In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes Caco-2 colon cells and the adrenal gland

Slominski, Andrzej T.; Kim, Tae-Kang; Shehabi, Haleem Z.; Tang, Edith K.Y.; Benson, Heather A.E.; Semak, Igor; Lin, Zongtao; Yates, Charles R.; Wang, Jin; Li, Wei; Tuckey, Robert C.

doi:10.1016/j.mce.2013.12.012

Cited by 100Vitamin D Research StudiesPharmacogenetics and Drug MetabolismCholesterol and Lipid Metabolism

In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes Caco-2 colon cells and the adrenal gland

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Slominski, Andrzej T., Kim, Tae-Kang, Shehabi, Haleem Z., Tang, Edith K.Y., Benson, Heather A.E., Semak, Igor, Lin, Zongtao, Yates, Charles R. +3 more·2014·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2013.12.012PMC PMC3997123

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Abstract

We investigated the metabolism of vitamin D2 to hydroxyvitamin D2 metabolites ((OH)D2) by human placentas ex-utero, adrenal glands ex-vivo and cultured human epidermal keratinocytes and colonic Caco-2 cells, and identified 20(OH)D2, 17,20(OH)₂D2, 1,20(OH)₂D2, 25(OH)D2 and 1,25(OH)₂D2 as products. Inhibition of product formation by 22R-hydroxycholesterol indicated involvement of CYP11A1 in 20- and 17-hydroxylation of vitamin D2, while use of ketoconazole indicated involvement of CYP27B1 in 1α-hydroxylation of products. Studies with purified human CYP11A1 confirmed the ability of this enzyme to convert vitamin D2 to 20(OH)D2 and 17,20(OH)₂D2. In placentas and Caco-2 cells, production of 20(OH)D2 was higher than 25(OH)D2 while in human keratinocytes the production of 20(OH)D2 and 25(OH)D2 were comparable. HaCaT keratinocytes showed high accumulation of 1,20(OH)₂D2 relative to 20(OH)D2 indicating substantial CYP27B1 activity. This is the first in vivo evidence for a novel pathway of vitamin D2 metabolism initiated by CYP11A1 and modified by CYP27B1, with the product profile showing tissue- and cell-type specificity.

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Molecular modeling using the crystal structure of CYP11A1 predicts that other intermediates of cholesterol synthesis could also serve as substrates for CYP11A1.
“Molecular modeling using the crystal structure of CYP11A1 predicts that other intermediates of cholesterol synthesis could also serve as substrates for CYP11A1.”
From Novel activities of CYP11A1 and their potential physiological significance (2015) · cites this paper as [9]
Recombinant human CYP11A1 shows a similar sequence of reactions for vitamin D2, with 20(OH)D2 as the major product and lower production of 17,20(OH)2D2 and 17,20,24(OH)3D2 and another unidentified D2 metabolite.
“A similar sequence of reactions was seen for recombinant human CYP11A1 [9]. The major product was 20(OH)D2 with lower production of 17,20(OH)2D2 and 17,20,24 (OH)3D2 and another unidentified D2 metabolite [28,29].”
From Novel activities of CYP11A1 and their potential physiological significance (2015) · cites this paper as [9]
Recombinant human CYP11A1 hydroxylates the prodrug 1α(OH)D2 to 1,20(OH)2D2.
“In addition, the prodrug, 1α (OH)D2, could be hydroxylated by recombinant human CYP11A1 to 1,20(OH)2D2 [9].”
From Novel activities of CYP11A1 and their potential physiological significance (2015) · cites this paper as [9]
Caco-2 cells produce more 20(OH)D2 and 17,20(OH)2D2 than HaCaT keratinocytes.
“Also, production of 20(OH)D2 and 17,20(OH)2D2 was higher in Caco-2 cells than in HaCaT keratinocytes [9]”
From Novel activities of CYP11A1 and their potential physiological significance (2015) · cites this paper as [9]
HaCaT keratinocytes produce more 1,20(OH)2D2 than Caco-2 cells.
