Dwork, Andrew J.

Global epigenomic reconfiguration during mammalian brain development

Lister, R., Mukamel, E. A., Nery, J. R., Urich, M., Puddifoot, C. A., Johnson, N. D., Lucero, J., Huang, Y., Dwork, A. J., Schultz, M. D., et al. (2013) · Science

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 1,830

Human Hippocampal Neurogenesis Persists throughout Aging

Boldrini, M., Fulmore, C. A., Tartt, A. N., Simeon, L. R., Pavlova, I., Poposka, V., Rosoklija, G. B., Stankov, A., Arango, V., Dwork, A. J., et al. (2018) · Cell Stem Cell

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 1,345

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

Tang, G., Gudsnuk, K., Kuo, S.-H., Cotrina, M. L., Rosoklija, G., Sosunov, A., Sonders, M. S., Kanter, E., Castagna, C., Yamamoto, A., et al. (2014) · Neuron

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 1,146

Antidepressants increase neural progenitor cells in the human hippocampus

Boldrini, M., Underwood, M. D., Hen, R., Rosoklija, G. B., Dwork, A. J., John Mann, J., & Arango, V. (2009) · Neuropsychopharmacology

Neurogenesis and neuroplasticity mechanismsTreatment of Major Depression

Cited by 686

A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide

Mann, J. J., Huang, Y.-Y., Underwood, M. D., Kassir, S. A., Oppenheim, S., Kelly, T. M., Dwork, A. J., & Arango, V. (2000) · Archives of General Psychiatry

Neurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

Cited by 613

Spatial epigenome–transcriptome co-profiling of mammalian tissues

Zhang, D., Deng, Y., Kukanja, P., Agirre, E., Bartosovic, M., Dong, M., Ma, C., Ma, S., Su, G., Bao, S., et al. (2023) · Nature

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 483

Spatial profiling of chromatin accessibility in mouse and human tissues

Deng, Y., Bartosovic, M., Ma, S., Zhang, D., Kukanja, P., Xiao, Y., Su, G., Liu, Y., Qin, X., Rosoklija, G. B., et al. (2022) · Nature

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 417

Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression

Boldrini, M., Santiago, A. N., Hen, R., Dwork, A. J., Rosoklija, G. B., Tamir, H., Arango, V., & John Mann, J. (2013) · Neuropsychopharmacology

Treatment of Major DepressionStress Responses and Cortisol

Cited by 361

Hippocampal Angiogenesis and Progenitor Cell Proliferation Are Increased with Antidepressant Use in Major Depression

Boldrini, M., Hen, R., Underwood, M. D., Rosoklija, G. B., Dwork, A. J., Mann, J. J., & Arango, V. (2012) · Biological Psychiatry

Neurogenesis and neuroplasticity mechanismsTreatment of Major Depression

Cited by 348

Synaptic and plasticity-associated proteins in anterior frontal cortex in severe mental illness

Honer, W. G., Falkai, P., Chen, C., Arango, V., Mann, J. J., & Dwork, A. J. (1999) · Neuroscience

Schizophrenia research and treatmentNeuroscience and Neuropharmacology Research

Cited by 244

Necessity of hippocampal neurogenesis for the therapeutic action of antidepressants in adult nonhuman primates

Perera, T. D., Dwork, A. J., Keegan, K. A., Thirumangalakudi, L., Lipira, C. M., Joyce, N., Lange, C., Higley, J. D., Rosoklija, G., Hen, R., et al. (2011) · PLoS ONE

Neurogenesis and neuroplasticity mechanismsTreatment of Major Depression

Cited by 244

Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity

Pantazatos, S. P., Huang, Y.-Y., Rosoklija, G. B., Dwork, A. J., Arango, V, & Mann, J. J. (2017) · Molecular Psychiatry

Treatment of Major DepressionSuicide and Self-Harm Studies

Cited by 229

Microglia of Prefrontal White Matter in Suicide

Schnieder, T. P., Trencevska, I., Rosoklija, G., Stankov, A., Mann, J. J., Smiley, J., & Dwork, A. J. (2014) · Journal of Neuropathology & Experimental Neurology

Neuroinflammation and Neurodegeneration MechanismsSuicide and Self-Harm Studies

Cited by 202

Mitochondrial abnormalities in temporal lobe of autistic brain

Tang, G., Gutierrez Rios, P., Kuo, S.-H., Akman, H. O., Rosoklija, G., Tanji, K., Dwork, A., Schon, E. A., DiMauro, S., Goldman, J., et al. (2013) · Neurobiology of Disease

