Simard, Jacques

Structure and tissue-specific expression of 3ß-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues

Labrie, F., Simard, J., Luu-The, V., Pelletier, G., Bélanger, A., Lachance, Y., Zhao, H. F., Labrie, C., Breton, N., de Launoit, Y., et al. (1992) · The Journal of Steroid Biochemistry and Molecular Biology

Adrenal Hormones and DisordersSteroid Chemistry and Biochemistry

Cited by 88

Stimulation of androgen-dependent gene expression by the adrenal precursors dehydroepiandrosterone and androstenedione in the rat ventral prostate.

LABRIE, C., SIMARD, J., ZHAO, H. F., BELANGER, A., PELLETIER, G., & LABRIE, F. (1989) · Endocrinology

Prostate Cancer Treatment and ResearchHormonal and reproductive studies

Cited by 80

11 Structure, regulation and role of 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase and aromatase enzymes in the formation of sex steroids in classical and peripheral intracrine tissues

Labrie, F., Simard, J., Luu-The, V., Pelletier, G., Belghmi, K., & Bélanger, A. (1994) · Baillière s Clinical Endocrinology and Metabolism

Estrogen and related hormone effectsSteroid Chemistry and Biochemistry

Cited by 78

Inhibitory Effect of Estrogens on GCDFP-15 mRNA Levels and Secretion in ZR-75-1 Human Breast Cancer Cells

Simard, J., Hatton, A. C., Labrief, C., Dauvois, S., Zhao, H. F., Haagensen, D. E., & Labrie, F. (1989) · Molecular Endocrinology

Estrogen and related hormone effectsBreast Cancer Treatment Studies

Cited by 72

Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32, 295 women

EMBRACE, Rebbeck, T. R., HEBON, Friebel, T. M., Mitra, N., Wan, F., Chen, S., Andrulis, I. L., Apostolou, P., Arnold, N., et al. (2016) · Breast Cancer Research

BRCA gene mutations in cancerMultiple and Secondary Primary Cancers

Cited by 71

Structure-function relationships of 3β-hydroxysteroid dehydrogenase: contribution made by the molecular genetics of 3β-hydroxysteroid dehydrogenase deficiency

Morel, Y., Mébarki, F., Rhéaume, E., Sanchez, R., Forest, M. G., & Simard, J. (1997) · Steroids

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 67

The Human Type II 17β-Hydroxysteroid Dehydrogenase Gene Encodes Two Alternatively Spliced mRNA Species

LABRIE, Y., DUROCHER, F., LACHANCE, Y., TURGEON, C., SIMARD, J., LABRIE, C., & LABRIE, F. (1995) · DNA and Cell Biology

Sexual Differentiation and DisordersEstrogen and related hormone effects

Cited by 64

Occurrence of cytochrome P450c17 mRNA and dehydroepiandrosterone biosynthesis in the rat gastrointestinal tract

Dalla Valle, L., Couët, J., Labrie, Y., Simard, J., Belvedere, P., Simontacchi, C., Labrie, F., & Colombo, L. (1995) · Molecular and Cellular Endocrinology

Steroid Chemistry and BiochemistryPharmacogenetics and Drug Metabolism

Cited by 43

Mutational analysis of the breast cancer susceptibility gene BRIP1 /BACH1/FANCJ in high-risk non-BRCA1/BRCA2 breast cancer families

BRCAs, I., Guénard, F., Labrie, Y., Ouellette, G., Joly Beauparlant, C., Simard, J., & Durocher, F. (2008) · Journal of Human Genetics

BRCA gene mutations in cancerDNA Repair Mechanisms

Cited by 38

Antagonism between estrogens and androgens on GCDFP-15 gene expression in ZR-75-1 cells and correlation between GCDFP-15 and estrogen as well as progesterone receptor expression in human breast cancer.

Dumont, M., Dauvois, S., Simard, J., Garcia, T., Schachter, B., & Labrie, F. (1989) · Journal of Steroid Biochemistry

Estrogen and related hormone effectsBreast Cancer Treatment Studies

Cited by 26

Structure-function relationships and molecular genetics of the 3β-hydroxysteroid dehydrogenase gene family

Simard, J., Sanchez, R., Durocher, F., Rhéaume, E., Turgeon, C., Labrie, Y., Luu-The, V., Mebarki, F., Morel, Y., de Launoit, Y., et al. (1995) · The Journal of Steroid Biochemistry and Molecular Biology

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 24

Androgenic 17 beta-hydroxysteroid dehydrogenase activity of expressed rat type I 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase

de Launoit, Y., Simard, J., Durocher, F., & Labrie, F. (1992) · Endocrinology

Steroid Chemistry and BiochemistryHormonal and reproductive studies

Cited by 23

Relative potencies of flutamide and casodex: preclinical studies.

Luo, S., Martel, C., LeBlanc, G., Candas, B., Singh, S. M., Labrie, C., Simard, J., Belanger, A., & Labrie, F. (1996) · Endocrine Related Cancer

Prostate Cancer Treatment and ResearchEstrogen and related hormone effects

Cited by 23

Pleiotropy-guided transcriptome imputation from normal and tumor tissues identifies candidate susceptibility genes for breast and ovarian cancer

Kar, S. P., Considine, D. P. C., Tyrer, J. P., Plummer, J. T., Chen, S., Dezem, F. S., Barbeira, A. N., Rajagopal, P. S., Rosenow, W. T., Moreno, F., et al. (2021) · Human Genetics and Genomics Advances

Genetic Associations and EpidemiologyBRCA gene mutations in cancer

Cited by 18