“but higher production of 1,20(OH)2D2 was seen in HaCaT keratinocytes [9].”
From Novel activities of CYP11A1 and their potential physiological significance (2015) · cites this paper as [9]

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Bocheva, G., Slominski, R. M., & Slominski, A. T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112798 · Cited by 137 · see citing works
Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management
Slominski, A. T., Brożyna, A. A., Zmijewski, M. A., Jóźwicki, W., Jetten, A. M., Mason, R. S., Tuckey, R. C., & Elmets, C. A. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2017.3 · Cited by 136 · see citing works
Self-citation
Steroid biosynthesis in adipose tissue
Li, J., Papadopoulos, V., & Vihma, V. (2015) · Steroids · doi:10.1016/j.steroids.2015.03.016 · Cited by 130 · see citing works
Differential and Overlapping Effects of 20,23(OH)2D3 and 1,25(OH)2D3 on Gene Expression in Human Epidermal Keratinocytes: Identification of AhR as an Alternative Receptor for 20,23(OH)2D3
Slominski, A. T., Kim, T., Janjetović, Z., Brożyna, A. A., Zmijewski, M. A., Xu, H., Sutter, T. R., Tuckey, R. C., Jetten, A. M., & Crossman, D. K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103072 · Cited by 119 · see citing works
Biological Effects of CYP11A1-Derived Vitamin D and Lumisterol Metabolites in the Skin
Slominski, A. T., Kim, T., Janjetović, Z., Slominski, R. M., Li, W., Jetten, A. M., Indra, A. K., Mason, R. S., & Tuckey, R. C. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.04.022 · Cited by 109 · see citing works
On the role of classical and novel forms of vitamin D in melanoma progression and management
Slominski, A. T., Brożyna, A. A., Skobowiat, C., Zmijewski, M. A., Kim, T., Janjetović, Z., Oak, A. S. W., Jóźwicki, W., Jetten, A. M., Mason, R. S., et al. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.06.013 · Cited by 99 · see citing works
Decreased VDR expression in cutaneous melanomas as marker of tumor progression: new data and analyses.
Brożyna, A. A., Jóźwicki, W., & Slominski, A. T. (2014) · PubMed · Cited by 87 · see citing works
Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols
Slominski, A. T., Kim, T.-K., Hobrath, J. V., Janjetovic, Z., Oak, A. S. W., Postlethwaite, A., Lin, Z., Li, W., Takeda, Y., Jetten, A. M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10202-7 · Cited by 82 · see citing works
Vitamin D Deficiency and Associated Risk Factors in Women from Riyadh, Saudi Arabia
AlFaris, N. A., AlKehayez, N. M., AlMushawah, F., AlNaeem, A., AlAmri, N., & AlMudawah, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-56830-z · Cited by 87 · see citing works
Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity
Slominski, A. T., Manna, P. R., & Tuckey, R. C. (2014) · Experimental Dermatology · doi:10.1111/exd.12376 · Cited by 79 · see citing works
Vitamin D Signaling in Psoriasis: Pathogenesis and Therapy
Brożyna, A. A., Slominski, R. M., Nedoszytko, B., Zmijewski, M. A., & Slominski, A. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158575 · Cited by 84 · see citing works
Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation
Slominski, A. T., Janjetovic, Z., Kim, T.-K., Wasilewski, P., Rosas, S., Hanna, S., Sayre, R. M., Dowdy, J. C., Li, W., & Tuckey, R. C. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.01.014 · Cited by 77 · see citing works
Evolutionary formation of melatonin and vitamin D in early life forms: insects take centre stage
Kim, T., Slominski, R. M., Pyza, E., Kleszczyński, K., Tuckey, R. C., Reiter, R. J., Holick, M. F., & Slominski, A. T. (2024) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.13091 · Cited by 68 · see citing works
Vitamin D Resistance as a Possible Cause of Autoimmune Diseases: A Hypothesis Confirmed by a Therapeutic High-Dose Vitamin D Protocol
