Aging-related tau astrogliopathy (ARTAG): Harmonized evaluation strategy
Open accessAbstract
Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of astroglial tau pathology in the aged brain, facilitating communication among neuropathologists and researchers, and informing interpretation of clinical biomarkers and imaging studies that focus on tau-related indicators.
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Primary age-related tauopathy (PART) and aging-related tau astrogliopathy (ARTAG) are independent tau pathologies commonly observed in patients over 80 years of age, and PART may account for a proportion of misdiagnosed clinical AD cases in the elderly.
“Primary age-related tauopathy (PART) and aging-related tau astrogliopathy (ARTAG) are independent tau pathologies commonly observed in patients over 80 years of age, and PART may account for a proportion of the misdiagnosed clinical AD cases in the elderly [130, 141, 142].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [141]
Split into 2 atoms — 0 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredPerivascular, subpial, and periventricular p-tau immunoreactive NFTs and astrocytic tangles in the neocortex have been reported to be characteristic of both primary age-related tauopathy and age-related tau astrogliopathy.
“Perivascular, subpial, and periventricular p-tau immunoreactive NFTs and astrocytic tangles in the neocortex have been reported to be characteristic of both primary age-related tauopathy (PART) [35] and age-related tau astrogliopathy (ARTAG) [36].”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [36]
The Evaluation of ARTAG section (page unavailable) identifies subpial, subependymal and perivascular tau-immunoreactive astrocytes, including examples in cortical regions. But the Introduction distinguishes ARTAG’s astrocytic pathology from neuronal neurofibrillary degeneration, and the paper does not characterize perivascular, subpial and periventricular NFTs in the neocortex as ARTAG lesions. Its subependymal example is at the lateral ventricle, not in the neocortex. (LLM, conf=0.88)
Experimental — accuracy not yet measuredPART and ARTAG appear to be more a manifestation of age than a subtype of neurodegenerative disease.
“PART refers to neuronal tau pathology and ARTAG is characterized by astrocytic tau pathology, although they are not mutually exclusive, and appear to be more a manifestation of age than a subtype of neurodegenerative disease.”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [36]
The Introduction (page not provided) says PART describes neuronal tau pathology, ARTAG describes astrocytic tau pathology, and both predominantly affect older people. The Summary (page not provided) associates ARTAG mostly with aging, but the paper does not establish that both are manifestations of age rather than neurodegenerative disease: the Introduction also says PART includes NFT-dementia, and the paper notes that ARTAG can coexist with neurodegenerative disorders. (LLM, conf=0.85)
Experimental — accuracy not yet measuredAge-related tau astrogliopathy (ARTAG) is a phenomenon in which p-tau accumulates in astrocytes of various brain regions.
“Another exemplary phenomenon is age-related tau astrogliopathy (ARTAG), in which p-tau accumulates in astrocytes of various brain regions [79].”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [79]
The 2016 consensus panel did not include pathology known to be associated with aging (PART and ARTAG) in the a priori criteria for CTE.
“The panel did not ultimately accept all of the a priori criteria for CTE; they did not include pathology known to be associated with aging (i.e.primary age-related tauopathy [PART] [16] and aging-related tau astrogliopathy [ARTAG] [17]).”
From Mild Chronic Traumatic Encephalopathy Neuropathology in People With No Known Participation in Contact Sports or History of Repetitive Neurotrauma (2019) · cites this paper as [17]
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Cites
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196 · cited 1× · see citing works
“In addition to these differences, reaction of astrocytes varies considerably between distinct diseases of the nervous system [60].”
Self-citationAssociation of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., et al. (1998) · Nature · doi:10.1038/31508 · Cited by 3,498 · cited 2× · see citing works
“Mutations in the tau gene (MAPT) can cause hereditary frontotemporal dementia and associate with frontotemporal lobar degeneration (FTLD) [23, 26, 51, 63].”
Self-citationGoedert, M., Spillantini, M. G., Jakes, R., Rutherford, D., & Crowther, R. A. (1989) · Neuron · doi:10.1016/0896-6273(89)90210-9 · Cited by 2,492 · cited 1× · see citing works
“The six isoforms differ from each other by the presence or absence of 29- or 58-amino acid inserts in the N-terminus domain and by the presence of either three (3R tau isoforms) or four (4R tau isoforms) tandem repeat sequences of 31 or 32 amino acids [24].”
Lee, V. M.-Y., Goedert, M., & Trojanowski, J. Q. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1121 · Cited by 2,480 · cited 1× · see citing works
“Tauopathies are characterized by the accumulation of abnormal and hyper-phosphorylated tau protein in the brain and are also classified as primary or secondary [32, 37].”
Self-citationChronic traumatic encephalopathy in athletes: Progressive tauopathy after repetitive head injury
McKee, A. C., Cantu, R. C., Nowinski, C. J., Hedley-Whyte, E. T., Gavett, B. E., Budson, A. E., Santini, V. E., Lee, H.-S., Kubilus, C. A., & Stern, R. A. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181a9d503 · Cited by 2,295 · see citing works
The spectrum of disease in chronic traumatic encephalopathy
McKee, A. C., Stein, T. D., Nowinski, C. J., Stern, R. A., Daneshvar, D. H., Alvarez, V. E., Lee, H.-S., Hall, G., Wojtowicz, S. M., Baugh, C. M., et al. (2013) · Brain · doi:10.1093/brain/aws307 · Cited by 2,098 · cited 12× · see citing works
“On the other hand, tau pathology, including neuronal and astroglial, in CTE is more abundant in the depths of the convexity cerebral sulci, especially in early stages [41], an aspect that has not been reported in tau astrogliopathy in the aging brain [29, 34-36, 46, 57].”
InfluentialMutation in the tau gene in familial multiple system tauopathy with presenile dementia
Spillantini, M. G., Murrell, J. R., Goedert, M., Farlow, M. R., Klug, A., & Ghetti, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7737 · Cited by 1,474 · cited 2× · see citing works
“Mutations in the tau gene (MAPT) can cause hereditary frontotemporal dementia and associate with frontotemporal lobar degeneration (FTLD) [23, 26, 51, 63].”
Primary age-related tauopathy (PART): a common pathology associated with human aging
Crary, J. F., Trojanowski, J. Q., Schneider, J. A., Abisambra, J. F., Abner, E. L., Alafuzoff, I., Arnold, S. E., Attems, J., Beach, T. G., Bigio, E. H., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1349-0 · Cited by 1,467 · cited 6× · see citing works
“The recently introduced term ‘primary age-related tauopathy’ (PART) encompasses neuronal changes previously considered as “normal aging” as well as NFT-dementia [14].”
InfluentialTau is a candidate gene for chromosome 17 frontotemporal dementia
Poorkaj, P., Bird, T. D., Wijsman, E., Nemens, E., Garruto, R. M., Anderson, L., Andreadis, A., Wiederholt, W. C., Raskind, M., & Schellenberg, G. D. (1998) · Annals of Neurology · doi:10.1002/ana.410430617 · Cited by 1,374 · cited 2× · see citing works
“Mutations in the tau gene (MAPT) can cause hereditary frontotemporal dementia and associate with frontotemporal lobar degeneration (FTLD) [23, 26, 51, 63].”
Cairns, N. J., Bigio, E. H., Mackenzie, I. R. A., Neumann, M., Lee, V. M.-Y., Hatanpaa, K. J., White, C. L., Schneider, J. A., Grinberg, L. T., Halliday, G., et al. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0237-2 · Cited by 1,110 · cited 1× · see citing works
“Tau pathology is characterized as 3R or 4R predominant or mixed 3R + 4R type [12, 30, 32].”
Bancher, C., Brunner, C., Lassmann, H., Budka, H., Jellinger, K., Wiche, G., Seitelberger, F., Grundke-Iqbal, I., Iqbal, K., & Wisniewski, H. M. (1989) · Brain Research · doi:10.1016/0006-8993(89)91396-6 · Cited by 818 · cited 1× · see citing works
“Some of the variation in the morphology of the immunolabeled structures was interpreted as representing stages of a process of aggregation and fibrillation, analogous to progression from pretangles to neurofibrillary tangles in AD [6, 11].”
Heterogeneity of astrocytic form and function.
Oberheim, N. A., Goldman, S. A., & Nedergaard, M. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-61779-452-0_3 · Cited by 638 · cited 1× · see citing works
“Protoplasmic and fibrous astrocytes differ substantially in their glutamate uptake capabilities and capacity and have very different degrees of coupling, which are important with regard to their respective calcium wave signals, resting membrane potentials, potassium buffering, glutamate metabolism, exchange of second…”
The Neuropathology of Chronic Traumatic Encephalopathy
McKee, A. C., Stein, T. D., Kiernan, P. T., & Alvarez, V. E. (2015) · Brain Pathology · doi:10.1111/bpa.12248 · Cited by 585 · cited 3× · see citing works
“CTE is associated with a history of repetitive concussive or subconcussive brain trauma and is characterized by widespread accumulation of hyper-phosphorylated tau in NFTs and astrocytes, which have similarity to TSA seen in ARTAG [41].”
