Penninger, Josef M.

Coupling of bone resorption and formation by RANKL reverse signalling

Ikebuchi, Y., Aoki, S., Honma, M., Hayashi, M., Sugamori, Y., Khan, M., Kariya, Y., Kato, G., Tabata, Y., Penninger, J. M., et al. (2018) · Nature

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 557

Caloric restriction mimetics enhance anticancer immunosurveillance

Pietrocola, F., Pol, J., Vacchelli, E., Rao, S., Enot, D. P., Baracco, E. E., Levesque, S., Castoldi, F., Jacquelot, N., Yamazaki, T., et al. (2016) · Cancer Cell

Autophagy in Disease and TherapyDietary Effects on Health

Cited by 542

The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

Akiyama, T., Shimo, Y., Yanai, H., Qin, J., Ohshima, D., Maruyama, Y., Asaumi, Y., Kitazawa, J., Takayanagi, H., Penninger, J. M., et al. (2008) · Immunity

T-cell and B-cell ImmunologyNF-κB Signaling Pathways

Cited by 503

Identification and functional analysis of endothelial tip cell–enriched genes

del Toro, R., Prahst, C., Mathivet, T., Siegfried, G., Kaminker, J. S., Larrivee, B., Breant, C., Duarte, A., Takakura, N., Fukamizu, A., et al. (2010) · Blood

Angiogenesis and VEGF in CancerDevelopmental Biology and Gene Regulation

Cited by 474

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

Paolino, M., Choidas, A., Wallner, S., Pranjic, B., Uribesalgo, I., Loeser, S., Jamieson, A. M., Langdon, W. Y., Ikeda, F., Fededa, J. P., et al. (2014) · Nature

Immune Cell Function and InteractionImmune cells in cancer

Cited by 456

An Immunosurveillance Mechanism Controls Cancer Cell Ploidy

Senovilla, L., Vitale, I., Martins, I., Tailler, M., Pailleret, C., Michaud, M., Galluzzi, L., Adjemian, S., Kepp, O., Niso-Santano, M., et al. (2012) · Science

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 436

The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator

Hikosaka, Y., Nitta, T., Ohigashi, I., Yano, K., Ishimaru, N., Hayashi, Y., Matsumoto, M., Matsuo, K., Penninger, J. M., Takayanagi, H., et al. (2008) · Immunity

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 433

RANK/RANKL: Regulators of Immune Responses and Bone Physiology

Leibbrandt, A., & Penninger, J. M. (2008) · Annals of the New York Academy of Sciences

Bone Metabolism and DiseasesRheumatoid Arthritis Research and Therapies

Cited by 420

Dendritic cell–induced autoimmune heart failure requires cooperation between adaptive and innate immunity

Eriksson, U., Ricci, R., Hunziker, L., Kurrer, M. O., Oudit, G. Y., Watts, T. H., Sonderegger, I., Bachmaier, K., Kopf, M., & Penninger, J. M. (2003) · Nature Medicine

Viral Infections and Immunology ResearchImmunotherapy and Immune Responses

Cited by 405

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes

Pospisilik, J. A., Knauf, C., Joza, N., Benit, P., Orthofer, M., Cani, P. D., Ebersberger, I., Nakashima, T., Sarao, R., Neely, G., et al. (2007) · Cell

Metabolism, Diabetes, and CancerMitochondrial Function and Pathology

Cited by 404

Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells

Loser, K., Mehling, A., Loeser, S., Apelt, J., Kuhn, A., Grabbe, S., Schwarz, T., Penninger, J. M., & Beissert, S. (2006) · Nature Medicine

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 402

A microfluidic platform integrating functional vascularized organoids-on-chip

Quintard, C., Tubbs, E., Jonsson, G., Jiao, J., Wang, J., Werschler, N., Laporte, C., Pitaval, A., Bah, T.-S., Pomeranz, G., et al. (2024) · Nature Communications

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 387

LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

Luo, J., Yang, Z., Ma, Y., Yue, Z., Lin, H., Qu, G., Huang, J., Dai, W., Li, C., Zheng, C., et al. (2016) · Nature Medicine

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 370

Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction

Jeon, M.-S., Atfield, A., Venuprasad, K., Krawczyk, C., Sarao, R., Elly, C., Yang, C., Arya, S., Bachmaier, K., Su, L., et al. (2004) · Immunity

T-cell and B-cell ImmunologyImmune Response and Inflammation

Cited by 348

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

Liu, Q., Sasaki, T., Kozieradzki, I., Wakeham, A., Itie, A., Dumont, D. J., & Penninger, J. M. (1999) · Genes & Development

PI3K/AKT/mTOR signaling in cancerProtein Tyrosine Phosphatases

Cited by 341

Generation of blood vessel organoids from human pluripotent stem cells

Wimmer, R. A., Leopoldi, A., Aichinger, M., Kerjaschki, D., & Penninger, J. M. (2019) · Nature Protocols

Pluripotent Stem Cells ResearchAngiogenesis and VEGF in Cancer

Cited by 317

The Role of Iron Regulation in Immunometabolism and Immune-Related Disease

Cronin, S. J. F., Woolf, C. J., Weiss, G., & Penninger, J. M. (2019) · Frontiers in Molecular Biosciences

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 299

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Cronin, S. J. F., Seehus, C., Weidinger, A., Talbot, S., Reissig, S., Seifert, M., Pierson, Y., McNeill, E., Longhi, M. S., Turnes, B. L., et al. (2018) · Nature

T-cell and B-cell ImmunologyBiochemical and Molecular Research

Cited by 285

Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury

Yang, P., Gu, H., Zhao, Z., Wang, W., Cao, B., Lai, C., Yang, X., Zhang, L., Duan, Y., Zhang, S., et al. (2014) · Scientific Reports

Influenza Virus Research StudiesRenin-Angiotensin System Studies

Cited by 283

Complete cardiac regeneration in a mouse model of myocardial infarction

Haubner, B. J., Adamowicz-Brice, M., Khadayate, S., Tiefenthaler, V., Metzler, B., Aitman, T., & Penninger, J. M. (2012) · Aging

Congenital heart defects researchCardiac Fibrosis and Remodeling

Cited by 261

Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice.

Pummerer, C. L., Luze, K., Grässl, G., Bachmaier, K., Offner, F., Burrell, S. K., Lenz, D. M., Zamborelli, T. J., Penninger, J. M., & Neu, N. (1996) · Journal of Clinical Investigation

Viral Infections and Immunology ResearchCardiac Fibrosis and Remodeling

Cited by 205

Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity

Dalgaard, K., Landgraf, K., Heyne, S., Lempradl, A., Longinotto, J., Gossens, K., Ruf, M., Orthofer, M., Strogantsev, R., Selvaraj, M., et al. (2016) · Cell

Genetic Syndromes and ImprintingEpigenetics and DNA Methylation

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Activation of Dendritic Cells through the Interleukin 1 Receptor 1 Is Critical for the Induction of Autoimmune Myocarditis

Eriksson, U., Kurrer, M. O., Sonderegger, I., Iezzi, G., Tafuri, A., Hunziker, L., Suzuki, S., Bachmaier, K., Bingisser, R. M., Penninger, J. M., et al. (2003) · The Journal of Experimental Medicine

Viral Infections and Immunology ResearchImmunotherapy and Immune Responses

Cited by 158

Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota

Nagashima, K., Sawa, S., Nitta, T., Tsutsumi, M., Okamura, T., Penninger, J. M., Nakashima, T., & Takayanagi, H. (2017) · Nature Immunology

Gut microbiota and healthT-cell and B-cell Immunology

Cited by 154