Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat

Glutamate neurotoxicity and diseases of the nervous system

Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works

Handbook of Chemical Neuroanatomy

Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,159 · see citing works

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works

Mitochondrial Complex I Deficiency in Parkinson's Disease

Schapira, A. H. V., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb02325.x · Cited by 2,283 · see citing works

Purification of a new neurotrophic factor from mammalian brain.

Barde, Y. A., Edgar, D., & Thoenen, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01207.x · Cited by 1,822 · see citing works

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

Hyman, C., Hofer, M., Barde, Y., Juhasz, M., Yancopoulos, G. D., Squinto, S. P., & Lindsay, R. M. (1991) · Nature · doi:10.1038/350230a0 · Cited by 1,494 · see citing works

Molecular cloning and expression of brain-derived neurotrophic factor

Leibrock, J., Lottspeich, F., Hohn, A., Hofer, M., Hengerer, B., Masiakowski, P., Thoenen, H., & Barde, Y. (1989) · Nature · doi:10.1038/341149a0 · Cited by 1,458 · see citing works

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

Wallace, D. C. (1992) · Science · doi:10.1126/science.1533953 · Cited by 1,256 · see citing works

Abnormalities of the electron transport chain in idiopathic parkinson's disease

Parker, W. D., Boyson, S. J., & Parks, J. K. (1989) · Annals of Neurology · doi:10.1002/ana.410260606 · Cited by 1,061 · see citing works

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

Beal, M. F. (1992) · Annals of Neurology · doi:10.1002/ana.410310202 · Cited by 956 · see citing works

Nerve Growth Factor Treatment After Brain Injury Prevents Neuronal Death

Kromer, L. F. (1987) · Science · doi:10.1126/science.3798108 · Cited by 932 · see citing works

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

Squinto, S. P., Stitt, T. N., Aldrich, T. H., Davis, S. H., Blanco, S. M., Radziejewski, C. H., Glass, D. J., Masiakowski, P., Furth, M. E., Valenzuela, D. M., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90395-f · Cited by 830 · see citing works

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

Soppet, D., Escandon, E., Maragos, J., Middlemas, D. S., Raid, S. W., Blair, J., Burton, L. E., Stanton, B. R., Kaplan, D. R., Hunter, T., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90396-g · Cited by 820 · see citing works

A Dissection and tissue culture manual of the nervous system

Shahar, A. (1989) · Andalas University Repository (Andalas University) · Cited by 758 · see citing works

Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease

Mizuno, Y., Ohta, S., Tanaka, M., Takamiya, S., Suzuki, K., SATO, T. A., Oya, H., Ozawa, T., & Kagawa, Y. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91141-8 · Cited by 735 · see citing works

Binding of brain-derived neurotrophic factor to the nerve growth factor receptor

Rodrı́guez-Tébar, A., Dechant, G., & Barde, Y. (1990) · Neuron · doi:10.1016/0896-6273(90)90107-q · Cited by 711 · see citing works

Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section

Sendtner, M., Holtmann, B., Kolbeck, R., Thoenen, H., & Barde, Y. (1992) · Nature · doi:10.1038/360757a0 · Cited by 706 · see citing works

Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death

Qiao, Y., Elliott, J. L., & Snider, W. D. (1992) · Nature · doi:10.1038/360753a0 · Cited by 670 · see citing works

The neurotoxicity of excitatory amino acids is produced by passive chloride influx

Rothman, S. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-06-01483.1985 · Cited by 636 · see citing works

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

Sutter, A., Rj, R., Harris‐Warrick, R. M., & Shooter, E. M. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50507-x · Cited by 624 · see citing works

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo

Anderson, K. J., Dam, D., Lee, S., & Cotman, C. W. (1988) · Nature · doi:10.1038/332360a0 · Cited by 590 · see citing works

Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy

Sendtner, M., Schmalbruch, H., Stöckli, K. A., Carroll, P., Kreutzberg, G. W., & Thoenen, H. (1992) · Nature · doi:10.1038/358502a0 · Cited by 551 · see citing works

Brain-derived neurotrophic factor prevents neuronal death in vivo

Hofer, M., & Barde, Y. (1988) · Nature · doi:10.1038/331261a0 · Cited by 497 · see citing works

Brain‐Derived Neurotrophic Factor Protects Dopamine Neurons Against 6‐Hydroxydopamine and N‐Methyl‐4‐Phenylpyridinium Ion Toxicity: Involvement of the Glutathione System

Spina, M. B., Squinto, S. P., Miller, J. M., Lindsay, R. M., & Hyman, C. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08880.x · Cited by 460 · see citing works

Basic FGF reverses chemical and morphological deficits in the nigrostriatal system of MPTP-treated mice