Lemke, D., Klement, R. J., Schweiger, F., Schweiger, B., & Spitz, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.655739 · Cited by 70 · see citing works
PTH and Vitamin D
Khundmiri, S. J., Murray, R. D., & Lederer, E. D. (2016) · Comprehensive physiology · doi:10.1002/j.2040-4603.2016.tb00690.x · Cited by 66 · see citing works
COVID‐19 and Vitamin D: A lesson from the skin
Slominski, R. M., Stefan, J., Athar, M., Holick, M. F., Jetten, A. M., Raman, C., & Slominski, A. T. (2020) · Experimental Dermatology · doi:10.1111/exd.14170 · Cited by 62 · see citing works
Association of Maternal Vitamin D Status with Glucose Tolerance and Caesarean Section in a Multi-Ethnic Asian Cohort: The Growing Up in Singapore Towards Healthy Outcomes Study
Loy, S. L., Lek, N., Yap, F. K. P., Soh, S., Padmapriya, N., Tan, K. H., Biswas, A., Yeo, G. S. H., Kwek, K., Gluckman, P. D., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142239 · Cited by 60 · see citing works
Novel vitamin D analogs as potential therapeutics: metabolism, toxicity profiling, and antiproliferative activity.
Chen, J., Wang, J., Kim, T., Tieu, E. W., Tang, E. K. Y., Lin, Z., Kovacic, D., Miller, D. D., Postlethwaite, A. E., Tuckey, R. C., et al. (2014) · PubMed · Cited by 55 · see citing works
The Role of Classical and Novel Forms of Vitamin D in the Pathogenesis and Progression of Nonmelanoma Skin Cancers
Slominski, A. T., Brożyna, A. A., Zmijewski, M. A., Janjetović, Z., Kim, T., Slominski, R. M., Tuckey, R. C., Mason, R. S., Jetten, A. M., Guroji, P., et al. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-46227-7_13 · Cited by 54 · see citing works
Non-Musculoskeletal Benefits of Vitamin D beyond the Musculoskeletal System
Zhang, S., Miller, D. D., & Li, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042128 · Cited by 56 · see citing works
Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture
Wierzbicka, J., Binek, A., Ahrends, T., KA, J. D. N., SZYDŁOWSKA, A., Turczyk, L., Wasiewicz, T., Wierzbicki, P., Sądej, R., Tuckey, R. C., et al. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.3088 · Cited by 51 · see citing works
Antitumor Effects of Vitamin D Analogs on Hamster and Mouse Melanoma Cell Lines in Relation to Melanin Pigmentation
Wasiewicz, T., Szyszka, P., Cichorek, M., Janjetović, Z., Tuckey, R. C., Slominski, A. T., & Zmijewski, M. A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16046645 · Cited by 49 · see citing works
Primary Human Osteoblasts in Response to 25-Hydroxyvitamin D3, 1,25-Dihydroxyvitamin D3 and 24R,25-Dihydroxyvitamin D3
Meijden, K. V. D., Lips, P. T. A. M., van Driel, M., Heijboer, A. C., Schulten, E. A. J. M., den Heijer, M., & Bravenboer, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110283 · Cited by 48 · see citing works
Lumisterol is metabolized by CYP11A1: discovery of a new pathway
Tuckey, R. C., Slominski, A. T., Cheng, C. Y. S., Chen, J., Kim, T.-K., Xiao, M., & Li, W. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.08.004 · Cited by 43 · see citing works
Simultaneous measurement of 13 circulating vitamin D3 and D2 mono and dihydroxy metabolites using liquid chromatography mass spectrometry
Jenkinson, C., Desai, R., Slominski, A. T., Tuckey, R. C., Hewison, M., & Handelsman, D. J. (2021) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2021-0441 · Cited by 39 · see citing works
CYP11A1‑derived vitamin D hydroxyderivatives as candidates for therapy of basal and squamous cell carcinomas
Slominski, A. T., Brożyna, A. A., Kim, T., Elsayed, M., Janjetović, Z., Qayyum, S., Slominski, R. M., Oak, A. S. W., Li, C., Podgórska, E., et al. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5386 · Cited by 39 · see citing works