Autism Spectrum Disorder ResearchMitochondrial Function and Pathology

Cited by 194

Type III Neuregulin-1 Is Required for Normal Sensorimotor Gating, Memory-Related Behaviors, and Corticostriatal Circuit Components

Chen, Y.-J. J., Johnson, M. A., Lieberman, M. D., Goodchild, R. E., Schobel, S., Lewandowski, N., Rosoklija, G., Liu, R.-C., Gingrich, J. A., Small, S., et al. (2008) · Journal of Neuroscience

Schizophrenia research and treatmentNeuroscience and Neuropharmacology Research

Cited by 188

Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide

Youssef, M. M., Underwood, M. D., Huang, Y.-Y., Hsiung, S.-C., Liu, Y., Simpson, N. R., Bakalian, M. J., Rosoklija, G. B., Dwork, A. J., Arango, V., et al. (2018) · International Journal of Neuropsychopharmacology

Treatment of Major DepressionSuicide and Self-Harm Studies

Cited by 183

Serotonin receptors and suicide, major depression, alcohol use disorder and reported early life adversity

Underwood, M. D., Kassir, S. A., Bakalian, M. J., Galfalvy, H., Dwork, A. J., Mann, J. J., & Arango, V. (2018) · Translational Psychiatry

Neurotransmitter Receptor Influence on BehaviorSuicide and Self-Harm Studies

Cited by 128

Resilience Is Associated With Larger Dentate Gyrus, While Suicide Decedents With Major Depressive Disorder Have Fewer Granule Neurons

Boldrini, M., Galfalvy, H., Dwork, A. J., Rosoklija, G. B., Trencevska-Ivanovska, I., Pavlovski, G., Hen, R., Arango, V., & Mann, J. J. (2019) · Biological Psychiatry

Neurogenesis and neuroplasticity mechanismsStress Responses and Cortisol

Cited by 116

Increased DNA methylation in the suicide brain

Haghighi, F., Xin, Y., Chanrion, B., O'Donnell, A. H., Ge, Y., Dwork, A. J., Arango, V., & Mann, J. J. (2014) · Dialogues in Clinical Neuroscience

Epigenetics and DNA MethylationSuicide and Self-Harm Studies

Cited by 101

A pilot integrative genomics study of GABA and glutamate neurotransmitter systems in suicide, suicidal behavior, and major depressive disorder

Yin, H., Pantazatos, S. P., Galfalvy, H., Huang, Y., Rosoklija, G. B., Dwork, A. J., Burke, A., Arango, V., Oquendo, M. A., & Mann, J. J. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Suicide and Self-Harm StudiesTreatment of Major Depression

Cited by 91

A pilot genome wide association and gene expression array study of suicide with and without major depression

Galfalvy, H., Zalsman, G., Huang, Y.-Y., Murphy, L., Rosoklija, G., Dwork, A. J., Haghighi, F., Arango, V., & Mann, J. J. (2013) · The World Journal of Biological Psychiatry

Suicide and Self-Harm StudiesGenetic Associations and Epidemiology

Cited by 77

Considerations for Assessing the Extent of Hippocampal Neurogenesis in the Adult and Aging Human Brain

Tartt, A. N., Fulmore, C. A., Liu, Y., Rosoklija, G. B., Dwork, A. J., Arango, V., Hen, R., Mann, J. J., & Boldrini, M. (2018) · Cell Stem Cell

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 69

GLUCOCORTICOID RECEPTOR-RELATED GENES: GENOTYPE AND BRAIN GENE EXPRESSION RELATIONSHIPS TO SUICIDE AND MAJOR DEPRESSIVE DISORDER: Research Article: Glucocorticoid Receptor-Related Genes and Suicide

Yin, H., Galfalvy, H., Pantazatos, S. P., Huang, Y.-Y., Rosoklija, G. B., Dwork, A. J., Burke, A., Arango, V., Oquendo, M. A., & Mann, J. J. (2016) · Depression and Anxiety

Genetic Associations and EpidemiologySuicide and Self-Harm Studies

Cited by 57

Early life stress and macaque amygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene

Coplan, J. D., Fathy, H. M., Jackowski, A. P., Tang, C. Y., Perera, T. D., Mathew, S. J., Martinez, J., Abdallah, C. G., Dwork, A. J., Pantol, G., et al. (2014) · Frontiers in Behavioral Neuroscience

Stress Responses and CortisolChild Abuse and Trauma

Cited by 47