Structure of two in tandem human 17β-hydroxysteroid dehydrogenase genes
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Two human 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) genes (h17 beta-HSDI and h17 beta-HSDII) included in tandem within an approximately 13 kilobase pair fragment were isolated from a genomic lambda EMBL3 DNA library using cDNA encoding human 17 beta-HSD (hpE2DH216) as probe. We have determined the complete exon and intron sequences of the two genes as well as their 5' and 3'-flanking regions. Human 17 beta-HSDII contains six exons and five short introns for a total length of 3250 base pairs. The exon sequence of h17 beta-HSDII is identical to the previously reported hpE2DH216 cDNA while the overlapping nucleotide sequences of the corresponding exons and introns of h17 beta-HSDI and h17 beta-HSDII show 89% homology. In addition, we have used the hpE2DH216 cDNA to demonstrate the widespread expression of 17 beta-HSD mRNAs in steroidogenic and peripheral target tissues. These new findings provide the basis for a better understanding of the molecular mechanisms involved in 17 beta-HSD deficiency and peripheral sex steroid metabolism.
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In the late 1980s, three independent groups reported the cloning of its cDNA, the first of any human HSD.
“In the late 1980s, three independent groups reported the cloning of its cDNA, the first of any human HSD (503-505).”
From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [505]
The Introduction reports that the authors had previously isolated and characterized human placental 17β-HSD cDNAs, and Cloning and Nucleotide Sequencing describes using one as a probe. Neither passage establishes that three independent groups reported the cloning or that this was the first cDNA cloned for any human HSD. (LLM, conf=0.84)
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Cites
DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572 · see citing works
Detection of specific sequences among DNA fragments separated by gel electrophoresis
Southern, E. M. (1975) · Journal of Molecular Biology · doi:10.1016/s0022-2836(75)80083-0 · Cited by 32,245 · see citing works
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,512 · see citing works
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,725 · see citing works
Aviv, H., & Leder, P. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1408 · Cited by 6,636 · see citing works
Organization and Expression of Eucaryotic Split Genes Coding for Proteins
Breathnach, R., & Chambon, P. (1981) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.50.070181.002025 · Cited by 4,649 · see citing works
DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.
Tabor, S., & Richardson, C. C. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.14.4767 · Cited by 2,260 · see citing works
Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins
Dynan, W. S., & Tjian, R. (1985) · Nature · doi:10.1038/316774a0 · Cited by 1,251 · see citing works
In vivo sequence requirements of the SV40 early promoter region
Benoist, C., & Chambon, P. (1981) · Nature · doi:10.1038/290304a0 · Cited by 1,074 · see citing works
A multiplicity of CCAAT box-binding proteins
Dorn, A., Bollekens, J. A., Staub, A., Benoist, C. O., & Mathis, D. J. (1987) · Cell · doi:10.1016/0092-8674(87)90513-7 · Cited by 688 · see citing works
A strategy to reveal high-frequency RFLPs along the human X chromosome.