Vitamin D receptor regulates transcription of mitochondrial DNA and directly interacts with mitochondrial DNA and TFAM
Gezen‐Ak, D., Alaylıoğlu, M., Yurttaş, Z., Çamoğlu, T., Şengül, B., İşler, C., Kina, U. Y., Keskin, E., Atasoy, İ. L., Kafadar, A. M., et al. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109322 · Cited by 37 · see citing works
Vitamin D receptors (VDR), hydroxylases CYP27B1 and CYP24A1 and retinoid-related orphan receptors (ROR) level in human uveal tract and ocular melanoma with different melanization levels
Markiewicz, A., Brożyna, A. A., Podgórska, E., Elas, M., Urbańska, K., Jetten, A. M., Slominski, A. T., Jóźwicki, W., Orłowska-Heitzman, J., Dyduch, G., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-45161-8 · Cited by 38 · see citing works
Vitamin D3 mediated regulation of steroidogenesis mitigates testicular activity in an aged rat model
Jeremy, M., Gurusubramanian, G., & Roy, V. K. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.03.016 · Cited by 36 · see citing works
Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey
Kim, T., Atigadda, V. R., Brzeminski, P., Fabisiak, A., Tang, E. K. Y., Tuckey, R. C., & Slominski, A. T. (2020) · Molecules · doi:10.3390/molecules25112583 · Cited by 36 · see citing works
Common and personal target genes of the micronutrient vitamin D in primary immune cells from human peripheral blood
Hänel, A., Neme, A., Malinen, M., Hämäläinen, E., Malmberg, H.-R., Etheve, S., Tuomainen, T., Virtanen, J. K., Bendik, I., & Carlberg, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-78288-0 · Cited by 37 · see citing works
Calcitroic Acid–A Review
Yu, O. B., & Arnold, L. A. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00569 · Cited by 35 · see citing works
Decreased expression of CYP27B1 correlates with the increased aggressiveness of ovarian carcinomas
Brożyna, A. A., Jóźwicki, W., Jochymski, C., & Slominski, A. T. (2014) · Oncology Reports · doi:10.3892/or.2014.3666 · Cited by 33 · see citing works
Vitaminï¿½D derivatives potentiate the anticancer and anti-angiogenic activity of tyrosine kinase inhibitors in combination with cytostatic drugs in an A549 non-small cell lung cancer model
Maj, E., Filip‐Psurska, B., Milczarek, M., Psurski, M., Kutner, A., & Wietrzyk, J. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4228 · Cited by 32 · see citing works
Role of vitamin D3 in selected malignant neoplasms
Markowska, A., Antoszczak, M., Kojs, Z., Bednarek, W., Markowska, J., & Huczyński, A. (2020) · Nutrition · doi:10.1016/j.nut.2020.110964 · Cited by 32 · see citing works
Vitamin D-metabolic enzymes and related molecules: Expression at the maternal-conceptus interface and the role of vitamin D in endometrial gene expression in pigs
Jang, H.-H., Choi, Y., Yoo, I., Han, J., Hong, J., Kim, Y. Y., & Ka, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187221 · Cited by 32 · see citing works
Vitamin D3 improves lipophagy-associated renal lipid metabolism and tissue damage in diabetic mice
Lee, H., Lee, H., & Lim, Y. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.06.007 · Cited by 31 · see citing works
Vitamin D3/VDR inhibits inflammation through NF-κB pathway accompanied by resisting apoptosis and inducing autophagy in abalone Haliotis discus hannai
Huang, D., Guo, Y., Li, X., Pan, M., Liu, J., Zhang, W., & Mai, K. (2021) · Cell Biology and Toxicology · doi:10.1007/s10565-021-09647-4 · Cited by 29 · see citing works
Longitudinal, observational study on associations between postoperative nutritional vitamin D supplementation and clinical outcomes in esophageal cancer patients undergoing esophagectomy
Wang, L., Wang, C., Wang, J., Huang, X., & Cheng, Y. (2016) · Scientific Reports · doi:10.1038/srep38962 · Cited by 29 · see citing works
Vitamin D and COVID-19: where are we now?
