Karahan, Hande

Tubular human brain organoids to model microglia-mediated neuroinflammation

Ao, Z., Cai, H., Wu, Z., Song, S., Karahan, H., Kim, B., Lu, H.-C., Kim, J., Mackie, K., & Guo, F. (2021) · Lab on a Chip

Neuroinflammation and Neurodegeneration Mechanisms3D Printing in Biomedical Research

Cited by 87

Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming

Sun, Z., Kwon, J.-S., Ren, Y., Chen, S., Walker, C. K., Lu, X., Cates, K., Karahan, H., Sviben, S., Fitzpatrick, J. A. J., et al. (2024) · Science

Alzheimer's disease research and treatmentsPluripotent Stem Cells Research

Cited by 77

Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis

Karahan, H., Smith, D. C., Kim, B., Dabin, L. C., Al-Amin, M. M., Wijeratne, H. R. S., Pennington, T., Viana di Prisco, G., McCord, B., Lin, P. B.-C., et al. (2021) · Science Advances

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 53

Effects of SPI1-mediated transcriptome remodeling on Alzheimer's disease-related phenotypes in mouse models of Aβ amyloidosis

Kim, B., Dabin, L. C., Tate, M. D., Karahan, H., Sharify, A. D., Acri, D. J., Al-Amin, M. M., Philtjens, S., Smith, D. C., Wijeratne, H. R. S., et al. (2024) · Nature Communications

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 28

Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer’s disease

Jury-Garfe, N., Redding-Ochoa, J., You, Y., Martínez, P., Karahan, H., Chimal-Juárez, E., Johnson, T. S., Zhang, J., Resnick, S., Kim, J., et al. (2024) · Acta Neuropathologica

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 22

The effect of Abi3 locus deletion on the progression of Alzheimer’s disease-related pathologies

Karahan, H., Smith, D. C., Kim, B., McCord, B., Mantor, J., John, S. K., Al-Amin, M. M., Dabin, L. C., & Kim, J. (2023) · Frontiers in Immunology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 20

Deletion of the Alzheimer’s disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice

Smith, D. C., Karahan, H., Wijeratne, H. R. S., Al-Amin, M., McCord, B., Moon, Y., & Kim, J. (2022) · Frontiers in Aging Neuroscience

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 8

MicroRNAs on the move: microRNAs in astrocyte-derived ApoE particles regulate neuronal function

Karahan, H., Dabin, L. C., Tate, M. D., & Kim, J. (2021) · Neuron

MicroRNA in disease regulationNeuroinflammation and Neurodegeneration Mechanisms

Cited by 7

Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes

Al‐Amin, M. M., Kim, B., Karahan, H., Tate, M. D., Walsh, S. P., Puntambekar, S. S., Bissel, S. J., Lamb, B. T., Wang, N., & Kim, J. (2025) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsAdvanced Neuroimaging Techniques and Applications

Cited by 6

Comprehensive characterization of the transcriptional landscape in Alzheimer’s disease (AD) brains

Chen, C., Zhang, Z., Liu, Y., Hong, W., Karahan, H., Wang, J., Li, W., Diao, L., Yu, M., Saykin, A. J., et al. (2025) · Science Advances

Alzheimer's disease research and treatmentsCancer-related molecular mechanisms research

Cited by 6

Deletion of SPI1 in microglia exacerbates amyloid pathology by impairing microglial response in Alzheimer’s disease models

Kim, B., Tate, M. D., Karahan, H., Wijeratne, H. R. S., Sharify, A. D., Wang, S. S., Kim, J. R., Al-Amin, M. M., Hartigan, K., Chung, S., et al. (2026) · Neuron

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 6

APOE loss of function: A genetic shield against Alzheimer’s disease

Tate, M. D., Karahan, H., & Kim, J. (2024) · Neuron

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 5

Network analysis identifies strain-dependent response to tau and tau seeding-associated genes

Acri, D. J., You, Y., Tate, M. D., Karahan, H., Martinez, P., McCord, B., Sharify, A. D., John, S., Kim, B., Dabin, L. C., et al. (2023) · Journal of Experimental Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 3

Deletion of neuronal Idol ameliorates Alzheimer's disease–related pathologies via APOE receptors

Karahan, H., Hartigan, K., Al‐Amin, M. M., John, S. K., McCord, B., Wijeratne, H. R. S., Acri, D. J., Smith, D. C., Dabin, L. C., Cordero, H. M. R., et al. (2025) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 2

Unique transcriptomic alterations in 5XFAD;PS19 mouse model identify glial lipid dysregulation and coordinated microglial–oligodendrocyte responses

Park, J. H., Kim, B., Al‐Amin, M. M., Tate, M. D., Sharify, A. D., John, S. K., Karahan, H., Lu, H., Dabin, L. C., & Kim, J. (2026) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 0