Aldridge, J., Kunkel, L. M., Bruns, G. A. P., Tantravahi, U., Lalande, M., Brewster, T. D., Moreau, E. L. P., Wilson, M., Bromley, W. C., & Roderick, T. H. (1984) · PubMed · Cited by 365 · see citing works
Complete amino acid sequence of human placental 17β-hydroxysteroid dehydrogenase deduced from cDNA
Peltoketo, H., Isomaa, V., Mäentausta, O., & Vihko, R. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80548-9 · Cited by 294 · see citing works
The, V. L., Labrie, C., Zhao, H. F., Couët, J., Lachance, Y., Simard, J., Leblanc, G., Côté, J., Bérubé, D., Gagné, R., et al. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-8-1301 · Cited by 274 · see citing works
Self-citationMeasurement of the binding of transcription factor Sp1 to a single GC box recognition sequence
Letovsky, J., & Dynan, W. S. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.7.2639 · Cited by 236 · see citing works
Poulin, R., & Labrie, F. (1986) · PubMed · Cited by 200 · see citing works
Self-citationSaez, J. M., PERETTI, E. D., MORERA, A. M., David, M., & Bertrand, J. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-32-5-604 · Cited by 175 · see citing works
THE INTERCONVERSION OF ESTRONE AND ESTRADIOL BY HUMAN TISSUE SLICES1,2,3
Ryan, K. J., & Engel, L. L. (1953) · Endocrinology · doi:10.1210/endo-52-3-287 · Cited by 164 · see citing works
Thein Vitroandin VivoUptake and Metabolism of Steroids in Human Adipose Tissue1
Bleau, G., Roberts, K. D., & Chapdelaine, A. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-2-236 · Cited by 82 · see citing works
LABRIE, C., SIMARD, J., ZHAO, H. F., BELANGER, A., PELLETIER, G., & LABRIE, F. (1989) · Endocrinology · doi:10.1210/endo-124-6-2745 · Cited by 80 · see citing works
Self-citationQuantitative Studies on the Uptake and Metabolism of Estrogens and Progesterone by Human Endometrium
Tseng, L., Stolee, A., & Gurpide, E. (1972) · Endocrinology · doi:10.1210/endo-90-2-390 · Cited by 80 · see citing works
Weinstein, G. D., Frost, P., & Hsia, S. L. (1968) · Journal of Investigative Dermatology · doi:10.1038/jid.1968.84 · Cited by 44 · see citing works
Metabolism of Oestrone and Oestradiol-17β in Human Liver in vitro
BREUER, H., Knüppen, R., & Haupt, M. (1966) · Nature · doi:10.1038/212076a0 · Cited by 40 · see citing works
Testicular 17β-hydroxysteroid dehydrogenase: Molecular properties and reaction mechanism
Inano, H., & Bun-Ichi, T. (1986) · Steroids · doi:10.1016/0039-128x(86)90038-3 · Cited by 39 · see citing works
17β-Hydroxysteroid Dehydrogenase from Human Red Blood Cells
Jacobsohn, G. M., & Hochberg, R. B. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93369-7 · Cited by 35 · see citing works
Poulin, R., Poirier, D., Mérand, Y., Thériault, C., Bèlanger, A., & Labrie, F. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60536-8 · Cited by 30 · see citing works
Self-citationMurdock, G. L., Chin, C.-C., Offord, R. E., Bradshaw, R. A., & Warren, J. C. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44248-7 · Cited by 21 · see citing works
Interconversion of estrone and estradiol-17β in lung slices of the adult human
Milkwich, L., Hendricks, T. S., & Romero, L. H. (1982) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(82)90569-6 · Cited by 17 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Lacoste D, Belanger A, Labrie F 1989 Biosynthesis and degradation of androgens in human prostatic cancer cell lines. In: Bradlow H, Castagnetta L, d'Aquino S, Labrie F (eds) Steroid Formation, Degradation and Action in Pe- ripheral Normal and Neoplastic Tissues. Ann New York Acad Sci, NY, in press
- Greene JM 1987 Analysis of RNA structure and synthesis. In: Ausubel FM, Brent R, Kingston RE, Moore DD, Seid- man TG, Smith TA, Struhl K (eds) Current Protocols in Molecular Biology. Wiley and Sons, New York, pp 4.6.1- 4.6.5
Cited by
Sorted by citations
Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21
Hall, J., Lee, M. K., Newman, B. M., Morrow, J. E., Anderson, L. A., Huey, B., & King, M. (1990) · Science · doi:10.1126/science.2270482 · Cited by 2,544 · see citing works
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458 · see citing works
Functional role of estrogen metabolism in target cells: review and perspectives
Zhu, B. T. (1998) · Carcinogenesis · doi:10.1093/carcin/19.1.1 · Cited by 964 · see citing works
Labrie, F. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90116-a · Cited by 685 · see citing works
Self-citationMale pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3
Geissler, W. M., Davis, D. L., Wu, L., Bradshaw, K. D., Patel, S., Mendonca, B. B., Elliston, K. O., Wilson, J. D., Russell, D. W., & Andersson, S. (1994) · Nature Genetics · doi:10.1038/ng0594-34 · Cited by 570 · see citing works
Steroidogenic enzymes: Structure, function, and role in regulation of steroid hormone biosynthesis
Hanukoglu, I. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90307-5 · Cited by 551 · see citing works
Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544 · see citing works
Self-citationThe key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology
Labrie, F., Luu-The, V., Lin, S.-X., Claude, L., Simard, J., Breton, R., & Bélanger, A. (1997) · Steroids · doi:10.1016/s0039-128x(96)00174-2 · Cited by 480 · see citing works
Self-citationWang, R.-S., Yeh, S., Tzeng, C., & Chang, C. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0025 · Cited by 470 · see citing works
Is dehydroepiandrosterone a hormone?