Contreras-Bolívar, V., García-Fontana, B., García‐Fontana, C., & Muñoz‐Torres, M. (2021) · Postgraduate Medicine · doi:10.1080/00325481.2021.2017647 · Cited by 30 · see citing works
Associations of Genetic Polymorphisms Relevant to Metabolic Pathway of Vitamin D3 with Development and Prognosis of Childhood Bronchial Asthma
Zhang, Y., Wang, Z., & Ma, T. (2017) · DNA and Cell Biology · doi:10.1089/dna.2017.3730 · Cited by 25 · see citing works
Serum levels of vitamin D and immune system function in patients with COVID-19 admitted to intensive care unit
Soltani‐Zangbar, M. S., Mahmoodpoor, A., Dolati, S., Shamekh, A., Valizadeh, S., Yousefi, M., & Sanaie, S. (2022) · Gene Reports · doi:10.1016/j.genrep.2022.101509 · Cited by 26 · see citing works
Vitamin D from UV-Irradiated Mushrooms as a Way for Vitamin D Supplementation: A Systematic Review on Classic and Nonclassic Effects in Human and Animal Models
Rondanelli, M., Moroni, A., Zese, M., Gasparri, C., Riva, A., Petrangolini, G., Perna, S., & Mazzola, G. (2023) · Antioxidants · doi:10.3390/antiox12030736 · Cited by 25 · see citing works
Extending the vitamin D pathway to vitamin D3 and CYP27A1 in periodontal ligament cells
Zhang, C., Liu, K., & Hou, J. (2020) · Journal of Periodontology · doi:10.1002/jper.20-0225 · Cited by 21 · see citing works
Photobiology of vitamin D
Holick, M. F., & Slominski, A. T. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91386-7.00006-4 · Cited by 22 · see citing works
Alternative pathways for vitamin D metabolism
Slominski, A. T., Tuckey, R. C., Jenkinson, C., Li, W., & Jetten, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91386-7.00001-5 · Cited by 21 · see citing works
Beneficial health effects of ultraviolet radiation: expert review and conference report
Riedmann, U., Dibben, C. J. L., de Gruijl, F. R., Gorman, S., Hart, P. H., Hoel, D. G., Levy, C., Lindqvist, P. G., Norval, M., Parikh, S., et al. (2025) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-025-00743-6 · Cited by 22 · see citing works
Consideration of possible effects of vitamin D on established cancer, with reference to malignant melanoma
Hutchinson, P. E., & Pringle, J. H. (2022) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.13040 · Cited by 19 · see citing works
Editorial: Steroids and Secosteroids in the Modulation of Inflammation and Immunity
Slominski, A. T., Mahata, B., Raman, C., & Bereshchenko, O. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.825577 · Cited by 21 · see citing works
Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?
Moin, A. S. M., Sathyapalan, T., Butler, A. E., & Atkin, S. L. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.638621 · Cited by 21 · see citing works
Adrenal disorders: Is there Any role for vitamin D?
