Distler, Oliver

Nintedanib for systemic sclerosis–associated interstitial lung disease

Distler, O., Highland, K. B., Gahlemann, M., Azuma, A., Fischer, A., Mayes, M. D., Raghu, G., Sauter, W., Girard, M., Alves, M., et al. (2019) · New England Journal of Medicine

Systemic Sclerosis and Related DiseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 1,647

Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database

Tyndall, A. J., Bannert, B., Vonk, M., Airò, P., Cozzi, F., Carreira, P. E., Bancel, D. F., Allanore, Y., Müller-Ladner, U., Distler, O., et al. (2010) · Annals of the Rheumatic Diseases

Systemic Sclerosis and Related DiseasesPulmonary Hypertension Research and Treatments

Cited by 1,443

Update of EULAR recommendations for the treatment of systemic sclerosis

Kowal-Bielecka, O., Fransen, J., Avouac, J., Becker, M., Kulak, A., Allanore, Y., Distler, O., Clements, P., Cutolo, M., Czirjak, L., et al. (2017) · Annals of the Rheumatic Diseases

Systemic Sclerosis and Related DiseasesPulmonary Hypertension Research and Treatments

Cited by 1,104

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

Akhmetshina, A., Palumbo, K., Dees, C., Bergmann, C., Venalis, P., Zerr, P., Horn, A., Kireva, T., Beyer, C., Zwerina, J., et al. (2012) · Nature Communications

TGF-β signaling in diseasesWnt/β-catenin signaling in development and cancer

Cited by 843

Mortality in pulmonary arterial hypertension: prediction by the 2015 European pulmonary hypertension guidelines risk stratification model

Hoeper, M. M., Kramer, T., Pan, Z., Eichstaedt, C. A., Spiesshoefer, J., Benjamin, N., Olsson, K. M., Meyer, K., Vizza, C. D., Vonk-Noordegraaf, A., et al. (2017) · European Respiratory Journal

Pulmonary Hypertension Research and TreatmentsVascular Anomalies and Treatments

Cited by 660

Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis

Distler, J. H. W., Jüngel, A., Huber, L. C., Schulze‐Horsel, U., Zwerina, J., Gay, R. E., Michel, B. A., Hauser, T., Schett, G., Gay, S., et al. (2007) · Arthritis & Rheumatism

Systemic Sclerosis and Related DiseasesDupuytren's Contracture and Treatments

Cited by 383

Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis

Chakraborty, D., Šumová, B., Mallano, T., Chen, C.-W., Distler, A., Bergmann, C., Ludolph, I., Horch, R. E., Gelse, K., Ramming, A., et al. (2017) · Nature Communications

Systemic Sclerosis and Related DiseasesCytokine Signaling Pathways and Interactions

Cited by 356

Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis

Distler, O., Distler, J. H. W., Scheid, A., Acker, T., Hirth, A., Rethage, J., Michel, B. A., Gay, R. E., Müller-Ladner, U., Matucci-Cerinic, M., et al. (2004) · Circulation Research

Systemic Sclerosis and Related DiseasesAngiogenesis and VEGF in Cancer

Cited by 310

Platelet-derived serotonin links vascular disease and tissue fibrosis

Dees, C., Akhmetshina, A., Zerr, P., Reich, N., Palumbo, K., Horn, A., Jüngel, A., Beyer, C., Krönke, G., Zwerina, J., et al. (2011) · Journal of Experimental Medicine

Systemic Sclerosis and Related DiseasesTGF-β signaling in diseases

Cited by 266

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

Beyer, C., Schramm, A., Akhmetshina, A., Dees, C., Kireva, T., Gelse, K., Sonnylal, S., de Crombrugghe, B., Taketo, M. M., Distler, O., et al. (2012) · Annals of the Rheumatic Diseases

Systemic Sclerosis and Related DiseasesTGF-β signaling in diseases

Cited by 203

Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis

Huang, J., Beyer, C., Palumbo-Zerr, K., Zhang, Y., Ramming, A., Distler, A., Gelse, K., Distler, O., Schett, G., Wollin, L., et al. (2016) · Annals of the Rheumatic Diseases

Systemic Sclerosis and Related DiseasesDupuytren's Contracture and Treatments

Cited by 196

Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis

Akhmetshina, A., Dees, C., Pileckyte, M., Maurer, B., Axmann, R., Jüngel, A., Zwerina, J., Gay, S., Schett, G., Distler, O., et al. (2008) · The FASEB Journal