Labrie, F., Luu-The, V., Bèlanger, A., Lin, S.-X., Simard, J., Pelletier, G., & Labrie, C. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06264 · Cited by 454 · see citing works
Self-citationMolecular Endocrinology of Hydroxysteroid Dehydrogenases
Penning, T. M. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0302 · Cited by 436 · see citing works
Tannin, G. M., Agarwal, A. K., Monder, C., New, M. I., & White, P. C. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55351-5 · Cited by 436 · see citing works
Labrie, F., Luu-The, V., Labrie, C., & Simard, J. (2001) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0216 · Cited by 366 · see citing works
Self-citationRhéaume, E., Lachance, Y., Zhao, H.-F., Breton, N., Dumont, M., Launoit, Y. D., Trudel, C., Luu-The, V., Simard, J., & Labrie, F. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-8-1147 · Cited by 362 · see citing works
Self-citationThe role of 17 beta-hydroxysteroid dehydrogenases
Mindnich, R., Möller, G., & Adamski, J. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.12.006 · Cited by 354 · see citing works
Peltoketo, H., Luu-The, V, Simard, J., & Adamski, J. (1999) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0230001 · Cited by 302 · see citing works
Self-citationDHEA and peripheral androgen and estrogen formation: intracrinology
LABRIE, F., BÉLANGER, A., SIMARD, J., LUU‐THE, V., & LABRIE, C. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17369.x · Cited by 280 · see citing works
Self-citationLabrie, F., Luu-The, V, Lin, S., Simard, J., Labrie, C., El-Alfy, M., Pelletier, G., & Belanger, A. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0250001 · Cited by 278 · see citing works
Self-citationAnalysis and characteristics of multiple types of human 17β-hydroxysteroid dehydrogenase
Luu-The, V. (2001) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(00)00155-2 · Cited by 245 · see citing works
Self-citationStructure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2.20 å resolution
Ghosh, D., Pletnev, V. Z., Zhu, D.-W., Wawrzak, Z., Duax, W. L., Pangborn, W., Labrie, F., & Lin, S.-X. (1995) · Structure · doi:10.1016/s0969-2126(01)00183-6 · Cited by 239 · see citing works
Self-citationRhéaume, E., Simard, J., Morel, Y., Mebarki, F., Zachmann, M., Forest, M. G., New, M. I., & Labrie, F. (1992) · Nature Genetics · doi:10.1038/ng0792-239 · Cited by 235 · see citing works
Self-citationMartel, C., Rhéaume, E., Takahashi, M., Trudel, C., Couët, J., Luu-The, V., Simard, J., & Labrie, F. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90390-5 · Cited by 231 · see citing works
Self-citationLuu-The, V., Zhang, Y., Poirier, D., & Labrie, F. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00209-x · Cited by 224 · see citing works
Self-citationAdamski, J., Normand, T., Leenders, F., Monté, D., Begue, A., Stéhelin, D., Jungblut, P. W., & de Launoit, Y. (1995) · Biochemical Journal · doi:10.1042/bj3110437 · Cited by 214 · see citing works
