Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues

Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor

Arriza, J. L., Weinberger, C., Cerelli, G., Glaser, T. M., Handelin, B. L., Housman, D. E., & Evans, R. M. (1987) · Science · doi:10.1126/science.3037703 · Cited by 1,946 · see citing works

LXR, a nuclear receptor that defines a distinct retinoid response pathway.Preprint

Willy, P. J., Umesono, K., Ong, E. S., Evans, R. M., Heyman, R. A., & Mangelsdorf, D. J. (1995) · Genes & Development · doi:10.1101/gad.9.9.1033 · Cited by 1,124 · see citing works

Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1–AKR1C4) of the aldo–keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones

PENNING, T. M., BURCZYNSKI, M. E., JEZ, J. M., HUNG, C.-F., LIN, H.-K., MA, H., MOORE, M., PALACKAL, N., & RATNAM, K. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3510067 · Cited by 649 · see citing works

Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones

PENNING, T. M., BURCZYNSKI, M. E., JEZ, J. M., HUNG, C.-F., LIN, H.-K., MA, H., MOORE, M., PALACKAL, N., & RATNAM, K. (2000) · Biochemical Journal · doi:10.1042/bj3510067 · Cited by 649 · see citing works

Hypertensive disorders in pregnancy

Chesley, L. C. (1985) · Journal of Nurse-Midwifery · doi:10.1016/0091-2182(85)90116-8 · Cited by 632 · see citing works

Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3

Geissler, W. M., Davis, D. L., Wu, L., Bradshaw, K. D., Patel, S., Mendonca, B. B., Elliston, K. O., Wilson, J. D., Russell, D. W., & Andersson, S. (1994) · Nature Genetics · doi:10.1038/ng0594-34 · Cited by 570 · see citing works

Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity.

Krozowski, Z. S., & Funder, J. W. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.19.6056 · Cited by 524 · see citing works

11β-Hydroxysteroid Dehydrogenase and the Syndrome of Apparent Mineralocorticoid Excess*

White, P. C., Mune, T., & Agarwal, A. K. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0288 · Cited by 517 · see citing works

The aldo-keto reductase superfamily homepage

Hyndman, D., Bauman, D. R., Heredia, V. V., & Penning, T. M. (2003) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00193-x · Cited by 317 · see citing works

Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands

Rupprecht, R., Reul, J. M. H. M., van Steensel, B., Spengler, D., Söder, M., Berning, B., Holsboer, F., & Damm, K. (1993) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(93)90072-h · Cited by 297 · see citing works

Disorders of Steroid 11β-Hydroxylase Isozymes*

WHITE, P. C., CURNOW, K. M., & PASCOE, L. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-4-421 · Cited by 271 · see citing works

Human Cytosolic 3α-Hydroxysteroid Dehydrogenases of the Aldo-keto Reductase Superfamily Display Significant 3β-Hydroxysteroid Dehydrogenase Activity

Steckelbroeck, S., Jin, Y., Gopishetty, S., Oyesanmi, B., & Penning, T. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313308200 · Cited by 270 · see citing works

THE GENETICS, PATHOPHYSIOLOGX, AND MANAGEMENT OF HUMAN DEFICIENCIES OF P450c17

Auchus, R. J. (2001) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(08)70021-5 · Cited by 266 · see citing works

Immunohistochemical localization of the 11 beta-hydroxysteroid dehydrogenase type II enzyme in human kidney and placenta.

Krozowski, Z., MaGuire, J. A., Stein-Oakley, A. N., Dowling, J., Smith, R. E., & Andrews, R. K. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.7.7608280 · Cited by 252 · see citing works

Deoxycorticosterone Upregulates PDS ( Slc26a4 ) in Mouse Kidney

Verlander, J. W., Hassell, K. A., Royaux, I. E., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000088321.67254.b7 · Cited by 240 · see citing works

Biochemical Properties of Purified Recombinant Human β-Carotene 15,15′-Monooxygenase

Lindqvist, A., & Andersson, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202756200 · Cited by 239 · see citing works

11 -Hydroxysteroid Dehydrogenase and the Syndrome of Apparent Mineralocorticoid Excess

White, P. C. (1997) · Endocrine Reviews · doi:10.1210/er.18.1.135 · Cited by 213 · see citing works

Transactivation and synergistic properties of the mineralocorticoid receptor: relationship to the glucocorticoid receptor

Rupprecht, R., Arriza, J. L., Spengler, D., Reul, J. M. H. M., Evans, R. M., Holsboer, F., & Damm, K. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.4.8388999 · Cited by 206 · see citing works

Close kinship of human 20α-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes

Nishizawa, M., Nakajima, T., Yasuda, K., Kanzaki, H., Sasaguri, Y., Watanabe, K., & Ito, S. (2000) · Genes to Cells · doi:10.1046/j.1365-2443.2000.00310.x · Cited by 149 · see citing works

Localization of 11 beta-hydroxysteroid dehydrogenase type II in human epithelial tissues.