Tirabassi, G., Salvio, G., Altieri, B., Ronchi, C. L., Casa, S. D., Pontecorvi, A., & Balercia, G. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9391-y · Cited by 18 · see citing works
The Protective Effect of 1,25(OH)2D3 on Myocardial Function is Mediated via Sirtuin 3-Regulated Fatty Acid Metabolism
Yang, J., Zhang, Y., Pan, Y., Sun, C., Liu, Z., Liu, N., Fu, Y., Li, X., Li, Y., & Kong, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.627135 · Cited by 16 · see citing works
Low Vitamin D Status Predicts Poor Clinical Outcome in Advanced Melanoma Treated With Immune Checkpoint or BRAF/MEK Inhibitors: A Prospective Non-Interventional Side-by-Side Analysis
Reichrath, J., Biersack, F., Wagenpfeil, S., Schöpe, J., Pföhler, C., Saternus, R., & VOGT, T. M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.839816 · Cited by 16 · see citing works
Impacts of deficiency in vitamin D derivatives on disease severity in adult bronchial asthma patients
Althagfan, S. S., Alolayan, S. O., Ahmed, S., Emara, M. M., & Awadallah, M. F. (2021) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2021.102073 · Cited by 15 · see citing works
Vitamin D as an Adjuvant in Melanoma Therapy
Slominski, A. T., Brożyna, A. A., Jóźwicki, W., & Tuckey, R. C. (2015) · Melanoma Management · doi:10.2217/mmt.14.36 · Cited by 14 · see citing works
Melatonin and vitamin D as potential synergistic adjuvants for cancer therapy (Review)
Reiter, R. J., Chuffa, L. G. D. A., Simão, V. A., Giménez, V. M. M., Heras, N. D. L., Spandidos, D. A., & Manucha, W. A. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5702 · Cited by 15 · see citing works
Vitamin B12 enhances the antitumor activity of 1,25-dihydroxyvitamin D 3 via activation of caspases and targeting actin cytoskeleton
Atoum, M. F., Alzoughool, F. E., Al-Mazaydeh, Z. A., Rammaha, M. S., & Tahtamouni, L. H. (2022) · Tumor Biology · doi:10.3233/tub-211536 · Cited by 13 · see citing works
Calcitriol Inhibits Proliferation and Potentially Induces Apoptosis in B16-F10 Cells
Sutedja, E. K., Amarassaphira, D., Goenawan, H., Pratiwi, Y. S., Sylviana, N., Setiabudiawan, B., Suwarsa, O., Judistiani, R. T. D., Supratman, U., & Lesmana, R. (2022) · Medical science monitor basic research/Medical science monitor. Basic research · doi:10.12659/msmbr.935139 · Cited by 13 · see citing works
Metabolism of 20-hydroxyvitamin D3 by mouse liver microsomes
Cheng, C. Y. S., Slominski, A. T., & Tuckey, R. C. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.08.009 · Cited by 12 · see citing works
Relevance of vitamin D3 in COVID-19 infection
Afshan, F. U., Nissar, B., Chowdri, N. A., & Ganai, B. A. (2021) · Gene Reports · doi:10.1016/j.genrep.2021.101270 · Cited by 12 · see citing works
Fracture Risk in Relation to Serum 25-Hydroxyvitamin D and Physical Activity: Results from the EPIC-Norfolk Cohort Study
Julián, C., Lentjes, M. A. H., Huybrechts, I., Luben, R., Wareham, N. J., Moreno, L. A., & Khaw, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164160 · Cited by 12 · see citing works
Vitamin D Enhances Anticancer Properties of Cediranib, a VEGFR Inhibitor, by Modulation of VEGFR2 Expression in Melanoma Cells
Piotrowska, A., Beserra, F. P., Wierzbicka, J., Nowak, J. I., & Zmijewski, M. A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.763895 · Cited by 12 · see citing works
Metabolic activation of lumisterol to biologically active metabolites and their mechanism of action
Slominski, A. T., Kim, T., Janjetović, Z., Ravichandran, S., Song, Y., Podgórska, E., Slominski, R. M., Ewendt, F., Song, Y., Szpotan, J., et al. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.117711 · Cited by 11 · see citing works
A time-course regulatory and kinetic expression study of steroid metabolizing enzymes by calcitriol in primary cultured human placental cells
Noyola-Martínez, N., Halhali, A., Zaga‐Clavellina, V., Olmos‐Ortiz, A., Larrea, F., & Barrera, D. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.11.015 · Cited by 11 · see citing works
Association between histone deacetylase activity and vitamin D‐dependent gene expressions in relation to sulforaphane in human colorectal cancer cells
Hossain, S. A., Liu, Z., & Wood, R. J. (2020) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10797 · Cited by 11 · see citing works
Low dose ultraviolet B irradiation at 308 nm with light-emitting diode device effectively increases serum levels of 25(OH)D
Lin, M., Lim, L., Tsai, S., Jian, F.-X., Hwang, S., Lin, Y., & Chiu, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-82216-1 · Cited by 10 · see citing works
Vitamin D in autoimmune bullous disease
Tukaj, S. (2020) · Acta Biochimica Polonica · doi:10.18388/abp.2020_2905 · Cited by 10 · see citing works
Design, Synthesis and Biological Activities of Novel Gemini 20S-Hydroxyvitamin D3 Analogs.
