Tuckey, Robert C.

Production of 22-hydroxy metabolites of vitamin D3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cells

Tuckey, R. C., Li, W., Shehabi, H. Z., Janjetovic, Z., Nguyen, M. N., Kim, T.-K., Chen, J., Howell, D. E., Benson, H. A. E., Sweatman, T., et al. (2011) · Drug Metabolism and Disposition

Vitamin D Research StudiesSteroid Chemistry and Biochemistry

Cited by 88

Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols

Slominski, A. T., Kim, T.-K., Hobrath, J. V., Janjetovic, Z., Oak, A. S. W., Postlethwaite, A., Lin, Z., Li, W., Takeda, Y., Jetten, A. M., et al. (2017) · Scientific Reports

Cholesterol and Lipid MetabolismPsoriasis: Treatment and Pathogenesis

Cited by 82

Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes

Slominski, A. T., Kim, T.-K., Chen, J., Nguyen, M. N., Li, W., Yates, C. R., Sweatman, T., Janjetovic, Z., & Tuckey, R. C. (2012) · The International Journal of Biochemistry & Cell Biology

Steroid Chemistry and BiochemistryCholesterol and Lipid Metabolism

Cited by 81

Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity

Slominski, A. T., Manna, P. R., & Tuckey, R. C. (2014) · Experimental Dermatology

Dermatology and Skin DiseasesAdrenal Hormones and Disorders

Cited by 79

Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation

Slominski, A. T., Janjetovic, Z., Kim, T.-K., Wasilewski, P., Rosas, S., Hanna, S., Sayre, R. M., Dowdy, J. C., Li, W., & Tuckey, R. C. (2015) · The Journal of Steroid Biochemistry and Molecular Biology

Skin Protection and AgingVitamin D Research Studies

Cited by 77

Novel vitamin D photoproducts and their precursors in the skin

Slominski, A., Kim, T.-K., Zmijewski, M. A., Janjetovic, Z., Li, W., Chen, J., Kusniatsova, E. I., Semak, I., Postlethwaite, A., Miller, D. D., et al. (2013) · Dermato-Endocrinology

Vitamin D Research StudiesSteroid Chemistry and Biochemistry

Cited by 76

Enzymatic Metabolism of Ergosterol by Cytochrome P450scc to Biologically Active 17α,24-Dihydroxyergosterol

Slominski, A., Semak, I., Zjawiony, J., Wortsman, J., Gandy, M. N., Li, J., Zbytek, B., Li, W., & Tuckey, R. C. (2005) · Chemistry & Biology

Steroid Chemistry and BiochemistryCholesterol and Lipid Metabolism

Cited by 69

Chemical synthesis of 20S-hydroxyvitamin D3, which shows antiproliferative activity

Li, W., Chen, J., Janjetovic, Z., Kim, T.-K., Sweatman, T., Lu, Y., Zjawiony, J., Tuckey, R. C., Miller, D., & Slominski, A. (2010) · Steroids

Vitamin D Research StudiesSteroid Chemistry and Biochemistry

Cited by 68

Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein (StAR)

Tuckey, R. C., Headlam, M. J., Bose, H. S., & Miller, W. L. (2002) · Journal of Biological Chemistry

Lipid Membrane Structure and BehaviorCholesterol and Lipid Metabolism

Cited by 67

Correlation between secosteroid-induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength

Kim, T.-K., Wang, J., Janjetovic, Z., Chen, J., Tuckey, R. C., Nguyen, M. N., Tang, E. K. Y., Miller, D., Li, W., & Slominski, A. T. (2012) · Molecular and Cellular Endocrinology

Vitamin D Research StudiesRetinoids in leukemia and cellular processes

Cited by 67

CYP11A1 in skin: an alternative route to photoprotection by vitamin D compounds

Tongkao-on, W., Carter, S., Reeve, V. E., Dixon, K. M., Gordon-Thomson, C., Halliday, G. M., Tuckey, R. C., & Mason, R. S. (2015) · The Journal of Steroid Biochemistry and Molecular Biology

Skin Protection and AgingVitamin D Research Studies

Cited by 63

Metabolism of cholesterol, vitamin D3 and 20-hydroxyvitamin D3 incorporated into phospholipid vesicles by human CYP27A1

Tieu, E. W., Li, W., Chen, J., Baldisseri, D. M., Slominski, A. T., & Tuckey, R. C. (2012) · The Journal of Steroid Biochemistry and Molecular Biology