Self-citationAlzheimer and frontotemporal pathology in subsets of primary progressive aphasia
Mesulam, M., Wicklund, A., Johnson, N., Rogalski, E., Léger, G. C., Rademaker, A., Weintraub, S., & Bigio, E. H. (2008) · Annals of Neurology · doi:10.1002/ana.21388 · Cited by 513 · cited 1× · see citing works
“Subsequent reports also linked TSA to symptomatology, although not all found an association of ATACs with focal neurological syndromes [9, 43].”
Self-citationInvited review: Neuropathology of tauopathies: principles and practice
Kovacs, G. G. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12208 · Cited by 492 · cited 10× · see citing works
“Finally, tufted astrocytes in PSP, astrocytic plaques in CBD, globular astrocytic inclusions in GGT, and ramified astrocytes in PiD are distinct from tau-immunoreactive astrocytes in the gray matter in ARTAG (see Table 1).”
InfluentialAlafuzoff, I., Arzberger, T., Al‐Sarraj, S., Bodi, I., Bogdanovic, N., Braak, H., Bugiani, O., Del‐Tredici, K., Ferrer, I., Gelpi, E., et al. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00147.x · Cited by 467 · see citing works
Ghetti, B. F., Oblak, A. L., Boeve, B. F., Johnson, K. A., Dickerson, B. C., & Goedert, M. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12213 · Cited by 440 · cited 3× · see citing works
“Mutations in the tau gene (MAPT) can cause hereditary frontotemporal dementia and associate with frontotemporal lobar degeneration (FTLD) [23, 26, 51, 63].”
InfluentialAstrocyte phenotype in relation to Alzheimer‐type pathology in the ageing brain
Simpson, J. E., Ince, P. G., Lace, G., Forster, G., Shaw, P. J., Matthews, F., Savva, G., Brayne, C., & Wharton, S. B. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.015 · Cited by 381 · see citing works
Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)
Dickson, D. W., Kouri, N., Murray, M. E., & Josephs, K. A. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9589-0 · Cited by 380 · cited 5× · see citing works
“Finally, tufted astrocytes in PSP, astrocytic plaques in CBD, globular astrocytic inclusions in GGT, and ramified astrocytes in PiD are distinct from tau-immunoreactive astrocytes in the gray matter in ARTAG (see Table 1).”
InfluentialKovács, G. G., Milenković, I., Wöehrer, A., Höftberger, R., Gelpí, E., Haberler, C., Hönigschnabl, S., Reiner‐Concin, A., Heinzl, H., Jungwirth, S., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1157-y · Cited by 360 · cited 22× · see citing works
“Finally, tufted astrocytes in PSP, astrocytic plaques in CBD, globular astrocytic inclusions in GGT, and ramified astrocytes in PiD are distinct from tau-immunoreactive astrocytes in the gray matter in ARTAG (see Table 1).”
InfluentialPatterns of gliosis in alzheimer's disease and aging cerebrum
Beach, T. G., Walker, R., & McGeer, E. G. (1989) · Glia · doi:10.1002/glia.440020605 · Cited by 337 · cited 2× · see citing works
“The location of such reactive astrocytes varies considerably among individuals [8, 59].”
Spillantini, M. G., Goedert, M., Crowther, R. A., Murrell, J. R., Farlow, M. R., & Ghetti, B. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4113 · Cited by 334 · cited 1× · see citing works
“Following the description of a disorder in one family named ‘multiple system tauopathy with presenile dementia’ [62], the term tauopathy was introduced to refer to disorders in which tau protein deposition is the predominant feature [23].”
InfluentialStaging/typing of Lewy body related α-synuclein pathology: a study of the BrainNet Europe Consortium
Alafuzoff, I. I., Ince, P. G., Arzberger, T., Al‐Sarraj, S., Bell, J. E., Bódi, I., Bogdanović, N., Bugiani, O., Ferrer, I., Gelpí, E., et al. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0523-2 · Cited by 314 · see citing works
Widespread cytoskeletal pathology characterizes corticobasal degeneration.
Feany, M. Β., & Dickson, D. W. (1995) · PubMed · Cited by 276 · see citing works
Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine
Irwin, D. J., Cairns, N. J., Grossman, M., McMillan, C. T., Lee, E. B., Deerlin, V. M. V., Lee, V. M. ‐., & Trojanowski, J. Q. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1380-1 · Cited by 262 · cited 1× · see citing works
“Tau pathology is characterized as 3R or 4R predominant or mixed 3R + 4R type [12, 30, 32].”
Ferrer, I., Santpere, G., & van Leeuwen, F. W. (2008) · Brain · doi:10.1093/brain/awm305 · Cited by 256 · cited 8× · see citing works
“Indeed, astrocytic tau pathology is variably seen in AGD [22].”
InfluentialClinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias
Murray, M. E., Kouri, N., Lin, W.-L., Jack, C. R., Dickson, D. W., & Vemuri, P. (2014) · Alzheimer s Research & Therapy · doi:10.1186/alzrt231 · Cited by 237 · cited 6× · see citing works
“Finally, tufted astrocytes in PSP, astrocytic plaques in CBD, globular astrocytic inclusions in GGT, and ramified astrocytes in PiD are distinct from tau-immunoreactive astrocytes in the gray matter in ARTAG (see Table 1).”
InfluentialFerrer, I., López-González, I., Carmona, M., Arregui, L., Dalfó, E., Torrejón-Escribano, B., Diehl, R., & Kovacs, G. G. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000030 · Cited by 217 · see citing works
Glial Inclusions in CNS Degenerative Diseases
Chin, S., & Goldman, J. E. (1996) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199605000-00001 · Cited by 208 · cited 1× · see citing works
“TSA may occur in multiple conditions [13].”
Globular glial tauopathies (GGT): consensus recommendations
Ahmed, Z., Bigio, E. H., Budka, H., Dickson, D. W., Ferrer, I., Ghetti, B. F., Giaccone, G., Hatanpaa, K. J., Holton, J. L., Josephs, K. A., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1171-0 · Cited by 205 · cited 5× · see citing works
“Finally, tufted astrocytes in PSP, astrocytic plaques in CBD, globular astrocytic inclusions in GGT, and ramified astrocytes in PiD are distinct from tau-immunoreactive astrocytes in the gray matter in ARTAG (see Table 1).”
InfluentialAssessment of β-amyloid deposits in human brain: a study of the BrainNet Europe Consortium
Alafuzoff, I., Thal, D. R., Arzberger, T., Bogdanovic, N., Al-Sarraj, S., Bodi, I., Boluda, S., Bugiani, O., Duyckaerts, C., Gelpi, E., et al. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0485-4 · Cited by 193 · see citing works
Self-citationPhenotypic Heterogeneity and Plasticity of Isocortical and Hippocampal Astrocytes in the Human Brain
Sosunov, A. A., Wu, X., Tsankova, N. M., Guilfoyle, E., McKhann, G. M., & Goldman, J. E. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4037-13.2014 · Cited by 185 · see citing works
Thomas, T. L., Miners, J. S., & Love, S. (2015) · Brain · doi:10.1093/brain/awv025 · Cited by 184 · cited 1× · see citing works
“Potential etiologies are not known, although defective function of the blood–brain barrier [57], metabolic encephalopathy, neurodegenerative pathologies, hypoperfusion associated with aging, AD, or vascular dementia [39, 64], and even repeated minor trauma with possible genetic risk factors may play a role.”
Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease
Jellinger, K. A., & Attems, J. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0156-7 · Cited by 157 · cited 1× · see citing works
“Finally, a report on NFTdementia mentioned the presence of astrocytic tau pathology in white matter and cortex [31].”
Nishimura, M., Namba, Y., Ikeda, K., & Oda, M. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90227-x · Cited by 120 · cited 15× · see citing works
“Finally, tufted astrocytes in PSP, astrocytic plaques in CBD, globular astrocytic inclusions in GGT, and ramified astrocytes in PiD are distinct from tau-immunoreactive astrocytes in the gray matter in ARTAG (see Table 1).”
