Hurley, James H.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 5,894

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 2,897

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

Wollert, T., & Hurley, J. H. (2010) · Nature

Cellular transport and secretionUbiquitin and proteasome pathways

Cited by 804

THE ESCRT COMPLEXES: Structure and Mechanism of a Membrane-Trafficking Network

Hurley, J. H., & Emr, S. D. (2006) · Annual Review of Biophysics and Biomolecular Structure

Cellular transport and secretionUbiquitin and proteasome pathways

Cited by 546

Taxonomy and function of C1 protein kinase C homology domains

Hurley, J. H., Newton, A. C., Parker, P. J., Blumberg, P. M., & Nishizuka, Y. (1997) · Protein Science

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 362

Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex

Burgos, P. V., Mardones, G. A., Rojas, A. L., daSilva, L. L. P., Prabhu, Y., Hurley, J. H., & Bonifacino, J. S. (2010) · Developmental Cell

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 258

Architecture of the Atg17 Complex as a Scaffold for Autophagosome Biogenesis

Ragusa, M. J., Stanley, R. E., & Hurley, J. H. (2012) · Cell

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 253

Structure of a Lipid Droplet Protein

Hickenbottom, S. J., Kimmel, A. R., Londos, C., & Hurley, J. H. (2004) · Structure

Lipid metabolism and biosynthesisProtein Structure and Dynamics

Cited by 193

Structural Basis for Endosomal Targeting by the Bro1 Domain

Kim, J., Sitaraman, S., Hierro, A., Beach, B. M., Odorizzi, G., & Hurley, J. H. (2005) · Developmental Cell

Cellular transport and secretionUbiquitin and proteasome pathways

Cited by 174

Molecular Architecture and Functional Model of the Complete Yeast ESCRT-I Heterotetramer

Kostelansky, M. S., Schluter, C., Tam, Y. Y. C., Lee, S., Ghirlando, R., Beach, B., Conibear, E., & Hurley, J. H. (2007) · Cell

Cellular transport and secretionUbiquitin and proteasome pathways

Cited by 172

Structural and Functional Organization of the ESCRT-I Trafficking Complex

Kostelansky, M. S., Sun, J., Lee, S., Kim, J., Ghirlando, R., Hierro, A., Emr, S. D., & Hurley, J. H. (2006) · Cell

Cellular transport and secretionUbiquitin and proteasome pathways

Cited by 115

Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy

Young, L. N., Cho, K., Lawrence, R., Zoncu, R., & Hurley, J. H. (2016) · Proceedings of the National Academy of Sciences

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 89

Structural and Biochemical Basis for Ubiquitin Ligase Recruitment by Arrestin-related Domain-containing Protein-3 (ARRDC3)

Qi, S., O'Hayre, M., Gutkind, J. S., & Hurley, J. H. (2014) · Journal of Biological Chemistry

Receptor Mechanisms and SignalingUbiquitin and proteasome pathways

Cited by 72

Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation

Ren, X., Nguyen, T. N., Lam, W. K., Buffalo, C. Z., Lazarou, M., Yokom, A. L., & Hurley, J. H. (2023) · Science Advances

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 68

Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation

Ren, X., Nguyen, T. N., Lam, W. K., Buffalo, C. Z., Lazarou, M., Yokom, A. L., & Hurley, J. H. (2022) · Science Advances

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 68

Proline‐Rich Regions and Motifs in Trafficking: From ESCRT Interaction to Viral Exploitation

Ren, X., & Hurley, J. H. (2011) · Traffic

Cellular transport and secretionHIV Research and Treatment

Cited by 65

A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission

Flower, T. G., Takahashi, Y., Hudait, A., Rose, K., Tjahjono, N., Pak, A. J., Yokom, A. L., Liang, X., Wang, H.-G., Bouamr, F., et al. (2020) · Nature Structural & Molecular Biology

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 57

Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery

Adriaenssens, E., Schaar, S., Cook, A. S. I., Stuke, J. F. M., Sawa-Makarska, J., Nguyen, T. N., Ren, X., Schuschnig, M., Romanov, J., Khuu, G., et al. (2025) · Nature Cell Biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 53

Reconstitution of BNIP3/NIX-mediated autophagy reveals two pathways and hierarchical flexibility of the initiation machinery

Adriaenssens, E., Schaar, S., Cook, A. S. I., Stuke, J. F. M., Sawa-Makarska, J., Nguyen, T. N., Ren, X., Schuschnig, M., Romanov, J., Khuu, G., et al. (2024) · Nature Cell Biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 53

Crystallographic molecular replacement using an in silico‐generated search model of SARS‐CoV‐2 ORF8

Flower, T. G., & Hurley, J. H. (2021) · Protein Science

Enzyme Structure and FunctionProtein Structure and Dynamics

Cited by 49

Membrane curvature sensing and stabilization by the autophagic LC3 lipidation machinery

Jensen, L. E., Rao, S., Schuschnig, M., Cada, A. K., Martens, S., Hummer, G., & Hurley, J. H. (2022) · Science Advances

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 49

Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies

Carlson, L.-A., Bai, Y., Keane, S. C., Doudna, J. A., & Hurley, J. H. (2016) · eLife

HIV Research and TreatmentT-cell and Retrovirus Studies

Cited by 48

Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex

Chen, M., Nguyen, T. N., Ren, X., Khuu, G., Cook, A. S. I., Zhao, Y., Yildiz, A., Lazarou, M., & Hurley, J. H. (2023) · Nature Structural & Molecular Biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 40

Structural pathway for PI3-kinase regulation by VPS15 in autophagy

Cook, A. S. I., Chen, M., Nguyen, T. N., Cabezudo, A. C., Khuu, G., Rao, S., Garcia, S. N., Yang, M., Iavarone, A. T., Ren, X., et al. (2025) · Science

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 34