Vitamin D Research StudiesSteroid Chemistry and Biochemistry

Cited by 56

Catalytic properties of cytochrome P-450scc purified from the human placenta: comparison to bovine cytochrome P-450scc

Tuckey, R. C., & Cameron, K. J. (1993) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Steroid Chemistry and BiochemistryMetal-Catalyzed Oxygenation Mechanisms

Cited by 55

Vitamin D analogs 17, 20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity

Slominski, A. T., Li, W., Bhattacharya, S. K., Smith, R. A., Johnson, P. L., Chen, J., Nelson, K. E., Tuckey, R. C., Miller, D., Jiao, Y., et al. (2011) · Journal of Investigative Dermatology

Vitamin D Research StudiesParathyroid Disorders and Treatments

Cited by 51

Vitamin D derivatives enhance cytotoxic effects of H2O2 or cisplatin on human keratinocytes

Piotrowska, A., Wierzbicka, J., Ślebioda, T., Woźniak, M., Tuckey, R. C., Slominski, A. T., & Żmijewski, M. A. (2016) · Steroids

Vitamin D Research StudiesPhotodynamic Therapy Research Studies

Cited by 48

Metabolism of vitamin D2 to 17, 20,24-trihydroxyvitamin D2 by cytochrome p450scc (CYP11A1)

Nguyen, M. N., Slominski, A., Li, W., Ng, Y. R., & Tuckey, R. C. (2009) · Drug Metabolism and Disposition

Vitamin D Research StudiesSteroid Chemistry and Biochemistry

Cited by 48

Metabolism of 1α-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1α,20-dihydroxyvitamin D3

Tuckey, R. C., Janjetovic, Z., Li, W., Nguyen, M. N., Zmijewski, M. A., Zjawiony, J., & Slominski, A. (2008) · The Journal of Steroid Biochemistry and Molecular Biology

Vitamin D Research StudiesPharmacogenetics and Drug Metabolism

Cited by 48

Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models

Skobowiat, C., Oak, A. S. W., Kim, T.-K., Yang, C. H., Pfeffer, L. M., Tuckey, R. C., & Slominski, A. T. (2017) · Oncotarget

Vitamin D Research Studiesmelanin and skin pigmentation

Cited by 44

Rat CYP24A1 acts on 20-hydroxyvitamin D3 producing hydroxylated products with increased biological activity

Tieu, E. W., Tang, E. K. Y., Chen, J., Li, W., Nguyen, M. N., Janjetovic, Z., Slominski, A., & Tuckey, R. C. (2012) · Biochemical Pharmacology

Vitamin D Research StudiesPharmacogenetics and Drug Metabolism

Cited by 44

Lumisterol is metabolized by CYP11A1: discovery of a new pathway

Tuckey, R. C., Slominski, A. T., Cheng, C. Y. S., Chen, J., Kim, T.-K., Xiao, M., & Li, W. (2014) · The International Journal of Biochemistry & Cell Biology

Steroid Chemistry and BiochemistryVitamin D Research Studies

Cited by 43

Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1

Tang, E. K. Y., Chen, J., Janjetovic, Z., Tieu, E. W., Slominski, A. T., Li, W., & Tuckey, R. C. (2013) · Drug Metabolism and Disposition

Vitamin D Research StudiesPharmacogenetics and Drug Metabolism

Cited by 42

Purified Mouse CYP27B1 Can Hydroxylate 20,23-Dihydroxyvitamin D3, Producing 1α,20,23-Trihydroxyvitamin D3, Which Has Altered Biological Activity

Tang, E. K. Y., Li, W., Janjetovic, Z., Nguyen, M. N., Wang, Z., Slominski, A., & Tuckey, R. C. (2010) · Drug Metabolism and Disposition

Vitamin D Research StudiesPharmacogenetics and Drug Metabolism

Cited by 40

Side‐chain specificities of human and bovine cytochromes P‐450scc

TUCKEY, R. C., & CAMERON, K. J. (1993) · European Journal of Biochemistry

Steroid Chemistry and BiochemistryMetal-Catalyzed Oxygenation Mechanisms

Cited by 38

Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol

Tuckey, R. C., Nguyen, M. N., Chen, J., Slominski, A. T., Baldisseri, D. M., Tieu, E. W., Zjawiony, J. K., & Li, W. (2012) · Drug Metabolism and Disposition

Steroid Chemistry and BiochemistryMetal-Catalyzed Oxygenation Mechanisms

Cited by 32