Smith, R. E., Maguire, J. A., Stein-Oakley, A. N., Sasano, H., Takahashi, K., Fukushima, K., & Krozowski, Z. S. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.9.8784076 · Cited by 146 · see citing works

Disorders of steroid 17α-hydroxylase deficiency

Kater, C. E., & Biglieri, E. G. (1994) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30101-4 · Cited by 146 · see citing works

Disorders of steroid 17 alpha-hydroxylase deficiency.

Kater, C. E., & Biglieri, E. G. (1994) · PubMed · Cited by 145 · see citing works

Expression and Characterization of Four Recombinant Human Dihydrodiol Dehydrogenase Isoforms: Oxidation of trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene to the Activated o-Quinone Metabolite Benzo[a]pyrene-7,8-dione,

Burczynski, M. E., Harvey, R. G., & Penning, T. M. (1998) · Biochemistry · doi:10.1021/bi972725u · Cited by 134 · see citing works

Antioxidants Block Angiotensin II-Induced Increases in Blood Pressure and Endothelin

Ortíz, M. C., Manriquez, M. C., Romero, J. C., & Juncos, L. A. (2001) · Hypertension · doi:10.1161/01.hyp.38.3.655 · Cited by 134 · see citing works

Longitudinal Studies of Plasma Aldosterone, Corticosterone, Deoxycorticosterone, Progesterone, 17– Hydroxyprogesterone, Cortisol, and Cortisone Determined Simultaneously in Mother and Child at Birth and during the Early Neonatal Period. I. Spontaneous Delivery*

Sippell, W. G., Becker, H., VERSMOLD, H. T., BIDLINGMAIER, F., & Knorr, D. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-46-6-971 · Cited by 134 · see citing works

cDNA cloning, expression and characterization of human prostaglandin F synthase1

Suzuki-Yamamoto, T., Nishizawa, M., Fukui, M., Okuda‐Ashitaka, E., Nakajima, T., Ito, S., & Watanabe, K. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01551-3 · Cited by 131 · see citing works

Agonistic and antagonistic properties of progesterone metabolites at the human mineralocorticoid receptor

Quinkler, M., Meyer, B., Bumke-Vogt, C., Grossmann, C., Gruber, U., Oelkers, W., Diederich, S., & Bahr, V (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460789 · Cited by 130 · see citing works

The Intracellular Localization of the Mineralocorticoid Receptor Is Regulated by 11β-Hydroxysteroid Dehydrogenase Type 2

Odermatt, A., Arnold, P., & Frey, F. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100374200 · Cited by 129 · see citing works

Mineralocorticoid action

Rogerson, F. M., & Fuller, P. J. (2000) · Steroids · doi:10.1016/s0039-128x(99)00087-2 · Cited by 114 · see citing works

Immunolocalization of Renal Mineralocorticoid Receptors with an Antiserum against a Peptide Deduced from the Complementary Deoxyribonucleic Acid Sequence

Krozowski, Z. S., Rundle, S. E., Wallace, C., CASTELL, M. J., SHEN, J.-H., Dowling, J. P., Funder, J. W., & Smith, A. I. (1989) · Endocrinology · doi:10.1210/endo-125-1-192 · Cited by 101 · see citing works

Intrarenal Transport and Vasoactive Substances in Hypertension

Ortiz, P. A., & Garvin, J. L. (2001) · Hypertension · doi:10.1161/hy09t1.093361 · Cited by 99 · see citing works

The human kidney is a progesterone-metabolizing and androgen-producing organ

Quinkler, M., Bumke-Vogt, C., Meyer, B., Bähr, V., Oelkers, W., & Diederich, S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021970 · Cited by 87 · see citing works

General overview of mineralocorticoid hormone action

Agarwal, M. K., & Mirshahi, M. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00038-8 · Cited by 85 · see citing works

Extraadrenal Formation of a Mineralocorticosteroid: Deoxycorticosterone and Deoxycorticosterone Sulfate Biosynthesis and Metabolism*

CASEY, M. L., & MacDONALD, P. C. (1982) · Endocrine Reviews · doi:10.1210/edrv-3-4-396 · Cited by 82 · see citing works

Desoxycorticosterone in normal pregnancy. I. Sequential studies of the secretory patterns of desoxycorticosterone, aldosterone, and cortisol.

