Cited by 149Cell death mechanisms and regulationNF-κB Signaling PathwaysGene Regulatory Network Analysis

Surviving apoptosis: life–death signaling in single cells

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Flusberg, Deborah A., Sorger, Peter K.·2015·Trends in Cell Biology

Abstract

Tissue development and homeostasis are regulated by opposing pro-survival and pro-death signals. An interesting feature of the Tumor Necrosis Factor (TNF) family of ligands is that they simultaneously activate opposing signals within a single cell via the same ligand-receptor complex. The magnitude of pro-death events such as caspase activation and pro-survival events such as Nuclear Factor (NF)-κB activation vary not only from one cell type to the next but also among individual cells of the same type due to intrinsic and extrinsic noise. The molecules involved in these pro-survival and/or pro-death pathways, and the different phenotypes that result from their activities, have been recently reviewed. Here we focus on the impact of cell-to-cell variability in the strength of these opposing signals on shaping cell fate decisions.

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Crossref · 10.1016/j.tcb.2015.03.003

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Authors
Flusberg, D. A., & Sorger, P. K.
Affiliations
Harvard University (US)
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2015-08
Volume
25
Issue
8
Pages
446-458
ISSN
0962-8924 (ISSN-L)
OpenAlex
W2062880004
Cited by
149
References
186
Citations by year
2026: 9 · 2025: 4 · 2024: 11 · 2023: 8 · 2022: 14 · 2021: 10 · 2020: 18 · 2019: 13 · 2018: 22 · 2017: 16 · 2016: 19 · 2015: 5
FWCI
2.00
Type
journal article
Language
en
Open access
Locations
  • Trends in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (P01CA139980)
  • National Institute of General Medical Sciences (P50GM107618)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords
apoptosis, TNF family ligands, NF-κB activation, caspase activation, cell-to-cell variability, cell fate determination, receptor-ligand complex
MeSH terms
Animals, Cell Survival, Humans, Signal Transduction, Cell Death, Apoptosis, Receptors, Death Domain, TNF-Related Apoptosis-Inducing Ligand

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