Jackson, Stephen P.

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature

PARP inhibition in cancer therapyDNA Repair Mechanisms

Cited by 6,683

The DNA-damage response in human biology and disease

Jackson, S. P., & Bartek, J. (2009) · Nature

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 6,092

A DNA damage checkpoint response in telomere-initiated senescence

Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature

Telomeres, Telomerase, and SenescenceDNA Repair Mechanisms

Cited by 2,917

DNA double-strand breaks: signaling, repair and the cancer connection

Khanna, K. K., & Jackson, S. P. (2001) · Nature Genetics

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 2,455

Human CtIP promotes DNA end resection

Sartori, A. A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J., & Jackson, S. P. (2007) · Nature

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 1,362

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

Hickson, I., Zhao, Y., Richardson, C. J., Green, S. J., Martin, N. M. B., Orr, A. I., Reaper, P. M., Jackson, S. P., Curtin, N. J., & Smith, G. C. M. (2004) · Cancer Research

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 1,220

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

Polo, S. E., & Jackson, S. P. (2011) · Genes & Development

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 1,092

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C. M., Lukas, J., & Jackson, S. P. (2006) · Nature Cell Biology

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 1,064

Regulation of p53 in response to DNA damage

Lakin, N. D., & Jackson, S. P. (1999) · Oncogene

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 987

Deubiquitylating enzymes and drug discovery: emerging opportunities

Harrigan, J. A., Jacq, X., Martin, N. M., & Jackson, S. P. (2018) · Nature Reviews Drug Discovery

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 940

The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling

D'Amours, D., & Jackson, S. P. (2002) · Nature Reviews Molecular Cell Biology

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 874

A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci

Riballo, E., Kühne, M., Rief, N., Doherty, A., Smith, G. C. M., Recio, M.-J., Reis, C., Dahm, K., Fricke, A., Krempler, A., et al. (2004) · Molecular Cell

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 837

XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining

Ahnesorg, P., Smith, P., & Jackson, S. P. (2006) · Cell

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 794

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

Aymard, F., Bugler, B., Schmidt, C. K., Guillou, E., Caron, P., Briois, S., Iacovoni, J. S., Daburon, V., Miller, K. M., Jackson, S. P., et al. (2014) · Nature Structural & Molecular Biology

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 668

A Compendium of Mutational Signatures of Environmental Agents

Kucab, J. E., Zou, X., Morganella, S., Joel, M., Nanda, A. S., Nagy, E., Gomez, C., Degasperi, A., Harris, R., Jackson, S. P., et al. (2019) · Cell

Cancer Genomics and DiagnosticsCarcinogens and Genotoxicity Assessment

Cited by 660

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

Miller, K. M., Tjeertes, J. V., Coates, J., Legube, G., Polo, S. E., Britton, S., & Jackson, S. P. (2010) · Nature Structural & Molecular Biology

DNA Repair MechanismsHistone Deacetylase Inhibitors Research

Cited by 629

Regulation of DNA Damage Responses by Ubiquitin and SUMO

Jackson, S. P., & Durocher, D. (2013) · Molecular Cell

Ubiquitin and proteasome pathwaysDNA Repair Mechanisms

Cited by 601

Poly(ADP-ribose)–Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

Ahel, D., Hořejší, Z., Wiechens, N., Polo, S. E., Garcia-Wilson, E., Ahel, I., Flynn, H., Skehel, M., West, S. C., Jackson, S. P., et al. (2009) · Science

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 588

DNA end-joining: from yeast to man

Critchlow, S. E., & Jackson, S. P. (1998) · Trends in Biochemical Sciences

DNA Repair MechanismsNuclear Structure and Function

Cited by 584

MDC1 is required for the intra-S-phase DNA damage checkpoint

Goldberg, M., Stucki, M., Falck, J., D'Amours, D., Rahman, D., Pappin, D., Bartek, J., & Jackson, S. P. (2003) · Nature

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 506

Yeast Rtt109 Promotes Genome Stability by Acetylating Histone H3 on Lysine 56

Driscoll, R., Hudson, A., & Jackson, S. P. (2007) · Science

Genomics and Chromatin DynamicsDNA Repair Mechanisms

Cited by 439

Chemical inhibition of NAT10 corrects defects of laminopathic cells

Larrieu, D., Britton, S., Demir, M., Rodriguez, R., & Jackson, S. P. (2014) · Science

Nuclear Structure and FunctionDNA Repair Mechanisms

Cited by 431

Human cell senescence as a DNA damage response

Zglinicki, T. V., Saretzki, G., Ladhoff, J., Fagagna, F. D. D., & Jackson, S. P. (2005) · Mechanisms of Ageing and Development

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 419

γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes

Stucki, M., & Jackson, S. P. (2006) · DNA Repair

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 412