Oprea, Tudor I.

Artificial intelligence, drug repurposing and peer review

Levin, J. M., Oprea, T. I., Davidovich, S., Clozel, T., Overington, J. P., Vanhaelen, Q., Cantor, C. R., Bischof, E., & Zhavoronkov, A. (2020) · Nature Biotechnology

Academic Publishing and Open AccessComputational Drug Discovery Methods

Cited by 79

Pharmacokinetically Based Mapping Device for Chemical Space Navigation

Oprea, T. I., Zamora, I., & Ungell, A.-L. (2002) · Journal of Combinatorial Chemistry

Computational Drug Discovery MethodsDrug Solubulity and Delivery Systems

Cited by 77

Machine learning prediction and tau-based screening identifies potential Alzheimer’s disease genes relevant to immunity

Binder, J., Ursu, O., Bologa, C., Jiang, S., Maphis, N., Dadras, S., Chisholm, D., Weick, J., Myers, O., Kumar, P., et al. (2022) · Communications Biology

Alzheimer's disease research and treatmentsBioinformatics and Genomic Networks

Cited by 49

Chemoinformatics and artificial intelligence colloquium: progress and challenges in developing bioactive compounds

Bajorath, J., Chávez-Hernández, A. L., Duran-Frigola, M., Fernández-de Gortari, E., Gasteiger, J., López-López, E., Maggiora, G. M., Medina-Franco, J. L., Méndez-Lucio, O., Mestres, J., et al. (2022) · Journal of Cheminformatics

Computational Drug Discovery MethodsMachine Learning in Materials Science

Cited by 38

Chemoinformatics and Artificial Intelligence Colloquium: Progress and Challenges to Develop Bioactive Compounds

Bajorath, J., Chávez-Hernández, A. L., Duran-Frigola, M., Fernández-de Gortari, E., Gasteiger, J., López-López, E., Maggiora, G. M., Medina-Franco, J. L., Méndez-Lucio, O., Mestres, J., et al. (2022) · Journal of Cheminformatics

Computational Drug Discovery MethodsMachine Learning in Materials Science

Cited by 37

TIN-X: target importance and novelty explorer

Cannon, D. C., Yang, J. J., Mathias, S. L., Ursu, O., Mani, S., Waller, A., Schürer, S. C., Jensen, L. J., Sklar, L. A., Bologa, C. G., et al. (2017) · Bioinformatics

Biomedical Text Mining and OntologiesBioinformatics and Genomic Networks

Cited by 34

Chronic obstructive pulmonary disease phenotypes using cluster analysis of electronic medical records

Vazquez Guillamet, R., Ursu, O., Iwamoto, G., Moseley, P. L., & Oprea, T. (2018) · Health Informatics Journal

Chronic Obstructive Pulmonary Disease (COPD) ResearchMachine Learning in Healthcare

Cited by 30

Post-High-Throughput Screening Analysis: An Empirical Compound Prioritization Scheme

Oprea, T. I., Bologa, C. G., Edwards, B. S., Prossnitz, E. R., & Sklar, L. A. (2005) · SLAS Discovery

Computational Drug Discovery MethodsAnimal testing and alternatives

Cited by 24

Off-Patent drug repositioning

Avram, S., Curpan, R., Halip, L., Bora, A., & Oprea, T. I. (2020) · Journal of Chemical Information and Modeling

Computational Drug Discovery MethodsPharmaceutical Economics and Policy

Cited by 18

Novel drug targets in 2019

Avram, S., Halip, L., Curpan, R., & Oprea, T. I. (2020) · Nature Reviews Drug Discovery

Computational Drug Discovery MethodsScience, Research, and Medicine

Cited by 17

Novel drug targets in 2021

Avram, S., Halip, L., Curpan, R., & Oprea, T. I. (2022) · Nature Reviews Drug Discovery

Computational Drug Discovery MethodsPharmaceutical Economics and Policy

Cited by 15

Novel drug targets in 2020

Avram, S., Halip, L., Curpan, R., & Oprea, T. I. (2021) · Nature Reviews Drug Discovery

Computational Drug Discovery MethodsScience, Research, and Medicine

Cited by 13

Formalizing drug indications on the road to therapeutic intent

Nelson, S. J., Oprea, T. I., Ursu, O., Bologa, C. G., Zaveri, A., Holmes, J., Yang, J. J., Mathias, S. L., Mani, S., Tuttle, M. S., et al. (2017) · Journal of the American Medical Informatics Association

Biomedical Text Mining and OntologiesSemantic Web and Ontologies

Cited by 9

Autophagy dark genes: Can we find them with machine learning?

Ranjbar, M., Yang, J. J., Kumar, P., Byrd, D. R., Bearer, E. L., & Oprea, T. I. (2023) · Natural Sciences

Autophagy in Disease and TherapyBioinformatics and Genomic Networks

Cited by 7

Early ADME/T Predictions: Toy or Tool?

Tetko, I. V., & Oprea, T. I. (2008) · Chemoinformatics Approaches to Virtual Screening

Computational Drug Discovery MethodsPharmacogenetics and Drug Metabolism

Cited by 5

Annotating off-label drug usage from unconventional sources

Avram, S., Halip, L., Curpan, R., Borota, A., Bora, A., & Oprea, T. I. (2022) · medRxiv

Pharmaceutical industry and healthcarePharmacovigilance and Adverse Drug Reactions

Cited by 4