Integrated view on 17beta-hydroxysteroid dehydrogenases
Moeller, G., & Adamski, J. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.040 · Cited by 214 · see citing works
Casey, M. L., MacDonald, P. C., & Andersson, S. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117569 · Cited by 212 · see citing works
Lachance, Y., Luu-The, V, Labrie, C., Simard, J., Dumont, M., de Launoit, Y., Guérin, S., Leblanc, G., & Labrie, F. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30528-8 · Cited by 201 · see citing works
Self-citationMartel, C., Meiner, M. H., Gagné, D., Simard, J., & Labrie, F. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90056-6 · Cited by 190 · see citing works
Self-citationMIETTINEN, M. M., MUSTONEN, M. V. J., POUTANEN, M. H., ISOMAA, V. V., & VIHKO, R. K. (1996) · Biochemical Journal · doi:10.1042/bj3140839 · Cited by 188 · see citing works
Zhao, H., Labrie, C., Simard, J., de Launoit, Y., Trudel, C., Martel, C., Rhéaume, É., Dupont, É., Luu-The, V., & Pelletier, G. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52475-3 · Cited by 176 · see citing works
Self-citationGonadotropin-Releasing Hormone Agonists in the Treatment of Prostate Cancer
Labrie, F., Bélanger, A., Luu-The, V., Labrie, C., Simard, J., Cusan, L., Gomez, J., & Candas, B. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0017 · Cited by 169 · see citing works
Self-citationA guide to 17β-hydroxysteroid dehydrogenases
Adamski, J., & Jakob, F. J. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00383-x · Cited by 161 · see citing works
Physiology and molecular genetics of 17β-hydroxysteroid dehydrogenases
Andersson, S., & Moghrabi, N. N. (1997) · Steroids · doi:10.1016/s0039-128x(96)00173-0 · Cited by 157 · see citing works
The Intracrine Sex Steroid Biosynthesis Pathways
Luu-The, V., & Labrie, F. (2010) · Progress in brain research · doi:10.1016/s0079-6123(08)81010-2 · Cited by 147 · see citing works
Self-citationRole of 17β-Hydroxysteroid Dehydrogenases in Sex Steroid Formation in Peripheral Intracrine Tissues
Labrie, F., Luu-The, V., Lin, S., Simard, J., & Labrie, C. (2000) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00342-8 · Cited by 143 · see citing works
Self-citationMechanism of action and pure antiandrogenic properties of flutamide
Labrie, F. (1993) · Cancer · doi:10.1002/1097-0142(19931215)72:12+ · Cited by 140 · see citing works
Self-citationLabrie, F., Simard, J., Luu-The, V., Bélanger, A., & Pelletier, G. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90308-6 · Cited by 132 · see citing works
Self-citationLachance, Y., LUU-THE, V., Verreault, H., Dumont, M., Rhéaume, É., Leblanc, G., & Labrie, F. (1991) · DNA and Cell Biology · doi:10.1089/dna.1991.10.701 · Cited by 130 · see citing works
Self-citationSubunit identity of the dimeric 17 beta-hydroxysteroid dehydrogenase from human placenta.