InfluentialThorn-shaped astrocytes: possibly secondarily induced tau-positive glial fibrillary tangles
Ikeda, K., Akiyama, H., Kondo, H., Haga, C., Tanno, E., Tokuda, T., & Ikeda, S. (1995) · Acta Neuropathologica · doi:10.1007/bf00318575 · Cited by 119 · cited 1× · see citing works
“noted that the distribution of TSA was coexistent with prominent subpial and subependymal gliosis [29].”
Togo, T., & Dickson, D. W. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0569-x · Cited by 115 · cited 1× · see citing works
“In contrast, astrocytic tau pathologies in CBD or PSP involve protoplasmic astrocytes and are independent of reactive astrogliosis [19, 65].”
Multisite assessment of NIA‐AA guidelines for the neuropathologic evaluation of Alzheimer's disease
Montine, T. J., Monsell, S. E., Beach, T. G., Bigio, E. H., Bu, Y., Cairns, N. J., Frosch, M., Henriksen, J., Kofler, J., Kukull, W. A., et al. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.07.492 · Cited by 113 · see citing works
Glial Tau Pathology in Neurodegenerative Diseases: Their Nature and Comparison with Neuronal Tangles
Ikeda, K., Akiyama, H., Arai, T., & Nishimura, T. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00034-7 · Cited by 110 · cited 1× · see citing works
“All studies agree that the burden of TSA is independent of AD pathology, AGD, coiled bodies, dementia status at death, or presence of the APOE ε4 allele [27, 28, 36, 57, 66].”
Filamentous Tau Pathology in Nerve Cells, Astrocytes, and Oligodendrocytes of Aged Baboons
Schultz, C., Dehghani, F., Hubbard, G. B., Thal, D. R., Struckhoff, G., Braak, E., & Braak, H. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.1.39 · Cited by 99 · cited 1× · see citing works
“Interestingly, a similar distribution of TSA was reported in aged baboons [55].”
Botez, G., Probst, A., Ipsen, S., & Tolnay, M. (1999) · Acta Neuropathologica · doi:10.1007/s004010051077 · Cited by 96 · cited 11× · see citing works
“Indeed, astrocytic tau pathology is variably seen in AGD [22].”
InfluentialHigh prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe
Schultz, C., Ghebremedhin, E., Tredici, K. D., Rüb, U., & Braak, H. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00113-1 · Cited by 91 · cited 7× · see citing works
“TSA were absent in individuals under 60 years, but affected almost half of brains from those over 75 years [57].”
InfluentialA peculiar constellation of tau pathology defines a subset of dementia in the elderly
Kovács, G. G., Molnár, K., László, L., Ströbel, T., Botond, G., Hönigschnabl, S., Reiner‐Concin, A., Palkovits, M., Fischer, P. A., & Budka, H. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0819-x · Cited by 90 · cited 9× · see citing works
“Most previous studies have focused on the MTL, but more widespread involvement is possible [34, 35].”
InfluentialHippocampal Sclerosis Dementia with Tauopathy
Beach, T. G., Sue, L. I., Scott, S., Layne, K. J., Newell, A., Walker, D. G., Baker, M., Sahara, N., Yen, S.-H. C., Hutton, M. L., et al. (2003) · Brain Pathology · doi:10.1111/j.1750-3639.2003.tb00027.x · Cited by 89 · cited 1× · see citing works
“[7], in a series of cases with hippocampal sclerosis and also in a community-based study [34].”
Clinicopathological Outcomes of Prospectively Followed Normal Elderly Brain Bank Volunteers
Dugger, B. N., Hentz, J. G., Adler, C. H., Sabbagh, M. N., Shill, H. A., Jacobson, S. A., Caviness, J. N., Belden, C. M., Driver‐Dunckley, E. D., Davis, K. J., et al. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000046 · Cited by 80 · cited 14× · see citing works
“Finally, tufted astrocytes in PSP, astrocytic plaques in CBD, globular astrocytic inclusions in GGT, and ramified astrocytes in PiD are distinct from tau-immunoreactive astrocytes in the gray matter in ARTAG (see Table 1).”
InfluentialBigio, E. H., Mishra, M., Hatanpaa, K. J., White, C. L., Johnson, N., RADEMAKER, A. W., Weitner, B. B., Deng, H., Dubner, S., Weıntraub, S., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0681-2 · Cited by 78 · cited 1× · see citing works
“Subsequent reports also linked TSA to symptomatology, although not all found an association of ATACs with focal neurological syndromes [9, 43].”
Muñoz, D. G., Woulfe, J., & KERTESZ, A. E. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0266-x · Cited by 77 · cited 10× · see citing works
“They used the term “argyrophilic thorny astrocyte clusters (ATACs)” and observed them in the frontal, temporal, and parietal cortices and in subcortical white matter in a cohort of patients with nonfluent variant of primary progressive aphasia associated with AD pathology [46].”
InfluentialKovács, G. G., Horváth, M., Majtényi, K., Lutz, M. I., Hurd, Y. L., & Keller, É. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.07.018 · Cited by 75 · cited 1× · see citing works
“Indeed, another study also failed to find this type of tau astrogliopathy in younger individuals [33].”
Togo, T., & Dickson, D. W. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0520-1 · Cited by 72 · see citing works
Santpere, G., & Ferrer, I. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00173.x · Cited by 56 · cited 15× · see citing works
“Finally, tufted astrocytes in PSP, astrocytic plaques in CBD, globular astrocytic inclusions in GGT, and ramified astrocytes in PiD are distinct from tau-immunoreactive astrocytes in the gray matter in ARTAG (see Table 1).”
InfluentialNakano, I., Iwatsubo, T., Otsuka, N., Kamei, M., Matsumura, K., & Mannen, T. (1992) · Acta Neuropathologica · doi:10.1007/bf00296783 · Cited by 53 · cited 1× · see citing works
“Few studies reported tau immunopositivity in glial cells in AD cases with prolonged duration of the disease [5, 48, 68].”
Neuropathological findings of PSP in the elderly without clinical PSP: Possible incidental PSP?
Evidente, V. G. H., Adler, C. H., Sabbagh, M. N., Connor, D. J., Hentz, J. G., Caviness, J. N., Sue, L. I., & Beach, T. G. (2011) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2011.02.017 · Cited by 52 · cited 14× · see citing works
“Finally, tufted astrocytes in PSP, astrocytic plaques in CBD, globular astrocytic inclusions in GGT, and ramified astrocytes in PiD are distinct from tau-immunoreactive astrocytes in the gray matter in ARTAG (see Table 1).”
InfluentialMesial Temporal Astrocyte Tau Pathology in the MRC-CFAS Ageing Brain Cohort
Lace, G., Ince, P. G., Brayne, C., Savva, G. M., Matthews, F. E., de Silva, R., Simpson, J. E., & Wharton, S. B. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000341581 · Cited by 52 · cited 8× · see citing works
“Also, this study documented the 4R tau nature of TSA [36].”
InfluentialA sex difference in neurodegeneration of the human hypothalamus
Schultz, C., Braak, H., & Braak, E. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12787-7 · Cited by 45 · cited 1× · see citing works
“In aged individuals sex-dependent tau pathology, developing independently from AD has been also described in the hypothalamus [16, 54, 56].”
Familial Behavioral Variant Frontotemporal Dementia Associated With Astrocyte-Predominant Tauopathy
Ferrer, I., Legati, A., García‐Moncó, J. C., Gómez-Beldarrain, M., Carmona, M., Blanco, R. E., Seeley, W. W., & Coppola, G. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000180 · Cited by 44 · cited 1× · see citing works
“Interestingly, prominent tau astrogliopathy may be seen in familial disorders without MAPT mutation [20].”
White Matter Hypoperfusion and Damage in Dementia: Post‐Mortem Assessment
Love, S., & Miners, J. S. (2014) · Brain Pathology · doi:10.1111/bpa.12223 · Cited by 41 · cited 1× · see citing works
“Potential etiologies are not known, although defective function of the blood–brain barrier [57], metabolic encephalopathy, neurodegenerative pathologies, hypoperfusion associated with aging, AD, or vascular dementia [39, 64], and even repeated minor trauma with possible genetic risk factors may play a role.”
Patterns of Hippocampal Tau Pathology Differentiate Neurodegenerative Dementias
Milenković, I., Petrov, T., & Kovács, G. G. (2014) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000365548 · Cited by 36 · cited 1× · see citing works
“Mathematical modeling of hippocampal tau immunolabeling patterns suggested that some forms of tau astrogliopathy in the elderly involve hippocampal subregions in a different pattern from that of primary tauopathies [44].”
Schultz, C., Ghebremedhin, E., Braak, E., & Braak, H. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7185 · Cited by 36 · cited 1× · see citing works
“In aged individuals sex-dependent tau pathology, developing independently from AD has been also described in the hypothalamus [16, 54, 56].”
