Surviving apoptosis: life–death signaling in single cells
Open accessAbstract
Tissue development and homeostasis are regulated by opposing pro-survival and pro-death signals. An interesting feature of the Tumor Necrosis Factor (TNF) family of ligands is that they simultaneously activate opposing signals within a single cell via the same ligand-receptor complex. The magnitude of pro-death events such as caspase activation and pro-survival events such as Nuclear Factor (NF)-κB activation vary not only from one cell type to the next but also among individual cells of the same type due to intrinsic and extrinsic noise. The molecules involved in these pro-survival and/or pro-death pathways, and the different phenotypes that result from their activities, have been recently reviewed. Here we focus on the impact of cell-to-cell variability in the strength of these opposing signals on shaping cell fate decisions.
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Extrinsic apoptosis is an RCD modality initiated by perturbations of the extracellular microenvironment.
“Extrinsic apoptosis is an RCD modality initiated by perturbations of the extracellular microenvironment [265–268].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [266]
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- Authors
- Flusberg, D. A., & Sorger, P. K.
- Affiliations
- Harvard University (US)
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 25
- Issue
- 8
- Pages
- 446-458
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC4570028
- OpenAlex
- W2062880004
- Cited by
- 149
- References
- 186
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 11 · 2023: 8 · 2022: 14 · 2021: 10 · 2020: 18 · 2019: 13 · 2018: 22 · 2017: 16 · 2016: 19 · 2015: 5
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (P01CA139980)
- National Institute of General Medical Sciences (P50GM107618)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- apoptosis, TNF family ligands, NF-κB activation, caspase activation, cell-to-cell variability, cell fate determination, receptor-ligand complex
- MeSH terms
- Animals, Cell Survival, Humans, Signal Transduction, Cell Death, Apoptosis, Receptors, Death Domain, TNF-Related Apoptosis-Inducing Ligand
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