Lin, S., Yang, F. D., Jin, J. Z., Breton, R., Zhu, D.-W., Luu-The, V., & Labrie, F. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41984-9 · Cited by 117 · see citing works
Self-citationIris, F., Bougueleret, L., Prieur, S., Caterina, D., Primas, G., Perrot, V., Jurka, J., Rodriguez‐Tomé, P., Claverie, J., Dausset, J. B., et al. (1993) · Nature Genetics · doi:10.1038/ng0293-137 · Cited by 117 · see citing works
Regulation of Sexual Dimorphism in Mammals
Haqq, C. M., & Donahoe, P. K. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.1 · Cited by 110 · see citing works
Role of 17β-hydroxysteroid dehydrogenase type 1 in endocrine and intracrine estradiol biosynthesis
POUTANEN, M. H., ISOMAA, V. V., Peltoketo, H., & Vihko, R. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00201-4 · Cited by 104 · see citing works
Labrie, F., Bélanger, A., Simard, J., Labrie, C., & Dupont, A. (1993) · Cancer · doi:10.1002/1097-0142(19930201)71:3+ · Cited by 93 · see citing works
Self-citationMolecular cloning and amino acid sequence of the porcine 17β‐estradiol dehydrogenase
Leenders, F., Adamski, J., Husen, B., Thole, H. H., & Jungblut, P. W. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb18860.x · Cited by 94 · see citing works
Nokelainen, P., Puranen, T., Peltoketo, H., Orava, M., Vihko, P., & Vihko, R. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00482.x · Cited by 94 · see citing works
Mindnich, R., Deluca, D., & Adamski, J. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.11.010 · Cited by 91 · see citing works
Schörghofer, D., Kinslechner, K., Preitschopf, A., Schütz, B., Röhrl, C., Hengstschläger, M., Stangl, H., & Mikula, M. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0087-z · Cited by 81 · see citing works
de Launoit, Y., & Adamski, J. (1999) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0220227 · Cited by 79 · see citing works
Puranen, T., POUTANEN, M. H., Peltoketo, H., Vihko, P., & Vihko, R. (1994) · Biochemical Journal · doi:10.1042/bj3040289 · Cited by 81 · see citing works
Lorence, M. C., Corbin, C. J., Kamimura, N., Mahendroo, M. S., & Mason, J. I. (1990) · Molecular Endocrinology · doi:10.1210/mend-4-12-1850 · Cited by 80 · see citing works
Labrie, F., Simard, J., Luu-The, V., Pelletier, G., Belghmi, K., & Bélanger, A. (1994) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(05)80261-7 · Cited by 78 · see citing works
Self-citationPuranen, T., POUTANEN, M. H., Ghosh, D., Vihko, R., & Vihko, P. (1997) · Endocrinology · doi:10.1210/endo.138.8.5303 · Cited by 73 · see citing works
Corbould, A. M., Judd, S. J., & Rodgers, R. J. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.1.4495 · Cited by 75 · see citing works
POUTANEN, M. H., Miettinen, M., & Vihko, R. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243287 · Cited by 69 · see citing works
Environmental Pollutants and Hydroxysteroid Dehydrogenases
Ye, L., Guo, J., & Ge, R. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800095-3.00013-4 · Cited by 67 · see citing works
HSD17B1 Gene Polymorphisms and Risk of Endometrial and Breast Cancer
Setiawan, V. W., Hankinson, S. E., Colditz, G. A., Hunter, D. J., & Vivo, I. D. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-03-0241 · Cited by 68 · see citing works
The selective estrogen enzyme modulator (SEEM) in breast cancer
Chetrite, G. S., & Pasqualini, J. R. (2001) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(01)00046-2 · Cited by 68 · see citing works
Endocrine Therapy for Prostate Cancer
Labrie, F. (1991) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30247-0 · Cited by 65 · see citing works
Self-citationLABRIE, Y., DUROCHER, F., LACHANCE, Y., TURGEON, C., SIMARD, J., LABRIE, C., & LABRIE, F. (1995) · DNA and Cell Biology · doi:10.1089/dna.1995.14.849 · Cited by 64 · see citing works
Self-citationDuncan, L., Coldham, N. G., & Reed, M. J. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90301-8 · Cited by 64 · see citing works
Expression of human 17β-hydroxysteroid dehydrogenase in mammalian cells