Glial fibrillary tangles and argyrophilic threads: Classification and disease specificity
Ikeda, K. (1996) · Neuropathology · doi:10.1111/j.1440-1789.1996.tb00158.x · Cited by 31 · cited 2× · see citing works
“In comparison to the tufted astrocytes of PSP, TSA showed more voluminous perinuclear cytoplasm and their processes are often thicker and shorter [27].”
A comparison of Aβ amyloid pathology staging systems and correlation with clinical diagnosis
Boluda, S., Toledo, J. B., Irwin, D. J., Raible, K. M., Byrne, M., Lee, E. B., Lee, V. M. ‐., & Trojanowski, J. Q. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1308-9 · Cited by 30 · see citing works
López‐González, I., Carmona, M., Blanco, R., Luna‐Muñoz, J., Martínez‐Mandonado, A., Mena, R., & Ferrer, I. (2013) · Brain Pathology · doi:10.1111/j.1750-3639.2012.00627.x · Cited by 28 · cited 4× · see citing works
“Other antibodies that may prove useful in the characterization of ARTAG include those specific for tau phosphorylated at Thr181, Ser202, Ser214, Ser396, Ser422, N-terminus region epitopespecific, 4R tau isoform-specific, and some conformation-dependent antibodies such as Alz50 (but not MC-1) [21, 35, 38].”
InfluentialTuft-shaped astrocytes in Lewy body disease
Hishikawa, N., Hashizume, Y., Yoshida, M., Niwa, J.-I., Tanaka, F., & Sobue, G. (2005) · Acta Neuropathologica · doi:10.1007/s00401-004-0967-3 · Cited by 26 · cited 14× · see citing works
“Finally, tufted astrocytes in PSP, astrocytic plaques in CBD, globular astrocytic inclusions in GGT, and ramified astrocytes in PiD are distinct from tau-immunoreactive astrocytes in the gray matter in ARTAG (see Table 1).”
InfluentialSakai, K., Piao, Y.-S., Kikugawa, K., Ohara, S., Hasegawa, M., Takano, H., Fukase, M., Nishizawa, M., Kakita, A., & Takahashi, H. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0093-5 · Cited by 26 · see citing works
Yamazaki, M., Nakano, I., Imazu, O., & Terashi, A. (1995) · Acta Neuropathologica · doi:10.1007/bf00294456 · Cited by 22 · see citing works
Spinal cord tau pathology in cervical spondylotic myelopathy
Shimizu, H., Kakita, A., & Takahashi, H. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0321-7 · Cited by 19 · cited 1× · see citing works
“In a study on cervical spondylotic myelopathy, AT8 immunohistochemistry revealed tau-positive, neuropil threads, astrocytic foot-like perivascular or subpial structures, and glial cells with short and thick processes, which the authors termed TSA [58].”
Arima, K., Izumiyama, Y., Nakamura, M., Nakayama, H., Kimura, M., Ando, S., Ikeda, K., & Takahashi, K. (1998) · Acta Neuropathologica · doi:10.1007/s004010050762 · Cited by 18 · cited 1× · see citing works
“Few studies reported tau immunopositivity in glial cells in AD cases with prolonged duration of the disease [5, 48, 68].”
Primary progressive aphasia with focal glial tauopathy
Wakabayashi, K., Shibasaki, Y., Hasegawa, M., Horikawa, Y., Soma, Y., Hayashi, S., Morita, T., Iwatsubo, T., & Takahashi, H. (2000) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.2000.00266-2.x · Cited by 11 · see citing works
Uchikado, H., Fujino, Y., Lin, W., & Dickson, D. W. (2007) · Springer eBooks · doi:10.1007/978-0-387-72076-0_39 · Cited by 2 · see citing works
Dugger, B. N., Uchikado, H., Ahmed, Z., & Dickson, D. W. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.2219 · Cited by 1 · see citing works
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The neuropathological diagnosis of Alzheimer's disease
DeTure, M. A., & Dickson, D. W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0333-5 · Cited by 3,329 · see citing works
“gies commonly observed in patients over 80 years of age, and PART may account for a proportion of the misdiagnosed clinical AD cases in the elderly [130, 141, 142].”
BackgroundPathology of Neurodegenerative Diseases
Dugger, B. N., & Dickson, D. W. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028035 · Cited by 1,665 · see citing works
“Tau pathology in chronic traumatic encephalopathy (CTE) (A,B) and aging-related tau astrogliopathy (ARTAG) (C,D).”
BackgroundInfluentialSelf-citationLewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes
Shahmoradian, S. H., Lewis, A. J., Genoud, C., Hench, J., Moors, T. E., Navarro, P. P., Castaño‐Díez, D., Schweighauser, G., Graff-Meyer, A., Goldie, K. N., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0423-2 · Cited by 974 · see citing works
Structure-based classification of tauopathies
Shi, Y., Zhang, W., Yang, Y., Murzin, A. G., Falcon, B., Kotecha, A., van Beers, M., Tarutani, A., Kametani, F., Garringer, H. J., et al. (2021) · Nature · doi:10.1038/s41586-021-03911-7 · Cited by 878 · see citing works
“To expand our knowledge of the diversity of tau filaments in human disease, we determined the structures of tau filaments from the brains of individuals with typical and atypical PSP, GGT (Types I and II), AGD, ARTAG and MAPT intron 10 mutations (+3 and +16), as well as from the brains of individuals with FBD and FDD…”
InfluentialArendt, T., Stieler, J. T., & Holzer, M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.08.018 · Cited by 609 · see citing works
Propagation of Tau aggregates and neurodegeneration
Goedert, M., Eisenberg, D. S., & Crowther, R. A. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031153 · Cited by 632 · see citing works
Thijssen, E. H., La Joie, R., Strom, A., Fonseca, C., Iaccarino, L., Wolf, A., Spina, S., Allen, I. E., Cobigo, Y., Heuer, H., et al. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00214-3 · Cited by 607 · see citing works
Self-citationThe Neuropathology of Chronic Traumatic Encephalopathy
McKee, A. C., Stein, T. D., Kiernan, P. T., & Alvarez, V. E. (2015) · Brain Pathology · doi:10.1111/bpa.12248 · Cited by 585 · see citing works
Self-citationA systematic review of potential long-term effects of sport-related concussion.
Manley, G., Gardner, A. J., Schneider, K. J., Guskiewicz, K. M., Bailes, J., Cantu, R. C., Castellani, R. J., Turner, M., Jordan, B. D., Randolph, C., et al. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-097791 · Cited by 663 · see citing works
“68 Importantly, tau pathology and the accumulation of other altered proteins such as A β , α -synuclein and TDP-43-positive immunoreactivity occurs with human ageing and several neurodegenerative diseases, and can also be found in people who are cognitively normal 69 ; thus, it would be incorrect…”
BackgroundTau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation
Chen, Y., & Yu, Y. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02853-3 · Cited by 516 · see citing works
“In addition, tau is also present in the astrocytes of individuals with AD [144, 145].”
BackgroundAstrocytes in human central nervous system diseases: a frontier for new therapies
Verkhratsky, A., Butt, A., Li, B., Illes, P., Zorec, R., Semyanov, A., Tang, Y., & Sofroniew, M. V. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01628-9 · Cited by 428 · see citing works
“662 This latter type of astrocyte was also detected in argyrophilic grain disease, in AD and HD. 662”
BackgroundNeuropathology of Alzheimer's Disease
Trejo‐Lopez, J. A., Yachnis, A. T., & Prokop, S. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01146-y · Cited by 398 · see citing works
“The clinical relevance of ARTAG in the context of AD and other neurodegenerative diseases, as well as of ARTAG as a stand-alone pathology, still needs to be determined in systematic large cohort studies, but recently proposed standardized reporting criteria [13, 123] are an important first step towards identifying the…”
BackgroundMackenzie, I. R., & Neumann, M. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13588 · Cited by 374 · see citing works
Bieniek, K. F., Cairns, N. J., Crary, J. F., Dickson, D. W., Folkerth, R. D., Keene, C. D., Litvan, I., Perl, D. P., Stein, T. D., Vonsattel, J., et al. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab001 · Cited by 334 · see citing works
Tauopathies: new perspectives and challenges
Zhang, Y., Wu, K.-M., Yang, L., Dong, Q., & Yu, J.-T. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00533-z · Cited by 323 · see citing works
“ARTAG Aging-related tau astrogliopathy (ARTAG) mainly consists of 4R tau isoforms.”
BackgroundInfluentialKovács, G. G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020189 · Cited by 321 · see citing works
“ARTAG includes thorn-shaped astrocytes (TSA) in diverse locations (e.g., subpial, subependymal, perivascular, white and gray matter) and granular/fuzzy astrocytes (GFA) showing diffuse fine granular tau immunopositivity along astrocytic processes with dense tau immunoreactivity of the soma [110].”
BackgroundInfluentialComorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease
Spina, S., La Joie, R., Petersen, C., Nolan, A. L., Cuevas, D., Cosme, C., Hepker, M., Hwang, J.-H., Miller, Z. A., Huang, E. J., et al. (2021) · Brain · doi:10.1093/brain/awab099 · Cited by 278 · see citing works
“ARTAG was more commonly seen in LOAD cases compared to EOAD, as expected.(31) ATAC pathology has been associated with worse performance on neuropsychological scores in domains corresponding to the function of the anatomical area affected by this type of pathology.”
ResultSelf-citationDeciphering the astrocyte reaction in Alzheimer's disease
Perez-Nievas, B. G., & Serrano-Pozo, A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00114 · Cited by 282 · see citing works
TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading
Martini-Stoica, H., Cole, A. L., Swartzlander, D. B., Chen, F., Wan, Y.-W., Bajaj, L., Bader, D. A., Lee, V. M. Y., Trojanowski, J. Q., Liu, Z., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20172158 · Cited by 253 · see citing works
Mechanisms of Cell-to-Cell Transmission of Pathological Tau: A Review
Gibbons, G. S., Lee, V. M. Y., & Trojanowski, J. Q. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2018.2505 · Cited by 257 · see citing works
Ling, H., Morris, H. R., Neal, J. W., Lees, A. J., Hardy, J., Holton, J. L., Revesz, T., & Williams, D. D. R. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1680-3 · Cited by 252 · see citing works
“1 3 (PART) [10], and age-related tau astrogliopathy (ARTAG) [23].”
McKee, A. C., Stein, T. D., Huber, B. R., Crary, J. F., Bieniek, K., Dickson, D., Alvarez, V. E., Cherry, J. D., Farrell, K., Butler, M., et al. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02540-w · Cited by 244 · see citing works
“Several members of the consensus panel were involved in developing the harmonization criteria for ARTAG [58].”
BackgroundSelf-citationMolecular pathology of neurodegenerative diseases: principles and practice
Kovács, G. G. (2019) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2019-205952 · Cited by 243 · see citing works
“A further frequent finding in the ageing brain is ageing-related tau astrogliopathy (ARTAG), which describes tau-positive astrocytes in subpial, subependymal and perivascular locations, and white and grey matter.(109) Finally, due to its high societal impact, chronic traumatic encephalopathy (CTE) has to be mentioned;…”
BackgroundGaikwad, S., Puangmalai, N., Bittar, A., Montalbano, M., Garcia, S., McAllen, S., Bhatt, N., Sonawane, M., Sengupta, U., & Kayed, R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109419 · Cited by 234 · see citing works
Neuropathological criteria of anti-IgLON5-related tauopathy
Gelpí, E., Höftberger, R., Graus, F., Ling, H., Holton, J. L., Dawson, T., Popović, M., Oblak, J. P., Högl, B., Schmutzhard, E., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1591-8 · Cited by 239 · see citing works
Stratification of astrocytes in healthy and diseased brain
Verkhratsky, A., Zorec, R., & Parpura, V. (2017) · Brain Pathology · doi:10.1111/bpa.12537 · Cited by 236 · see citing works
Garwood, C. J., Ratcliffe, L. E., Simpson, J. E., Heath, P. R., Ince, P. G., & Wharton, S. B. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12338 · Cited by 233 · see citing works
Self-citation(2018) · Handbook of Clinical Neurology · doi:10.1016/b978-0-12-802395-2.00025-0 · Cited by 225 · see citing works
Self-citationRösler, T. W., Marvian, A. T., Brendel, M., Nykänen, N.-P., Höllerhage, M., Schwarz, S. C., Hopfner, F., Koeglsperger, T., Respondek, G., Schweyer, K., et al. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101644 · Cited by 219 · see citing works
Cellular and pathological heterogeneity of primary tauopathies
Chung, D. C., Roemer, S. F., Petrucelli, L., & Dickson, D. W. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00476-x · Cited by 219 · see citing works
“Reactive astrocytes are welldocumented in AD and other degenerative disorders [84, 111].”
BackgroundInfluentialRichetin, K., Steullet, P., Pachoud, M., Perbet, R., Parietti, E., Maheswaran, M., Eddarkaoui, S., Bégard, S., Pythoud, C., Rey, M. J., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00728-x · Cited by 212 · see citing works
Multiple System Atrophy: An Oligodendroglioneural Synucleinopathy
Jellinger, K. A. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170397 · Cited by 209 · see citing works
Amyloid-β and Tau at the Crossroads of Alzheimer’s Disease
Gallardo, G., & Holtzman, D. M. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9358-8_16 · Cited by 201 · see citing works
Repetitive Head Impacts and Chronic Traumatic Encephalopathy
McKee, A. C., Alosco, M. L., & Huber, B. R. (2016) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2016.05.009 · Cited by 192 · see citing works
“The group also defined supportive but nonspecific features of CTE (Box 1)(17) and determined that the diagnostic features of CTE were distinct from the age-related astrocytic p-tau pathology (ARTAG) commonly found in the white matter of the temporal lobe and basal regions of the brain.(18) ARTAG is nonspecific and non…”
Vilas, D., Iranzo, Á., TOLOSA, E. S., Aldecoa, I., Berenguer, J., Vilaseca, I., Martí, C. D., Serradell, M., Lomeña, F., Alós, L., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00080-6 · Cited by 177 · see citing works
Tau Protein and Its Role in Blood–Brain Barrier Dysfunction
Michalicová, A., Majerová, P., & Kováč, A. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.570045 · Cited by 179 · see citing works
Woerman, A. L., Aoyagi, A., Patel, S. S., Kazmi, S. A., Lobach, I. V., Grinberg, L. T., McKee, A. C., Seeley, W. W., Olson, S. H., & Prusiner, S. B. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616344113 · Cited by 174 · see citing works
“One possible source of distinct 4R aggregates in these samples is aging-related tau astrogliopathy (ARTAG), which is selectively immunostained with 4R tau antibodies, even in PiD patients (55).”
Lattanzio, F., Abu‐Rumeileh, S., Franceschini, A., Kai, H., Amore, G., Poggiolini, I., Rossi, M., Baiardi, S., McGuire, L. I., Ladogana, A., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1683-0 · Cited by 163 · see citing works
Non-Alzheimer’s contributions to dementia and cognitive resilience in The 90+ Study
Robinson, J. L., Corrada, M. M., Kovács, G. G., Dominique, M. A., Caswell, C., Xie, S. X., Lee, V. M. ‐., Kawas, C. H., & Trojanowski, J. Q. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1872-5 · Cited by 163 · see citing works
“ARTAG may originate in the medial temporal lobe in the white matter or subpial areas adjacent to the amygdala [23, 26, 43].”
“New Old Pathologies”: AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)
Nelson, P. T., Trojanowski, J. Q., Abner, E. L., Al-Janabi, O. M., Jicha, G. A., Schmitt, F. A., Smith, C. D., Fardo, D. W., Wang, W.-X., Kryscio, R. J., et al. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw033 · Cited by 158 · see citing works
Self-citationTownley, R. A., Graff-Radford, J., Mantyh, W. G., Botha, H., Polsinelli, A. J., Przybelski, S. A., Machulda, M. M., Makhlouf, A. T., Senjem, M. L., Murray, M. E., et al. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa068 · Cited by 145 · see citing works
“Aging-related tau astrogliopathy was reviewed on tau immunostained sections (Kovacs et al., 2016).”
BackgroundLee, E. B., Kinch, K., Johnson, V. E., Trojanowski, J. Q., Smith, D. H., & Stewart, W. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02030-y · Cited by 157 · see citing works
Self-citationPET Imaging of Neuroinflammation in Alzheimer’s Disease
Zhou, R., Ji, B., Kong, Y., Qin, L., Ren, W., Guan, Y., & Ni, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.739130 · Cited by 150 · see citing works
Distribution and Load of Amyloid-β Pathology in Parkinson Disease and Dementia with Lewy Bodies
Hepp, D. H., Vergoossen, D. L. E., Huisman, E., Lemstra, A. W., Bank, N. B., Berendse, H. W., Rozemüller, A. J. M., Foncke, E. M. J., & van de Berg, W. D. J. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw070 · Cited by 155 · see citing works
Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases
Jha, M. K., Kim, J.-H., Song, G. J., Lee, W., Lee, I. K., Lee, H., An, S. S. A., Kim, S., & Suk, K. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.12.003 · Cited by 149 · see citing works
Davidson, Y. S., Robinson, A., Prasher, V. P., & Mann, D. M. A. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0559-4 · Cited by 141 · see citing works
The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases
Nelson, P. T., Abner, E. L., Patel, E., Anderson, S., Wilcock, D. M., Kryscio, R. J., Eldik, L. J. V., Jicha, G. A., Gal, Z. T., Nelson, R. S., et al. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx099 · Cited by 138 · see citing works
Astroglial atrophy in Alzheimer’s disease
Verkhratsky, A., Rodriguez, J. J., Pivoriūnas, A., Zorec, R., & Semyanov, A. V. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-019-02310-2 · Cited by 140 · see citing works
“cific forms of age-associated dementia [71].”
