Intracrinology: Role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease
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In women and men, an important proportion of estrogens and androgens are synthesized locally at their site of action in peripheral target tissues. This new field of endocrinology has been called intracrinology. In postmenopausal women, 100% of active sex steroids are synthesized in peripheral target tissues from inactive steroid precursors while, in adult men, approximately 50% of androgens are made locally in intracrine target tissues. The last and key step in the formation of all estrogens and androgens is catalyzed by members of the family of 17beta-hydroxysteroid dehydrogenases (17 beta-HSDs) while different 17 beta-HSDs inactivate these steroids in the same cell where synthesis takes place. To date, seven human 17 beta-HSDs have been cloned, sequenced and characterized. The 17 beta-HSDs provide each cell with the means of precisely controlling the intracellular concentration of each sex steroid according to local needs.
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Peripheral tissue metabolism of steroids (intracrinology) is accepted as a key way in which tissues such as the endometrium can utilise inactive steroids present in the blood to respond to local physiological demands and fine-tune activation or inhibition of steroid hormone receptor-dependent processes.
“Peripheral tissue metabolism of steroids (intracrinology) is now accepted as a key way in which tissues, such as the endometrium, can utilise inactive steroids present in the blood to respond to local physiological demands and ‘fine-tune’ the activation or inhibition of steroid hormone receptor-dependent processes.”
From Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders (2018) · cites this paper as [6]
Supplementation with physiological amounts of exogenous DHEA permits the biosynthesis of androgens and estrogens only in target tissues that contain the specific steroidogenic enzymes.
“supplementation with physiological amounts of exogenous DHEA permits the biosynthesis of androgens (essentially testosterone and DHT) and estrogens only in the target tissues that contain the specific steroidogenic enzymes (25,33).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [33]
Women at menopause are not only deprived from estrogens because of rapid loss of ovarian activity but also have been deprived from androgens for a longer period because of progressive decrease of serum DHEA levels starting years before menopause.
“women, at menopause, are not only deprived from estrogens because of a rapid loss of ovarian activity but also have been deprived from androgens for a longer period because of a progressive decrease of serum DHEA levels starting quite a few years before menopause.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [33]
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- Authors
- Labrie, F., Luu-The, V, Lin, S., Simard, J., Labrie, C., El-Alfy, M., Pelletier, G., & Belanger, A.
- Affiliations
- Centre hospitalier de l'Université Laval (CA)
- ORCID
- Simard, J
- Venue
- Journal of Molecular Endocrinology
- Publisher
- Bioscientifica
- Published
- 2000-08-01
- Volume
- 25
- Issue
- 1
- Pages
- 1-16
- ISSN
- 0952-5041 (ISSN-L)
- 1479-6813
- OpenAlex
- W2127529986
- Cited by
- 278
- References
- 87
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 6 · 2023: 1 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 9 · 2017: 9 · 2016: 10 · 2015: 7 · 2014: 13 · 2013: 8 · 2012: 10
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Molecular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- intracrinology, 17β-hydroxysteroid dehydrogenase, estrogen synthesis, androgen production, postmenopausal women, sex steroid metabolism
- MeSH terms
- Adrenal Glands, Adult, Androgens, Breast Neoplasms, Dehydroepiandrosterone, Endocrinology, Estrogens, Female, Genitalia, Humans, Male, Middle Aged, Neoplasms, Hormone-Dependent, 17-Hydroxysteroid Dehydrogenases
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