Dumont, M., Luu-The, V., de Launoit, Y., & Labrie, F. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90391-u · Cited by 62 · see citing works
Self-citationCloning and sequence of the human adrenodoxin reductase gene
Lin, D., Shi, Y. F., & Miller, W. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8516 · Cited by 61 · see citing works
Simard, J., Melner, M. H., Breton, N., Low, K. G., Zhao, H., Penman, L. M., & Labrie, F. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90224-g · Cited by 60 · see citing works
Self-citationMannermaa, A., Peltoketo, H., Winqvist, R., Ponder, B. A. J., Kiviniemi, H., Easton, D. F., POUTANEN, M. H., ISOMAA, V. V., & Vihko, R. (1994) · Human Genetics · doi:10.1007/bf00212030 · Cited by 58 · see citing works
Expression of 17beta-hydroxysteroid dehydrogenase types 1, 2, 3 and 4 in the human temporal lobe
Stoffel‐Wagner, B., Watzka, M., Steckelbroeck, S., Schramm, J., Bidlingmaier, J., & Klingmüller, D. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600119 · Cited by 59 · see citing works
Han, Q., Campbell, R. L., Gangloff, A., Huang, Y., & Lin, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1105 · Cited by 56 · see citing works
Two 17β-hydroxysteroid dehydrogenases (17HSDs) of estradiol biosynthesis: 17HSD type 1 and type 7
Peltoketo, H., Nokelainen, P., Piao, Y.-S., Vihko, R., & Vihko, P. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(99)00064-3 · Cited by 54 · see citing works
The molecular biology of androgenic 17β-hydroxysteroid dehydrogenases
Andersson, S., Geissler, W. M., Patel, S., & Wu, L. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00039-3 · Cited by 54 · see citing works
Couture, P., Thériault, C., Simard, J., & Labrie, F. (1993) · Endocrinology · doi:10.1210/endo.132.1.8380373 · Cited by 54 · see citing works
Self-citationTestosterone metabolism in primary cultures of human prostate epithelial cells and fibroblasts
́los, S. D., Carsol, J.-L., Ghazarossian, E., Raynaud, J., & Martin, P. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00184-0 · Cited by 54 · see citing works
Piao, Y.-S., Peltoketo, H., Vihko, P., & Vihko, R. (1997) · Endocrinology · doi:10.1210/endo.138.8.5329 · Cited by 55 · see citing works
Charbonneau, A., & The, V. L. (2001) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00278-5 · Cited by 53 · see citing works
Structural Characterization and Expression of the Human Dehydroepiandrosterone Sulfotransferase Gene
LUU-THE, V., Dufort, I., Paquet, N., Reimnitz, G., & Labrie, F. (1995) · DNA and Cell Biology · doi:10.1089/dna.1995.14.511 · Cited by 52 · see citing works
Self-citationMoghrabi, N. N., Head, J. R., & Andersson, S. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.11.4391 · Cited by 53 · see citing works
Lacy, W. R., Washenick, K. J., Cook, R. G., & Dunbar, B. S. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.1.8446108 · Cited by 51 · see citing works
Regulation of estrogen action: role of 17 beta-hydroxysteroid dehydrogenases.
Peltoketo, H., Vihko, P., & Vihko, R. (1999) · PubMed · Cited by 50 · see citing works
Nguyen, B. ‐., Chetrite, G., & Pasqualini, J. R. (1995) · Breast Cancer Research and Treatment · doi:10.1007/bf00665786 · Cited by 49 · see citing works
POUTANEN, M. H., ISOMAA, V. V., Kainulainen, K., & Vihko, R. (1990) · International Journal of Cancer · doi:10.1002/ijc.2910460524 · Cited by 48 · see citing works
Cloning of 17β-Hydroxysteroid Dehydrogenase-I cDNAs from Japanese Eel Ovary
Kazeto, Y., Ijiri, S., Matsubara, H., Adachi, S., & Yamauchi, K. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3974 · Cited by 46 · see citing works
Regulation of Oestrogen Action: Role of 17β-hydroxysteroid Dehydrogenases
POUTANEN, M. H., ISOMAA, V. V., Peltoketo, H., & Vihko, R. (1995) · Annals of Medicine · doi:10.3109/07853899509019255 · Cited by 46 · see citing works
Yoshimura, N., Harada, N., Bukholm, I., Kåresen, R., Børresen‐Dale, A., & Kristensen, V. N. (2003) · Breast Cancer Research · doi:10.1186/bcr746 · Cited by 45 · see citing works