OTTO, D., & Unsicker, K. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-06-01912.1990 · Cited by 367 · see citing works

Mitochondrial oxidative phosphorylation defects in parkinson's disease

Shoffner, J. M., Watts, R. L., Juncos, J. L., Torroni, A., & Wallace, D. C. (1991) · Annals of Neurology · doi:10.1002/ana.410300304 · Cited by 333 · see citing works

The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia [published erratum appears in J Neurosci 1992 Mar;12(3):685]

Engele, J., & Bohn, M. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-10-03070.1991 · Cited by 303 · see citing works

Survival of Adult Basal Forebrain Cholinergic Neurons After Loss of Target Neurons

Sofroniew, M. V., Galletly, N. P., Ole Isacson, A., & Svendsen, C. N. (1990) · Science · doi:10.1126/science.1688664 · Cited by 284 · see citing works

Nerve growth factor infusion in the primate brain reduces lesion- induced cholinergic neuronal degeneration

Tuszynski, M. H., U, H., Amaral, D., & Gage, F. H. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-11-03604.1990 · Cited by 281 · see citing works

Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain

Knüsel, B., Beck, K., Winslow, J. W., Rosenthal, A., Burton, L., Widmer, H., Nikolics, K., & Hefti, F. F. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04391.1992 · Cited by 278 · see citing works

Regional Mitochondrial Respiratory Activity in Huntington's Disease Brain

Brennan, W. A., Bird, E. D., & Aprille, J. R. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb07192.x · Cited by 265 · see citing works

Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo.

Hagg, T., & Varon, S. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6315 · Cited by 229 · see citing works

Neural grafting in a rat model of huntington's disease: Progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting

Isacson, O., Brundin, P., Gage, F. H., et al. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90095-8 · Cited by 203 · see citing works

Effects of biologically delivered NGF, BDNF and bFGF on striatal excitotoxic lesions

Frim, D. M., Uhler, T. A., Short, M. P., Ezzedine, Z. D., Klagsbrun, M., Breakefield, X. O., & Ole Isacson, A. (1993) · Neuroreport · doi:10.1097/00001756-199304000-00006 · Cited by 199 · see citing works

1‐Methyl‐4‐Phenylpyridinium Produces Excitotoxic Lesions in Rat Striatum as a Result of Impairment of Oxidative Metabolism

Storey, E., Hyman, B. T., Jenkins, B. G., Brouillet, E., Miller, J. M., Rosen, B. R., & Beal, M. F. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10080.x · Cited by 164 · see citing works

A “calcium set-point hypothesis” of neuronal dependence on neurotrophic factor

Johnson, E. M., Koike, T., & Franklin, J. L. (1992) · Experimental Neurology · doi:10.1016/0014-4886(92)90242-i · Cited by 161 · see citing works

The MPTP model: versatile contributions to the treatment of idiopathic Parkinson's disease

Bloem, B. R., Irwin, I., Buruma, O. J. S., Haan, J., Roos, R. A. C., Tetrud, J. W., & Langston, J. W. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90225-c · Cited by 160 · see citing works

Role of nerve growth factor in oxidant‐antioxidant balance and neuronal injury. I. Stimulation of hydrogen peroxide resistance

Jackson, G. R., Apffel, L., Werrbach‐Perez, K., & Perez-Polo, J. R. (1990) · Journal of Neuroscience Research · doi:10.1002/jnr.490250313 · Cited by 159 · see citing works

Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids

Schumacher, J. M., Short, M. P., Hyman, B. T., Breakefield, X. O., & Ole Isacson, A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90271-o · Cited by 152 · see citing works

Loss of transmitter-associated enzyme staining following axotomy does not indicate death of brainstem cholinergic neurons

Lams, B. E., Ole Isacson, A., & Sofroniew, M. V. (1988) · Brain Research · doi:10.1016/0006-8993(88)90635-x · Cited by 123 · see citing works

Mitochondrial Impairment Reduces the Threshold for in Vivo NMDA-Mediated Neuronal Death in the Striatum

Simpson, J. R., & Isacson, O. (1993) · Experimental Neurology · doi:10.1006/exnr.1993.1071 · Cited by 113 · see citing works

Local protective effects of nerve growth factor-secreting fibroblasts against excitotoxic lesions in the rat striatum

Frim, D. M., Short, M. P., Rosenberg, W. S., Simpson, J. R., Breakefield, X. O., & Ole Isacson, A. (1993) · Journal of neurosurgery · doi:10.3171/jns.1993.78.2.0267 · Cited by 111 · see citing works

On neuronal health

Ole Isacson, A. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90104-t · Cited by 72 · see citing works

Distribution of degeneration of cholinergic neurons in the septum following axotomy in different portions of the fimbria-fornix: a correlation between degree of cell loss and proximity of neuronal somata to the lesion.