Lin, Z., Marepally, S. R., Kim, T., Janjetović, Z., Oak, A. S. W., Postlethwaite, A. E., Myers, L. K., Tuckey, R. C., Slominski, A. T., Miller, D. D., et al. (2016) · PubMed · Cited by 9 · see citing works
Vitamin D endocrine system in breast cancer
Linowiecka, K., Wolnicka-Głubisz, A., & Brożyna, A. A. (2021) · Acta Biochimica Polonica · doi:10.18388/abp.2020_5961 · Cited by 9 · see citing works
Vitamin D Status Assessment: Lack of Correlation between Serum and Hair 25-Hydroxycholecalciferol Levels in Healthy Young Adults
Gáll, Z., Csukor, B., Urkon, M., Farczádi, L., & Kolcsár, M. (2022) · Diagnostics · doi:10.3390/diagnostics12051229 · Cited by 8 · see citing works
Evaluation of Vitamin D Status and the Analysis of Risk Factors of Vitamin D Deficiency in Twin Pregnancies
Le, J., Lv, Z., Peng, R., Li, Y., & Wang, S. (2023) · Laboratory Medicine · doi:10.1093/labmed/lmad005 · Cited by 8 · see citing works
Milk protein complexation enhances post prandial vitamin D 3 absorption in rats
Lindahl, I. E. I., Danielsen, M., Dalsgaard, T. K., Rejnmark, L., Bollen, P. J. A., & Bertram, H. C. (2020) · Food & Function · doi:10.1039/d0fo01062f · Cited by 8 · see citing works
Serum Vitamin D Concentrations in Baboons (Papio spp.) during Pregnancy and Obesity.
