11 Structure, regulation and role of 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase and aromatase enzymes in the formation of sex steroids in classical and peripheral intracrine tissues

Labrie, Fernand; Simard, Jacques; Van Luu-The; Pelletier, Georges; Belghmi, Khalid; Bélanger, Alain

doi:10.1016/s0950-351x(05)80261-7

Cited by 78Estrogen and related hormone effectsSteroid Chemistry and BiochemistryAdrenal Hormones and Disorders

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11 Structure, regulation and role of 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase and aromatase enzymes in the formation of sex steroids in classical and peripheral intracrine tissues

Labrie, Fernand, Simard, Jacques, Van Luu-The, Pelletier, Georges, Belghmi, Khalid, Bélanger, Alain·1994·Baillière s Clinical Endocrinology and Metabolism

DOI 10.1016/s0950-351x(05)80261-7

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Abstract

In addition to the classical steroidogenic tissues, namely the ovaries, testes, adrenals and placenta, a large series of human peripheral tissues possess all the enzymatic systems required for the formation of active androgens and oestrogens from a relatively large supply of precursor steroids provided by the adrenals. This chapter describes the structure, function, tissue-specific expression and regulation of the 3 beta-HSD and 17 beta-HSD gene families as well as some information about the aromatase gene. While, so far, most therapeutic approaches have been aimed and limited at controlling steroid formation by the classical steroidogenic tissues, it is clear that major efforts should now be turned towards intracrinology in order to understand better the physiological mechanisms controlling local steroid formation in peripheral target tissues and thus be in a position to develop novel therapeutic approaches that take into account the high proportion of steroids that are made locally and are responsible for the growth and function of normal as well as cancerous tissue.

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Women at menopause are not only deprived from estrogens because of rapid loss of ovarian activity but also have been deprived from androgens for a longer period because of progressive decrease of serum DHEA levels starting years before menopause.
“women, at menopause, are not only deprived from estrogens because of a rapid loss of ovarian activity but also have been deprived from androgens for a longer period because of a progressive decrease of serum DHEA levels starting quite a few years before menopause.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [90]

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Androgens and breast cancer.
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Regulation of 3β-Hydroxysteroid Dehydrogenase/Δ5→4- Isomerase Expression by Adrenocorticotropin in Bovine Adrenocortical Cells*
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A common ancestor for mammalian 3 β-hydroxysteroid dehydrogenase and plant dihydroflavonol reductase
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Simard, J., Zhao, H. F., Labrie, C., et al. (1991) · Springer eBooks · doi:10.1007/978-1-4612-3200-1_28 · Cited by 3
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Research works printed but not linked: 2

Dupont, 1992, Immunochemical localization of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) in human ovary, Journal of Clinical Endocrinology and Metabolism, 74, 994, 10.1210/jc.74.5.994 · DOI
Riley, 1992, Immunohistochemical localization of 3β-hydroxy-5-ene-steroid dehydrogenase/Δ5-Δ4 isomerase in human placenta and fetal membranes, Journal of Clinical Endocrinology and Metabolism, 96, 127

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Authors: Labrie, F., Simard, J., Luu-The, V., Pelletier, G., Belghmi, K., & Bélanger, A.
Affiliations: Centre hospitalier de l'Université Laval (CA)
ORCID: Simard, Jacques
Venue: Baillière s Clinical Endocrinology and Metabolism
Publisher: Elsevier BV
Published: 1994-04
Volume: 8
Issue: 2
Pages: 451-474
ISSN: 0950-351X (ISSN-L)
DOI: 10.1016/s0950-351x(05)80261-7
OpenAlex: W2032143202
Cited by: 78
References: 114
Citations by year: 2023: 1 · 2022: 1 · 2021: 1 · 2014: 4 · 2013: 1
FWCI: 1.89
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Baillière s Clinical Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase, aromatase, sex steroid biosynthesis, tissue-specific gene expression, steroidogenic enzyme regulation, androgens, estrogen, adrenal steroids, intracrinology
MeSH terms: Amino Acid Sequence, Animals, Aromatase, Chemistry, Genes, Humans, Isoenzymes, Molecular Sequence Data, Gonadal Steroid Hormones, Structure-Activity Relationship, 17-Hydroxysteroid Dehydrogenases, 3-Hydroxysteroid Dehydrogenases, Chemical Phenomena

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11 Structure, regulation and role of 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase and aromatase enzymes in the formation of sex steroids in classical and peripheral intracrine tissues

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