Evolving concepts in progressive supranuclear palsy and other 4-repeat tauopathies
Stamelou, M., Respondek, G., Giagkou, N., Whitwell, J. L., Kovács, G. G., & Höglinger, G. U. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00541-5 · Cited by 143 · see citing works
Mechanobiology of the brain in ageing and Alzheimer's disease
Hall, C. M., Moeendarbary, E., & Sheridan, G. K. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14766 · Cited by 137 · see citing works
“Interestingly, depending on the brain regions affected, individuals that present with either PART or ARTAG usually display only mild or undetectable cognitive impairment.”
BackgroundInfluentialInduction of a transmissible tau pathology by traumatic brain injury
Zanier, E. R., Bertani, I., Sammali, E., Pischiutta, F., Chiaravalloti, M. A., Vegliante, G., Masone, A., Corbelli, A., Smith, D. H., Menon, D. K., et al. (2018) · Brain · doi:10.1093/brain/awy193 · Cited by 136 · see citing works
“One further TBI case, an 87-year-old male with a 5-year survival following a road traffic accident, showed clusters of P-tau immunoreactive subpial astrocytes in the medial temporal lobe, consistent with ageing-related tau astrogliopathy (Kovacs et al., 2016).”
BackgroundKovacs, G. G., Robinson, J. L., Xie, S. X., Lee, E. B., Grossman, M., Wolk, D. A., Irwin, D. J., Weintraub, D., Kim, C. F., Schuck, T., et al. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlx007 · Cited by 132 · see citing works
Kovács, G. G., Xie, S. X., Robinson, J. L., Lee, E. B., Smith, D. H., Schuck, T., Lee, V. M. ‐., & Trojanowski, J. Q. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0552-y · Cited by 133 · see citing works
“further astroglial tau pathologies such as thorn-shaped astrocytes (TSA) and granular/fuzzy astrocytes (GFA) has been emphasized and the term, aging-related tau astrogliopathy (ARTAG) has been defined [31].”
BackgroundMethodRecent advances in neuropathology, biomarkers and therapeutic approach of multiple system atrophy
Koga, S., & Dickson, D. W. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2017-315813 · Cited by 130 · see citing works
Roemer, S. F., Grinberg, L. T., Crary, J. F., Seeley, W. W., McKee, A. C., Kovács, G. G., Beach, T. G., Duyckaerts, C. J., Ferrer, I., Gelpí, E., et al. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02479-4 · Cited by 128 · see citing works
“5, online resource), including common age-related tauopathies such as AGD [27] and ARTAG [31].”
BackgroundDiversity of astroglial responses across human neurodegenerative disorders and brain aging
Ferrer, I. (2017) · Brain Pathology · doi:10.1111/bpa.12538 · Cited by 123 · see citing works
Psychosis in neurodegenerative disease: differential patterns of hallucination and delusion symptoms
Naasan, G., Shdo, S. M., Morenas‐Rodríguez, E., Spina, S., Grinberg, L. T., López, L., Karydas, A., Seeley, W. W., Miller, B. L., & Rankin, K. P. (2020) · Brain · doi:10.1093/brain/awaa413 · Cited by 124 · see citing works
“In six patients with FTLD-TDP and visual misperceptions, one had brainstem only LBD, one had an infarct in the globus pallidus, and one had argyrophilic thorny astrocyte clusters (ATAC) in the amygdala consistent with ageing-related tau astrogliopathy (ARTAG) (Kovacs et al., 2016).”
BackgroundPetersen, C., Nolan, A., Resende, E. D. P. F., Miller, Z., Ehrenberg, A. J., Gorno‐Tempini, M. L., Rosen, H. J., Kramer, J. H., Spina, S., Rabinovici, G. D., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02036-6 · Cited by 125 · see citing works
“We included ninety-four participants with a primary neuropathologic diagnosis of AD neuropathological change based on consensus criteria with varying levels of severity, and with or without argyrophilic grain disease (AGD) and age-related tau astrogliopathy [16].”
MethodConformational strains of pathogenic amyloid proteins in neurodegenerative diseases
Li, D., & Liu, C. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00603-7 · Cited by 122 · see citing works
Astroglia and Tau: New Perspectives
Kovacs, G. G. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00096 · Cited by 115 · see citing works
“Due to the morphological similarities and anatomical overlap of astrocytic inclusions in AGD and ARTAG, the bush-like astrocytes in AGD are better interpreted as GFAs (Kovacs et al., 2016).”
BackgroundInfluentialXia, Y., Prokop, S., Gorion, K.-M. M., Kim, J. D., Sorrentino, Z. A., Bell, B. M., Manaois, A. N., Chakrabarty, P., Davies, P., & Giasson, B. I. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00967-w · Cited by 114 · see citing works
“AD: Alzheimer’s disease; ADNC: Alzheimer’s disease with neuropathologic change; Aβ: Beta-amyloid; ABC: Avidin-biotin complex; ARTAG: Aging-related tau astrogliopathy; CAA: Cerebral amyloid angiopathy; CBD: Corticobasal degeneration; CSF: Cerebrospinal fluid; CTRND: Center for Translational Research in Neurodegenerativ…”
InfluentialBieniek, K. F., Blessing, M. M., Heckman, M. G., Diehl, N. N., Serie, A. M., Paolini, M. A., Boeve, B. F., Savica, R., Reichard, R. R., & Dickson, D. W. (2019) · Brain Pathology · doi:10.1111/bpa.12757 · Cited by 119 · see citing works
The neuropathology of chronic traumatic encephalopathy
McKee, A. C., Abdolmohammadi, B., & Stein, T. D. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63954-7.00028-8 · Cited by 118 · see citing works
Extracellular Monomeric Tau Is Internalized by Astrocytes
Perea, J. R., López, E., Díez-Ballesteros, J. C., Ávila, J., Hernández, F., & Bolós, M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00442 · Cited by 114 · see citing works
“, 2015; Leyns and Holtzman, 2017) and astrocytes (Kovacs et al., 2016; Ferrer et al., 2018), despite their lack of Tau expression.”
BackgroundTherapeutic strategies for the treatment of tauopathies: Hopes and challenges
Khanna, M. R., Kovalevich, J., Lee, V. M. ‐., Trojanowski, J. Q., & Brunden, K. R. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.06.006 · Cited by 112 · see citing works
“[28] Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, et al.”
BackgroundTau biology, tauopathy, traumatic brain injury, and diagnostic challenges
Castellani, R. J., & Perry, G. (2019) · Journal of Alzheimer’s Disease · doi:10.3233/jad-180721 · Cited by 110 · see citing works
Dementia with Lewy bodies: Impact of co‐pathologies and implications for clinical trial design
Toledo, J. B., Ruiz, C. A., Weil, R. S., Ferreira, D., Rodriguez‐Porcel, F. E., Pilotto, A., Wyman‐Chick, K. A., Grothe, M. J., Kane, J. P. M., Taylor, A., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12814 · Cited by 109 · see citing works
Silverberg, N. B., Elliott, C. L., Ryan, L. M., Masliah, E., & Hodes, R. J. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.03.004 · Cited by 102 · see citing works
The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease
Jembrek, M. J., Slade, N., Hof, P. R., & Šimić, G. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.05.001 · Cited by 99 · see citing works
Iverson, G. L., Gardner, A. J., Shultz, S. R., Solomon, G. S., McCrory, P. R., ZAFONTE, R. D., Perry, G. L., Hazrati, L., Keene, C. D., & Castellani, R. J. (2019) · Brain · doi:10.1093/brain/awz286 · Cited by 99 · see citing works
“ependymal, and perivascular), in individuals with or without cognitive problems (Kovacs et al., 2016).”
BackgroundInfluentialCurrent Concepts of Mixed Pathologies in Neurodegenerative Diseases
Forrest, S. L., & Kovács, G. G. (2022) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2022.34 · Cited by 99 · see citing works
“56 Identification of five ARTAG types including grey and white matter, perivascular, subpial (Figure 2) and subependymal, characterised by two astrocytic morphologies: 1) thorn-shaped and/or 2) granular fuzzy astrocytes.”