Schlabritz‐Loutsevitch, N., Comuzzie, A. G., Mahaney, M. M., Hubbard, G. B., Dick, E. J., Koçak, M., Gupta, S., Carrillo, M., Schenone, M., Postlethwaite, A. E., et al. (2016) · PubMed Central · Cited by 7 · see citing works
The role of the transsulfuration pathway in spermatogenesis of vitamin D deficient mice
Jamshidian-Ghalehsefidi, N., Rabiee, F., Tavalaee, M., Kiani, S., Pouriayevali, F., Razi, M., Dattilo, M., & Nasr‐Esfahani, M. H. (2023) · Scientific Reports · doi:10.1038/s41598-023-45986-4 · Cited by 7 · see citing works
Liquid chromatography-tandem mass spectrometry for monitoring vitamin D hydroxymetabolites in human aqueous humor
Fabregat-Cabello, N., Darimont, P., Huyghebaert, L., Reynier, P., Annweiler, C., Miléa, D., Goff, C. M. L., & Cavalier, E. (2019) · Analytical Methods · doi:10.1039/c9ay01896d · Cited by 7 · see citing works
RETRACTED ARTICLE: Middle east pain syndrome is a pollution-induced new disease mimicking rheumatoid arthritis
Elbeialy, A. A., Bauomi, A. M., Elnaggar, B. M., & Elzomor, H. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-01698-1 · Cited by 5 · see citing works
Retracted
Using Machine Learning to Identify the Relationships between Demographic, Biochemical, and Lifestyle Parameters and Plasma Vitamin D Concentration in Healthy Premenopausal Chinese Women
Wang, C.-K., Chang, C., Chu, T.-W. D., & Liang, Y. (2023) · Life · doi:10.3390/life13122257 · Cited by 7 · see citing works
1,25(OH)2D3 and VDR Signaling Pathways Regulate the Inhibition of Dectin-1 Caused by Cyclosporine A in Response to Aspergillus Fumigatus in Human Corneal Epithelial Cells
Xia, Y., Zhao, G., Lin, J., Li, C., Lin, C., Jiang, N., Xu, Q., & Wang, Q. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164717 · Cited by 6 · see citing works
Determination of 24,25-dihydroxyvitamin D3 in Vitamin D External Quality Assessment Scheme samples using a reference measurement procedure
Wise, S. A., Hahm, G., Burdette, C. Q., Tai, S. S.-C., Camara, J. E., Sempos, C. T., & Williams, E. L. (2023) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2023.106318 · Cited by 4 · see citing works
Vitamin D Status in a Rural Italian Population
Morsilli, O., Guerriero, R., Palmieri, L., Noce, C. L., Zeller, T., Blankenberg, S., Lonardo, A. D., Vannucchi, S., Gabbianelli, M., & Donfrancesco, C. (2021) · Reports — Medical Cases Images and Videos · doi:10.3390/reports5010001 · Cited by 5 · see citing works
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Authors: Slominski, A. T., Kim, T.-K., Shehabi, H. Z., Tang, E. K. Y., Benson, H. A. E., Semak, I., Lin, Z., Yates, C. R., Wang, J., Li, W., & Tuckey, R. C.
Affiliations: University of Tennessee Health Science Center (US)
Curtin University (AU)
The University of Western Australia (AU)
Belarusian State University (BY)
Corresponding author: Slominski, Andrzej T.
Tuckey, Robert C.
ORCID: Slominski, Andrzej T.
Kim, Tae-Kang
Tang, Edith K.Y.
Benson, Heather A.E.
Semak, Igor
Lin, Zongtao
Yates, Charles R.
Wang, Jin
Tuckey, Robert C.
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2014-03
Volume: 383
Issue: 1-2
Pages: 181-192
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2013.12.012
PMC: PMC3997123
OpenAlex: W1968274590
Cited by: 100
References: 54
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 10 · 2021: 15 · 2020: 14 · 2019: 6 · 2018: 2 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 10
FWCI: 8.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
eSpace (Curtin University) (submittedVersion)
Funders: National Institutes of Health (1s10od010678-01)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR052190, R21AR063242, R01AR056666)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords: 25-hydroxyvitamin D2, CYP11A1, CYP27B1, 22R-hydroxycholesterol, ketoconazole, placenta, epidermal keratinocytes, Caco-2 cells, adrenal gland
MeSH terms: Epidermal Cells, Adrenal Glands, Animals, Cholesterol Side-Chain Cleavage Enzyme, Epidermis, Ergocalciferols, Female, Gene Expression Regulation, Humans, Hydroxycholesterols, Hydroxylation, Ketoconazole, Mitochondria, Organ Specificity, Placenta, Pregnancy, Recombinant Proteins, 25-Hydroxyvitamin D3 1-alpha-Hydroxylase, Signal Transduction, Keratinocytes, Rats, Wistar, Caco-2 Cells, Tissue Culture Techniques, Rats

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In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes Caco-2 colon cells and the adrenal gland

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