Nolten, W. E., Lindheimer, M. D., Oparil, S., & Ehrlich, E. N. (1978) · PubMed · Cited by 82 · see citing works

Plasma Deoxycorticosterone in Normal and Abnormal Human Pregnancy1

Brown, R. D., Strott, C. A., & Liddle, G. W. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-35-5-736 · Cited by 81 · see citing works

Immunodetection of 11β-Hydroxysteroid Dehydrogenase Type 2 in Human Mineralocorticoid Target Tissues: Evidence for Nuclear Localization*

Shimojo, M., Ricketts, M., Petrelli, M., Moradi, P., Johnson, G. D., Bradwell, A. R., Hewison, M., Howie, A. J., & Stewart, P. M. (1997) · Endocrinology · doi:10.1210/endo.138.3.4994 · Cited by 80 · see citing works

Adenovirus VA RNAI mediates a translational stimulation which is not restricted to the viral mRNAs.

Svensson, C., & Akusjärvi, G. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03724.x · Cited by 77 · see citing works

Desoxycorticosterone in normal pregnancy

Nolten, W. E., Lindheimer, M. D., Oparil, S., et al. (1978) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(78)90777-9 · Cited by 68 · see citing works

Calcium-phosphate-mediated Transfection of Eukaryotic Cells with Plasmid DNAsPreprint

Sambrook, J., & Russell, D. W. (2006) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot3871 · Cited by 61 · see citing works

Identification and implications of new types of mineralocorticoid hypertension

Biglieri, E. G., Irony, I., & Kater, C. E. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90164-7 · Cited by 61 · see citing works

Progesterone Metabolism in the Human Kidney and Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 2 by Progesterone and Its Metabolites1

Quinkler, M. O., Johanssen, S., Großmann, C., Bähr, V., Müller, M., Oelkers, W., & Diederich, S. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.11.6163 · Cited by 57 · see citing works

Immunohistochemical and lectin dissection of the human nephron in health and disease.

Silva, F. G., Nádasdy, T., & Laszik, Z. G. (1993) · PubMed · Cited by 55 · see citing works

Cell Type-Specific Expression of 17β-Hydroxysteroid Dehydrogenase Type 2 in Human Placenta and Fetal Liver1

Moghrabi, N. N., Head, J. R., & Andersson, S. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.11.4391 · Cited by 53 · see citing works

Hormone production during pregnancy in the primigravid patient

Parker, C. R., Everett, R. B., Whalley, P. J., Quirk, J. G., Gant, N. F., & MacDonald, P. C. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(80)90078-2 · Cited by 47 · see citing works

Adrenocortical carcinoma producing 11-deoxycorticosterone: a rare cause of mineralocorticoid hypertension

Müssig, K., Wehrmann, M., Horger, M., Maser-Gluth, C., Häring, H.-U., & Overkamp, D. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03345531 · Cited by 43 · see citing works

The adrenal and hypertension: From cloning to clinic

(1990) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(90)90386-y · Cited by 38 · see citing works

Extraadrenal Steroid 21-Hydroxylase Activity in a Woman with Congenital Adrenal Hyperplasia due to Steroid 21-Hydroxylase Deficiency*

Winkel, C. A., CASEY, M. L., Worley, R. J., et al. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-1-104 · Cited by 36 · see citing works

The human 11β-hydroxysteroid dehydrogenase type II enzyme: Comparisons with other species and localization to the distal nephron

Krozowski, Z. S., Albiston, A. L., Obeyesekere, V. R., Andrews, R. K., & Smith, R. E. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00194-8 · Cited by 36 · see citing works

Enzyme-mediated protection of the mineralocorticoid receptor against progesterone in the human kidney

Quinkler, M. O., Johanssen, S., Bumke‐Vogt, C., Oelkers, W., Bähr, V., & Diederich, S. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00429-9 · Cited by 34 · see citing works

Cell Type-Specific Expression of 17 -Hydroxysteroid Dehydrogenase Type 2 in Human Placenta and Fetal Liver

Moghrabi, N. N. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.11.3872 · Cited by 23 · see citing works

Forms of Mineralocorticoid Hypertension

Ferrari, P., & Bonny, O. (2003) · Vitamins and hormones · doi:10.1016/s0083-6729(03)01004-5 · Cited by 20 · see citing works

Immunodetection of 11 -Hydroxysteroid Dehydrogenase Type 2 in Human Mineralocorticoid Target Tissues: Evidence for Nuclear Localization