Reid, M. J., Beltran-Lobo, P., Johnson, L., Perez‐Nievas, B. G., & Noble, W. J. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.572850 · Cited by 92 · see citing works
Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy
Chornenkyy, Y., Fardo, D. W., & Nelson, P. T. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0196-y · Cited by 93 · see citing works
Self-citationClassification of diseases with accumulation of Tau protein
Kovács, G. G., Ghetti, B. F., & Goedert, M. (2022) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12792 · Cited by 92 · see citing works
“• Aging-related Tau astrogliopathy (ARTAG) [74]”
InfluentialProtein astrogliopathies in human neurodegenerative diseases and aging
Kovács, G. G., Lee, V. M., & Trojanowski, J. Q. (2017) · Brain Pathology · doi:10.1111/bpa.12536 · Cited by 89 · see citing works
Sánchez‐Juan, P., Valeriano-Lorenzo, E., Ruiz-González, A., Pastor, A. B., Lara, H. R., López-González, F., Zea‐Sevilla, M. A., Valentí, M., Payo, B. F., Ruiz, P., et al. (2024) · Brain · doi:10.1093/brain/awae035 · Cited by 89 · see citing works
“32 The latter was registered as present or absent, both in the medial temporal lobe and the cerebral neocortex/yuxtacortical white matter.”
BackgroundNeuropathology of Dementia Disorders
Schneider, J. A. (2022) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001137 · Cited by 88 · see citing works
Thal, D. R., & Tomé, S. O. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.10.006 · Cited by 85 · see citing works
Neuropathological assessment of the Alzheimer spectrum
Jellinger, K. A. (2020) · Journal of Neural Transmission · doi:10.1007/s00702-020-02232-9 · Cited by 82 · see citing works
Omalu, B. I., Small, G. W., Bailes, J. E., Ercoli, L. M., Merrill, D. A., Wong, K. P., Huang, S., Satyamurthy, N., Hammers, J., Lee, J., et al. (2017) · Neurosurgery · doi:10.1093/neuros/nyx536 · Cited by 82 · see citing works
Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study
Iida, M. A., Farrell, K. W., Walker, J. M., Richardson, T. E., Marx, G. A., Bryce, C., Purohit, D. P., Ayalon, G., Beach, T. G., Bigio, E. H., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01233-3 · Cited by 78 · see citing works
Involvement of Oligodendrocytes in Tau Seeding and Spreading in Tauopathies
Ferrer, I., Aguiló, M., Carmona, M., Andrés‐Benito, P., Torrejón-Escribano, B., Garcia‐Esparcia, P., & del Rı́o, J. A. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00112 · Cited by 76 · see citing works
“Cases were categorized and selected following well-established neuropathological criteria (Braak et al., 2006; Dickson et al., 2011; Muñoz et al., 2011; Ahmed et al., 2013; Crary et al., 2014; Kovacs et al., 2016; Borrego-Écija et al., 2017) excluding cases with combined pathologies (excepting discrete small blood ves…”
MethodYoshida, K., Hata, Y., Kinoshita, K., Takashima, S., Tanaka, K., & Nishida, N. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1665-7 · Cited by 78 · see citing works
Aging‐related tau astrogliopathy (ARTAG): not only tau phosphorylation in astrocytes
Ferrer, I., Aguiló, M., González, I. L., Lucena, D. D., Roig, A., Carmona, M., Llorens, F., Garcia‐Esparcia, P., Martínez-Maldonado, A., Frau‐Méndez, M. A., et al. (2018) · Brain Pathology · doi:10.1111/bpa.12593 · Cited by 75 · see citing works
“3 Introduction Aging-related tau astrogliopathy (ARTAG) is defined by the presence of two types of tau-bearing astrocytes: thorn-shaped astrocytes (TSAs) and granular/fuzzy astrocytes (GFAs) in the brain of old-aged individuals (28).”
BackgroundResultMapping of SARS-CoV-2 Brain Invasion and Histopathology in COVID-19 DiseasePreprint
Serrano, G. E., Walkera, J., Arce, R., Glass, M. J., Vargas, D., Sue, L. I., Intorcia, A. J., Nelson, C. M., Oliver, J., Papa, J. D., et al. (2021) · medRxiv · doi:10.1101/2021.02.15.21251511 · Cited by 81 · see citing works
The Neuropathology of Chronic Traumatic Encephalopathy: The Status of the Literature
McKee, A. C. (2020) · Seminars in Neurology · doi:10.1055/s-0040-1713632 · Cited by 77 · see citing works
Astrocytic propagation of Tau in the context of Alzheimer's disease
Fleeman, R. M., & Proctor, E. A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.645233 · Cited by 75 · see citing works
“While 3R and 4R tau are both found in neuronal tau pathology in the AD brain, studies describing ARTAG in AD report mainly 4R tau pathology in astrocytes (Ferrer et al., 2014; Kovacs et al., 2016; Kovacs, 2020).”
BackgroundResultA critical appraisal of tau‐targeting therapies for primary and secondary tauopathies
Imbimbo, B. P., Ippati, S., Watling, M., & Balducci, C. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12453 · Cited by 72 · see citing works
Moloney, C. M., Labuzan, S. A., Crook, J. E., Siddiqui, H., Castanedes‐Casey, M., Lachner, C., Petersen, R. C., Duara, R., Graff‐Radford, N. R., Dickson, D. W., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12749 · Cited by 74 · see citing works
Arena, J. D., Smith, D. H., Lee, E. B., Gibbons, G. S., Irwin, D. J., Robinson, J. L., Lee, V. M. ‐., Trojanowski, J. Q., Stewart, W. B., Jr., & Johnson, V. E. (2020) · Brain · doi:10.1093/brain/awaa071 · Cited by 73 · see citing works
“In addition, non-demented control cases without history of TBI and with known ageing-related tau pathologies were selected including: PART (n = 1), ARTAG and PART (n = 3) and ARTAG with low Alzheimer’s disease neuropathological change (n = 4) (Cairns et al., 2007; Montine et al., 2012; Crary et al., 2014; Kovacs et al…”
BackgroundMethodResultInfluentialThe Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features
Iverson, G. L., Keene, C. D., Perry, G., & Castellani, R. J. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-170654 · Cited by 72 · see citing works
Cellular and regional vulnerability in frontotemporal tauopathies
Forrest, S. L., Kril, J. J., & Halliday, G. M. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02035-7 · Cited by 71 · see citing works
Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer’s disease
Initiative, A. D. N., Tissot, C., Benedet, A. L., Therriault, J., Pascoal, T. A., Lussier, F. Z., Saha‐Chaudhuri, P., Chamoun, M., Savard, M., Mathotaarachchi, S. S., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00802-x · Cited by 72 · see citing works
“In WM, tau hyperphosphorylation can potentially come from glia or merely be associated to GM tau [27].”
BackgroundChronic traumatic encephalopathy-like abnormalities in a routine neuropathology service
Noy, S., Krawitz, S., & Del Bigio, M. R. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw092 · Cited by 70 · see citing works
“Tau hyperphosphorylation may be a nonspecific response to damage; it also occurs in the context of hypoglycemia, hypoxia, stroke, and normal aging (21, 31).”
BackgroundAstrocytic Tau Deposition Is Frequent in Typical and Atypical Alzheimer Disease Presentations
Nolan, A., Resende, E. D. P. F., Petersen, C., Neylan, K. D., Spina, S., Huang, E. J., Seeley, W. W., Miller, Z., & Grinberg, L. T. (2019) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlz094 · Cited by 69 · see citing works
“Astrocytic tau deposits were classified according to the recent harmonized evaluation strategy (12).”
Backgroundde Ruyter, F. J. H., Morrema, T. H. J., den Haan, J., Bank, N. B., Twisk, J. W. R., de Boer, J. F., Scheltens, P., Boon, B. D. C., Thal, D. R., Rozemüller, A. J. M., et al. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02525-1 · Cited by 68 · see citing works
“1 3 as primary age-related tauopathy (PART) [5] and agingrelated tau astrogliopathy (ARTAG) [6].”