Sofroniew, M. V., & Isacson, O. (1990) · PubMed · Cited by 69 · see citing works

Retrovirus-mediated gene transfer of beta-nerve growth factor into mouse pituitary line AtT-20.

Wolf, D., Richter‐Landsberg, C., Mp, S., et al. (1988) · PubMed · Cited by 31 · see citing works

Is activation of the Na+K+ pump necessary for NGF-mediated neuronal survival?

Sendtner, M., Gnahn, H., Wakade, A. R., et al. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-02-00458.1988 · Cited by 25 · see citing works

Evidence for retrograde axonal transport of MPP+ in the rat

Campbell, K. J., Takada, M., & Hattori, T. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90614-f · Cited by 22 · see citing works

Considerations in the treatment of neurological disorders with trophic factors

Morgan, D. G. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90126-7 · Cited by 10 · see citing works

Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease

Murer, M. G., Yan, Q., & Raisman-Vozari, R. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00014-9 · Cited by 874 · see citing works

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

Nagahara, A. H., & Tuszynski, M. H. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3366 · Cited by 867 · see citing works

BDNF as a Promising Therapeutic Agent in Parkinson’s Disease

Palasz, E., Wysocka, A., Gasiorowska, A., Chalimoniuk, M., Niewiadomski, W., & Niewiadomska, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031170 · Cited by 504 · see citing works

Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson’s disease

Levivier, M., Przedborski, S., Bencsics, C., & Kang, U. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07810.1995 · Cited by 274 · see citing works

A role for AMPA receptors in mood disorders

Alt, A., Nisenbaum, E. S., Bleakman, D., & Witkin, J. M. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.022 · Cited by 238 · see citing works

Astrocytes retrovirally transduced with BDNF elicit behavioral improvement in a rat model of Parkinson’s disease

Yoshimoto, Y., Lin, Q., Collier, T. J., Frim, D. M., Breakefield, X. O., & Bohn, M. C. (1995) · Brain Research · doi:10.1016/0006-8993(95)00596-i · Cited by 146 · see citing works

Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer

Klein, R. L., Lewis, M. H., Muzyczka, N., & Meyer, E. M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02116-2 · Cited by 128 · see citing works

<scp>MPTP</scp>‐induced changes in hippocampal synaptic plasticity and memory are prevented by memantine through the <scp>BDNF</scp>‐<scp>TrkB</scp> pathway

Zhu, G., Li, J., He, L., Wang, X., & Hong, X. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13061 · Cited by 118 · see citing works

Progranulin Gene Delivery Protects Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease

Van Kampen, J. M., Baranowski, D., & Kay, D. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097032 · Cited by 76 · see citing works

Physical Exercise-Induced Myokines in Neurodegenerative Diseases

Lee, B., Shin, M., Park, Y., Won, S.-Y., & Cho, K. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115795 · Cited by 79 · see citing works

Striatal dopamine transporter binding correlates with serum BDNF levels in patients with striatal dopaminergic neurodegeneration

Ziebell, M., Khalid, U., Klein, A. B., Aznar, S., Thomsen, G., Jensen, P., & Knudsen, G. M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.11.010 · Cited by 62 · see citing works

Acute and Chronic 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Administrations Elicit Similar Microglial Activation in the Substantia Nigra of Monkeys

Vázquez‐Claverie, M., Garrido‐Gil, P., Sebastián, W. S., Izal‐Azcárate, A., Belzunegui, S., Marcilla, I., López, B., & Luquín, M. R. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181b35e41 · Cited by 44 · see citing works

Protective effect of Actinidia arguta in MPTP-induced Parkinson’s disease model mice

Kitamura, Y., Sakanashi, M., Ozawa, A., Saeki, Y., Nakamura, A., Hara, Y., Saeki, K., & Arimoto‐Kobayashi, S. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.03.116 · Cited by 15 · see citing works

Expression of c-Jun in dopaminergic neurons of the substantia nigra in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice

Nishi, K. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00862-7 · Cited by 33 · see citing works

Proteome analysis of substantia nigra and striatal tissue in the mouse MPTP model of Parkinson's disease

Zhao, X. S., Li, Q., Zhao, L., & Pu, X. (2007) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200700077 · Cited by 11 · see citing works

Presence of reactive microglia in monkey substantia nigra years after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine administration

McGeer, P. L., Schwab, C., Parent, A., & Doudet, D. (2003) · Annals of Neurology · doi:10.1002/ana.10728 · Cited by 400 · see citing works