Prodynorphin mRNA expression is increased in the patch vs matrix compartment of the caudate nucleus in suicide subjects
Abstract
Experimental and clinical studies suggest an involvement of the opioid neuropeptide system in psychiatric disorders. Notably, opioid peptide immunoreactivity is altered in the cerebrospinal fluid of chronic schizophrenics and manic-depressive subjects. Despite these clinical findings, few postmortem investigations have examined the association of endogenous opioid neuropeptides with schizophrenia and suicide. Anatomically, a tight interaction exists within the neostriatum between the opioid peptide (dynorphin and enkephalin) system and classical neurotransmitters such as dopamine which has been implicated in both the psychotic symptoms and the cognitive deficits that characterize schizophrenia (see review). The neostriatum is differentially organized into patch and matrix neurochemical mosaic compartments anatomically connected to limbic- and sensorimotor-related brain regions, respectively. Moreover, the human neostriatum is characterized by a heterogenous expression of the prodynorphin opioid gene: high in the patch, but low in the matrix compartment. The present results show for the first time a differential alteration of prodynorphin within distinct striatal compartments in postmortem tissue from nonschizophrenic suicide subjects. The prodynorphin patch/matrix mRNA expression was elevated in the caudate nucleus of suicide subjects as compared to normal controls and schizophrenics in which no alterations in opioid peptides or D1 and D2 mRNA expression were apparent. Altogether the findings suggest that discrete dysfunction of the endogenous opioid dynorphin system might contribute to depression and the risk of suicide in nonschizophrenic subjects.
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Prodynorphin is elevated in the caudate nucleus in suicide decedents.
“Prodynorphin, the precursor to endogenous kappa opioid dynorphin, is elevated in the caudate nucleus in suicide decedents (146).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [146]
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Sorted by citations
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- Authors
- Hurd, Y. L., Herman, M. M., Hyde, T. M., Bigelow, L. B., Weinberger, D. R., & Kleinman, J. E.
- Affiliations
- Karolinska Institutet (SE)
- National Institutes of Health (US)
- Venue
- Molecular Psychiatry
- Published
- 1997-10-01
- Volume
- 2
- Issue
- 6
- Pages
- 495-500
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2022174561
- Cited by
- 75
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 2 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Keywords
- prodynorphin, dynorphin, caudate nucleus, suicide, endogenous opioid system, neostriatum, schizophrenia, dopamine D1 receptor, dopamine D2 receptor, postmortem brain, depression, gene expression
- MeSH terms
- Caudate Nucleus, Enkephalins, Female, Humans, Male, Middle Aged, Nucleus Accumbens, Protein Precursors, Putamen, RNA, Messenger, Schizophrenia, Suicide, Transcription, Genetic, Receptors, Dopamine D1, Receptors, Dopamine D2, Opioid Peptides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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