Breakefield, Xandra O.

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles

Extracellular vesicles in diseaseCellular transport and secretion

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Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology

Extracellular vesicles in diseaseMicroRNA in disease regulation

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Extracellular vesicles: biology and emerging therapeutic opportunities

EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery

Extracellular vesicles in diseaseNanoparticle-Based Drug Delivery

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RNA delivery by extracellular vesicles in mammalian cells and its applications

O’Brien, K., Breyne, K., Ughetto, S., Laurent, L. C., & Breakefield, X. O. (2020) · Nature Reviews Molecular Cell Biology

Extracellular vesicles in diseaseRNA Interference and Gene Delivery

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Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A

Brunner, H. G., Nelen, M., Breakefield, X. O., Ropers, H. H., & van Oost, B. A. (1993) · Science

Genetics and Neurodevelopmental DisordersNeurotransmitter Receptor Influence on Behavior

Cited by 1,644

Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation

Kalra, H., Simpson, R. J., Ji, H., Aikawa, E., Altevogt, P., Askenase, P., Bond, V. C., Borràs, F. E., Breakefield, X., Budnik, V., et al. (2012) · PLoS Biology

Extracellular vesicles in diseaseCellular transport and secretion

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Advances in therapeutic applications of extracellular vesicles

Wiklander, O. P. B., Brennan, M. Á., Lötvall, J., Breakefield, X. O., & EL Andaloussi, S. (2019) · Science Translational Medicine

Extracellular vesicles in diseaseNanoparticle-Based Drug Delivery

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Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

Eimer, W. A., Vijaya Kumar, D. K., Navalpur Shanmugam, N. K., Rodriguez, A. S., Mitchell, T., Washicosky, K. J., György, B., Breakefield, X. O., Tanzi, R. E., & Moir, R. D. (2018) · Neuron

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 674

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

Ricklefs, F. L., Alayo, Q., Krenzlin, H., Mahmoud, A. B., Speranza, M. C., Nakashima, H., Hayes, J. L., Lee, K., Balaj, L., Passaro, C., et al. (2018) · Science Advances

Extracellular vesicles in diseaseCancer Immunotherapy and Biomarkers

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Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

Lai, C. P., Kim, E. Y., Badr, C. E., Weissleder, R., Mempel, T. R., Tannous, B. A., & Breakefield, X. O. (2015) · Nature Communications

Extracellular vesicles in diseaseCellular transport and secretion

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Microfluidic isolation and transcriptome analysis of serum microvesicles

Chen, C., Skog, J., Hsu, C.-H., Lessard, R. T., Balaj, L., Wurdinger, T., Carter, B. S., Breakefield, X. O., Toner, M., & Irimia, D. (2010) · Lab Chip

Extracellular vesicles in diseaseMicrofluidic and Bio-sensing Technologies

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High levels of AAV vector integration into CRISPR-induced DNA breaks

Hanlon, K. S., Kleinstiver, B. P., Garcia, S. P., Zaborowski, M. P., Volak, A., Spirig, S. E., Muller, A., Sousa, A. A., Tsai, S. Q., Bengtsson, N. E., et al. (2019) · Nature Communications

Virus-based gene therapy researchCRISPR and Genetic Engineering

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Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

Mizrak, A., Bolukbasi, M. F., Ozdener, G. B., Brenner, G. J., Madlener, S., Erkan, E. P., Ströbel, T., Breakefield, X. O., & Saydam, O. (2013) · Molecular Therapy

Extracellular vesicles in diseaseRNA Interference and Gene Delivery

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Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain

van der Vos, K. E., Abels, E. R., Zhang, X., Lai, C., Carrizosa, E., Oakley, D., Prabhakar, S., Mardini, O., Crommentuijn, M. H. W., Skog, J., et al. (2016) · Neuro-Oncology

Extracellular vesicles in diseaseGlioma Diagnosis and Treatment

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Emerging Roles of Extracellular Vesicles in the Nervous System

Rajendran, L., Bali, J., Barr, M. M., Court, F. A., Krämer-Albers, E.-M., Picou, F., Raposo, G., van der Vos, K. E., van Niel, G., Wang, J., et al. (2014) · The Journal of Neuroscience

Extracellular vesicles in diseaseCellular transport and secretion

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Microvesicle-associated AAV Vector as a Novel Gene Delivery System

Maguire, C. A., Balaj, L., Sivaraman, S., Crommentuijn, M. H., Ericsson, M., Mincheva-Nilsson, L., Baranov, V., Gianni, D., Tannous, B. A., Sena-Esteves, M., et al. (2012) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

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Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat

Frim, D. M., Uhler, T. A., Galpern, W. R., Beal, M. F., Breakefield, X. O., & Isacson, O. (1994) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsNerve injury and regeneration

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Rescue of hearing by gene delivery to inner-ear hair cells using exosome-associated AAV

György, B., Sage, C., Indzhykulian, A. A., Scheffer, D. I., Brisson, A. R., Tan, S., Wu, X., Volak, A., Mu, D., Tamvakologos, P. I., et al. (2017) · Molecular Therapy

Virus-based gene therapy researchHearing, Cochlea, Tinnitus, Genetics

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Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

Abels, E. R., Maas, S. L. N., Nieland, L., Wei, Z., Cheah, P. S., Tai, E., Kolsteeg, C.-J., Dusoswa, S. A., Ting, D. T., Hickman, S., et al. (2019) · Cell Reports

Extracellular vesicles in diseaseMicroRNA in disease regulation

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Viral vectors for therapy of neurologic diseases

Choudhury, S. R., Hudry, E., Maguire, C. A., Sena-Esteves, M., Breakefield, X. O., & Grandi, P. (2017) · Neuropharmacology

Virus-based gene therapy researchRNA Interference and Gene Delivery

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RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls

Noerholm, M., Balaj, L., Limperg, T., Salehi, A., Zhu, L. D., Hochberg, F. H., Breakefield, X. O., Carter, B. S., & Skog, J. (2012) · BMC Cancer

Extracellular vesicles in diseaseMicroRNA in disease regulation

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Astrocytes retrovirally transduced with BDNF elicit behavioral improvement in a rat model of Parkinson’s disease

Yoshimoto, Y., Lin, Q., Collier, T. J., Frim, D. M., Breakefield, X. O., & Bohn, M. C. (1995) · Brain Research

Parkinson's Disease Mechanisms and TreatmentsNerve injury and regeneration

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Down-Regulation of miR-101 in Endothelial Cells Promotes Blood Vessel Formation through Reduced Repression of EZH2

Smits, M., Mir, S. E., Nilsson, R. J. A., van der Stoop, P. M., Niers, J. M., Marquez, V. E., Cloos, J., Breakefield, X. O., Krichevsky, A. M., Noske, D. P., et al. (2011) · PLoS ONE

Angiogenesis and VEGF in CancerMicroRNA in disease regulation

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Adenoassociated virus serotype 9-mediated gene therapy for x-linked adrenoleukodystrophy

Gong, Y., Mu, D., Prabhakar, S., Moser, A., Musolino, P., Ren, J., Breakefield, X. O., Maguire, C. A., & Eichler, F. S. (2015) · Molecular Therapy

Virus-based gene therapy researchLysosomal Storage Disorders Research

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