CASTAGNETTA, L. A. M., Carruba, G., Traina, A., Granata, O. M., Markus, M., Pavone‐Macaluso, M., Blomquist, C. H., & Adamski, J. (1997) · Endocrinology · doi:10.1210/endo.138.11.5497 · Cited by 47 · see citing works
Sha, J. A., Dudley, K., Rajapaksha, W. R. A. K. J. S., & O’Shaughnessy, P. J. (1997) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(96)00165-3 · Cited by 46 · see citing works
Rösler, A. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90327-f · Cited by 44 · see citing works
Luu-The, V., Pelletier, G., & Labrie, F. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.01.003 · Cited by 42 · see citing works
Self-citationTremblay, M. R., Luu-The, V., Leblanc, G., Noël, P., Breton, E., Labrie, F., & Poirier, D. (1999) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(98)00260-0 · Cited by 43 · see citing works
Self-citation17β-Hydroxysteroid dehydrogenases: physiological roles in health and disease
Moghrabi, N., & Andersson, S. (1998) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(98)00066-6 · Cited by 42 · see citing works
Zhu, S., Li, Y., Li, H., Wang, Y., Xiao, Z., Vihko, P., & Piao, Y. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1720031 · Cited by 42 · see citing works
Genetic Diseases of Steroid Metabolism
White, P. C. (1994) · Vitamins and hormones · doi:10.1016/s0083-6729(08)61147-4 · Cited by 42 · see citing works
Peltoketo, H., ISOMAA, V. V., & Vihko, R. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb17310.x · Cited by 41 · see citing works
Heinosalo, T., Saarinen, N., & POUTANEN, M. H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.08.004 · Cited by 40 · see citing works
Piao, Y.-S., Peltoketo, H., Jouppila, A., & Vihko, R. (1997) · Endocrinology · doi:10.1210/endo.138.3.5008 · Cited by 41 · see citing works
Immunocytochemical localization of type I 17β-hydroxysteroid dehydrogenase in the rat brain
Pelletier, G., Luu-The, V., & Labrie, F. (1995) · Brain Research · doi:10.1016/0006-8993(95)01119-6 · Cited by 41 · see citing works
Self-citationBeaudoin, C., Blomquist, C. H., & Tremblay, Y. (1995) · Endocrinology · doi:10.1210/endo.136.9.7649088 · Cited by 39 · see citing works
The search for the familial breast/ovarian cancer gene
Black, D. M., & Solomon, E. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90068-s · Cited by 37 · see citing works
7 Testicular steroidogenesis and androgen use and abuse
Wu, F. C. W. (1992) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(05)80155-7 · Cited by 37 · see citing works
Regulation of Estrogen Action: Role of 17β-Hydroxysteroid Dehydrogenases
Peltoketo, H., Vihko, P., & Vihko, R. (1998) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60939-5 · Cited by 37 · see citing works
Specific estradiol biosynthetic pathway in choriocarcinoma (JEG-3) cell line
Samson, M., Labrie, F., & Luu-The, V. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.05.009 · Cited by 35 · see citing works
Self-citationBlack, D. M., Nicolai, H., Borrow, J., & Solomon, E. (1993) · PubMed · Cited by 34 · see citing works
SUZUKI, T. A., Sasano, H., Andersson, S., & Mason, J. I. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.10.6918 · Cited by 32 · see citing works
- Authors
- Luu-The, V., Labrie, C., Simard, J., Lachance, Y., Zhao, H.-F., Couët, J., Leblanc, G., & Labrie, F.
- Affiliations
- Université Laval (CA)
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1990-02
- Volume
- 4
- Issue
- 2
- Pages
- 268-275
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2074285202
- Cited by
- 173
- References
- 27
- Citations by year
- 2024: 1 · 2018: 1 · 2017: 2 · 2015: 5 · 2014: 1
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- 17β-hydroxysteroid dehydrogenase, tandem gene duplication, gene structure, exon-intron organization, 5' and 3' flanking regions, steroidogenic tissues, mRNA expression
- MeSH terms
- Amino Acid Sequence, Base Sequence, Chromosome Mapping, Genes, Humans, Molecular Sequence Data, RNA, Messenger, 17-Hydroxysteroid Dehydrogenases, Restriction Mapping, DNA Probes, Genomic Library
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