Lu, Ake T.

An epigenetic biomarker of aging for lifespan and healthspan

Levine, M. E., Lu, A. T., Quach, A., Chen, B. H., Assimes, T. L., Bandinelli, S., Hou, L., Baccarelli, A. A., Stewart, J. D., Li, Y., et al. (2018) · Aging

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 3,675

DNA methylation GrimAge strongly predicts lifespan and healthspan

Lu, A. T., Quach, A., Wilson, J. G., Reiner, A. P., Aviv, A., Raj, K., Hou, L., Baccarelli, A. A., Li, Y., Stewart, J. D., et al. (2019) · Aging

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 2,540

DNA methylation-based measures of biological age: meta-analysis predicting time to death

Chen, B. H., Marioni, R. E., Colicino, E., Peters, M. J., Ward-Caviness, C. K., Tsai, P.-C., Roetker, N. S., Just, A. C., Demerath, E. W., Guan, W., et al. (2016) · Aging

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 1,126

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

Horvath, S., Oshima, J., Martin, G. M., Lu, A. T., Quach, A., Cohen, H., Felton, S., Matsuyama, M., Lowe, D., Kabacik, S., et al. (2018) · Aging

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 815

Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

Quach, A., Levine, M. E., Tanaka, T., Lu, A. T., Chen, B. H., Ferrucci, L., Ritz, B., Bandinelli, S., Neuhouser, M. L., Beasley, J. M., et al. (2017) · Aging

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 801

GrimAge Outperforms Other Epigenetic Clocks in the Prediction of Age-Related Clinical Phenotypes and All-Cause Mortality

McCrory, C., Fiorito, G., Hernandez, B., Polidoro, S., O’Halloran, A. M., Hever, A., Ni Cheallaigh, C., Lu, A. T., Horvath, S., Vineis, P., et al. (2021) · The Journals of Gerontology: Series A

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 464

Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning

Levine, M. E., Lu, A. T., Bennett, D. A., & Horvath, S. (2015) · Aging

Dementia and Cognitive Impairment ResearchEpigenetics and DNA Methylation

Cited by 455

DNA methylation-based estimator of telomere length

Lu, A. T., Seeboth, A., Tsai, P.-C., Sun, D., Quach, A., Reiner, A. P., Kooperberg, C., Ferrucci, L., Hou, L., Baccarelli, A. A., et al. (2019) · Aging

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 440

Biological age is increased by stress and restored upon recovery

Poganik, J. R., Zhang, B., Baht, G. S., Tyshkovskiy, A., Deik, A., Kerepesi, C., Yim, S. H., Lu, A. T., Haghani, A., Gong, T., et al. (2023) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 246

The cerebellum ages slowly according to the epigenetic clock

Horvath, S., Mah, V., Lu, A. T., Woo, J. S., Choi, O.-W., Jasinska, A. J., Riancho, J. A., Tung, S., Coles, N. S., Braun, J., et al. (2015) · Aging

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 191

Multi-omic rejuvenation and lifespan extension on exposure to youthful circulation

Zhang, B., Lee, D. E., Trapp, A., Tyshkovskiy, A., Lu, A. T., Bareja, A., Kerepesi, C., McKay, L. K., Shindyapina, A. V., Dmitriev, S. E., et al. (2023) · Nature Aging

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 134

DNA methylation networks underlying mammalian traits

Haghani, A., Li, C. Z., Robeck, T. R., Zhang, J., Lu, A. T., Ablaeva, J., Acosta-Rodríguez, V. A., Adams, D. M., Alagaili, A. N., Almunia, J., et al. (2023) · Science

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 128

Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons

Reid, D. A., Reed, P. J., Schlachetzki, J. C. M., Nitulescu, I. I., Chou, G., Tsui, E. C., Jones, J. R., Chandran, S., Lu, A. T., McClain, C. A., et al. (2021) · Science

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 121

Allowing for sex differences increases power in a GWAS of multiplex Autism families

Lu, A. T.-H., & Cantor, R. M. (2012) · Molecular Psychiatry

Autism Spectrum Disorder ResearchGenetic Associations and Epidemiology

Cited by 51

Umbilical cord plasma concentrate has beneficial effects on DNA methylation GrimAge and human clinical biomarkers

Clement, J., Yan, Q., Agrawal, M., Coronado, R. E., Sturges, J. A., Horvath, M., Lu, A. T., Brooke, R. T., & Horvath, S. (2022) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 34

Divergent age-related methylation patterns in long and short-lived mammals

Haghani, A., Wang, N., Lu, A. T., Mozhui, K., Mammalian Methylation Consortium, Raj, K., Yang, X. W., & Horvath, S. (2022) · bioRxiv (Cold Spring Harbor Laboratory)

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 9