Systemic Sclerosis and Related DiseasesDupuytren's Contracture and Treatments

Cited by 187

PU.1 controls fibroblast polarization and tissue fibrosis

Wohlfahrt, T., Rauber, S., Uebe, S., Luber, M., Soare, A., Ekici, A., Weber, S., Matei, A.-E., Chen, C.-W., Maier, C., et al. (2019) · Nature

TGF-β signaling in diseasesLiver physiology and pathology

Cited by 187

The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis

Reich, N., Maurer, B., Akhmetshina, A., Venalis, P., Dees, C., Zerr, P., Palumbo, K., Zwerina, J., Nevskaya, T., Gay, S., et al. (2010) · Arthritis & Rheumatism

Systemic Sclerosis and Related DiseasesDupuytren's Contracture and Treatments

Cited by 112

Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis

Krämer, M., Dees, C., Huang, J., Schlottmann, I., Palumbo-Zerr, K., Zerr, P., Gelse, K., Beyer, C., Distler, A., Marquez, V. E., et al. (2013) · Annals of the Rheumatic Diseases

Systemic Sclerosis and Related DiseasesDupuytren's Contracture and Treatments

Cited by 109

Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis

Svegliati, S., Marrone, G., Pezone, A., Spadoni, T., Grieco, A., Moroncini, G., Grieco, D., Vinciguerra, M., Agnese, S., Jüngel, A., et al. (2014) · Science Signaling

Systemic Sclerosis and Related DiseasesConnective tissue disorders research

Cited by 100

The Fra-2 transgenic mouse model of systemic sclerosis

Maurer, B., Distler, J. H. W., & Distler, O. (2013) · Vascular Pharmacology

Systemic Sclerosis and Related DiseasesPulmonary Hypertension Research and Treatments

Cited by 71

Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis

Zhang, Y., Dees, C., Beyer, C., Lin, N.-Y., Distler, A., Zerr, P., Palumbo, K., Susok, L., Kreuter, A., Distler, O., et al. (2015) · Annals of the Rheumatic Diseases

Systemic Sclerosis and Related DiseasesTGF-β signaling in diseases

Cited by 64

The histone demethylase Jumonji domain-containing protein 3 (JMJD3) regulates fibroblast activation in systemic sclerosis

Bergmann, C., Brandt, A., Merlevede, B., Hallenberger, L., Dees, C., Wohlfahrt, T., Pötter, S., Zhang, Y., Chen, C.-W., Mallano, T., et al. (2018) · Annals of the Rheumatic Diseases

Systemic Sclerosis and Related DiseasesTGF-β signaling in diseases

Cited by 62

Nucleofection: a new, highly efficient transfection method for primary human keratinocytes*

Distler, J. H. W., Jüngel, A., Kurowska‐Stolarska, M., Michel, B. A., Gay, R. E., Gay, S., & Distler, O. (2005) · Experimental Dermatology

RNA Interference and Gene DeliveryMicrobial Inactivation Methods

Cited by 53

Bone Mineral Density Quantification from Localizer Radiographs: Accuracy and Precision of Energy-integrating Detector CT and Photon-counting Detector CT

Nowak, T., Eberhard, M., Schmidt, B., Frey, D., Distler, O., Saltybaeva, N., Alkadhi, H., & Euler, A. (2021) · Radiology

Advanced X-ray and CT ImagingBone health and osteoporosis research

Cited by 41

Treatment of systemic sclerosis: is there any hope for the future?

Allanore, Y., Matucci-Cerinic, M., & Distler, O. (2016) · RMD Open

Systemic Sclerosis and Related DiseasesConnective tissue disorders research

Cited by 19

Assessment of Bone Mineral Density From a Computed Tomography Topogram of Photon-Counting Detector Computed Tomography—Effect of Phantom Size and Tube Voltage

Euler, A., Nowak, T., Bucher, B., Eberhard, M., Schmidt, B., Flohr, T. G., Frey, D., Distler, O., & Alkadhi, H. (2021) · Investigative Radiology

Advanced X-ray and CT ImagingBone health and osteoporosis research

Cited by 19

Effects of vitamin D3, omega-3s, and a simple strength training exercise program on bone health: the DO-HEALTH randomized controlled trial

Kistler-Fischbacher, M., Armbrecht, G., Gängler, S., Theiler, R., Rizzoli, R., Dawson-Hughes, B., Kanis, J. A., Hofbauer, L. C., Schimmer, R. C., Vellas, B., et al. (2024) · Journal of Bone and Mineral Research

Bone health and osteoporosis researchVitamin D Research Studies

Cited by 15