BackgroundInfluentialTau pathology in Creutzfeldt‐Jakob disease revisited
Kovács, G. G., Rahimi, J., Ströbel, T., Lutz, M. I., Regelsberger, G., Streichenberger, N., Perret‐Liaudet, A., Höftberger, R., Liberski, P. P., Budka, H., et al. (2016) · Brain Pathology · doi:10.1111/bpa.12411 · Cited by 68 · see citing works
Cognitive trajectories and spectrum of neuropathology in S uper A gers: The first 10 cases
Rogalski, E. J., Gefen, T. D., Mao, Q., Connelly, M., Weıntraub, S., Geula, C., Bigio, E. H., & Mesulam, M. M. (2018) · Hippocampus · doi:10.1002/hipo.22828 · Cited by 67 · see citing works
“Aging-related tau astrogliopathy (ARTAG), another common feature in individuals over 60 years old (Kovacs et al., 2016), was present in each of the 10 SuperAging cases.”
BackgroundJosephs, K. A., Mackenzie, I., Frosch, M. P., Bigio, E. H., Neumann, M., Arai, T., Dugger, B. N., Ghetti, B., Grossman, M., Hasegawa, M., et al. (2019) · Brain · doi:10.1093/brain/awz224 · Cited by 66 · see citing works
Lebouvier, T., Pasquier, F., & Buée, L. (2017) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000502 · Cited by 68 · see citing works
- Authors
- Kovacs, G. G., Ferrer, I., Grinberg, L. T., Alafuzoff, I., Attems, J., Budka, H., Cairns, N. J., Crary, J. F., Duyckaerts, C., Ghetti, B., Halliday, G. M., Ironside, J. W., Love, S., Mackenzie, I. R., Munoz, D. G., Murray, M. E., Nelson, P. T., Takahashi, H., Trojanowski, J. Q., Ansorge, O., Arzberger, T., Baborie, A., Beach, T. G., Bieniek, K. F., Bigio, E. H., Bodi, I., Dugger, B. N., Feany, M., Gelpi, E., Gentleman, S. M., Giaccone, G., Hatanpaa, K. J., Heale, R., Hof, P. R., Hofer, M., Hortobágyi, T., Jellinger, K., Jicha, G. A., Ince, P., Kofler, J., Kövari, E., Kril, J. J., Mann, D. M., Matej, R., McKee, A. C., McLean, C., Milenkovic, I., Montine, T. J., Murayama, S., Lee, E. B., Rahimi, J., Rodriguez, R. D., Rozemüller, A., Schneider, J. A., Schultz, C., Seeley, W., Seilhean, D., Smith, C., Tagliavini, F., Takao, M., Thal, D. R., Toledo, J. B., Tolnay, M., Troncoso, J. C., Vinters, H. V., Weis, S., Wharton, S. B., White, C. L., Wisniewski, T., Woulfe, J. M., Yamada, M., & Dickson, D. W.
- Affiliations
- Universidade de São Paulo (BR)
- Uppsala University (SE)
- Newcastle University (GB)
- University Hospital Zurich (CH)
- Washington University in St. Louis (US)
- Icahn School of Medicine at Mount Sinai (US)
- Sorbonne Université (FR)
- Indiana University School of Medicine (US)
- UNSW Sydney (AU)
- University of Edinburgh (GB)
- Southmead Hospital (GB)
- University of British Columbia (CA)
- Mayo Clinic (US)
- University of Kentucky (US)
- Brain Research Institute, Niigata University (JP)
- University of Pennsylvania (US)
- John Radcliffe Hospital (GB)
- Institut für Neuropathologie (DE)
- Walton Centre (GB)
- Banner Sun Health Research Institute (US)
- Northwestern University (US)
- University of California, San Francisco (US)
- Brigham and Women's Hospital (US)
- Imperial College London (GB)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- The University of Texas Southwestern Medical Center (US)
- University of Debrecen (HU)
- University of Sheffield (GB)
- University of Pittsburgh (US)
- The University of Sydney (AU)
- University of Manchester (GB)
- Boston University (US)
- The Alfred Hospital (AU)
- University of Washington (US)
- Tokyo Metropolitan Institute of Gerontology (JP)
- Vienna General Hospital (AT)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Rush University Medical Center (US)
- Heidelberg University (DE)
- Saitama International Medical Center (JP)
- Universität Ulm (DE)
- University Hospital of Basel (CH)
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- Johannes Kepler University of Linz (AT)
- University of Ottawa (CA)
- Kanazawa University (JP)
- Corresponding author
- Dickson, Dennis W.
- ORCID
- Grinberg, Lea T.
- Alafuzoff, Irina
- Attems, Johannes
- Budka, Herbert
- Cairns, Nigel J.
- Crary, John F.
- Duyckaerts, Charles
- Ghetti, Bernardino
- Halliday, Glenda M.
- Ironside, James W.
- Love, Seth
- Mackenzie, Ian R.
- Murray, Melissa E.
- Nelson, Peter T.
- Takahashi, Hitoshi
- Trojanowski, John Q.
- Ansorge, Olaf
- Arzberger, Thomas
- Beach, Thomas G.
- Bieniek, Kevin F.
- Bigio, Eileen H.
- Dugger, Brittany N.
- Feany, Mel
- Giaccone, Giorgio
- Hatanpaa, Kimmo J.
- Heale, Richard
- Hof, Patrick R.
- Hofer, Monika
- Hortobágyi, Tibor
- Jellinger, Kurt
- Jicha, Gregory A.
- Ince, Paul
- Kofler, Julia
- Kril, Jillian J.
- Mann, David M.
- McKee, Ann C.
- McLean, Catriona
- Montine, Thomas J.
- Murayama, Shigeo
- Lee, Edward B.
- Rodriguez, Roberta D.
- Rozemüller, Annemieke
- Schneider, Julie A.
- Schultz, Christian
- Seeley, William
- Seilhean, Danielle
- Smith, Colin
- Tagliavini, Fabrizio
- Takao, Masaki
- Thal, Dietmar Rudolf
- Toledo, Jon B.
- Tolnay, Markus
- Troncoso, Juan C.
- Vinters, Harry V.
- Weis, Serge
- Wharton, Stephen B.
- White, Charles L.
- Woulfe, John M.
- Yamada, Masahito
- Dickson, Dennis W.
- Venue
- Acta Neuropathologica
- Published
- 2015-12-10
- Volume
- 131
- Issue
- 1
- Pages
- 87-102
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC4879001
- OpenAlex
- W2195527239
- Cited by
- 532
- References
- 69
- Citations by year
- 2026: 37 · 2025: 49 · 2024: 66 · 2023: 48 · 2022: 57 · 2021: 56 · 2020: 54 · 2019: 51 · 2018: 49 · 2017: 38 · 2016: 25 · 2015: 1
- FWCI
- 27.47
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Explore Bristol Research (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Bristol Research (University of Bristol) (submittedVersion, other-oa)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, other-oa)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
- Lirias (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Purdue University Indianapolis (Indiana University) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- FP7 EU Project (Develage No. 278486)
- National Institutes of Health (NIH P30 AG10133, R01 AG040311, P01 AG019724-03, P50 AG023501, AG010124, AG017586, P50 AG005138, AG028383, P50AG05146, grants P50 AG05136 and P50 NS062684, P50 AG016574 and P50 NS072187)
- NIA Grant (P50 AG05681, P01 AG03991)
- Nelson Family Foundation
- Alzheimer’s Research UK
- Alzheimer's Society, National Institute for Health Research
- Medical Research Council (G0400074, MR/L016400/1, MR/L016400/1 Edinburgh Brain Bank)
- National Health and Medical Research Council of Australia (Senior Principal Research Fellow (#630434))
- Grant Agency of Ministry of Health of Czech Republic (IGA NT12094-5)
- NIA P50 (P50 AG005133)
- National Institute of Neurological Disorders and Stroke (1U01NS086659-01)
- National Institute of Aging Boston University Alzheimer’s Disease Center (P30AG13846; supplement 0572063345–5)
- MRC (MC-PC-13044)
- National Brain Research Program, Hungary (KTIA_13_NAP-A-II/7)
- Grant-in-Aid (KAKEN 26250017)
- NIH (P30AG12300)
- DFG Grant (SFB 1134/A03)
- Alzheimer's Disease Core Center (P30AG008051-26)
- Grant (AG13854)
- JSPS KAKENHI (26430060)
- Italian Ministry of Health
- Vienna KIN-Neurobiobank and VITA–study
- France Alzheimer, France Parkinson, Fondacion ARSEP and CSC (GIE NeuroCEB)
- Neuroscience Research Australia and the University of New South Wales (Sydney Brain Bank)
- Sheffield and Cambridge Brain Banks (Brain Banks)
- Parkinson's UK (Parkinson's UK Tissue Bank at Imperial College)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- tau phosphorylation, astrocytes, glia limitans, white matter, gray matter, primary tauopathies, nomenclature, brain aging, clinical biomarkers
- MeSH terms
- Aging, Animals, Astrocytes, Brain, Humans, Neuroglia, tau Proteins, Tauopathies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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