations: Johns Hopkins University (US)
Corresponding author: Hyde, Thomas M.
ORCID: Tao, Ran
Kleinman, Joel E.
Hyde, Thomas M.
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2015-01
Volume: 161
Issue: 1
Pages: 85-93
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2014.09.040
OpenAlex: W2010607311
Cited by: 135
References: 180
Citations by year: 2026: 6 · 2025: 6 · 2024: 10 · 2023: 13 · 2022: 12 · 2021: 13 · 2020: 6 · 2019: 19 · 2018: 13 · 2017: 13 · 2016: 16 · 2015: 8
FWCI: 1.70
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Schizophrenia Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: myelin, dysmyelination
MeSH terms: Demyelinating Diseases, Humans, Myelin Sheath, Nerve Fibers, Myelinated, Oligodendroglia, Psychotic Disorders, Diffusion Tensor Imaging, White Matter

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