Shimojo, M. (1997) · Endocrinology · doi:10.1210/en.138.3.1305 · Cited by 19 · see citing works

ACTH-Induced Sodium Retention in Pregnancy. Role of Desoxycorticosterone and Corticosterone*†

Ehrlich, E. N., Biglieri, E. G., & Lindheimer, M. D. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-4-701 · Cited by 18 · see citing works

Steroid characteristics of mineralocorticoid adrenocortical hypertension

Biglieri, E. G., & Kater, C. E. (1991) · Clinical Chemistry · doi:10.1093/clinchem/37.10.1843 · Cited by 16 · see citing works

Progesterone Metabolism in the Human Kidney and Inhibition of 11 -Hydroxysteroid Dehydrogenase Type 2 by Progesterone and Its Metabolites

Quinkler, M. O. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.11.4165 · Cited by 16 · see citing works

Increased sensitivity of the obese Zucker rat to deoxycorticosterone-salt-induced hypertension

Morrison, R. G., Carpenter, A. B., Moore, S. K., Mangiarua, E. I., Valentovic, M. A., Walker, E. M., Wehner, P. S., Rhoten, W. B., Touchon, R. C., & McCumbee, W. D. (2002) · Journal of Hypertension · doi:10.1097/00004872-200211000-00025 · Cited by 9 · see citing works

Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism

Rižner, T. L., & Penning, T. M. (2014) · Steroids · doi:10.1016/j.steroids.2013.10.012 · Cited by 217 · see citing works

A Lifetime of Aldosterone Excess: Long-Term Consequences of Altered Regulation of Aldosterone Production for Cardiovascular Function

Connell, J. M. C., MacKenzie, S. M., Freel, E. M., Fraser, R., & Davies, E. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0030 · Cited by 182 · see citing works

Structural and functional biology of aldo-keto reductase steroid transforming enzymes

Penning, T. M., Wangtrakuldee, P., & Auchus, R. J. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00089 · Cited by 164 · see citing works

Aldo–keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer

Byrns, M. C., Duan, L., Lee, S. H., Blair, I. A., & Penning, T. M. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.12.009 · Cited by 116 · see citing works

AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase): Roles in malignancy and endocrine disorders

Penning, T. M. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.07.002 · Cited by 117 · see citing works

The multifaceted mineralocorticoid receptor

Gomez‐Sanchez, E., & Gomez‐Sanchez, C. E. (2014) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2014.tb00569.x · Cited by 55 · see citing works

Aldo–keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis

Hevir, N., Vouk, K., Šinkovec, J., Ribič-Pucelj, M., & Lanišnik Rižner, T. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.01.003 · Cited by 48 · see citing works

Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3

Beranič, N., Gobec, S., & Rižner, T. L. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.12.012 · Cited by 39 · see citing works

Expression of human aldo–keto reductase 1C2 in cell lines of peritoneal endometriosis: potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins

Beranič, N., Brožič, P., Brus, B., Sosič, I., Gobec, S., & Rižner, T. L. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.12.011 · Cited by 16 · see citing works

Is intracrinology of endometriosis relevant in clinical practice? A systematic review on estrogen metabolism

Mercorio, A., Giampaolino, P., Romano, A., Dällenbach, P., & Pluchino, N. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.950866 · Cited by 16 · see citing works

Introduction

Farman, N., & Verrey, F. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00956.x · Cited by 1 · see citing works

Renal Receptor-Binding Activity of Reduced Metabolites of Aldosterone: Evidence for a Mineralocorticoid Effect outside of the Classic Aldosterone Receptor System*

Gómez-Sánchez, C. E., Smith, J. S. C., Ferris, M. W., et al. (1984) · Endocrinology · doi:10.1210/endo-115-2-712 · Cited by 8 · see citing works

Aldosterone and Mineralocorticoid Receptors

Funder, J. W. (2006) · Hypertension · doi:10.1161/01.hyp.0000249855.29529.84 · Cited by 7 · see citing works

Valine 571 Functions as a Regional Organizer in Programming the Glucocorticoid Receptor for Differential Binding of Glucocorticoids and Mineralocorticoids

Lind, U., Greenidge, P. A., Gustafsson, J.-Α., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18515 · Cited by 24 · see citing works

Critical role of the mineralocorticoid receptor in aldosterone-dependent and aldosterone-independent regulation of ENaC in the distal nephron

Nesterov, V., Bertog, M., Canonica, J., Hümmler, E., Coleman, R. A., Welling, P. A., & Korbmacher, C. (2021) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00139.2021 · Cited by 44 · see citing works